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Pharmaceutical Drug Allergens

  • A. J. Bircher

Abstract

With few exceptions, such as peptides and hormones, drugs and their precursors are typically low-molecular-weight compounds and, therefore, haptens. To build a complete antigen, they must bind to macromolecules e.g. human tissue or serum proteins. Some drugs are primarily reactive while, in others, reactive metabolites are only generated in vivo. Oral administration is usually better tolerated and may even induce tolerance. However, intermittent exposure by epi- or intradermal application or by inhalation, as it typically occurs in occupational settings, carries the highest risk of sensitization (Bircher 1996).

Keywords

Contact Dermatitis Alopecia Areata Contact Urticaria Squaric Acid Occupational Contact 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alomar A, Puig L, Vilaltella I (1987) Allergic contact dermatitis due to ranitidine. Contact Dermatitis 17:54–55PubMedGoogle Scholar
  2. Altomare GF, Capella GL, Veraldi S (1992) Occupational drug dermatitis. Clin Dermatol 10:141–147PubMedGoogle Scholar
  3. Ancona A (1985) Allergic contact dermatitis to nitrofurazone. Contact Dermatitis 13:35PubMedGoogle Scholar
  4. Arevalo A, Blancas R, Ancona A (1995) Occupational contact dermatitis from piroxicam. Am J Contact Dermat 6:113–114Google Scholar
  5. Barbaud A, Trechot P, Bertrand O, Schmutz JL (1995) Occupational allergy to propacetamol. Lancet 346:902PubMedGoogle Scholar
  6. Barberda E, De la Cuadra J (1989) Occupational airborne allergic contact dermatitis from tylosin. Contact Dermatitis 20:308Google Scholar
  7. Barriga A, Romaguera C, Vilaplana J (1992) Contact dermatitis from avoparcin. Contact Dermatitis 27:115PubMedGoogle Scholar
  8. Bause GS, Kugelman LC (1990) Contact anaphylactoid response to labetalol. Contact Dermatitis 23:51PubMedGoogle Scholar
  9. Belsito DV (1993) Contact urticaria from pentamidine isethionate. Contact Dermatitis 29:158PubMedGoogle Scholar
  10. Benyoussef K, Bottlaender A, Pfister HR, Caussade P, Heid E, Grosshans E (1996) Allergic contact dermatitis from mesna. Contact Dermatitis 34:228–229PubMedGoogle Scholar
  11. Bernstein JA, Stauder T, Bernstein DI, Bernstein IL (1994) A combined respiratory and cutaneous hypersensitivity syndrome induced by work exposure to quaternary amines. J Allergy Clin Immunol 94:257–259PubMedGoogle Scholar
  12. Bircher AJ (1996) Arzneimittelallergie und Haut. Georg Thieme, StuttgartGoogle Scholar
  13. Bircher AJ, Bigliardi P, Langaver Messmer S, Surber C (1999) Occupational airborne contact dermatitis from diphency-prone in a pharmacy employee. Contact Dermatitis 41:52PubMedGoogle Scholar
  14. Bjorkner BE (1994) Industrial airborne dermatoses. Dermatol Clin 12:501–509PubMedGoogle Scholar
  15. Burden AD, Beck MH (1992) Contact hypersensitivity to azathi-oprine. Contact Dermatitis 27:329–330PubMedGoogle Scholar
  16. Calnan CD (1975) Occupational piperazine dermatitis. Contact Dermatitis 1:126Google Scholar
  17. Camarasa G, Alomar A (1980) Contact dermatitis to an H2 antagonist. Contact Dermatitis 6:152–153PubMedGoogle Scholar
  18. Camarasa JG, Barnadas M (1982) Occupational dermatosis by vitamin K3 sodium bisulphite. Contact Dermatitis 8:268PubMedGoogle Scholar
  19. Caraffini S, Assalve D, Stingeni L, Lisi P (1994) Tylosin, an airborne contact allergen in veterinarians. Contact Dermatitis 31:327–328PubMedGoogle Scholar
  20. Castelain PY, Piriou A (1980) Contact dermatitis due to propanidid in an anesthesist. Contact Dermatitis 6:360Google Scholar
  21. Cockayne SE, Gawkrodger W (1997) Occupational contact dermatitis in an aromatherapist. Contact Dermatitis 37: 306–307PubMedGoogle Scholar
  22. Conde-Salazar L, Guimaraens D, Romero L (1984) Occupational contact dermatitis from cytosine arabinoside synthesis. Contact Dermatitis 10:44–45PubMedGoogle Scholar
  23. Conde-Salazar L, Guimaraens D, Romero LV, Gonzalez MA (1986) Occupational dermatitis from cephalosporins. Contact Dermatitis 14:70–71PubMedGoogle Scholar
  24. Conde-Salazar L, Llinas MG, Guimaraens D, Romero L (1988) Occupational allergic contact dermatitis from amethocaine. Contact Dermatitis 19:69–70PubMedGoogle Scholar
  25. Conde-Salazar L, Guimaraens D, Llinas G, Romero L, Gonzalez MA (1989) Occupational allergic contact dermatitis from oxolamine. Contact Dermatitis 21:206Google Scholar
  26. Conde-Salazar L, Guimaraens D, Gonzdlez M, Fuente C (1991) Occupational allergic contact dermatitis from opium alkaloids. Contact Dermatitis 25:202–203PubMedGoogle Scholar
  27. Corazza M, Mantovani L, Trimurti S, Virgili A (1994) Occupational contact sensitization to ethylenediamine in a nurse. Contact Dermatitis 31:328–329PubMedGoogle Scholar
  28. Dahlquist I (1977) Allergic reactions to apomorphine. Contact Dermatitis 3:349–350PubMedGoogle Scholar
  29. Dal Monte A, Laffi G, Mancini G (1994) Occupational contact dermatitis due to spectinomycin. Contact Dermatitis 31:204–205Google Scholar
  30. Davies MG (1983) Contact allergy to dicyclohexyl-carbodiimide. Contact Dermatitis 9:318PubMedGoogle Scholar
  31. De Boer J, Van Joost T (1988) Sensitisation to dichlorobenzoyl chloride. Contact Dermatitis 18:116–117PubMedGoogle Scholar
  32. De Groot AC, Conemans JMH (1990) Contact allergy to furazolidone. Contact dermatitis 22:202–205PubMedGoogle Scholar
  33. De Groot AC, Van Wijnen WG, Van Wijnen-Vos M (1990) Occupational contact dermatitis of the eyelids, without ocular involvement, from thimerosal in contact lens fluid. Contact Dermatitis 23:195PubMedGoogle Scholar
  34. Deschamps D, Gamier R, Savoye J, Chabaux C, Efthymiou ML, Fournier E (1988) Allergic and irritant contact dermatitis from diethyl-b-chloroethylamine. Contact Dermatitis 18: 103–105PubMedGoogle Scholar
  35. Dinis A, Branddo M, Faria A (1988) Occupational contact dermatitis from vitamin K3 sodium bisulphite. Contact Dermatitis 18:170–171PubMedGoogle Scholar
  36. Dooms-Goossens A, Gevers D, Mertens A, Vanderheyden D (1983) Allergic contact urticaria due to chloramine. Contact Dermatitis 9:319–320PubMedGoogle Scholar
  37. Dooms-Goossens A, De Boulle K, Snauwaert J, Degreef H (1986a) Sensitization to 3,4,6-trichloropyridazine. Contact Dermatitis 14:64–65PubMedGoogle Scholar
  38. Dooms-Goossens AE, Debusschere KM, Gevers DM, Dupre KM, Degreef HJ, Loncke JP, Snauwaert JE (1986b) Contact dermatitis caused by airborne agents. A review and case reports. J Am Acad Dermatol 15:1–10PubMedGoogle Scholar
  39. Dooms-Goossens A, Bedert R, Degreef H, Vandaele M (1990) Airborne allergic contact dermatitis from kitasamycin and midecamycin. Contact Dermatitis 23:118–119PubMedGoogle Scholar
  40. Dorado Bris JM, Aragues Montailes M, Sols Candela M, Garcia Diez A (1992) Contact sensitivity to pyrazinobutazone (Carudol) with positive oral provocation test. Contact Dermatitis 26:355–356Google Scholar
  41. Dziuk M, Gall H, Sterry W (1994) Contact dermatitis from the ACE-inhibitor Captopril. Dermatosen Beruf Umwelt 42: 159–161Google Scholar
  42. Ekenvall L, Forsbeck M (1978) Contact eczema produced by a β-adrenergic blocking agent (alprenolol). Contact Dermatitis 4:190–194PubMedGoogle Scholar
  43. Filipe P, Soares Almeida RSL, Guerra Rodrigo FG (1996) Occupational allergic contact dermatitis from cephalosporins. Contact Dermatitis 34:226PubMedGoogle Scholar
  44. Fisher AA (1991) Allergic contact dermatitis to mitomycine C. Cutis 47:225–227PubMedGoogle Scholar
  45. Foti C, Vena GA, Angelini G (1992) Occupational contact allergy to benzydamine hydrochloride. Contact Dermatitis 27: 328–329PubMedGoogle Scholar
  46. Foti C, Vena GA, Cucurachi MR, Angelini G (1994) Occupational contact allergy from cephalosporins. Contact Dermatitis 31:129–130PubMedGoogle Scholar
  47. Foti C, Bonamonte D, Trenti R, Vena GA, Angelini G (1997) Occupational contact allergy to cephalosporins. Contact Dermatitis 36:104–105PubMedGoogle Scholar
  48. Foussereau J (1989) Accidental occupational sensitization to p-nitrobenzoyl chloride in a chemistry student synthesizing procaine. Contact Dermatitis 20:397–398PubMedGoogle Scholar
  49. Foussereau J, Benezra C, Maibach HI (1982) Occupational contact dermatitis. Munksgaard Kopenhagen.Google Scholar
  50. Francalanci S, Gola M, Giorgini S, Muccinelli A, Sertoli A (1986) Occupational photocontact dermatitis from olaquindox. Contact Dermatitis 15:112–114PubMedGoogle Scholar
  51. Frattasio A, Germino M, Cargnello S, Patrone P (1997) Side-effects during treatment with SADBE. Contact Dermatitis 36:118–119PubMedGoogle Scholar
  52. Fumagalli M, Bigardi AS, Legori A, Pigatto PD (1992) Occupational contact dermatitis from airborne nicergoline. Contact Dermatitis 27:256PubMedGoogle Scholar
  53. Fung MA, Geisse JK, Maibach HI (1996) Airborne contact dermatitis from metaproterenol in a respiratory therapist. Contact Dermatitis 35:317–318PubMedGoogle Scholar
  54. Gamboa P, Muregui I, Urrutia I (1995) Occupational sensitization to aminopenicillins with oral tolerance to penicillin V. Contact Dermatitis 32:48–49PubMedGoogle Scholar
  55. Garcia-Bravo B, Gines E, Russo F (1995) Occupational contact dermatitis from ceftiofur sodium. Contact Dermatitis 33: 62–63PubMedGoogle Scholar
  56. Garcia-Perez A (1978) Occupational dermatitis from DNFB with cross sensitivity to DWB. Contact Dermatitis 4:125–127PubMedGoogle Scholar
  57. Gauchia R, Rodriguez-Serna M, Silvestre JF, Linana JJ, Aliaga A (1996) Allergic contact dermatitis from streptomycin in a cattle breed. Contact Dermatitis 35:374–375PubMedGoogle Scholar
  58. Goday-Bujan JJ, Yanguas-Bayona I, Soloeta-Arechavala R (1994) Allergic contact dermatitis from cyanamide: report of 3 cases. Contact Dermatitis 31:331–332PubMedGoogle Scholar
  59. Goh CL, Ng SK (1984) Allergic contact dermatitis to ranitidine. Contact Dermatitis 11:252PubMedGoogle Scholar
  60. Goh CL, Ng SK (1985) Photoallergic contact dermatitis to Carbimazole. Contact Dermatitis 12:58–59PubMedGoogle Scholar
  61. Guerra L, Venturo N, Tardio M, Tosti A (1991) Airborne contact dermatitis from animal feed antibiotics. Contact Dermatitis 25:333–334PubMedGoogle Scholar
  62. Guimaraens D, Gonzales MA, Conde-Salazar L (1994) Occupational allergic contact dermatitis from intermediate products in famotidine synthesis. Contact Dermatitis 31:259–260PubMedGoogle Scholar
  63. Haddar M, Araibia A, Laibldder C, Mekki R, Benmami F (1993) Contact dermatitis due to ethylene oxide. Arch Mal Prof Med Trav Secur Soc 54:358–359Google Scholar
  64. Happle R, Kalveram KJ, Buchner U, Echtemacht-Happle K, Goggelmann W, Summer KH (1980) Contact allergy as a therapeutic tool for alopecia areata: application of squaric acid dibutylester. Dermatologica 161:289–297PubMedGoogle Scholar
  65. Hardie RA, Savin JA, White DA, Pumford S (1978) Quinine dermatitis: investigation of a factory outbreak. Contact Dermatitis 4:121–124PubMedGoogle Scholar
  66. Harle DG, Baldo BA, Coroneos NJ, Fisher MM (1989) Anaphylaxis following administration of papaveretum. Case report: implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant. Anesthesiology 71:489–494PubMedGoogle Scholar
  67. Hausen BM (1980) Amikaallergie. Hautarzt 31:10–17Google Scholar
  68. Heidenheim M, Jemec GBE (1995) Occupational allergic contact dermatitis from vitamin A acetate. Contact Dermatitis 33:439PubMedGoogle Scholar
  69. Hjorth N, Weisman K (1973) Occupational dermatitis among veterinary surgeons caused by spiramycin, tylosin and penethamate. Contact Dermatitis 53:229–232Google Scholar
  70. Holdiness MR (1986a) Contact dermatitis to ethambutol. Contact Dermatitis 15:96–97PubMedGoogle Scholar
  71. Holdiness MR (1986b) Contact dermatitis to antituberculosis drugs. Contact Dermatitis 15:282PubMedGoogle Scholar
  72. Hsu CK, Sun CC, Su MS, Kuo EF, Wu YC (1992) Systemic contact allergy from occupational contact with ethyl ethoxymethylene cyanoacetate. Contact Dermatitis 27:58–59PubMedGoogle Scholar
  73. Ingemann-Larsen A, Jepsen JR, Thulin H (1989) Allergic contact dermatitis from thiamine. Contact Dermatitis 20:387–388PubMedGoogle Scholar
  74. Isaaksson M, Bruze M, Gruvberger B, Ljunggren B (1994) Quinine and quinidine photoproducts can be identical. Acta Derm Venereol 74:286–288Google Scholar
  75. Johansson G (1988) Contact urticaria from levomepromazine. Contact Dermatitis 19:304PubMedGoogle Scholar
  76. Jolanki R, Alanko K, Pfaffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Contact Dermatitis 36:53–54PubMedGoogle Scholar
  77. Kanerva L, Estlander T, Jolanki R (1994) Occupational skin allergy in the dental profession. Dermatol Clin 12:517–532PubMedGoogle Scholar
  78. Kanerva L, Alanko K, Estlander T, Sihvonen T, Jolanki R (1997) Occupational allergic contact urticaria from chloramine-T solution. Contact Dermatitis 37:180–181PubMedGoogle Scholar
  79. Keller K, Schwanitz HJ (1992) Combined immediate and delayed hypersensitivity to mezlocillin. Contact Dermatitis 27:348–349PubMedGoogle Scholar
  80. Kellett JK, Beck MH (1984) Contact sensitivity to chloroquine sulphate. Contact Dermatitis 11:47PubMedGoogle Scholar
  81. Klijn J (1984) Contact dermatitis from spironolactone. Contact Dermatitis 10:105PubMedGoogle Scholar
  82. Lahti A, Puurunen J, Hannuksela M (1990) Occupational contact allergy to 2,4-di-amino-6-chloromethylpteridine hydrochloride: an intermediate in methotrexate synthesis. Contact Dermatitis 22:294PubMedGoogle Scholar
  83. Lerman Y, Ribak J, Skulsky M, Ingber A (1995) An outbreak of irritant contact dermatitis from ethylene oxide among pharmaceutical workers. Contact Dermatitis 33:280–281PubMedGoogle Scholar
  84. Ljunggren B, Hindsen M, Isaaksson M (1992) Systemic quinine photosensitivity with photoepicutaneous cross-reactivity to quinidine. Contact Dermatitis 26:14Google Scholar
  85. Lo JS, Taylor JS, Oriba H (1990) Occupational allergic contact dermatitis to airborne nitrofurazone. Dermatol Clin 8:165–168PubMedGoogle Scholar
  86. Lombardi P, Gola M, Acciai MC, Sertoli A (1989) Unusual occupational allergic contact dermatitis in a nurse. Contact Dermatitis 20:302–303PubMedGoogle Scholar
  87. Lubbe D (1993) Professional dinitrochlorobenzene contact dermatitis. Eleven cases in the nitration facility of a chemical plant. Derm Beruf Umwelt 41:19–24Google Scholar
  88. Macedo NA, Pineyro I, Carmona C (1991) Contact urticaria and contact dermatitis from albendazole. Contact Dermatitis 25:73–75PubMedGoogle Scholar
  89. Mancuso G, Staffa M, Errani A, Berdondini RM, Fabbri P (1990) Occupational dermatitis in animal feed mill workers. Contact Dermatitis 22:37–41PubMedGoogle Scholar
  90. Marcos NIL, Garces MM, Alonso L, Juste S, Carretero P, Blanco J, Garcia F, Perez R, Herrero D (1997) Occupational allergic contact dermatitis from homatropine and phenylephrine eyedrops. Contact Dermatitis 37:189PubMedGoogle Scholar
  91. Mathelier-Fusade P, Leynadier F (1994) Occupational allergic contact reaction to disulfiram. Contact Dermatitis 31:121–122PubMedGoogle Scholar
  92. Mathelier-Fusade P, Mansouri S, Aissaoui M, Chabane MH, Aractingi S, Leynadier F (1997) Airborne contact dermatitis from propacetamol. Contact Dermatitis 36:267–268PubMedGoogle Scholar
  93. Meding B (1986) Contact allergy to omeprazole. Contact Dermatitis 15:36Google Scholar
  94. Menne T, Veien NK, Maibach HI (1989) Systemic contact-type dermatitis to drugs. Semin Dermatol 8:144–148PubMedGoogle Scholar
  95. Mitchell JC, Maibach HI (1975) Allergic contact dermatitis from phenoxybenzamine hydrochloride. Contact Dermatitis 1:363–366PubMedGoogle Scholar
  96. Miyahara H, Koga T, Imayama S, Hori Y (1993) Occupational contact urticaria syndrome from cefotiam hydrochloride. Contact Dermatitis 29:210–211PubMedGoogle Scholar
  97. Moller NE, Jeppesen K (1987) Patch testing with semisynthetic penicillins. Contact Dermatitis 16:227–228PubMedGoogle Scholar
  98. Moller NE, Kromann N (1989) Bumetanide allergy in factory workers. Contact Dermatitis 20:393–394PubMedGoogle Scholar
  99. Moller NE, Von Würden K (1992) Hypersensitivity to semisyn thetic penicillins and crossreactiviry with penicillin. Contact Dermatitis 26:351–352PubMedGoogle Scholar
  100. Moller NE, Nielsen B, Von Würden K (1986) Contact dermatitis to semisynthetic penicillins in factory workers. Contact Dermatitis 14:307–311PubMedGoogle Scholar
  101. Moller NE, Nielsen B, Von Würden K (1990) Changes in penicillin contamination and allergy in factory workers. Contact Dermatitis 22:106–107PubMedGoogle Scholar
  102. Monteseirin J, Conde J (1990) Contact eczema from famotidine. Contact Dermatitis 22:290PubMedGoogle Scholar
  103. Moscato G, Galdi E, Scibilia J, Dellabianca A, Omodeo P, Vittadini G, Biscaldi GP (1995) Occupational asthma, rhinitis and urticaria due to piperacillin sodium in a pharmaceutical worker. Eur Respir J 8:467–469PubMedGoogle Scholar
  104. Newton JA, White I (1987) Connubial dermatitis from morantel. Contact Dermatitis 16:38–39PubMedGoogle Scholar
  105. Niklasson B, Bjorkner B (1990) Contact allergy to 3,4-dicarbethoxyhexane-2,5-dione. Contact Dermatitis 23:46–47PubMedGoogle Scholar
  106. Niklasson B, Bjorkner B, Hansen L (1990) Occupational contact dermatitis from antitumor agent intermediates. Contact Dermatitis 22:233–235PubMedGoogle Scholar
  107. Norris PG, Hawk JL, White IR (1988) Photoallergic contact dermatitis from fentichlor. Contact Dermatitis 18:318–320PubMedGoogle Scholar
  108. Noster U, Hausen BM, Krische B, Schulz KH (1976) Squaric acid diethylester — a strong sensitizer. Contact Dermatitis 2:99–104PubMedGoogle Scholar
  109. Ortiz-Frutos FJ, Alonso J, Hergueta JP, Quintana I, Iglesias L (1995) Tetrazepam an allergen with several clinical expressions. Contact Dermatitis 33:63–65PubMedGoogle Scholar
  110. Pecegueiro M (1990) Occupational contact dermatitis from penicillin. Contact Dermatitis 23:190–191PubMedGoogle Scholar
  111. Pickering FC, Ive FA (1982) Allergic contact dermatitis from 4,7-dichloroquinoline. Contact Dermatitis 8:269–270PubMedGoogle Scholar
  112. Placucci F, Benini A, Guerra L, Tosti A (1996) Occupational allergic contact dermatitis from disinfectant wipes used in dentistry. Contact Dermatitis 35:306PubMedGoogle Scholar
  113. Poesen N, De Moor A, Busschots A, Dooms-Goossens A (1995) Contact allergy to dicyclohexyl carbodiimide and diisopropyl carbodiimide. Contact Dermatitis 32:368–369PubMedGoogle Scholar
  114. Quirce S, Olaguibel JM, Garcia BE, Tabar AI (1993) Occupational airborne contact dermatitis due to benzoyl peroxide. Contact Dermatitis 29:165–166PubMedGoogle Scholar
  115. Rademaker M (1994) Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 31:58–59PubMedGoogle Scholar
  116. Rebandel P, Rudzki E (1986a) Dermatitis from quinazoline oxide. Contact Dermatitis 15:63–5PubMedGoogle Scholar
  117. Rebandel P, Rudzki E (1986b) Occupational contact sensitivity in oculists. Contact Dermatitis 15:92PubMedGoogle Scholar
  118. Rebandel P, Rudzki E (1990) Dermatitis caused by epic-hlorohydrin, Oxprenolol hydrochloride and propranolol hydrochloride. Contact Dermatitis 23:199PubMedGoogle Scholar
  119. Rodriguez A, Echechipia S, Alvarez M, Muro MD (1994) Occupational contact dermatitis from vitamin B12. Contact Dermatitis 31:271PubMedGoogle Scholar
  120. Romaguera C, Grimait F (1983) Occupational dermatitis from codeine. Contact Dermatitis 9:170PubMedGoogle Scholar
  121. Romaguera C, Grimait F, Conde-Salazar L (1980) Occupational dermatitis from vitamin K3 sodium bisulfite. Contact Dermatitis 6:355–356PubMedGoogle Scholar
  122. Romaguera C, Grimait F, Vilaplana J (1988) Epidemic of occupational contact dermatitis from ranitidine. Contact Dermatitis 18:177–178PubMedGoogle Scholar
  123. Romaguera C, Grimait F, Vilaplana F (1990) Contact dermatitis caused by intermediate products in the manufacture of clenbutol, ranitidine base, and ranitidine hydrochloride. Dermatol Clin 8:115–117PubMedGoogle Scholar
  124. Rudzki E (1990) Contact sensitivity to systemically administered drugs. Dermatol Clin 8:177PubMedGoogle Scholar
  125. Rudzki E, Grzywa Z (1977) Occupational piperazine dermatitis. Contact Dermatitis 3:216PubMedGoogle Scholar
  126. Rudzki E, Rebandel P (1985) Occupational contact urticaria from penicillin. Contact Dermatitis 13:192PubMedGoogle Scholar
  127. Rudzki E, Rebandel P (1991) Hypersensitivity to semisynthetic penicillins but not to natural penicillin. Contact Dermatitis 25:192PubMedGoogle Scholar
  128. Rudzki E, Rebandel P, Grzywa Z (1989a) Patch tests with occupational contactants in nurses, doctors and dentists. Contact Dermatitis 20:247–250PubMedGoogle Scholar
  129. Rudzki E, Rebandel P, Grzywa Z (1989b) Contact allergy in the pharmaceutical industry. Contact Dermatitis 21:121–122PubMedGoogle Scholar
  130. Rycroft RJG (1981) Occupational contact sensitization to 2,6-dichloropurine. Contact Dermatitis 7:349–350PubMedGoogle Scholar
  131. Rycroft RJG (1983) Allergic contact dermatitis from a novel diamino intermediate, 5-[(2-aminoethyl)-thiomethyl]-N,AT-di-methyl-2-furanmethanamine, in laboratory synthesis. Contact Dermatitis 9:456–458PubMedGoogle Scholar
  132. Sansom JE, Molloy KC, Lovell CR (1995) Occupational sensitization to diphencyprone in a chemist. Contact Dermatitis 32:363PubMedGoogle Scholar
  133. Savini C, Morelli R, Piancastelli E, Restani S (1989) Contact dermatitis due to ethoxyquin. Contact Dermatitis 21:342–343PubMedGoogle Scholar
  134. Schauder S, Schrbder W, Geier J (1996) Olaquindox-induced airborne photoallergic contact dermatitis followed by transient or persistent light reactions in 15 pig breeders. Contact Dermatitis 35:344–354PubMedGoogle Scholar
  135. Schena D, Barba A, Costa G (1996) Occupational contact urticaria due to cisplatin. Contact Dermatitis 34:220–221PubMedGoogle Scholar
  136. Schmidt RJ (1986) Compositae. Clin Dermatol 4:46Google Scholar
  137. Schwank R, Jirdsek L (1963) Kontaktallergie gegen Chloramphenicol mit besonderer Ber Ucksichtigung der Gruppensensibilisierung. Hautarzt 14:24–30PubMedGoogle Scholar
  138. Schwenck K, Gali H, Sterry W (1994) Aerogene Kontaktdermatitis auf das Neuroleptikurn Chlorprothixen. Allergologie 17: 467–469Google Scholar
  139. Selvaag E, Holm JO, Thune P (1995) Allergie contact dermatitis in an aroma therapist with multiple sensitizations to essential oils. Contact Dermatitis 33:354–355PubMedGoogle Scholar
  140. Sherertz EF (1994) Occupational skin disease in the pharmaceutical industry. Dermatol Clin 12:533–536PubMedGoogle Scholar
  141. Soni BP, Sherertz EF (1996) Allergic contact dermatitis from azathioprine. Am J Contact Dermatitis 7:116–117PubMedGoogle Scholar
  142. Sonnex TS, Rycroft RJ (1986) Allergic contact dermatitis from chloromethyl heterocyclic intermediates in the synthesis of a histamine antagonist. Contact Dermatitis 14:265–267PubMedGoogle Scholar
  143. Stejskal VDM, Olin RG, Forsbeck M (1986) The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. J Allergy Clin Immunol 77:411–426PubMedGoogle Scholar
  144. Szczurko C, Dompmartin A, Michel M, Castel B, Leroy D (1996) Occupational contact dermatitis from propacetamol. Contact Dermatitis 35:299–301PubMedGoogle Scholar
  145. Tadokoro K, Niimi N, Ohtoshi T, Nakajima, K, Takafuji S, Onodera K, Suzuki S, Murunaka M (1994) Cefotiam-induced IgE-mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature. Clin Exp Allergy 24:127–133PubMedGoogle Scholar
  146. Tas J, Weissberg D (1958) Allergy to aminophylline. Allergy 12: 39–42Google Scholar
  147. Tennstedt D, Dumont-Fruytier M, Lachapelle JM (1978) Occupational allergic contact dermatitis to virginiamycin, an antibiotic used as a food additive for pigs and poultry. Contact Dermatitis 4:133–134PubMedGoogle Scholar
  148. Testud F, Descotes J, Evreux JC (1994) Pathologie professionnelle due aux medicaments. Arch Mal Prof 55:279–286Google Scholar
  149. Tuomi ML, Rasanen L (1995) Contact allergy to tylosin and cobalt in a pig-farmer. Contact Dermatitis 33:285PubMedGoogle Scholar
  150. Valsecchi R, Cassina P, Cainelli T (1987) Contact toxic epidermal necrolysis. Contact Dermatitis 16:277PubMedGoogle Scholar
  151. Valsecchi R, Rohrich O, Cainelli T (1989) Contact allergy to cistoran, an intermediate in ranitidine synthesis. Contact Dermatitis 20:396–397PubMedGoogle Scholar
  152. Van Hecke E (1981) Contact sensitivity to vincamine tartrate. Contact Dermatitis 7:53PubMedGoogle Scholar
  153. Vanuytrecht-Henderickx D, Bourgeois M, Mariën K, Dooms-Goossens A (1986) Occupational fixed eruption by inhalation of pyrazolones. Contact Dermatitis 14:115PubMedGoogle Scholar
  154. Veien NK, Hattel T, Justesen 0, Norholm A (1980) Occupational contact dermatitis due to spiramycin and/or tylosin among farmers. Contact Dermatitis 6:410–413PubMedGoogle Scholar
  155. Veraldi S, Benelli C, Pigatto PD (1992) Occupational allergic contact dermatitis from minoxidil. Contact Dermatitis 26: 211–212PubMedGoogle Scholar
  156. Verschaeve A, Loncke J, Dooms-Goossens A (1984) Occupational contrast media dermatitis: meglumine diatrizoate. Contact Dermatitis 11:318–319PubMedGoogle Scholar
  157. Vilaplana J, Grimait F, Romaguera C (1990) Contact dermatitis from furaltadone in animal feed. Contact Dermatitis 22:232–233PubMedGoogle Scholar
  158. Vilaplana J, Romaguera C, Grimait F (1991) Contact dermatitis from lincomycin and spectinomycin in chicken vaccinators. Contact Dermatitis 24:225–226PubMedGoogle Scholar
  159. Waclawski ER, Aldridge R (1995) Occupational dermatitis from thebaine and codeine. Contact Dermatitis 33:51PubMedGoogle Scholar
  160. Wahlberg JE, Boman A (1981) Contact sensitivity to quinidine sulfate from occupational exposure. Contact Dermatitis 7:27–31PubMedGoogle Scholar
  161. Watsky KL, Reynolds K, Berube D, Bayer FJ (1993) Occupational contact dermatitis from tosyl chloride in a chemist. Contact Dermatitis 29:211–212PubMedGoogle Scholar
  162. Wigger-Alberti W, Eisner P (1997) Occupational contact dermatitis due to pyritinol. Contact Dermatitis 37:91–92PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2000

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  • A. J. Bircher

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