Pharmaceutical Drug Allergens

  • A. J. Bircher


With few exceptions, such as peptides and hormones, drugs and their precursors are typically low-molecular-weight compounds and, therefore, haptens. To build a complete antigen, they must bind to macromolecules e.g. human tissue or serum proteins. Some drugs are primarily reactive while, in others, reactive metabolites are only generated in vivo. Oral administration is usually better tolerated and may even induce tolerance. However, intermittent exposure by epi- or intradermal application or by inhalation, as it typically occurs in occupational settings, carries the highest risk of sensitization (Bircher 1996).


Contact Dermatitis Alopecia Areata Contact Urticaria Squaric Acid Occupational Contact 
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  • A. J. Bircher

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