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The Pharmaceutical and Cosmetic Industries

  • A. Goossens
  • L. Geusens

Abstract

Depending on the type of product and exposition, several occupation-induced dermatoses may occur among workers in the pharmaceutical industry. They include irritation, contact allergy, photosensitivity, urticaria, acne venenata, and, less frequently, fixed drug eruption and steroid rosacea (H. Degreef, personal communication), and even toxic epidermal necrolysis (as was the case with the transcutaneous absorption of an intermediary product in the synthesis of tetramisole, an anthelminthic drug; Valsecchi et al. 1987).

Keywords

Contact Dermatitis Methyl Ethyl Ketone Allergic Contact Dermatitis Butyl Acetate Intermediary Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adisesh A, Beck M, Cherry NM (1997) Hazards in the use of diphencyprone. Br J Dermatol 136:465CrossRefGoogle Scholar
  2. Alomar A, Puig L, Villatella I (1987) Allergic contact dermatitis due to ranitidine. Contact Dermatitis 17:54–55PubMedCrossRefGoogle Scholar
  3. Brando F, Fousserau J (1982) Contact dermatitis to phenylbutazone-piperazine suppositories (Carudol). Contact Dermatitis 8:264–265CrossRefGoogle Scholar
  4. Brasch J (1991) Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan. Contact Dermatitis 25:121–124PubMedCrossRefGoogle Scholar
  5. Buisson H, Vaillant L, Lasfargues G, Muller C, Loretter G (1991) Occupational contact dermatitis from trans-methyl-3-(4-methoxyphenyl)glycidate. Contact Dermatitis 25:262–263PubMedCrossRefGoogle Scholar
  6. Burden A, Beck M (1992) Contact hypersensitivity to azathioprine. Contact Dermatitis 27:329–330PubMedCrossRefGoogle Scholar
  7. Calnan C (1975) Occupational piperazine dermatitis. Contact Dermatitis 1:126Google Scholar
  8. Camarasa G, Alomar A (1980) Contact dermatitis to an H2-antagonist. Contact Dermatitis 6:152–153PubMedCrossRefGoogle Scholar
  9. Camarasa J, Barnadas M (1982) Occupational dermatosis by vitamin K3 sodium bisulfite. Contact Dermatitis 8:268PubMedCrossRefGoogle Scholar
  10. Conde-Salazar L, Guimraens D, Romero L (1984) Occupational contact dermatitis from cytosine arabinoside synthesis. Contact Dermatitis 10:44–45PubMedCrossRefGoogle Scholar
  11. Conde-Salazar L, Guimraens D, Romero LV, Gonzalez MA (1986) Occupational dermatitis from cephalosporins. Contact Dermatitis 14:70–71PubMedCrossRefGoogle Scholar
  12. Conde-Salazar L, Guimraens D, Llinas G, Romero L, Gonzalez MA (1989) Occupational allergic contact dermatitis from oxolamine. Contact Dermatitis 21:206CrossRefGoogle Scholar
  13. Conde-Salazar L, Guimraens D, Gonzalez MA, Fuente C (1991) Occupational allergic contact dermatitis from opium alkaloids. Contact Dermatitis 25:202–203PubMedCrossRefGoogle Scholar
  14. Davies M (1983) Contact allergy to dicyclohexyl carbodiimide. Contact Dermatitis 9:318PubMedCrossRefGoogle Scholar
  15. De Veylder H, Dooms Goosens A, Dupre K, Degreef H (1986) Airborne dermatitis due to 2,2-dimethyl-1,3-propane diamine. Contact Dermatitis 15:47CrossRefGoogle Scholar
  16. Deschamps D, Gamier R, Savoye J, Chabaux C, Efthymiou ML, Fournier E (1988) Allergic and irritant contact dermatitis from diethyl-beta-chloroethylamine. Contact Dermatitis 18: 103–105PubMedCrossRefGoogle Scholar
  17. Dias M, Fernandez C, Pereira F, Pacheco A (1995) Occupational dermatitis from ethylenediamine. Contact Dermatitis 33: 129–130PubMedCrossRefGoogle Scholar
  18. Dooms-Goossens A, de Boulle K, Snauwaert J, Degreef H (1986) Sensitization to 3,4,6-trichloropyridazine. Contact Dermatitis 14:64–65PubMedCrossRefGoogle Scholar
  19. Dooms-Goossens A, Bedert R, Degreef H, Vandaele M (1990) Airborne allergic contact dermatitis from kitasamycin and midecamycin. Contact Dermatitis 23:118–119PubMedCrossRefGoogle Scholar
  20. Dorado Bris J, Aragues Montanes M, Sols Candela M, Garcia Diez A (1992) Contact sensitivity to pyrazinobutazone (Carudol) with positive oral provocation test. Contact Dermatitis 26:355–356PubMedCrossRefGoogle Scholar
  21. Ekenvall L, Forsbeck M (1978) Contact eczema produced by a beta-adrenergic blocking agent (alprenolol). Contact Dermatitis 4:190–194PubMedCrossRefGoogle Scholar
  22. English J, Rycroft J (1988) Allergic contact dermatitis from methyl heptine and methyl octine carbonates. Contact Dermatitis 18:174–175PubMedCrossRefGoogle Scholar
  23. Foussereau J (1989) Accidental occupational sensitization to p-nitrobenzoyl chloride in a chemistry student synthesizing procaine. Contact Dermatitis 20:397–398PubMedCrossRefGoogle Scholar
  24. Foussereau J, Benerza C, Maiback HI (1982) Occupational contact dermatitis: clinical and chemical aspects. Saunders, PhiladelphiaGoogle Scholar
  25. Fregert S, Gustafsson K, Trulsson L (1983) Contact allergy to N-hydroxyphtalimide. Contact Dermatitis 9:84–85PubMedCrossRefGoogle Scholar
  26. Fumagalli M, Bigardi AS, Legori A, Pigatto PD (1992) Occupational contact dermatitis from airborne nicergoline. Contact Dermatitis 27:256PubMedCrossRefGoogle Scholar
  27. Goh C, Ng S (1984) Allergic contact dermatitis to ranitidine. Contact dermatitis 11:252PubMedCrossRefGoogle Scholar
  28. Goh C, Ng S (1985) Photoallergic contact dermatitis to Carbimazole. Contact Dermatitis 12:58–59PubMedCrossRefGoogle Scholar
  29. Grimait F, Romaguera C (1977) Occupational dermatitis partly elicited by coal tar. Contact Dermatitis 3:54CrossRefGoogle Scholar
  30. Guimaraens D, Gonzalez MA, Conde-Salazar L (1994) Occupational allergic contact dermatitis from intermediate products in famotidine synthesis. Contact Dermatitis 31:259–260PubMedCrossRefGoogle Scholar
  31. Hardie R, Savin JA, White DA, Pumford S (1978) Quinine dermatitis: investigation of a factory outbreak. Contact Dermatitis 4:121–124PubMedCrossRefGoogle Scholar
  32. Heidenheim M, Jemec G (1995) Occupational allergic contact dermatitis from vitamin A acetate. Contact Dermatitis 33:439PubMedCrossRefGoogle Scholar
  33. Hogan D (1990) Allergic contact dermatitis to ethylenediamine. Dermatol Clin 8:133–136PubMedGoogle Scholar
  34. Hsu C, Sun CC, Su MS, Kuo EF, Wu YC (1992) Systemic contact allergy from occupational contact with ethyl ethoxymethylene cyanoacetate. Contact Dermatitis 27:58–59PubMedCrossRefGoogle Scholar
  35. Jirasek L, Schwank R (1965) Berufskontaktekzem durch Vitamin K. Hautarzt 16:351–353PubMedGoogle Scholar
  36. Jolanki R, Alanko K, Pfaffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Contact Dermatitis 36:53–54PubMedCrossRefGoogle Scholar
  37. Kanerva L, Laine R, Jolanki R, Tarvainen K, Estlander T, Helander I (1991) Occupational allergic contact dermatitis caused by nitroglycerin. Contact Dermatitis 24:356–362PubMedCrossRefGoogle Scholar
  38. Kanerva L, Tarvainen K, Pinola A, et al. (1994) A single accidental exposure may result in a chemical burn, primary sensitization and allergic contact dermatitis. Contact Dermatitis 31:229–235PubMedCrossRefGoogle Scholar
  39. Kanerva L, Estlander T, Jolanki R (1995) Occupational allergic contact dermatitis caused by ylang-ylang oil. Contact Dermatitis 33:198–199CrossRefGoogle Scholar
  40. Kanzaki T, Sakakibara N (1992) Occupational allergic contact dermatitis from ethyl-2-bromo-p-methoxyphenylacetate. Contact Dermatitis 26:204–205PubMedCrossRefGoogle Scholar
  41. Kellet J, Beck M (1984) Contact sensitivity to chloroquine sulphate. Contact Dermatitis 11:47CrossRefGoogle Scholar
  42. Kleine-Natrop H, Richter G (1980) Arbeitsdermatosen in der pharmazeutischen Industrie. Derm Beruf Umwelt 28:8–10PubMedGoogle Scholar
  43. Lahti A, Puurunen J, Hannuksela M (1990) Occupational contact allergy to 2,4-diamino-6-chloromethylpteridine hydrochloride: an intermediate product in methotrexate synthesis. Contact Dermatitis 22:294PubMedCrossRefGoogle Scholar
  44. Larsen AJ, Jespen JR, Thulin H (1989) Allergic contact dermatitis from thiamine. Contact Dermatitis 20:387–388CrossRefGoogle Scholar
  45. Lerman Y, Ribak J, Skulsky M, Ingber A (1995) An outbreak of irritant contact dermatitis from ethylene oxide among pharmaceutical workers. Contact Dermatitis 33:280–281PubMedCrossRefGoogle Scholar
  46. Macedo N, Pineyro MI, Carmona C (1991) Contact urticaria and contact dermatitis from albendazole. Contact Dermatitis 2573–75PubMedCrossRefGoogle Scholar
  47. Martindale (1993) The extra pharmacopoeia, 30th edn. The Pharmaceutical Press, London, p 123Google Scholar
  48. Meding B (1986) Contact allergy to omeprazole. Contact Dermatitis 15:36CrossRefGoogle Scholar
  49. Möller N, Kromann N (1989) Bumetanide allergy in factory workers. Contact Dermatitis 20:393–394PubMedCrossRefGoogle Scholar
  50. Möller N, von Würden K (1992) Hypersensitivity to semisynthetic penicillins and cross-reactivity with penicillin. Contact Dermatitis 26:351–352PubMedCrossRefGoogle Scholar
  51. Möller N, Nielsen B, von Wurden K (1986) Contact dermatitis to semi-synthetic penicillins in factory workers. Contact Dermatitis 14:307–311PubMedCrossRefGoogle Scholar
  52. Möller N, Nielsen B, von Wurden K (1990) Changes in penicillin contamination and allergy in factory workers. Contact Dermatitis 22:106–107PubMedCrossRefGoogle Scholar
  53. Nethercott J, Lawrence MJ, Roy AM, Gibson BL (1984) Airborne contact urticaria due to sodium benzoate in a pharmaceutical manufacturing plant. J Occup Med 26:734–736PubMedCrossRefGoogle Scholar
  54. Newton J, White I (1987) Connubial dermatitis from morantel. Contact Dermatitis 16:38–39PubMedCrossRefGoogle Scholar
  55. Niklasson B, Björkner B (1990) Contact allergy to 3,4-dicarbethoxyhexane-2,5-dione. Contact Dermatitis 23:46PubMedCrossRefGoogle Scholar
  56. Niklasson B, Björkner B, Hansen L (1990) Occupational contact dermatitis from antitumor agent intermediates. Contact Dermatitis 22:294CrossRefGoogle Scholar
  57. Opdyke DLJ (1979) Fragrance raw materials monographs. Food Chem Toxicol 17:375–376Google Scholar
  58. Pickering F, Ive F (1982) Allergic contact dermatitis from 4,7-dichloroquinoline. Contact Dermatitis 8:269–270PubMedCrossRefGoogle Scholar
  59. Pickering F, Ive F (1983) Allergic contact dermatitis due to highly reactive halogenated compounds. Contact Dermatitis 9: 500–503PubMedCrossRefGoogle Scholar
  60. Poesen N, de Moor A, Busschots A, Dooms-Goosens A (1995) Contact allergy to dicyclohexylcarbodiimide and diisopropyl carbodiimide. Contact Dermatitis 32:368–396PubMedCrossRefGoogle Scholar
  61. Rebandel P, Rudzki E (1986) Dermatitis from quinazoline oxide. Contact Dermatitis 15:63–65PubMedCrossRefGoogle Scholar
  62. Rebandel P, Rudzki E (1990) Dermatitis caused by epic-hlorohydrin, Oxprenolol hydrochloride and propranolol hydrochloride. Contact Dermatitis 23:199PubMedCrossRefGoogle Scholar
  63. Roed-Petersen J (1980) Allergic contact dermatitis from butyl acetate. Contact Dermatitis 6:55CrossRefGoogle Scholar
  64. Romaguera C, Grimait F (1983) Occupational dermatitis from codeine. Contact Dermatitis 9:170PubMedCrossRefGoogle Scholar
  65. Romaguera C, Grimait F, Conde-Salazar L (1980) Occupational dermatitis from vitamin K3 sodium bisulfite. Contact Dermatitis 6:355–356PubMedCrossRefGoogle Scholar
  66. Romaguera C, Grimait F, Vilaplana J (1988) Epidemic of occupational contact dermatitis from ranitidine. Contact Dermatitis 18:177–178PubMedCrossRefGoogle Scholar
  67. Romaguera C, Grimait F, Vilaplana J (1990) Contact dermatitis caused by intermediate products in the manufacture of clenbuterol, ranitidine base, and ranitidine hydrochloride. Dermatol Clin 8:115–117PubMedCrossRefGoogle Scholar
  68. Rudzki E (1990) Contact sensitivity to systemically administered drugs. Dermatol Clin 8:177–180PubMedGoogle Scholar
  69. Rudzki E, Grzywa Z (1977) Occupational piperazine dermatitis. Contact Dermatitis 3:216PubMedCrossRefGoogle Scholar
  70. Rudzki E, Rebandel P (1990) Dermatitis from methyl-2,3-epoxy-3-(4-methoxyphenyl)propionate. Contact Dermatitis 23:382PubMedCrossRefGoogle Scholar
  71. Rudzki E, Rebandel P (1991) Hypersensitivity to semi-synthetic penicillins but not to natural penicillin. Contact Dermatitis 25:192PubMedCrossRefGoogle Scholar
  72. Rudzki E, Rebandel P, Grzywa Z (1989) Contact allergy in the pharmaceutical industry. Contact Dermatitis 21:121–122PubMedCrossRefGoogle Scholar
  73. Rudzki E, Rebandel P, Grzywa Z (1993) Occupational dermatitis from cosmetic creams. Contact Dermatitis 29:210PubMedCrossRefGoogle Scholar
  74. Rycroft RJG (1981a) Allergic contact dermatitis from laboratory synthesis of 4-bromomethyl-6,8-dimethyl-2(iH)-quinolone. Contact Dermatitis 7:39–42PubMedCrossRefGoogle Scholar
  75. Rycroft RJG (1981b) Occupational contact sensitization to 2,6-dichloropurine. Contact Dermatitis 7:349–350PubMedCrossRefGoogle Scholar
  76. Rycroft RJG (1983) Allergic contact dermatitis from a novel diamino intermediate, 5-(2-aminoethyl)thiomethyl-N,N-di-methyl-2-furanmethanamine, in laboratory synthesis. Contact Dermatitis 9:456–458PubMedCrossRefGoogle Scholar
  77. Rycroft R, Marshal PE, Fraser-Moodie A, Taylor SWC (1991) Dermatitis and patch test problems from 2-aminothiophenol. Contact Dermatitis 23:270CrossRefGoogle Scholar
  78. Sansom J, Molloy KC, Lovell CR (1995) Occupational sensitization to diphencyprone in a chemist. Contact Dermatitis 32:363PubMedCrossRefGoogle Scholar
  79. Schultz K, Schöpf E (1967) Klinische und experimentelle Untersuchungen zur Kontaktallergie durch Chlormethylimi-dazolin. Hautarzt 18 (12) 1547–550Google Scholar
  80. Schwank R, Jirasek L (1963) Kontaktallergie gegen Chloramphenicol mit besonderer Berücksichtigung der Gruppensensi-bilisierung. Hautarzt 14:24–30PubMedGoogle Scholar
  81. Shah M, Lewis FM, Messenger AG (1996) Hazards in the use of diphencyprone. Br J Dermatol 134:1151CrossRefGoogle Scholar
  82. Sherertz E (1994) Occupational skin disease in the pharmaceutical industry. Dermatol Clin 12:533–536PubMedGoogle Scholar
  83. Soni B, Sherertz E (1996) Allergic contact dermatitis from azathioprine. Am J Contact Dermat 7:116–117PubMedCrossRefGoogle Scholar
  84. Sonnex T, Rycroft R (1986) Allergic contact dermatitis from chloromethyl heterocyclic intermediates in the synthesis of a histamine antagonist. Contact Dermatitis 14:265–267PubMedCrossRefGoogle Scholar
  85. Tennstedt D, Dumont-Fruytier M, Lachapelle JM (1978) Occupational allergic contact dermatitis to virginiamycin, an antibiotic used as a food additive for pigs and poultry. Contact Dermatitis 4:133–134PubMedCrossRefGoogle Scholar
  86. Todaro A, Nava C (1991) La patologica allergica da dibutilestere dell’acido squarico: descrizione di due casi in ambiente laborativo. Med Lav 82:276–279PubMedGoogle Scholar
  87. Torinuki J (1995) Contact dermatitis to biperiden and photocontact dermatitis to phenothiazines in a pharmacist. Tohoku J Exp Med 176:249–252PubMedCrossRefGoogle Scholar
  88. Valsecchi R, Cassina P, Cainelli P (1987) Contact toxic epidermal necrolysis. Contact Dermatitis 16:277PubMedCrossRefGoogle Scholar
  89. van Hecke E (1981) Contact sensitivity to vincamine tartrate. Contact Dermatitis 7:53PubMedCrossRefGoogle Scholar
  90. Waclawski E, Aldridge R (1995) Occupational dermatitis from thebaine and codeine. Contact Dermatitis 33:51PubMedCrossRefGoogle Scholar
  91. Wahlberg J, Boman A (1981) Contact sensitivity to quinidine sulfate from occupational exposure. Contact Dermatitis 7:27–31PubMedCrossRefGoogle Scholar
  92. Watsky K, Reynolds K, Berube D, Bayer FJ (1993) Occupational contact dermatitis from tosyl chloride in a chemist. Contact Dermatitis 29:211–212PubMedCrossRefGoogle Scholar
  93. Wigger-Alberti W, Eisner P (1997) Occupational dermatitis due to pyritinol. Contact Dermatitis 37:91–92PubMedCrossRefGoogle Scholar
  94. Zschunke E, Folesky H (1975) Some effects of dicyclohexylcarbodiimide on human skin. Contact Dermatitis 1:188PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • A. Goossens
  • L. Geusens

There are no affiliations available

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