α2-Makroglobulin und Protease Nexin 1: Struktur und Funktion

  • T. Koyama
  • N. Aoki

Zusammenfassung

Bei der Regulation des fibrinolytischen Systems spielt die Inaktivierung von Plasmin und der Plasminogenaktivatoren durch PAI-1, PAI-2 und α2-Antipiasmin eine entscheidende Rolle. Aufgrund ihrer hohen Substratspezifität werden PAI-1, PAI-2 und α2-Antiplasmin als spezifische fibrinolytische Inhibitoren bezeichnet. Daneben gibt es unspezifische fibrinolytische Inhibitoren, die neben anderen Proteinasen auch Plasmin und die Plasminogenaktivatoren inhibieren können. Zu dieser Gruppe gehört α2-Makroglobulin und die Protease Nexin 1. Im folgenden wird die biologische Struktur und Funktion dieser beiden Proteine sowie deren Stellung innerhalb des Hä-mostasesystems beschrieben.

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© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • T. Koyama
  • N. Aoki

There are no affiliations available

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