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Protein-C-Mangelerkrankungen: Pathophysiologie, Diagnostik, Klinik und Therapie

  • I. Pabinger-Fasching

Zusammenfassung

Als Protein-C-Mangelpatienten werden prinzipiell Individuen bezeichnet, bei denen Protein-C-Antigen- und/oder Protein-C-Aktivitätswerte unterhalb des Normbereiches gemessen werden, nachdem andere Ursachen einer Protein-C-Verminde-rung, wie Lebererkrankung oder orale Antikoa-gulanzientherapie, ausgeschlossen wurden. Aus einer Studie an Überträgern, also genetisch determinierten Protein-C-Mangelpatienten, ist bekannt, daß die Werte der meisten Protein-C-Mangelpatienten zwischen 35 und 65% liegen. Einzelne Patienten weisen jedoch nach oben und unten stark abweichende Werte auf. Der Bereich der Protein-C-Aktivitäts- und Antigenwerte bei Protein-C-Mangelpatienten vom Typ I betrug 18–88,5%. Daraus kann gefolgert werden, daß einzelne, genetisch determinierte, heterozygote Mangelpatienten durch die Protein-C-Messung allein nicht von normalen Individuen unterschieden werden können.

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© Springer-Verlag Berlin Heidelberg 1999

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  • I. Pabinger-Fasching

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