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Hämostaseologie pp 266–268Cite as

Faktor-V-Mangelerkrankungen: Pathophysiologie, Klinik, Diagnostik und Therapie

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Zusammenfassung

Faktor V ist ein Glykoprotein, das im Plasma und in Plättchen gefunden wird. Aktivierter Faktor V ist als Kofaktor für das Enzym Faktor Xa an der Thrombinbildurig aus Prothrombin beteiligt und damit ein Bestandteil des Prothrombina-sekomplexes. Die Funktion von aktiviertem Faktor V besteht unter anderem darin, daß er, gebunden an Phospholipide, nun selbst wiederum einen Teil des Faktor-Xa-Rezeptors darstellt. Aufgrund der zentralen Stellung von Faktor V im Gerinnungssystem weisen Patienten mit einem schweren Faktor-V-Mangel eine lebenslange und z.T. klinisch stark ausgeprägte hämorrhagische Diathese auf.

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Authors
  1. E. F. Mammen
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Editors and Affiliations

  1. Kerckhoff-Klinik, Abteilung Hämostaseologie und Transfusionsmedizin, Max-Planck-Institut für physiologische und klinische Forschung, Sprudelhof 11, D-61231, Bad Nauheim, Deutschland

    Gert Müller-Berghaus  & Bernd Pötzsch  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Mammen, E.F. (1999). Faktor-V-Mangelerkrankungen: Pathophysiologie, Klinik, Diagnostik und Therapie. In: Müller-Berghaus, G., Pötzsch, B. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07673-6_30

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  • DOI: https://doi.org/10.1007/978-3-662-07673-6_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07674-3

  • Online ISBN: 978-3-662-07673-6

  • eBook Packages: Springer Book Archive

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