Faktor-V-Mangelerkrankungen: Pathophysiologie, Klinik, Diagnostik und Therapie

  • E. F. Mammen

Zusammenfassung

Faktor V ist ein Glykoprotein, das im Plasma und in Plättchen gefunden wird. Aktivierter Faktor V ist als Kofaktor für das Enzym Faktor Xa an der Thrombinbildurig aus Prothrombin beteiligt und damit ein Bestandteil des Prothrombina-sekomplexes. Die Funktion von aktiviertem Faktor V besteht unter anderem darin, daß er, gebunden an Phospholipide, nun selbst wiederum einen Teil des Faktor-Xa-Rezeptors darstellt. Aufgrund der zentralen Stellung von Faktor V im Gerinnungssystem weisen Patienten mit einem schweren Faktor-V-Mangel eine lebenslange und z.T. klinisch stark ausgeprägte hämorrhagische Diathese auf.

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© Springer-Verlag Berlin Heidelberg 1999

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  • E. F. Mammen

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