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Hämostaseologie pp 172–178Cite as

Faktor VIII: Biochemie und Physiologie

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Zusammenfassung

Faktor VIII (FVIII) ist ein Glykoprotein, das nur in Spurenkonzentrationen im Humanplasma vorkommt. Als Kofaktor von Faktor IXa (F IXa) ist FVIII für die Aktivierung von Faktor X (FX) essentiell. Mangel und Defekte dieses Proteins kennzeichnen das Bild der klassischen Hämophilie A, die bereits vor 1700 Jahren im Talmud beschrieben wurde. Im Blut zirkuliert der FVIII als Komplex mit dem Von-Willebrand-Faktor (VWF), der zur primären Hämostase beiträgt. Zwischen beiden Faktoren bestehen vielfältige Wechselwirkungen von physiologischer Bedeutung. Die Molekularstruktur des F VIII wurde durch die Klonierung der F VIII-cDNA bekannt.

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Authors
  1. N. Heimburger
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Editors and Affiliations

  1. Kerckhoff-Klinik, Abteilung Hämostaseologie und Transfusionsmedizin, Max-Planck-Institut für physiologische und klinische Forschung, Sprudelhof 11, D-61231, Bad Nauheim, Deutschland

    Gert Müller-Berghaus  & Bernd Pötzsch  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Heimburger, N. (1999). Faktor VIII: Biochemie und Physiologie. In: Müller-Berghaus, G., Pötzsch, B. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07673-6_19

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  • DOI: https://doi.org/10.1007/978-3-662-07673-6_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07674-3

  • Online ISBN: 978-3-662-07673-6

  • eBook Packages: Springer Book Archive

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