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Enzym- und Proteinanalytik

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Grundlagen der Molekularen Medizin

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Zusammenfassung

Proteine (Eiweißstoffe) sind für eine Vielfalt dynamischer Lebensfunktionen wie Bewegung, Kraftentwicklung, Stoffwechselkontrolle sowie Signaltransduktion, Differenzierung, Entwicklung und Regulation verantwortlich. Andere Proteine bilden intrazelluläre Strukturen und bestimmen die Form und die Funktion von Organismen. Schließlich gibt es Proteine mit enzymatischen Eigenschaften, die die Verknüpfung oder die Auflösung von kovalenten Bindungen katalysieren. Zur Realisierung dieser vielfältigen Funktionen enthält das menschliche Genom, das etwa 109 Basenpaare umfasst, etwa 30 000–40 000 Gene. Die Produkte dieser Gene sind die Proteine, die zu verschiedenen Zeiten und in unterschiedlichen Konzentrationen in den einzelnen Zellen und Geweben gebildet werden. Das physiologische Geschehen einer Zelle wird wesentlich durch das Zusammenspiel der Gene und der jeweils angeschalteten Proteine reguliert.

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Westermann, P., Wittmann-Liebold, B. (2003). Enzym- und Proteinanalytik. In: Ganten, D., Ruckpaul, K. (eds) Grundlagen der Molekularen Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07588-3_14

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