Genetic Linkage in Schizophrenia: Perspectives from Genetic Epidemiology

  • M. McGue
  • I. I. Gottesman
Conference paper


Research on the genetic epidemiology of schizophrenia is briefly and selectively reviewed. Three salient features of schizophrenia that represent challenges to the design of linkage studies are identified. These are:
  1. a)

    analysis of twin and family data have consistently failed to identify a single major gene effect upon schizophrenia risk;

  2. b)

    ascertainment of multiplex families does not guarantee the sampling of families who are segregating for the major gene, even if a major gene effect exists, and

  3. c)

    environmental influences appear to play an essential role in the etiology of at least some schizophrenia. The implications of these features for the design of linkage studies in schizophrenia are discussed.



Familial Risk Genetic Epidemiology Family Data Multiplex Family Major Gene Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. McGue
  • I. I. Gottesman

There are no affiliations available

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