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The Potential and the Pitfalls of Molecular Genetics for Psychiatry: An Overview

  • R. M. Murray
  • M. Gill
Conference paper

Abstract

The successful application of molecular genetic techniques to psychiatric disorders is likely to require the expertise of at least three separate types of researcher:
  1. a)

    clinicians familiar with the use of operational definitions of psychiatric illness,

     
  2. b)

    molecular biologists knowledgeable about neurobiology, and

     
  3. c)

    statistical geneticists sufficiently versatile to be able not only to perform various types of analyses on complex diseases but also to place the results in the appropriate epidemiological context.

     

Keywords

Molecular Biologist Bipolar Affective Disorder Molecular Genetic Technique Epidemiological Context Single Major Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bassett AS, Jones BD, McGillivray BC, Pantzar JT (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet 1:799–801PubMedCrossRefGoogle Scholar
  2. Byerley W, Mellon C, O’Connell PO, Lalouel JM Nakamura Y, Leppert M, White R (1989) Mapping genes for manic-depression and schizophrenia with DNA markers. Trends Neurosci 12:46–48PubMedCrossRefGoogle Scholar
  3. Edwards JH, Watt DC (1989) Caution in locating the gene(s) for affective disorder. Psychol Med 19:273–275PubMedCrossRefGoogle Scholar
  4. Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325:783–787PubMedCrossRefGoogle Scholar
  5. Goate AM, Haynes AR, Owen MJ, Jarrall M, James LA, Lai LY-C, Mullan MJ, Roques P, Rosser MN, Williamson R, Hardy JA (1989) Predisposing locus to Alzheimer’s disease on chromosome 21. Lancet 1:352–355PubMedCrossRefGoogle Scholar
  6. Goldstein BJ, Santangelo SL, Simpson JC, Tsuang MT (1989) The role of gender in identifying subtypes of schizophrenia. Schizophr Bull (in press)Google Scholar
  7. Hodgkinson S, Sherrington R, Gurling H, Marchbanks R, Reeders S, Mallet J, McInnis M, Petursson H, Brynjolfsson J (1987) Molecular genetic evidence for heterogeneity in manic depression. Nature 325:805–806PubMedCrossRefGoogle Scholar
  8. Kelsoe JR, Ginns EI, Egeland JA, Goldstein AM, Bale SJ, Pauls DL, Long RT, Conte G, Gerhard DS, Houseman DE, Paul SM (1989) Reevaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the old order Amish. Nature 342:238–242PubMedCrossRefGoogle Scholar
  9. Kennedy JL, Giuffra LA, Moises HW, Cavalli-Sforza LL, Pakstis AJ, Kidd JR, Castiglione C, Sjøogren B, Wetterberg L, Kidd KK (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336:167–169PubMedCrossRefGoogle Scholar
  10. Lander ES (1988) Splitting schizophrenia. Nature 336:105–106PubMedCrossRefGoogle Scholar
  11. Martin JB (1987) Molecular genetics: application to the clinical neurosciences. Science 238:765–772PubMedCrossRefGoogle Scholar
  12. Mullan M and Murray RM (1989) The impact of molecular genetics on our undertanding of the psychoses. Br J Psychiatry 154:591–595PubMedCrossRefGoogle Scholar
  13. Murray RM, Lewis SW, Reveley AM (1985) Towards an aetiological classification of schizophrenia. Lancet 1:1023–1026PubMedCrossRefGoogle Scholar
  14. Murray RM, Lewis SW, Owen MJ, Foerster A (1988) The neurodevelopmental origins of dementia praecox. In: Bebbington P, McGuffin P (eds) Schizophrenia: the major issues. Heinman, London, pp 90–107Google Scholar
  15. Pelosi AJ, David AS (1990) Ethical implications of the new genetics for psychiatry. Int Rev Psychiatry (in press)Google Scholar
  16. Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dudleston K, Barraclough B, Wasmuth J, Dobbs M, Gurling H (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336:164–167PubMedCrossRefGoogle Scholar
  17. St. George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Meyers RH, Feldman RG, Pollen D, Drachman D, Growdon J, Bruni A, Foncin J-F, Salmon G, Fromhelt P, Amaducci L, Sorgi S, Placentini S, Stewaqrt GD, Hobbs W, Conneally PM, Gusella JF (1987) The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science 235:885–890CrossRefGoogle Scholar
  18. Sturt E, McGuffin P (1985) Can linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument. Psychol Med 15:455–462PubMedCrossRefGoogle Scholar
  19. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660–669PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. M. Murray
  • M. Gill

There are no affiliations available

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