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Chromatography with Supercritical Fluids (Supercritical Fluid Chromatography, SFC)

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Gas Extraction

Part of the book series: Topics in Physical Chemistry ((TOPPHYSCHEM,volume 4))

Abstract

In a chromatographic separation a mixture of substances is transported by a carrier, called mobile phase, along a not moving surface, called stationary phase. Chromatography is therefore a separation based on two mass separating agents: the mobile phase and the stationary phase. Between the two phases mass transfer processes take place, which lead to a different transport velocity along the surface of the stationary phase for the different components of a mixture. The components reach the end of the stationary phase at different times and can be detected and collected separately.

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References

  1. Alkio M, Harvala T, Komppa V (1988) Preparative scale supercritical fluid chromatography. In: Perrut M (ed) Proc 2nd Int Symposium on Supercritical Fluids, pp 389–396

    Google Scholar 

  2. Applied Chromatography Systems (1987) Instruction manual for evaporative analyzer model 750/14

    Google Scholar 

  3. Berger C, Perrut M (1988) Purification de Molecules d’interet biologique par Chromatografie Preparative Avec Eluant Supercritique. Technoscope Biofutur 25: 3–8

    Google Scholar 

  4. Bruns A, Berg D, Werner–Busse A (1988) Isolation of tocopherol homologues by preparative high–performance liquid chromatography. J Chromatogr 450: 111–113

    Article  CAS  Google Scholar 

  5. Coors U, Montag A (1988) Untersuchungen zur Stabilität des Tocopherolgehaltes pflanzlicher Öle. Fat Sci Technol 90:129–136

    CAS  Google Scholar 

  6. Deemter JJ van, Zuiderweg FJ, Klinkenberg A (1965) Longitudinal diffusion and resistance to mass transfer as causes of nonideality in chromatography. Chem Eng Sci 5: 271–289

    Google Scholar 

  7. Eble JE, Grob RL, Antle PE, Snyder LR (1987) Simplified description of high–performance liquid chromatographic separation under overload conditions, based on the Craig distribution model. III. Computer simulations for two co–eluting bands assuming a Langmuir isotherm. J Chromatogr 405: 1–29

    Article  CAS  Google Scholar 

  8. Gere D, Board R, Mc Manigill D (1982) Parameters of supercritical fluid chromatography using HPLC columns. Hewlett–Packard Publ 43–5953–1647, Avondale, Pennsylvania, pp 7–15

    Google Scholar 

  9. Golshan Shirazi S, Guiochon G (1989) Theoretical study of system peaks and elution profiles for large concentration bands in the case of a binary eluent containing a strongly sorbed additive. J Chromatogr 461:1–18

    Article  Google Scholar 

  10. Kern JR, Lokensgard DM, Manes LV, Matsuo M, Nakamura K (1988) Separation of the stereoisomers of an allenic E–Type prostaglandin. J Chromatogr 450: 233–240

    Article  CAS  Google Scholar 

  11. Klesper E, Leyendecker D (1986) Supercritical fluid chromatography: Retention and resolution. Intl Lab 16(9): 18–30

    Google Scholar 

  12. Knox JH, Pyper HM (1986) Framework for maximizing throughput in preparative liquid chromatography. J Chromatogr 363: 1–30

    Article  CAS  Google Scholar 

  13. Lee ML, Markides KE (eds) (1990) Analytical Supercritical Fluid Chromatography and Extraction. Chromatography Conferences, Provo, Utah

    Google Scholar 

  14. Leyendecker D, Leyendecker D, Schmitz FP, Klesper E (1986) Chromatographic behaviour of various eluents and eluent mixtures in the liquid and in the supercritical state. J Chromatogr 371: 93–107

    Article  CAS  Google Scholar 

  15. Lohmus M, Kirjanes I, Lopp M, Lille Ü (1988) Solvent selectivity in the resolution of some regioisomeric and diastereomeric prostaglandin intermediates on silica. J Chromatogr 449: 77–94

    Article  CAS  Google Scholar 

  16. Lohmus M, Lopp M, Lille Ü, Veisserik J (1988) Preparative liquid chromatographic separation of prostacyclin carba–analogues and their intermediates. J Chromatogr 450: 105–109

    Article  CAS  Google Scholar 

  17. Markides KE, Fields SM, Lee ML (1986) Capillary Supercritical Fluid Chromatography of Labile Carboxylic Acids. J Chromatogr Sci 24: 254–257

    Article  CAS  Google Scholar 

  18. Mollerup J, Staby A, Sloth HC (1992) Thermodynamics of supercritical fluid chromatography. 9th Int Symp on Prep and Ind Chromatography “PREP–92”, Nancy

    Google Scholar 

  19. Martire DE, Boehm RE (1987) Unified molecular theory of chromatography and its application to supercritical fluid mobile phases. 1. Fluid–liquid (absorption) chromatography. J Phys Chem 91: 2433–2446

    Article  CAS  Google Scholar 

  20. Perrut M (1982) Demande de brevet francais, No. 82 09 649, 3 juin 1982

    Google Scholar 

  21. Perrut M (1983) Brevet europeen No. 00 99 765, 25. 05. 1983

    Google Scholar 

  22. Perrut M (1984) US patent, No. 44 78 720, Oct. 23, 1984

    Google Scholar 

  23. Pickel KH (1986) Chromatografische Untersuchungen mit hochkompressiblen mobilen Phasen. Dissertation, Universität Erlangen–Nürnberg

    Google Scholar 

  24. Randall LG (1984) Carbon dioxide based supercritical fluid chromatography. Column efficiencies and mobile phase solvent powers. In: ACS Symposium Series 250: 135–169

    Google Scholar 

  25. Saito M, Yamauchi Y, Hondo T, Senda M (1988) Laboratory Scale Preparative Supercritical Fluid Chromatography in Recycle Operation: Instrumentation and Applications. In: Perrut M (ed) Proc 2nd Int Symposium on Supercritical Fluids, pp 381–388

    Google Scholar 

  26. Saito M, Yamauchi Y (1988) Recycle chromatography with supercritical carbon dioxide as mobile phase. HRC & CC 11: 741 -743

    Article  CAS  Google Scholar 

  27. Saito M, Yamauchi Y, Inomata K, Kottkamp W (1989) Enrichment of tocopherols in wheat germ by directly coupled supercritical fluid extraction with semi–preparative supercritical fluid chromatography. J Chromatogr Sci 27: 79–85

    Article  CAS  Google Scholar 

  28. Saito M, Yamauchi Y (1990) Isolation of tocopherols from wheat germ oil by recycle semi–preparative supercritical fluid chromatography. J Chromatogr 505: 257–271

    Article  CAS  Google Scholar 

  29. Schoenmakers PJ, Verhoeven FCCJG (1986) Effect of pressure on retention in supercritical fluid chromatography with packed columns. J Chromatogr 352: 315–328

    Article  CAS  Google Scholar 

  30. Schoenmakers PJ, Uunk LG (1987) Supercritical fluid chromatography — recent and future developments. Eur Chromatogr News 13: 14–22

    Google Scholar 

  31. Smith RM (ed) (1988) Supercritical Fluid Chromatography. Roy Soc Chem, London

    Google Scholar 

  32. Snyder LR, Cox GB, Antle PE (1987) A simplified description of HPLC separation under overload conditions. A synthesis and extension of two recent approaches. Chromatographia 24: 82–96

    Article  CAS  Google Scholar 

  33. Upnmoor D, Brunner G (1989) Investigation of retention behaviour on packed column SFC. Ber Bunsenges Phys Chem 93: 1009–1015

    Article  CAS  Google Scholar 

  34. Upnmoor D, Brunner G (1989) Anwendungen der Fluidchromatographie (SFC) in der on–line Analytik. GIT Fachz Lab 33: 311–317

    CAS  Google Scholar 

  35. Upnmoor D, Brunner G (1989) Retention of acidic and basic compounds in packed column supercritical fluid chromatography. Chromatographia 28: 449–454

    Article  CAS  Google Scholar 

  36. Upnmoor D, Brunner G (1992) Packed column supercritical fluid chromatography with light scattering detection. I. Optimization of parameters with a carbon dioxide/methanol mobile phase. Chromatographia 33: 255–260

    Article  CAS  Google Scholar 

  37. Upnmoor D, Brunner G (1992) Packed column supercritical fluid chromatography with light scattering detection. II. Retention behaviour of squalene and glucose with mixed mobile phases. Chromatographia 33: 261–266

    Article  CAS  Google Scholar 

  38. Upnmoor D (1992) Untersuchungen zur präparativen Fluidchromatographie am Beispiel von Tocopherolen und Prostaglandinen. Dissertation, Technische Universität Hamburg–Harburg

    Google Scholar 

  39. Wenclawiak B (ed) (1992) Analysis With Supercritical Fluids: Extraction and Chromatography. Springer, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest

    Google Scholar 

  40. White CM (ed) (1988) Modern Supercritical Fluid Chromatography. Hüthig, Heidelberg Basel New York

    Google Scholar 

  41. Yamauchi Y, Saito M, Hondo T, Senda M, Milet JL, Castiglioni E (1988) Coupled supercritical fluid extraction — supercritical fluid chromatography using pre–concentration/separation column: Application to fractionation of lemon peel oil. In: Perrut M (ed) Proc 2nd Int Symposium on Supercritical Fluids, pp 381–388

    Google Scholar 

  42. Yamauchi Y, Saito M (1990) Fractionation of lemon–peel oil by semi–preparative supercritical fluid chromatography. J Chromatogr 505: 237–246

    Article  CAS  Google Scholar 

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© 1994 Springer-Verlag Berlin Heidelberg

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Brunner, G. (1994). Chromatography with Supercritical Fluids (Supercritical Fluid Chromatography, SFC). In: Gas Extraction. Topics in Physical Chemistry, vol 4. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-07380-3_9

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  • DOI: https://doi.org/10.1007/978-3-662-07380-3_9

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-07382-7

  • Online ISBN: 978-3-662-07380-3

  • eBook Packages: Springer Book Archive

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