Abstract
There are many reports on the peripheral vasodilator properties of verapamil and gallopamil. A few studies have also been carried out on cerebral vessels; these are mainly studies in vitro on basilar artery strips (for review of literature see Flaim 1982). In 1973 Vlahov and Enzenross reported that the constriction of feline pia vessels induced in vivo by reducing the pH was inhibited by local administration of gallopamil (D 600) in concentrations upwards of 1 mg/1. In contrast, the effects of verapamil and gallopamil on metabolic reactions in the brain have not been investigated hitherto. This study was made to compare the effect of gallopamil and verapamil on cerebrocortical blood flow and energy metabolism with that of adenosine.
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References
Berne RM, Rubio R, Curnish RR (1974) Release of adenosine from ischemic brain. Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 35: 262–271
Brandt L, Andersson KE, Edvinsson L, Ljunggren B (1981) Effects of extracellular calcium antagonists on the contractile responses of isolated human pial and mesenteric arteries. J Cereb Blood Flow Metabol 1: 339–347
Dora E, Kovách AGB (1982) Effect of acute arterial hypo- and hypertensin on cerebrocortical NAD/NADH redox state and vascular volume. J Cereb Blood Flow Metabol. Im Druck
Dutta P, Mustafa SJ, Jones AW (1980) Effect of adenosine on the uptake and efflux of calcium by coronary arteries of dog (abstract). Federation Proc 39: 530
Fenton PA, Bruttig SP, Rubio R, Berne RM (1982) Effect of adenosine on calcium uptake by intact and cultured vascular smooth muscle. Am J Physiol 242: H707–H804
Flaim SF (1982) Comparative pharmacology of calcium blockers based on studies of vascular smooth muscle. In: Flaim SF, Zelis R, (Hrsg.) Calcium blockers — mechanisms of action and clinical applications. Urban & Schwarzenberg, Baltimore München
Harper AM, Craigen L, Kazda S (1981) Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metabol 1: 349–356
Hayashi S, Toda N (1977) Inhibition by Cd++, verapamil and papaverine of Ca++-induced concentrations in isolated cerebral and peripheral arteries of the dog. Br J Pharmac 60: 35–43
Huang M, Drummond GI (1979) Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other antagonists. Mol. Pharmacol. 16: 462–472
Ibrahim MZM (1975) Glycogen and its related enzymes of metabolism in the central nervous system. Adv Anat Embryol Cell Biol 52:1–84
Kovâch AGB, Dora E, Szedlacsek S, Koller A (1982) Effect of organic calcium antagonist, D 600, on cerebrocortical vascular and metabolic responses evoked by adenosine, anoxia and epilepsy. J Cereb Blood Flow Metabol, im Druck
McCalden TA, Bevan JA (1981) Sources of activator calcium in rabbit basilar artery. Am J Physiol 241:H129–H133
2. Alexander JE, Seibert JJ, Glasier CM et al. (1989) Highresolution hip ultrasound in the limping child. J Clin Ultrasound 17: 19, Nasuya Y (1980) Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine. Japan J Pharmacol 30: 731–742
Nawrath H, Blei J, Gegner R, Ludwig Ch, Zong X (1981) No stereospecific effects of the optical isomers of verapamil and D 600 on the heart. In: Zanchetti A, Krikler OM (Hrsg.): Calcium antagonism in cardiovascular therapy. Excerpta medica, Amsterdam Oxford Princeton
Nimit Y, Skolnick P, Daly JW (1981) Adenosine and cyclic AMP in rat cerebral cortical slices: effects of adenosine uptake inhibitors and adenosine deaminase inhibitors. J Neurochem 36: 908–912
Siesjö BK (1978) Brain Energy Metabolism. John Wiley & Sons, Chichester New York Brisbane Toronto
Siesjö BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metabol 1: 155
Verhaeghe RH (1977) Action of adenosine and adenine nucleotides on dog’s isolated veins. Am J Physiol 233: H114–H121
Ververken D, Van Veldhoven P, Proost C, Carton H, De Wulf H (1982) On the role of calcium ions in the regulation of glycogenosis in mouse brain cortical slices. J Neurochem 38: 1286–1295
Vlahov V, Enzenross HG (1973) Einfluß der Ca++-Ionen auf die Kontraktilität der glatten Muskulatur von Piagefäßen. Verh Dtsch Ges Kreislaufforsch 39:129–132
Wahl M, Kuschinsky W (1976) The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline. Pflügers Arch 362: 55–59
Winn RH, Rubio R, Berne RM (1981) Brain adenosine concentration during hypoxia in rats. Am J Physiol 241: H235–H242
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Kovách, A.G.B., Dora, E., Koller, A. (1984). Antihypoxic Effect of Gallopamil in the Brain. In: Kaltenbach, M., Hopf, R. (eds) Gallopamil. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07364-3_7
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DOI: https://doi.org/10.1007/978-3-662-07364-3_7
Publisher Name: Springer, Berlin, Heidelberg
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