Advertisement

Gallopamil pp 58-65 | Cite as

Studies in Vitro and in Vivo on the Effect of Gallopamil on Coronary Vessels

  • A. G. B. Kovách
  • L. Ligeti
  • M. Bakos
  • G. Rubányi
  • A. Koller
Conference paper

Abstract

Clinical studies have shown that spasms of the coronary arteries are fairly common and can cause myocardial ischaemia both in arteriosclerotic and in radio-graphically normal coronary arteries. Coronary spasms are not only the cause of Prinzmetal’s angina (variant angina), but are also important in typical angina pectoris and in myocardial infarction (Braunwald 1978; Hellström 1973; Hillis and Braunwald 1978; Maseri et al. 1975, 1978). The mechanisms which trigger coronary spasm are not understood. Experimental results suggest that possible causes are α-adrenergic transmitters, thromboxan A2 from platelets, and serotonin (Ellis et al. 1976; Hillis and Braunwald 1978; Holtz et al. 1978). Our own experimental and clinical studies suggest that the trace element nickel, which can cause vascular contraction and which is found in a higher concentration in the serum of patients, might also be an aetiological factor in coronary vascular spasm (Rubânyi 1981 ; Rubânyi et al. 1981).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bevan JA (1979) Some bases of differences in vascular response to sympathetic activity. Circ Res 45:161–171PubMedCrossRefGoogle Scholar
  2. Bohr DF (1973) Vascular smooth muscle updated. Circ Res 32: 665–672PubMedCrossRefGoogle Scholar
  3. Braunwald E (1978) Coronary spasm and acute myocardial infarction — new possibility for treatment and prevention. N Engl J Med 299:1301–1303PubMedCrossRefGoogle Scholar
  4. Ellis EF, Oelz O, Roberts LJ II, Payne NA, Sweetmann BJ, Nies AS, Oates JA (1976) Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science 193:1135–1137PubMedCrossRefGoogle Scholar
  5. Fleckenstein A (1977) Specific pharmacology of calcium in myocardium, cardiac pacemakers and vascular smooth muscle. Ann Rev Pharmacol Toxicol 17:149–166CrossRefGoogle Scholar
  6. Fleckenstein A (1981) Pharmacology and electrophysiology of calcium antagonists. In: Zanchetti A, Kritzler DM (eds): Calcium antagonism in cardiovascular therapy: experience with verapamil. Excerpta Medica, Amsterdam Oxford Princeton, p. 10–29Google Scholar
  7. Hellström HR (1973) Vasospasm in ischemic heart disease a hypothesis. Perspect Biol Med 16: 427–440PubMedGoogle Scholar
  8. Hillis LD, Braunwald E (1978) Coronary-artery spasm. N Engl J Med 299: 695–702PubMedCrossRefGoogle Scholar
  9. Holtz J, Held W, Sommer O, Kühn G, Bassenge E (1982) Ergonovine-induced constrictions of epicardial coronary arteries in conscious dogs: a-adrenoceptors are not involved. Basic Res Cardiol 77: 278–291PubMedCrossRefGoogle Scholar
  10. Kaufmann R, Fleckenstein A (1965) Ca++-kompetitive elektromechanische Entkoppelung durch Ni++- und Co++-Ionen am Warmblütermyokard. Pflügers Arch 282: 290–297CrossRefGoogle Scholar
  11. Kohlhardt M, Bauer B, Krause H, Fleckenstein A (1973) Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni, Co and Mn Ions. Pflügers Arch 338:115–123PubMedCrossRefGoogle Scholar
  12. Koller A, Rubányi G, Ligeti L, Kovách AGB (1982) Inhibition of myocardial reactive hyper-aemia but not of hypoxic coronary vasodilatation by constant verapamil infusion in the in situ dog heart. Acta Physiol Acad Sci Hung 59:187–195PubMedGoogle Scholar
  13. Maseri A, Mimmo R, Chierchia S, Marchesi C, Pesola A, L’ Abbate A (1975) Coronary artery spasm as a cause of acute myocardial ischemia in man. Chest 68: 625–633CrossRefGoogle Scholar
  14. Maseri A, L’Abbate A, Baroldi G, Chierchia S, Marzili M, Ballestra AM, Severi S, Parodi O, Biagini A, Distante A, Pesola A (1978) Coronary vasospasm as a possible cause of myocardial infarction. N Engl J Med 229:1271–1277CrossRefGoogle Scholar
  15. Rubányi G (1981a) Control of coronary vascular tone in hemorrhagic shock. In: Biro Z, Kovách AGB, Spitzer JJ, Stoner HB (eds) Homeostasis and injury in shock. Adv Physiol Sci 26: 99–108Google Scholar
  16. Rubányi G, Ligeti L, Koller A (1981b) Nickel is released from the ischemic myocardium and contracts coronary vessels by a Ca-dependent mechanism. J Mol Cell Cardiol 13:1023–1026PubMedCrossRefGoogle Scholar
  17. Singh BN, Ellrodt G, Peter CT (1978) Verapamil: a review of its pharmacological properties and therapeutic use. Drugs 15:169–197PubMedCrossRefGoogle Scholar
  18. Somlyo AP, Somlyo AV (1970) Vascular smooth muscle. II. Pharmacology of normal and hypertensive vessels. Pharmacol Rev 22: 249–353PubMedGoogle Scholar
  19. Van Nueten JM, Van Beek J, Vanhoutte PM (1980) Inhibitory effect of lidoflazine on contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. J Pharmacol Exp Therap 213:179–187Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • A. G. B. Kovách
  • L. Ligeti
  • M. Bakos
  • G. Rubányi
  • A. Koller

There are no affiliations available

Personalised recommendations