Effect of Gallopamil on Coronary Arteries and Haemodynamics
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The dilator effect of Ca2+ antagonists on coronary arteries and on the peripheral vascular bed has been known for a long time. Marked coronary dilatation has been reported for diltiazem and nifedipine; this effect is less pronounced with verapamil. Rafflenbeul and Lichtlen have reported only recently (1982) a 29% increase in the calibre of some coronary stenoses after sublingual nifedipine. The same stenoses showed a 33% dilatation after sublingual nitroglycerin. In addition, the authors found that nifedipine and nitroglycerin had an additive effect, enlarging the calibre of coronary stenoses by 48%. This study was to find out whether the calibre of coronary arteries and coronary stenoses is affected by intravenous gallopamil, and how the haemodynamics respond.
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- Rafflenbeul W, Lichtlen PR (1982) Release of residual vascular tone in coronary artery stenoses with Nifedipine and Nitroglycerine. Circulation 66:11–81 [Abstr]Google Scholar
- Rafflenbeul W, Heim R, Dzuiba M, Henkel B, Lichtlen P (1976) Morphometric analysis of coronary arteries. In: Lichtlen PR (ed) Coronary angiography and angina pectoris. Thieme, Stuttgart, p 255Google Scholar