Anti-anginal Effect of the Calcium Antagonist Gallopamil
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The beneficial effect of calcium antagonists on coronary spasms has, in recent years, led to these drugs being used increasingly for the treatment of patients with coronary heart disease (Maseri 1980; Mellemgaard et al. 1978). Because there are distinct differences in the pharmacokinetics and pharmacodynamics of the substances available it is necessary to establish precisely the recommended dosages and dosage intervals for each new preparation of this group. The new calcium antagonist gallopamil (Procorum) is a methoxy derivative of verapamil which was found in animals to be three to five times more potent than verapamil. Our studies showed that a peak plasma concentration occurs approximately 1–2h after administration (Neuss et al. 1982). The controlled study reported here was to investigate the anti-anginal effect of gallopamil in patients with coronary heart disease.
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