Randomized trial with intracoronary streptokinase versus placebo (The Netherlands)
In 1981 we initiated a randomized trial at the Thoraxcenter in Rotterdam which was later extended to include four other hospitals cooperating in the Netherlands Interuniversity Cardiology Institute: the Zuiderziekenhuis in Rotterdam, the Free University in Amsterdam, the St. Annadal Hospital in Maastricht and the Leiden University Hospital. Since the global results of the study have been published in the Lancet (4) and in other journals (3, 5) we present a summary of the findings and discuss the clinical consequences of the trial.
KeywordsAcute Myocardial Infarction Infarct Size Thrombolytic Therapy Radionuclide Angiography Intravenous Streptokinase
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- 2.Laarse A vd, Vermeer F, Hermens WT, Willems GM, Neef K de, Simoons ML, Serruys PW, Res J, Verheugt FWA, Krauss XH, Bär F, Zwaan C de, Lubsen J (1986) Effects of early intracoronary streptokinase on infarct size estimated from cumulative enzyme release and on enzyme release rate. Am Heart J (in press)Google Scholar
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