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Randomized trial with intracoronary streptokinase versus placebo (The Netherlands)

  • M. L. Simoons
  • P. W. Serruys
  • M. v/d Brand
  • F. Bar
  • C. de Zwaan
  • J. Res
  • F. W. A. Verheugt
  • X. H. Krauss
  • W. J. Remme
  • F. Vermeer
  • J. Lubsen
Conference paper

Abstract

In 1981 we initiated a randomized trial at the Thoraxcenter in Rotterdam which was later extended to include four other hospitals cooperating in the Netherlands Interuniversity Cardiology Institute: the Zuiderziekenhuis in Rotterdam, the Free University in Amsterdam, the St. Annadal Hospital in Maastricht and the Leiden University Hospital. Since the global results of the study have been published in the Lancet (4) and in other journals (3, 5) we present a summary of the findings and discuss the clinical consequences of the trial.

Keywords

Acute Myocardial Infarction Infarct Size Thrombolytic Therapy Radionuclide Angiography Intravenous Streptokinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kennedy JW, Ritchie JL, Davis KB, Fritz JK (1983) Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 308:1312–1318CrossRefGoogle Scholar
  2. 2.
    Laarse A vd, Vermeer F, Hermens WT, Willems GM, Neef K de, Simoons ML, Serruys PW, Res J, Verheugt FWA, Krauss XH, Bär F, Zwaan C de, Lubsen J (1986) Effects of early intracoronary streptokinase on infarct size estimated from cumulative enzyme release and on enzyme release rate. Am Heart J (in press)Google Scholar
  3. 3.
    Serruys PW, Simoons ML, Suryapranata H, Vermeer F, Wijns W, Brand M vd, Bär F, Zwaan C de, Krauss XH, Remme WJ, Res J, Verheugt FWA, Domburg R van, Lubsen L, Hugenholtz PG (1986) Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction. JACC 7:717–728PubMedCrossRefGoogle Scholar
  4. 4.
    Simoons ML, Serruys PW, Brand M vd, Bär F, Zwaan C de, Res J, Verheugt FWA, Krauss XH, Remme WJ, Vermeer F, Lubsen J (1985) Improved survival after early thrombolysis in acute myocardial infarction. A randomized trial conducted by the Interuniversity Cardiology Institute in the Netherlands. Lancet II:578–582CrossRefGoogle Scholar
  5. 5.
    Simoons ML, Serruys PW, Brand M vd, Res J, Verheugt FWA, Krauss XH, Remme WJ, Bär F, Zwaan C de, Laarse A vd, Vermeer F, Lubsen J (1986) Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival. JACC 7:729–742PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • M. L. Simoons
    • 1
    • 6
  • P. W. Serruys
    • 1
  • M. v/d Brand
    • 1
  • F. Bar
    • 4
  • C. de Zwaan
    • 4
  • J. Res
    • 2
  • F. W. A. Verheugt
    • 2
  • X. H. Krauss
    • 3
  • W. J. Remme
    • 3
  • F. Vermeer
    • 5
  • J. Lubsen
    • 5
  1. 1.ThoraxcenterErasmus University and University Hospital DijkzigtRotterdamThe Netherlands
  2. 2.Department of CardiologyFree University AmsterdamThe Netherlands
  3. 3.Department of CardiologyZuiderziekenhuisRotterdamThe Netherlands
  4. 4.Department of CardiologySt. Annadal HospitalMaastrichtThe Netherlands
  5. 5.Data Processing Center, ThoraxcenterErasmus UniversityRotterdamThe Netherlands
  6. 6.Thoraxcentrum/CardiologieAcademisch ZiekenhuisRotterdamThe Netherlands

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