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Sjögren’s syndrome

  • A. G. Tzioufas
  • H. M. Moutsopoulos
Chapter

Abstract

Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown aetiology, characterized by lymphocyte infiltration of exocrine glands resulting in xerostomia and keratoconjunctivitis sicca. In more than one-third of patients, extraglandular manifestations, such as skin, lung, kidney, liver, muscle and blood vessel involvement, can occur. SS can be found alone (primary SS) or in association with other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma (secondary SS). Five per cent of patients may develop B-cell lymphoma.

Synonyms

Sicca syndrome autoimmune epithelitis Gougerot disease Mikulicz’s disease 

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Further reading

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  8. Vlachoyiannopoulos PG, Moutsopoulos HM. Therapy of Sjögren’s syndrome. In: van de Putte LBA, Furst DE, Williams WJ, van Riel PLCM, eds. Therapy of Systemic Rheumatic Disorders. New York: Marcel Dekker, 1998: 615–28.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • A. G. Tzioufas
  • H. M. Moutsopoulos

There are no affiliations available

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