Skip to main content

Abstract

Malignant melanoma is a malignant tumour originating from the transformation of melanocytes or naevus cells. These cells, arising from the neural crest are not only encountered in the skin and the adjacent mucous membranes, but also in the uvea, retina and central nervous system. Nonetheless, between 85% and 90% of melanomas arise on the outer skin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further reading

  • Andreassi L, Balda B-R, Landi G. Current trends in the treatment of melanoma. Skin Cancer 1993; 8: 103–13.

    Google Scholar 

  • Bachter D, Balda B-R, Vogt H, Büchels H. Die ‘sentinel’ Lymphonodektomie mittels Szintillationsdetektor. Hautarzt 1996; 47: 754–8.

    Article  PubMed  CAS  Google Scholar 

  • Bachter D, Balda B-R, Vogt H, Büchels H. Primary therapy of malignant melanomas: Sentinel lymphadenectomy. IntJDermatol 1998; 37: 278–82.

    CAS  Google Scholar 

  • Balch C, Buzaid AC, Atkins MB etal. A New American Joint Committee on Cancer Staging System for Cutaneous Melanoma. Cancer 2000; 88: 1484–91.

    Article  PubMed  CAS  Google Scholar 

  • Balch C, Buzaid AC, Soong S-J, et al. Final version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma. J Clin Oncol 2001; 19: 3635–48.

    PubMed  CAS  Google Scholar 

  • Balda B-R, Herrmann R. Neoplasien der Haut. In: Huhn D, Herrmann R, eds. Medikamentöse Therapie Maligner Erkrankungen, 3rd edn. Stuttgart: Fischer, 1995: 393–405.

    Google Scholar 

  • Balda B-R. Die Sentinel-Lymphonodektomie bei malignen Melanomen—mehr als ein Diagnostikum? In: Konz B, Plewig G, eds. Fortschr Dermatol. Darmstadt: Steinkopf, 2002: 7–14.

    Chapter  Google Scholar 

  • Bastian B, LeBoit P, Hamm H, Bröcker EB, Pinkel D. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 1998; 58: 2170–5.

    PubMed  CAS  Google Scholar 

  • Bastian B, Kashani-Sabet M, Hann H. Gene amplifications characterize acral melanoma and permit detection of occult tumor cells surrounding skin. Cancer Res 2000; 60: 1968–73.

    PubMed  CAS  Google Scholar 

  • Berger W, Ebling L, Micksche M. Chemoresistance of human malignant melanoma. Cellular Mol Aspects Onkol 1998; 21: 105–10.

    Google Scholar 

  • Cochran A, Balda B-R, Starz H, Bachter D, Krag DN, Cruse CW, Pijpers R, Morton DL. The Augsburg Consensus. Techniques, lymphatic mapping, sentinel lymphadenectomy, completion lymphadenectomy, cutaneous malignancies. Cancer 2000; 89: 236–41.

    Article  PubMed  CAS  Google Scholar 

  • Elsässer-Beile U, Schöpf E, Neumann HA, Drews H, Hundhammer K, Balda B-R. Rekombiniertes Leukozyten-A-Interferon beim metastasierten malignen Melanom. Dtsch med Wschr 1987; 112: 373–7.

    Article  PubMed  Google Scholar 

  • Enk AH, Nashan D, Knop J. Therapie von Lungenmetastasen des malignen Melanoms mit inhalativem IL-2. Hautarzt 1997; 48: 894–6.

    Article  PubMed  CAS  Google Scholar 

  • Falkson CI, Ibrahim J, Kirkwood JM, Coates AS, Atkins MB, Blum RH. Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative Oncology Group Study. J Clin Oncol 1998; 16: 1743–51.

    PubMed  CAS  Google Scholar 

  • Katsambas A, Nicolaidou E. Cutaneous malignant melanoma and sun exposure. Recent developments in epidemiology. Arch Dermatol 1996; 132: 444–50.

    Article  PubMed  CAS  Google Scholar 

  • Kirkwood JM, Hunt-Straderman M, Ernstorff MS, Smith TJ. Interferon alpha-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol 1996; 14: 7–17.

    PubMed  CAS  Google Scholar 

  • Krämer K-U, Prang N, Balda B-R. Evaluation of plasma 5-S-cysteinyldopa as a tumor marker of malignant melanoma. Ann Ital Dermatol 1999; 53: 75–9.

    Google Scholar 

  • Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, Foshag LJ, Cochran AJ. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992; 127: 392–9.

    Article  PubMed  CAS  Google Scholar 

  • Serrone L, Hersey P. The chemoresistance of human malignant melanoma: an update. Melanoma Res 1999; 9: 51–8.

    Article  PubMed  CAS  Google Scholar 

  • Starz H, Balda B-R. Sentinel lymphonodectomy and micromorphometric S-staging, a successful new strategy in the management of cutaneous malignancies. G Ital Dermatol Venereol 2000; 135: 161–9.

    Google Scholar 

  • Starz H, Balda B-R, Büchels H. Sentinel-Lymphonodektomie bei malignen Melanomen. Eine vorläufige Bilanz aus histomorphologischer

    Google Scholar 

  • Sicht. In: Garbe C, Rassner G, eds. Dermatologie. Leitlinien und Qualitätssicherung für Diagnostik und Therapie. Heidelberg: Springer, 1998; 274–7.

    Google Scholar 

  • Starz H, Balda B-R, Kramer KU, Büchels H, Wang JH. A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma. Cancer 2001; 91: 2110–21.

    Article  PubMed  CAS  Google Scholar 

  • Starz H, De Donno A, Balda B-R. The Augsburg Experience: Histological Aspects and Patient Outcomes. Ann Surg Oncol 2001; 8 (9S): 48–51.

    Google Scholar 

  • Starz H, Cochran AJ, Balda B-R. Die SentinelLymphonodektomie aus histopathologischer Sicht. Akt Dermatol 2002; 28: 273–8.

    Article  Google Scholar 

  • Volkenandt M, Schmidt M, Konz B, Gummer M, Hein R, Plewig G, Hölzel D. Klinisch-epidemiologische Daten von Patienten mit malignen Melanomen aus dem Bereich des Tumorzentrums München von 1977 bis 1997. Hautarzt 1999; 50: 470–78.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Balda, BR., Starz, H. (2003). Malignant melanoma. In: Katsambas, A.D., Lotti, T.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07131-1_57

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07131-1_57

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05657-4

  • Online ISBN: 978-3-662-07131-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics