Abstract
Hypertrophic scars and keloids are benign cutaneous lesions produced by an overgrowth of dense fibrous tissue for uncontrolled synthesis and deposition of dermal collagen. The former remain confined to the site of the primary lesion, the latter invade the surrounding skin extending for variable distances beyond the site of injury.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Asawanonda P, Khoo LS, Fitzpatrick TB, Taylor CR. Arch Dermatol 1999; 135: 348–9.
Berman B, Bieley H. Keloids. J Am Acad Dermatol 1995; 33: 117–23.
Blumenkranz MS, Ophir A, Claflin AJ, Hajek A. Fluorouracil for the treatment of massive peri-retinal proliferation. Am J Ophthalmol 1982; 94: 458–67.
Brent B. The role of pressure therapy in management of car lobe keloids: preliminary report of a controlled study. Ann Plast Surg 1978; 1: 579–81.
Campanile G, Hautmann G, Lotti T. A topical pharmacological approach to wound healing. Current 1994; 1: 33–8.
Ceillev RI, Sabin RW. The combined use of cryosurgery and intralesional injections of suspensions of fluorinated adrenocorticosteroids for reducing keloids and hypertrophic scar. J Dermatol Surg Oncol 1979; 5: 54–6.
Cordero A Jr. Non-conventional uses of retinoic acid. In: Burgdorf WHC, Katz SI, eds. Dermatology: Progress and Perspectives. Proccedings of the 18th World Congress of Dermatology. New York: Parthenon Publishing, 1993: 542–43.
Cosman B, Crikelair CF, Ju DMC et al. The surgical treatment of keloids. Plast Reconstr Surg 1961; 27: 335–58.
Datubo-Brown DD. Keloids: a review of the literature. BrJPlastSurg 1990; 43 (1): 70–7.
Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 1999; 25: 224–32.
Gold M. A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. J Am Acad Dermatol 1994; 30 (3): 506–7.
Grandstein RD, Rook A, Flotte TJ. A controlled trial of intralesional recombinant interferon -y in the treatment of keloid scarring. Arch Dermatol 1990; 126: 1285–302.
Griffith BH, Monroe CW, McKinney R A follow-up study on the treatment of keloids with triamcinolone acetonide. Plast Reconstr Surg 1970; 46: 145–50.
Gruss C, Stucker M, von Kobyletzki G et al. Low dose UVA-1 phototherapy in disabling pan-sclerotic morphoea of childhood (letter). Br J Dermatol 1997; 136: 293–4.
Henderson D. The effect of carbon dioxide laser surgery on the recurrence of keloids: discussion. Plast Reconstr Surg 1991; 87 (1): 53–6.
Kerscher M, Volkenandt M, Gruss C et al. Low-dose UVA1 phototherapy for treatment of localized scieroderma. JAm Acad Dermatol 1998; 38: 21–6.
Kiil JC. Keloids treated with topical injections of triamcinolone acetonide (Kenalog): immediate and long term results. Scand J Plast Reconstr Surg 1977; 11: 169–72.
Kischer CW, Shetiar MR, Shetlar CL. Alteration of hypertrophic scars induced by mechanical pressure. Arch Dermatol 1975; 111: 60–4.
Lee R. The response of burns scars to intralesional verapamil. Arch Surg 1994; 129: 107–11.
Lee R, Ping A. Calcium antagonist retard extracellular matrix production in connective tissue equivalent. JSurgRes 1990; 49: 463–6.
Levy DS, Salter MM, Roth RE. Postoperative irradiation in the prevention of keloids. Am J Roentgenol 1976; 127: 509–10.
Malaker K, Ellis E, Paine CH. Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy. Clin Radiol 1976; 27: 179–83.
Mallick KS, Hajek AS, Parrish RK. 5-Fluorouracil (5-FU) and cytarabine (ara-C) inhibition of corneal epithelial cell and conjunctival fibroblast proliferation. Arch Ophthalmol 1985; 103: 1398–402.
Murray JC, Pollack SV, Pinnel SR. Keloids: a review. J Am Acad Dermatol 1981; 14: 461–70.
Norris J. The effect of carbon dioxide laser surgery on the recurrence of keloids. Plast Reconstr Surg 1991; 87 (1): 50–3.
Petersen MJ, Hansen C, Craig S. Ultraviolet A radiation stimulates collagenase production in cultured human fibroblasts. J Invest Dermatol 1992; 99: 440–4.
Sawada Y, Sone J. Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg 1992; 45(8): 599–603.
Scharfetter K, Wlaschek M, Hogg A et al. UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res 1991; 283: 506–11.
Sproat JE, Dalcin A, Weitauer N et al. Hypertrophic sternal scars: silicone gel sheet versus kenalog injection treatment. Plast Reconstr Surg 1992; 90 (5): 988–92.
Stege H, Berneburg M, Humke S et al. High-dose UVA1 radiation therapy for localized scleroderma. JAm Acad Dermatol 1997; 36: 938–44.
Vallis CR Intralesional injection of keloids and hypertrophic scars with the Dermojet. Plast Reconstr Surg 1967; 40: 255–62.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hautmann, G., Mastrolorenzo, A., Menchini, G., Lotti, T.M. (2003). Keloids and hypertrophic scars. In: Katsambas, A.D., Lotti, T.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07131-1_46
Download citation
DOI: https://doi.org/10.1007/978-3-662-07131-1_46
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-05657-4
Online ISBN: 978-3-662-07131-1
eBook Packages: Springer Book Archive