Actinic keratosis

  • F. M. Camacho-Martínez


Actinic keratosis (AK) is a circumscribed cutaneous neoplasm presenting chromosomal abnormalities which occurs primarily on sun-exposed skin surfaces in fair-skinned individuals in the form of horny papules. Currently, Ackerman considers that AK is not a premalignant lesion but a real ‘malignant neoplasm’ from the very beginning. It should be considered a superficial squamous cell carcinoma in the same form, as there are superficial basal cell carcinomas. Some have stated clearly and emphatically their belief that AKs are on continuum and may or may not become malignant. Yantsos proposed a change in nomenclature to refer to AKs as keratinocytic intraepidermal neoplasia (KIN) with three grades of evolution that range from AKs to SCCs.


Photodynamic Therapy Basal Cell Carcinoma Superficial Basal Cell Carcinoma Epidermolytic Hyperkeratosis Superficial Squamous Cell Carcinoma 
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Further reading

  1. Ackerman AB. Respect at last for solar keratosis. Dermatopathology: Pract Conceptual 1997; 3: 101–3.Google Scholar
  2. Alvanopoulos K et al Photodynamic therapy of superficial basal cell carcinoma using 5aminolevulinic acid and 517-nm light. J Eur Acad Dermatol Venereol 1997; 9: 134–6.CrossRefGoogle Scholar
  3. Beutner KR, Geisse JK, Heiman D, Fox TL, Ginkel A, Owens ML. Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J Am Acad Dermatol 1999; 41: 1002–7.PubMedCrossRefGoogle Scholar
  4. Camacho F. Queratomas actínicos. In: Ledo A, ed. Avances en Terapéutica Dermatológica. Madrid: Gaceta Dermatologica Ed, 1988: 259–60.Google Scholar
  5. Camacho F. Precancer epitelial cutaneo-mucoso. In: Armijo M, Camacho F, eds. Dermatologia, 2nd edn. Madrid: Grupo Aula Médica Ed, 1997: 403–17.Google Scholar
  6. Camacho FM. Chronic radiation dermatitis: what’s new in management? Editorial. J Eur Acad Dermatol Venereol 2000; 14: 246–7.PubMedCrossRefGoogle Scholar
  7. Camacho F, Dulanto F. Colgajos locales. In: Camacho F, Dulanto F, eds. Cirugía Dermatologica. Madrid: Grupo Ala Médica Ed, 1995: 167–89.Google Scholar
  8. Camacho F, Garcia-Hernandez MJ, Pérez-Bernal AM. Modelación cutanea (resurfacing). Concepto y fundamentos. In: Cisneros JL, eds. Laser y Fuentes de Luz Pulsada Intensa en Dermatologia y Dermocosmética. Madrid: Grupo Aula Médica Ed, 2000: 205–16.Google Scholar
  9. Ceburkov O, Golnick H. Photodynamic therapy in dermatology. Eur J Dermatol 2000; 10: 568–76.PubMedGoogle Scholar
  10. Diffey BL. Sun protection with clothing. Editorial comments. Br J Dermatol 2001; 144: 449–50.PubMedCrossRefGoogle Scholar
  11. Edwards L. The interferons. Dermatol Clin 2001; 19: 139–46.PubMedCrossRefGoogle Scholar
  12. Ferrandiz C, Fuente MJ, Fernández-Figueras MT, Bielsa I, Just M. p53 immunohistochemical expression in early posttransplant-associated malignant and premalignant cutaneous lesions. Dermatol Surg 1999; 25: 97–101.PubMedCrossRefGoogle Scholar
  13. Haller JC, Cairnduff F, Slack G et al Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy. Br J Dermatol 2000; 143: 1270–4.PubMedCrossRefGoogle Scholar
  14. Kalka K, Merk H, Mukhtar H. Photodynamic therapy in dermatology. J Am Acad Dermatol 2000; 42: 389–413.PubMedCrossRefGoogle Scholar
  15. Persaud AN, Shamuelova E, Sherer D et al Clinical effect of imiquimod 5% cream in the treatment Actinic keratosis 15 of actinic keratosis. J Am Acad Dermatol 2002; 47: 553–6.PubMedCrossRefGoogle Scholar
  16. Sander CA, Pfeiffer Ch, Kligman AM, Plewig G. Chemotherapy for disseminated actinic keratoses with 5-fluorouracil and isotretinoin. JAm Acad Dermatol 1997; 36: 236–8.CrossRefGoogle Scholar
  17. Varma S, Wilson H, Kurwa HA et al Bowen’s disease, solar keratoses and superficial basal cell carcinomas treated by photodynamic therapy using a large-field incoherent light source. Br J Dermatol 2001; 144: 567–74.PubMedCrossRefGoogle Scholar
  18. Witheiler DD, Lawrence N, Cox SE, Cruz Ch, Cockerell CJ, Freemen RG. Long-term efficacy and safety of Jessner’s solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratosis. Dermatol Surg 1997; 23: 191–6.PubMedCrossRefGoogle Scholar
  19. Yantsos V. Continuous spectrum between actinic keratoses and SCC, analogous to CIN (cervical intraepithelial neoplasia). Semin Cutan Med Surg 1999; 18: 3–14.CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2003

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  • F. M. Camacho-Martínez

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