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Antihistamines

  • A. D. Katsambas
  • A. J. Stratigos
  • T. M. Lotti
Chapter

Abstract

The histamine-receptor antagonists or antihistamines are classified into three types:
  1. 1

    Traditional, classic or first-generation H1-type antihistamines.

     
  2. 2

    Low-sedating or second-generation H1-type antihistamines.

     
  3. 3

    H2-type antihistamines.

     
There are three types of histamine receptors: H1, H2 and H3. The H1-receptors mediate the following effects: vasodilatation of small blood vessels resulting in increased permeability, smooth muscle contraction and itching. The H2-receptors are best known for mediating the effects on gastric acid production, and the H3-receptors are found in the brain and are responsible for autoregulation of histamine production and release. The H1-antihistamines, both the traditional and the low sedating, and the H2-type antihistamines to a much less extent are considered first-line medications in dermatological practice. However, the inhibitors of the H3-receptors have not as yet found a role in dermatological treatment.

Keywords

Atopic Dermatitis Chronic Urticaria Chronic Idiopathic Urticaria Chlorpheniramine Maleate Urticaria Pigmentosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Further reading

  1. Food and Drug Administration (FDA). Talk paper. T97. 3 13 Jan 1997.Google Scholar
  2. Lawlor F, Greaves MW. In: Lichtenstein FM, Fauci A, eds. Chronic Urticaria in Current Therapy in Allergy, Immunology and Rheumatology. Philadelphia: Mosby, 1997.Google Scholar
  3. Maddin S. Efficacy and safety of antihistamines in allergic skin disorders. JEur Acad Dermatol Venereol 1997; 8 (Suppl. 1): S18 - S23.CrossRefGoogle Scholar
  4. Monroe E. Therapy of acute chronic urticaria. J Eur Acad Dermatol Venereol 1997; 8 (Suppl. 1): S11 - S17.CrossRefGoogle Scholar
  5. Simons FER, Simons KJ. The pharmacology and use of Hl receptor-antagonist drugs. N Engl JMed 1994; 330 (23): 1667.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • A. D. Katsambas
  • A. J. Stratigos
  • T. M. Lotti

There are no affiliations available

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