The histamine-receptor antagonists or antihistamines are classified into three types:
There are three types of histamine receptors: H1, H2 and H3. The H1-receptors mediate the following effects: vasodilatation of small blood vessels resulting in increased permeability, smooth muscle contraction and itching. The H2-receptors are best known for mediating the effects on gastric acid production, and the H3-receptors are found in the brain and are responsible for autoregulation of histamine production and release. The H1-antihistamines, both the traditional and the low sedating, and the H2-type antihistamines to a much less extent are considered first-line medications in dermatological practice. However, the inhibitors of the H3-receptors have not as yet found a role in dermatological treatment.
Traditional, classic or first-generation H1-type antihistamines.
Low-sedating or second-generation H1-type antihistamines.
KeywordsHistamine Glaucoma Dermatitis Cimetidine Ranitidine
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