• C. Antoniou


Photochemotherapy (psoralen and ultraviolet A or PUVA) is a treatment carried out by oral or topically administered psoralens (a linear isomer of furocoumarins) plus UVA light (320–400 nm). At present, the drug most frequently used for this treatment is 8-methoxypsoralen (8-MOP) although 5-methoxypsoralen (5-MOP) and 4,5′,8-trimethylpsoralen (TMP) are also employed.


Lichen Planus Skin Type Mycosis Fungoides Alopecia Areata PUVA Therapy 
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Further reading

  1. Abel EA. Photochemotherapy in Dermatology. New York: Igaku-Shoin Medical Publishers, 1992.Google Scholar
  2. Antoniou C, Petropoulos E, Theocharis S, Hasapi V, Georga E, Katsambas A. Photochemotherapy for mycosis fungoides. Iatriki 1997; 72 (3): 290–2.Google Scholar
  3. Frappaz A, Thivolet J. Calcipotriol in combination with PUVA: A randomized double-blind placebo study in severe psoriasis. Eur J Dermatol 1993; 3: 351–4.Google Scholar
  4. Gonzalez E. PUVA for psoriasis. Dermatol Clin 1995; 13 (4): 851–66. Google Scholar
  5. Lowe NJ, Weingarten D, Bourget T et al. PUVA therapy for psoriasis: Comparison of oral and bathwater delivery of 8-methoxypsoralen J Am Acad Dermatol 1986; 14: 754–60 Google Scholar
  6. Momtaz KT, Fitzpatrick TB. Modifications of PUVA. Dermatol Clin 1995; 13 (4): 867–73.Google Scholar
  7. Morison WL. Phototherapy and Photochemotherapy of Skin Disease. Philadelphia: Decker, 1991.Google Scholar
  8. Morison WL, Momtaz TK, Parrish JA et al Combined methotrexate—PUVA therapy in the treatment of psoriasis. J Am Acad Dermatol 1982; 6: 46–51.PubMedCrossRefGoogle Scholar
  9. Salo OP, Lassus A, Taskinen J. Trioxsalen bath plus UVA treatment of psoriasis. Acta Dermatonever (Stochkh) 1981; 61: 551–4. Google Scholar
  10. Ster RS. Malignant melanoma in patients treated for psoriasis with PUVA. Photodermatol Photoimmunol Photomed 1999; 15: 37–8. Google Scholar
  11. Stern RS, Laird N. The carcinogenic risk of treatments for severe psoriasis. Photochemotherapy Follow-up Study. Cancer 1994; 73: 2759–64.PubMedCrossRefGoogle Scholar
  12. Stern RS, Nickols KT, Vakeva LH. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-up Study. NEngl /Med 1997; 336: 1041–5.CrossRefGoogle Scholar
  13. Wolff K. Should PUVA be abandoned N Engl J Med 1997; 336: 1090–1. Google Scholar
  14. Wolff K, Gschnait F, Hönigsmann et al. Phototesting and Dosimetry for photochemotherapy Br J Dermatol 1977; 96: 1–10 Google Scholar

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© Springer-Verlag Berlin Heidelberg 2003

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  • C. Antoniou

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