Abstract
Photochemotherapy (psoralen and ultraviolet A or PUVA) is a treatment carried out by oral or topically administered psoralens (a linear isomer of furocoumarins) plus UVA light (320–400 nm). At present, the drug most frequently used for this treatment is 8-methoxypsoralen (8-MOP) although 5-methoxypsoralen (5-MOP) and 4,5′,8-trimethylpsoralen (TMP) are also employed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Further reading
Abel EA. Photochemotherapy in Dermatology. New York: Igaku-Shoin Medical Publishers, 1992.
Antoniou C, Petropoulos E, Theocharis S, Hasapi V, Georga E, Katsambas A. Photochemotherapy for mycosis fungoides. Iatriki 1997; 72 (3): 290–2.
Frappaz A, Thivolet J. Calcipotriol in combination with PUVA: A randomized double-blind placebo study in severe psoriasis. Eur J Dermatol 1993; 3: 351–4.
Gonzalez E. PUVA for psoriasis. Dermatol Clin 1995; 13 (4): 851–66.
Lowe NJ, Weingarten D, Bourget T et al. PUVA therapy for psoriasis: Comparison of oral and bathwater delivery of 8-methoxypsoralen J Am Acad Dermatol 1986; 14: 754–60
Momtaz KT, Fitzpatrick TB. Modifications of PUVA. Dermatol Clin 1995; 13 (4): 867–73.
Morison WL. Phototherapy and Photochemotherapy of Skin Disease. Philadelphia: Decker, 1991.
Morison WL, Momtaz TK, Parrish JA et al Combined methotrexate—PUVA therapy in the treatment of psoriasis. J Am Acad Dermatol 1982; 6: 46–51.
Salo OP, Lassus A, Taskinen J. Trioxsalen bath plus UVA treatment of psoriasis. Acta Dermatonever (Stochkh) 1981; 61: 551–4.
Ster RS. Malignant melanoma in patients treated for psoriasis with PUVA. Photodermatol Photoimmunol Photomed 1999; 15: 37–8.
Stern RS, Laird N. The carcinogenic risk of treatments for severe psoriasis. Photochemotherapy Follow-up Study. Cancer 1994; 73: 2759–64.
Stern RS, Nickols KT, Vakeva LH. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-up Study. NEngl /Med 1997; 336: 1041–5.
Wolff K. Should PUVA be abandoned N Engl J Med 1997; 336: 1090–1.
Wolff K, Gschnait F, Hönigsmann et al. Phototesting and Dosimetry for photochemotherapy Br J Dermatol 1977; 96: 1–10
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Antoniou, C. (2003). Photochemotherapy. In: Katsambas, A.D., Lotti, T.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07131-1_115
Download citation
DOI: https://doi.org/10.1007/978-3-662-07131-1_115
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-05657-4
Online ISBN: 978-3-662-07131-1
eBook Packages: Springer Book Archive