Abstract
We dedicate this chapter to the memory of Dr. Stephen J. Young, mentor, colleague and friend. For decades Steve contributed tirelessly and selflessly to the advancement of the science of countless students, colleagues and scientists around the world. His presence is sorely missed.
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References
Abercrombie ED, Keefe KA, DiFrischia DS, Zigmond MJ (1989) Differential effects of stress on in vivo dopamine release in striatum, nucleus accumbens and medial frontal cortex. J Neurochem 52:1655–1658
Aceto MD, Scates SM, Lowe JA, Martin BR (1995) Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716 A. Eur J Pharmacol 282:R1–2
Aceto MD, Scates SM, Lowe JA, Martin BR (1996) Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal. J Pharmacol Exp Ther 278:1290–1295
Ackerman JM, White FJ (1990) A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment. Neurosci Lett 117:181–187
Ackerman JM, White FJ (1992) Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine. Eur J Pharmacol 218:171–173
Aghajanian GK, Bunney BS (1973) Central dopaminergic neurons: Neurophysiological identification and responses to drugs. Snyder SH Usdin E (eds) Frontiers in Catecholamine Research, Pergamon Press, NY, pp 643–648
Aghajanian GK, Bunney BS (1977) Dopamine “autoreceptors”: pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg’s Arch Pharmacol 297:1–7
Akaoka H, Charléty P, Saunier C-F, Buda M, Chouvet G (1992) Inhibition of nigral dopamine neurons by systemic and local apomorphine: Possible contribution of dendritic autoreceptors. Neuroscience 49:879–891
Anden NE, Carlsson A, Dahlstrom A, Fuxe K, Hillarp NA, Larsson K (1964) Demonstration and mapping out of nigro-neostriatal dopamine neurons. Life Sci 3:523–530
Anden NE, Dahlstrom A, Fuxe K, Larsson K (1965) Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and dien-cephalon. Life Sci 4:1275–1279
Arai H, Sirinathsinghiji DJS, Emson PC (1985) Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum. Neurosci Res 5:167–171
Arnold EB, Molinoff PB, Rutledge CO (1977) The release of endogenous norepinephrine and dopamine from cerebral cortex by amphetamine. J Pharmacol Exp Ther 202:544–557
Bailey CP, Manley SJ, Watson WP, Wonnacott S, Molleman A, Little HJ (1998) Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability. Brain Res 803:144–152
Bannon MJ, Bunney EB, Roth RH (1981) Mesocortical dopamine neurons: Rapid transmitter turnover compraed to other brain catecholamine systems. Brain Res 218:376–382
Bannon MJ, Reinhard Jr. JF, Bunney EB, Roth RH (1982) Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones. Nature 296:444–446
Bean AJ, Shepard PD, Bunney BS, Nestler EJ, Roth RH (1988) The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Mol Pharmacol 34:715–718
Beart PM, McDonald D (1982) 5-Hydroxytryptamine and 5-hydroxytryptaminergic-dopaminergic interactions in the ventral tegmental area of rat brain. J Pharm Pharmacol 34:591–593
Beninato M, Spencer RF (1988) The cholinergic innervation of the rat substantia nigra: a light and electron microscopic immunohistochemical study. Exp Brain Res 72:178–184
Bertler A, Falck B, Gottfries CG, Lijunggren L, Rosengren E (1964) Some observations on adrenergic connections between mesencephalon and cerebral emispheres. Acta Pharmacol Toxicol 21:283–289
Bjorklund A, Lindvall O (1975) Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals. Brain Res 83:531–537
Blaschko H (1939) The specific action of L-DOPA decarboxylase. J Physiol (Lond) 96:50–51
Bolam JP, Smith Y (1990) The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain Res 529:57–78
Bonci A, Williams JT (1997) Increased probability of GABA release during withdrawal from morphine. J Neurosci 17:796–803
Bonci A, Grillner P, Siniscalchi A, Mercuri NB, Bernardi G (1997) Glutamate metabotropic receptor agonists depress excitatory and inhibitory transmission on rat mesencephalic principal neurons. Eur J Neurosci 9:2359–2369
Bowery B, Rothwell LA, Seabrook GR (1994) Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. Br J Pharmacol 112:873–880
Boyar WC, Altar CA (1987) Modulation of in vivo dopamine release by D2 but not D1 receptor agonists and antagonists. J Neurochem 48:824–831
Brodie MS, Appel SB (1998) The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin Exp Res 22:236–244
Brodie MS, McElvain MA, Bunney EB, Appel SB (1999a) Pharmacological reduction of small conductance calcium-activated potassium current (SK) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons. J Pharmacol Exp Ther 290:325–333
Brodie MS, Pesold C, Appel SB (1999b) Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcohol Clin Exp Res 23:1848–1852
Bunney BS (1979) The electrophysiological pharmacology of midbrain dopaminergic systems. In: Horn AS, Korf J, Westerink BHC (ed) The Neurobiology of Dopamine. New York, Academic Press, pp 417–452
Bunney BS, Aghajanian GK (1973) Electrophysiological effects of amphetamine on dopaminergic neurons. In: Snyder SH, Usdin E (eds) Frontiers in Catecholamine Research. Pergamon Press, NY, pp 957–962
Bunney BS, Grace AA (1978) Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life Sci 23:1715–1727
Bunney BS, Aghajanian GK, Roth RH (1973a) Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature New Biology 245:123–125
Bunney BS, Walters JR, Roth RH, Aghajanian GK (1973b) Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharm Exp Ther 185:560–571
Calabresi P, Lacey MG, North RA (1989) Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording. Br J Pharmacol 98:135–140
Cameron DL, Williams JT (1993) Dopamine D1 receptors facilitate transmitter release. Nature 366:344–347
Canavier CC (1999) Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci 6:49–69
Carboni E, Bortone L, Giua C, Di Chiara G (2000) Dissociation of physical abstinence from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats. Drug and Alcohol Dependence 58: 93–102
Cardozo DL, Bean BP (1995) Voltage-dependent calcium channels in rat midbrain dopamine neurons: Modulations by dopamine and GABAB receptors. J Neuro-physiol 74:1137–1148
Carlsson A, Lindqvist M (1963) Effects of chlorpromazine and haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 20:140–144
Carlsson A, Lindqvist M, Magnusson T, Waldeck B (1958) On the presence of three-hydroxytyramine in brain. Science 27:471
Carlsson A, Kehr W, Lindqvist M, Magnusson T, Atack CV (1972) Regulation of monoamine metabolism in the central nervous system. Pharmacol Rev 24:371–384
Cass WA, Gerhardt GA (1995) In vivo assessment of dopamine uptake in rat medial prefrontal cortex: comparison with dorsal striatum and nucleus accumbens. J Neurochem 65:201–207
Cathala L, Paupardin-Tritsch D (1999) Effect of catecholamines on the hyperpolarization-activated cationic Ih and the inwardly rectifying potassium IKir currents in the rat substantia nigra pars compacta. Eur J Neurosci 11:398–406
Celada P, Paladini CA, Tepper JM (1999) GABAergic control of rat substantia nigra dopaminergic neurons: Role of globus pallidus and substantia nigra pars reticulata. Neuroscience 89:813–825
Chang HT, Kita H, Kitai ST (1984) The ultrastructural morphology of the subthalamicnigral axon terminals intracellularly labeled with horseradish peroxidase. Brain Res 299:182–185
Charlety PJ, Grenhoff J, Chergui K, De La Chapelle Buda M, Svensson TH, Chouvet G (1991) Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate. Acta Physiol Scand 142:105–112
Chen J, Paredes W, Lowinson JH, Gardner EL (1990) Delta 9-tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex. Eur J Pharmacol 190:259–262
Cheramy A, Leviel V, Glowinski J (1981) Dendritic release of dopamine in the substantia nigra. Nature 289:537–542
Chergui K, Charlety PJ, Akaoka H, Saunier CF, Brunet J-L, Buda M, Svensson TH, Chouvet G (1993) Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci 5:137–144
Chergui K, Akaoka H, Charlety PJ, Saunier CF, Buda M, Chouvet G (1994) Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors. NeuroReport 5:1185–1188
Chien P-Y, Farkas RH, Nakajima S, Nakajima Y (1996) Single-channel properties of the non-selective cation conductance induced by neurotensin in dopaminergic neurons. Proc Natl Acad Sci (USA) 93:14917–14921
Chiodo LA, Antelman SM (1980) Electroconvulsive shock: progressive dopamine autoreceptor subsensitivity independent of repeated treatment. Science 210: 799–801
Chiodo LA, Bunney BS (1983) Typical and atypical neuroleptics: Differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. J Neurosci 3:1607–1619
Chiodo LA, Bunney BS (1987) Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. J Neurosci 7:629–33
Chiodo LA, Bannon MJ, Grace AA, Roth RH, Bunney BS (1984) Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 12:1–16
Clark D, Chiodo LA (1988) Electrophysiological and pharmacological characterization of identified nigrostriatal and mesoaccumbens dopamine neurons in the rat. Synapse 2:474–485
Clarke PBS, Hommer DW, Pert A, Skirboll LR (1987) Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience 23:1011–1019
Collingridge GL, Davies J (1982) Actions of substance P and opiates in the rat substantia nigra. Neuropharmacology 21:715–719
Collingridge GL, James TA, MacLeod NK (1980) Antidromic latency variations of nigral compacta neurones. Experientia 36:970–971
Connelly ST, Shepard PD (1997) Competitive NMDA receptor antagonists differentially affect dopamine cell firing pattern. Synapse 25:234–242
Coombs JS, Curtis DR, Eccles JC (1957) The interpretation of spike potentials of motoneurones. J Physiol (Lond) 139:198–231
Corvaja N, Doucet G, Bolam JP (1993) Ultrastructure and synaptic targets of the raphe-nigral projection in the rat. Neuroscience 55:417–427
Cubeddu, LX, Hoffmann IS, Talmaciu RK (1990) Is the release of dopamine from medial prefrontal cortex modulated by presynaptic autoreceptors? In: Kalsner S, Westfall TC (eds) Presynaptic Receptors and the Question of Autoregulation of Neurotransmitter Release, Ann NY Acad Sci 604:452–461
Dahlstrom A, Fuxe K (1964) Localization of monoamines in the lower brain stem. Experientia 15:398–399
Dai M, Tepper JM (1998) Do silent dopaminergic neurons exist in rat substantia nigra in vivo? Neuroscience 85:1089–1099
Damlama M (1994) Subthalamic and Pedunculopontine inputs to Substantia Nigra: A Light and Electron Microscopic Analysis. Ph.D. Thesis, Rutgers University, University Microfilms International, Ann Arbor
Damlama M, Tepper JM (1993) Subcortical excitatory inputs to nigral dopaminergic and non-dopaminergic neurons: A light and electron microscopic study. Proc. 51st Annual Meeting of the Microscopy Society of America, pp 94–95
Dani JA, Radcliffe KA, Pidoplichko VI (2000) Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas. Eur J Pharmacol 393:31–38
De Blasi A, Conn PJ, Pin J, Nicoletti F (2001) Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol Sci 22:114–120
Deniau JM, Hammond C, Riszk A, Feger J (1978) Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): evidences for the existence of branched neurons. Exp Brain Res 32:409–422
Deniau JM, Kitai ST, Donoghue JP, Grofova I (1982) Neuronal Interactions in the substantia nigra pars reticulata through axon collaterals of the projection neurons. Exp Brain Res 47:105–113
Devoto P, Collu M, Muntoni AL, Pistis M, Serra G, Gessa GL, Diana M (1995) Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic system. Synapse 20:153–155
Diana M (1996) Dopaminergic neurotransmission and drug withdrawal: relevance to drug craving. In: Ohye C, Kimura M, McKenzie J (eds) The Basal Ganglia V, Adv in Behav Biol 47: Plenum Press New York, pp 123–130
Diana M (1998) Drugs of abuse and dopamine cell activity. Adv Pharmacol 42:998–1001
Diana M, Young SJ, Groves PM (1988) Modulation of dopaminergic terminal excitability by D1 selective agents. Neuropharmacology 28:99–101
Diana M, Garcia-Munoz M, Richards J, Freed CR (1989) Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats. Exp Brain Res 74:625–630
Diana M, Young SJ, Groves PM (1991a). Modulation of dopaminergic terminal excitability by D1 selective agents: Further characterization. Neuroscience 42:441–449
Diana M, Mereu G, Mura A, Fadda F, Passino N, Gessa GL (1991b) Low doses of gamma-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unanesthetized rats. Brain Res 566:208–211
Diana M, Rossetti ZL, Gessa GL (1992) Lack of tolerance to ethanol-induced stimulation of mesolimbic dopamine system. Alcohol & Alcoholism 27:329–334
Diana M, Pistis M, Carboni S, Gessa GL, Rossetti ZL (1993a) Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. Proc Natl Acad Sci (USA) 90:7966–7969
Diana M, Pistis M, Muntoni AL, Gessa GL (1993b) Heterogeneous responses of substantia nigra pars reticulata neurons to gamma-hydroxybutyric acid administration. Eur J Pharmacol 230:363–365
Diana M, Pistis M, Muntoni AL, Gessa GL (1995a) Ethanol withdrawal does not induce a reduction in the number of spontaneously active dopaminergic neurons in the mesolimbic system. Brain Res 682:29–34
Diana M, Pistis M, Muntoni AL, Gessa GL (1995b) Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J Pharm Exp Ther 272:781–785
Diana M, Rossetti ZL, Gessa GL (1995c) Central dopaminergic mechanisms of alcohol and opiate withdrawal syndromes. In: Tagliamonte A, Maremmani I (eds) Drug Addiction and related clinical problems. Springer-Verlag Wien New York, pp 19–26
Diana M, Pistis M, Muntoni AL, Gessa GL (1996) Mesolimbic dopaminergic reduction outlasts ethanol withdrawal syndrome: evidence of protracted abstinence. Neuroscience 71:411–415
Diana M, Melis M, Muntoni AL, Gessa GL (1998a) Mesolimbic dopaminergic decline after cannabinoid withdrawal. Proc Natl Acad Sci (USA) 95:10269–10273
Diana M, Melis M, Gessa GL (1998b) Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids. Eur J Neurosci 10: 2825–2830
Diana M, Muntoni AL, Pistis M, Melis M, Gessa GL (1999) Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal. Eur J Neurosci 11:1037–1041
Di Chiara, G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci (USA) 85:5274–5278
Diaz J, Pilon C, Le Foll B, Triller A, Schwartz J-C, Sokoloff P (2000) Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci 20:8677–8684
Di Loreto S, Florio T, Scarnati E (1992) Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons. Exp Brain Res 89:79–86
Dray A, Gonye TJ, Oakley NR, Tanner T (1976) Evidence for the existence of a raphe projection to the substantia nigra in rat. Brain Res 113:45–57
Eccles JC (1957) The Physiology of Nerve Cells, Johns Hopkins Press, Baltimore, pp 47–56
Einhorn LC, Johansen PA, White FJ (1988) Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area. J Neurosci 8:100–112
Engberg G, Kling-Petersen T, Nissbrandt H (1993) GABAB-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra. Synapse 15:229–238
Erhardt S, Andersson B, Nissbradt H, Engberg G (1998) Inhibition of firing rate and changes in the firing pattern on nigral dopaminergic neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABAB receptors. Naunyn-Schmiedeberg’s Arch Pharmacol 357:611–619
Erhardt S, Nissbrandt H, Engberg G (1999) Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911. J Neural Trans 106:383–394
Falck B, Hillarp NA, Thieme G, Torp A (1962) Fluorescence of catechol amines and related compounds condensed with formaldehyde. J Histochem Cytochem 10:348–354
Fallon JH (1981) Collateralization of monoamine neurons: Mesotelencephalic dopamine projections to caudate, septum, and frontal cortex. J Neurosci 1:1361–1368
Fallon JH, Laughlin SE (1995) Substantia nigra. In: Paxinos G (ed) The Rat Nervous System, 2nd Edition. Academic Press, San Diego, pp 215–237
Farkas RH, Chien R-Y, Nakajima S, Nakajima Y (1997) Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons. Neurosci Lett 231:21–24
Farnebo LO, Hamberger B (1971) Drug-induced changes in the release of 3H-monoamines from field stimulated rat brain slices. Acta Physiol Scand 371:35–44
Fibiger HC, Miller JJ (1977) An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat. Neuroscience 2:975–987
Fiorillo CD, Williams JT (1998) Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons. Nature 394:78–82
Francois C, Percheron G, Yelnik J, Heyner S (1979) Demonstration of the existence of small local circuit neurons in the Golgi-stained primate substantia nigra. Brain Res 172:160–164
Freeman AS, Bunney BS (1987) Activity of A9 and A10 dopaminergic neurons in unrestrained rats: Further characterization and effects of apomorphine and cholecystokinin. Brain Res 405:46–55
Freeman AS, Meltzer LT, Bunney BS (1985) Firing properties of substantia nigra dopaminergic neurons in freely moving rats. Life Sci 36:1983–1994
Freeman AS, Chiodo LA, Lentz SI, Wade K, Bunney BS (1991) Release of cholecystokinin from rat midbrain slices and modulatory effect of D2 receptor stimulation. Brain Res 555:281–287
French ED (1997) Delta9-tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 226:159–162
French ED, Dillon K, Wu X (1997) Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport 10:649–652
Freund TF, Powell JF, Smith AD (1984) Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 13:1189–1215
Futami T, Takakusaki K, Kitai ST (1995) Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta. Neurosci Res 21:331–342
Galarraga E, Bargas J (1995) Firing patterns in substantia nigra compacta indentified neurons in vitro. Arch Med Res 26:191–199
Gao WY, Lee TH, King GR, Ellinwood EH (1998) Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment. Neuropsychopharmacology 18:222–232
Garcia-Munoz M, Segal DS, Patino P, Young SJ, Kuczenski R, Groves PM (1996) Amphetamine-induced changes in nigrostriatal terminal excitability are modified following repeated amphetamine pretreatment. Brain Res 720:131–138
Gardner EL, Lowinson JH (1991) Marijuana’s interaction with brain reward systems: update 1991. Pharmacol Biochem Behav 40:571–580
Gariano RF, Groves PM (1988) Burst firing in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices. Brain Res 462: 194–198
Gariano RF, Sawyer SF, Tepper JM, Young SJ, Groves PM (1989a) Mesocortical dopaminergic neurons. 2. Electrophysiological consequences of terminal auto-receptor activation Brain Res Bull 22:517–523
Gariano RF, Tepper JM, Sawyer SF, Young SJ, Groves PM (1989b) Mesocortical dopaminergic neurons. 1. Electrophysiological properties and evidence for somadendritic autoreceptors. Brain Res Bull 22:511–516
Gariano RF, Young SJ, Jeste DV, Segal DS, Groves PM (1990) Effects of long-term administration of haloperidol on electrophysiolgic properties of rat mesencephalic neurons. J Pharmacol Exp Ther 255:108–113
Geffen LB, Jessell TM, Cuello AC, Iversen LL (1976) Release of dopamine from dendrites in rat substantia nigra. Nature 18:258–260
Gerfen CR, Herkenham M, Thibault J (1987) The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. J Neurosci 7:3915–3934
Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348:201–203
Gessa GL, Melis M, Muntoni AL, Diana M (1998) Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur J Pharmacol 341:39–44
Gifford AN, Gardner EL, Ashby CR Jr (1997) The effect of intravenous administration of delta-9-tetrahydrocannabinol on the activity of A10 dopamine neurons recorded in vivo in anesthetized rats. Neuropsychobiology 36:96–99
Giralt MT, Bonanno G, Raiteri M (1990) GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB. Eur J Pharmacol 175:137–144
Glowinski J, Cheramy A (1981) Dendritic release of dopamine: Its role in the substantia nigra. In: Stjarne L, Hedqvist P, Lagercrantz H, Wennmalm A (eds) Chemical Neurotransmission: 75 Years, Academic Press, New York, pp 285–299
Gonon FG (1988) Nonlinear Relationship Between Impulse Flow and Dopamine Released by Rat Midbrain Dopaminergic Neurons as Studied by In Vitro Electrochemistry. Neuroscience 24:19–28
Gonon F (1997) Prolonged and extrasynaptic excitatory action of dopamine mediated by D1 receptors in the rat striatum in vivo. J Neurosci 17:5972–5978
Gould E, Woolf NJ, Butcher LL (1989) Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei. Neuroscience 28:611–623
Grace AA (1987) The regulation of dopamine neuron activity as determined by in vivo and in vitro intracellular recordings. In: Chiodo LA, Freeman AS (eds) Neurophysiology of Dopaminergic Systems-Current Status and Clinical Perspectives. Grosse Pointe, Lakeshore Publishing Company, pp 1–66
Grace AA (1990) Evidence for the functional compartmentalization of spike generating regions of rat midbrain dopamine neurons recorded in vitro. Brain Res 524:31–41
Grace AA, Bunney BS (1979) Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. Eur J Pharmacol 59:211–218
Grace AA, Bunney BS (1980) Nigral dopamine neurons: intracellular recording and identification with L-dopa injection and histofluorescence. Science 210:654–656
Grace AA, Bunney BS (1983a) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-1. Identification and characterization. Neuroscience 10:301–316
Grace AA, Bunney BS (1983b) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-2. Action potential generating mechanisms and morphological correlates. Neuroscience 10:317–331
Grace AA, Bunney BS (1984a) The control of firing pattern in nigral dopamine neurons: Single spike firing. J Neurosci 4:2866–2876
Grace AA, Bunney BS (1984b) The control of firing pattern in nigral dopamine neurons: Burst firing. J Neurosci 4:2877–2890
Grace AA, Bunney BS (1985) Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Res 333:271–284
Grace AA, Bunney BS (1986) Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. J Pharmacol Exp Ther 238:1092–1100
Grace AA, Hommer DW, Bunney BS (1980) Peripheral and striatal influences on nigral dopamine cells: Mediations by reticula neurons. Brain Res Bull 5:105–109
Grace AA, Bunney BS, Moore H, Todd CL (1997) Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends Neurosci 20:31–37
Grenhoff J, Svensson TH (1988) Clonidine regularizes substantia nigra dopamine cell firing. Life Sci 42:2003–2009
Grenhoff J, Svensson TH (1989) Clonidine modulates dopamine cell firing in rat ventral tegmental area. Eur J Pharmacol 165:11–18
Grenhoff J, Aston-Jones G, Svensson TH (1986) Nicotinic effects on the firing pattern of midbrain dopamine neurons. Acta Physiol Scand 128:351–358
Grenhoff J, Ugedo L, Svensson TH (1988) Firing patterns of midbrain dopamine neurons differences between A9 and A10 cells. Acta Physiol Scand 134:127–132
Grenhoff J, Nisell M, Ferré S, Aston-Jones G, Svensson TH (1993) Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of locus coeruleus in the rat. J Neural Trans 93:11–25
Grenhoff J, North RA, Johnson SW (1995) Alpha 1-adrenergic effects on dopamine neurons recorded intracellularly in the rat midbrain slice. Eur J Neurosci 7:1707–1713
Grillner P, Berretta N, Bernardi G, Svensson TH, Mercuri NB (2000) Muscarinic receptors depress GABAergic synaptic transmission in rat midbrain dopamine neurons. Neuroscience 96:299–307
Grinspoon L, Bakalar JB (1997) Marihuana. In: Substance abuse A comprehensive textbook. Third Edition. (Ed. Lowinson JH, Ruiz P, Millman RB, Langrod JG) Williams and Wilkins. pp 199–206
Grofova I, Rinvik E (1970) An experimental electron microscopic study on the striatonigral projection in the cat. Exp Brain Res 11:249–262
Grofova I, Deniau JM, Kitai ST (1982) Morphology of the substantia nigra pars reticulata projection neurons intracellularly labeled with HRP. J Comp Neurol 208:352–368
Groves PM, Wilson CJ, Young SJ, Rebec GV (1975) Self-inhibition by dopaminergic neurons. Science 190:522–529
Groves PM, Fenster GA, Tepper JM, Nakamura S, Young SJ (1981) Changes in dopaminergic terminal excitability induced by amphetamine and haloperidol. Brain Res 221:425–431
Guatteo E, Mercuri NB, Bernardi G, Knopfel T (1999) Group I metabotropic glutamate receptors mediate an inward current in rat substantia nigra dopamine neurons that is independent from calcium mobilization. J Neurophysiol 82: 1974–1981
Guyenet PG, Aghajanian GK (1978) Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Res 150:69–84
Gysling K, Wang RY (1983) Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res 277:119–127
Hajos M, Greenfield SA (1994) Synaptic connections between pars compacta and pars reticulata neurones: Electrophysiological evidence for functional modules within the substantia nigra. Brain Res 660:216–224
Hammond C, Deniau JM, Rizk A, Feger J (1978) Electrophysiological demonstration of an excitatory subthalamonigral pathway in the rat. Brain Res 151:235–244
Harris GC, Aston-Jones G (1994) Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome. Nature 8371:155–157
Harris NC, Webb C, Greenfield SA (1989) A possible pacemaker mechanism in pars compacta neurons of the guinea-pig substantia nigra revealed by various ion channel blocking agents. Neuroscience 31:355–362
Harrison MB, Wiley RG, Wooten GF (1990) Selective localization of striatal D1 receptors to striatonigral neurons. Brain Res 528:317–322
Hattori T, Fibiger HC, McGeer PL (1975) Demonstration of a pallid-nigral projection innervating dopaminergic neurons. J Comp Neurol 162:487–504
Hausser MA, Yung WH (1994) Inhibitory synaptic potentials in guinea-pig substantia nigra dopamine neurones in vitro. J Physiol (Lond) 479:401–422
Hausser M, Stuart G, Racca C, Sakmann B (1995) Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 15:637–647
Helmreich I, Reimann W, Hertting G, Starke K (1982) Are presynaptic dopamine autoreceptors and postsynaptic dopamine receptors in the rabbit caudate nucleus pharmacologically different? Neuroscience 7:1559–1566
Henry DJ, Greene MA, White FJ (1989) Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration. J Pharmacol Exp Ther 251:833–839
Herkenham M, Lynn AB, de Costa BR, Richfield EK (1991) Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res 547:267–274
Hernandez L, Hoebel BG (1989) Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis. Brain Res Bull 22:763–769
Hertel P, Fagerquist MV, Svensson TH (1999) Enhanced cortical dopamine output and antipsychotic-like effects of raclopride by alpha2 adrenoceptor blockade. Science 286:105–107
Hervé D, Pickel VM, Joh TH, Beaudet A (1987) Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons. Brain Res 435:71–83
Inanobe A, Yoshimoto Y, Horio Y, Morishige K-I, Hibino H, Matsumoto S, Tokunaga Y, Maeda T, Hata Y, Takai Y, Kurachi Y (1999) Characterization of G-protein-gated K+ channels compsed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. J Neurosci 19:1006–1017
Hollerman JR, Abercrombie ED, Grace AA (1992) Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience 47:589–601
Hommer DW, Skirboll LR (1983) Cholecystokinin-like peptides potentiate apomor-phine-induced inhibition of dopamine neurons. Eur J Pharmacol 91:151–152
Ianobe A, Yoshimoto Y, Horio Y, Morishige KI, Hibino H, Matsumoto S, Tokunaga Y, Maeda T, Hata Y, Takai Y, Kurachi Y (1999) Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. J Neurosci 19:1006–10017
Innis RB, Aghajanian GK (1987) Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Res 411:139–143
Innis R, Andrade R, Aghajanian G (1985) Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Res 335:381–383
Iribe Y, Moore K, Pang KC, Tepper JM (1999) Subthalamic stimulation-induced synaptic responses in nigral dopaminergic neurons in vitro. J Neurophysiol 82:925–933
Israel JM, Kirk C, Vincent JD (1987) Electrophysiological responses to dopamine of rat hypophysial cells in lactotroph-enriched primary cultures. J Physiol 390:1–22
Iwatsubo K, Clouet DH (1977) Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons. J Pharmacol Exp Ther 202:429–436
Johnson SW, North RA (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12:483–488
Johnson SW, Seutin V, North RA (1992) Burst firing in dopaminergic neurons induced by N-methyl-D aspartate: Role of electrogenic sodium pump. Science 258:665–667
Jones LS, Gauger L, Davis JN (1985) Anatomy of brain alpha-1-adrenergic receptors: In vitro autoradiography with [125I]-HEAT. J Comp Neurol 231:190–208
Jones SR, Gainetdinov RR, Hu X-T, Cooper DC, Wightman RM, White FJ, Aron MG (1999) Loss of autoreceptor functions in mice lacking the dopamine transporter. Nat Neurosci 2:649–655
Juraska JM, Wilson CJ, Groves PM (1977) The substantia nigra of the rat: A Golgi study. J Comp Neurol 4:585–599
Kalivas PW (1993) Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Rev 18:75–113
Kamal LA, Arbilla S, Anger SZ (1981) Presynaptic modulation of the release of dopamine from the rabbit caudate nucleus: Differences between electrical stimulation, amphetamine and tyramine. J Pharmacol Exp Ther 216:592–598
Kamata K, Rebec GV (1983) Dopaminergic and neostriatal neurons: dose-dependent changes in sensitivity to amphetamine following long-term treatment. Neuropharmacology 22:1377–1382
Kamata K, Rebec GV (1984a) Long-term amphetamine treatment attenuates or reverses the depression of neuronal activity produced by dopamine agonists in the ventral tegmental area. Life Sci 34:2419–2427
Kamata K, Rebec GV (1984b) Nigral dopaminergic neurons: Differential sensitivity to apomorphine following long-term treatment with low and high doses of amphetamine. Brain Res 321:147–150
Kang Y, Kitai ST (1993a) Calcium spike underlying rhythmic firing in the dopaminergic neurons of the rat substantia nigra. Neurosci Res 18:195–207
Kang Y, Kitai ST (1993b) A whole cell patch-clamp study on the pacemaker potential in dopaminergic neurons of rat substantia nigra compacta. Neurosci Res 18: 209–221
Kang Y, Kubota Y, Kitai ST (1989) Synaptic action on substantia nigra compacta neurons by subthalamic inputs studied by a spike trigger averaging method. Soc Neurosci Abstr 15:900
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96
Keegan KD, Woodruff GN, Pinnock RD (1992) The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol 105:3–5
Kelland MD, Chiodo LA, Freeman AS (1990a) Anesthetic influences on the basal activity and pharmacological responsiveness of nigrostriatal dopamine neurons. Synapse 6:207–209
Kelland MD, Freeman AS, Chiodo LA (1990b) Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons. J Pharmacol Exp Ther 253:803–811
Kilts CD, Anderson CM, Ely TD, Nishita JK (1987) Absence of synthesis-modulating nerve terminal autoreceptors on mesoamygdaloid and other mesolimbic dopamine neuronal populations. J Neurosci 7:3961–3975
Kinon BJ, Lieberman JA (1996) Mechanisms of action of atypical antipsychotic drugs: a critical analysis. Psychopharmacology 124:2–34
Kita T, Kita H, Kitai ST (1986) Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparation. Brain Res 372:21–30
Kita H, Kitai ST (1987) Efferent projections of the subthalamic nucleus in the rat: light and electron microscopic analysis with the PHA-L method. J Comp Neurol 260: 435–452
Kitai ST, Shepard PD, Callaway JC, Scroggs R (1999) Afferent modulation of dopamine neuron firing patterns. Curr Opin Neurobiol 9:690–697
Klitenick MA, Taber MT, Fibiger HC (1996) Effects of chronic haloperidol on stress-and stimulation-induced increases in dopamine release: Tests of the depolarization block hypothesis. Neuropsychopharmacology 15:424–428
Koeltzow TE, Xu M, Cooper DC, Hu XT, Tonegawa S, Wolf ME, White FJ (1998) Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J Neurosci 18:2231–2238
Kondo Y, Iwatsubo K (1980) Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum. Brain Res 181:237–240
Konig JFR, Klippel RA (1963) The Rat Brain: A Stereotaxic Atlas of the Forebrain and Lower Brainstem, Williams and Wilkins, Baltimore, MD
Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242:715–723
Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52–58
Kuczenski R (1983) Biochemical actions of amphetamine and other stimulants In: Creese I (ed) Stimulants: Neurochemical Behavioral and Clinical Perspectives. New York, Raven Press, pp 31–62
Lacey MG (1993) Neurotransmitter receptors and ionic conductances regulating the activity of neurones in substantia nigra pars compacta and ventral tegmental area. In: Arbuthnott GW, Emson PC (ed) Progress in Brain Research. Vol. 99 Elsevier Science Publishers BV, pp 251–276
Lacey MG, Mercuri NB, North RA (1987) Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J Physiol (Lond) 392:397–416
Lacey MG, Mercuri NB, North RA (1988) On the potassium conductance increase activated by GABAb and dopamine D2 receptors in rat substantia nigra neurones. J Physiol (Lond) 401:437–453
Lacey MG, Mercuri NB, North RA (1989) Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids. J Neurosci 9:1233–1241
Lacey MG, Mercuri NB, North RA (1990) Actions of cocaine on rat dopaminergic neurones in vitro. Br J Pharmacol 99:731–735
Letchworth SR, Smith HR, Porrino LJ, Bennett BA, Davies HM, Sexton T, Childers SR (2000) Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain. J Pharmacol Exp Ther 293:686–696
Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M (1982) Stimulation of nigrostriatal dopamine neurones by nicotine. Neuropharmacology 21: 963–968
Liu L-X, Burgess LH, Gonzalez AM, Sibley DR, Chiodo LA (1999) D2 S, D2L, D3 and D4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 x mesencephalon hybrid cell (MES-23.5) via distinct G proteins. Synapse 31:108–118
Llinás R, Greenfield SA, Jahnsen HJ (1984) Electrophysiology of pars compacta cells in the in vitro substantia nigra — a possible mechanism for dendritic release. Brain Res 294:127–132
Lokwan SJ, Overton PG, Berry MS, Clark D (1999) Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons. Neuroscience 92:245–254
Mahalik TJ (1988) Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: An ultrastructural study. Synapse 2:508–515
Maitre M, Andriamampandry C, Kemmel V, Schmidt C, Hode Y, Hechler V, Gobaille S (2000) Gamma-hydroxybutyric acid as a signaling molecule in brain. Alcohol 20:277–283
Manzoni OJ, Williams JT (1999) Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal. J Neurosci 19:6629–6636
Matthews RT, German DC (1984) Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine. Neuroscience 11:617–625
McGeer PL, Eccles JC, McGeer EL (1987) Molecular Neurobiology of the Mammalian Brain, 2nd Ed., New York, Plenum Press, pp 149–224
McGeer PL, Eccles JC, McGeer EL (1987) Molecular Neurobiology of the Mammalian Brain, 2nd Ed., New York, Plenum Press, pp 553–594
Meador-Woodruff JH, Mansour A, Bunzow JR, Van Tol HH, Watson SJ Jr, Civelli O (1989) Distribution of D2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci (USA) 86:7625–7628
Melis M, Mereu GP, Lilliu V, Quartu M, Diana M, Gessa GL (1998) Haloperidol does not produce dopamine cell depolarization-block in immobilized rats. Brain Res 783:127–132
Melis M, Gessa GL, Diana M (2000) Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain. Prog Neuropsychopharmacol Biol Psychiatry 24:993–1006
Meltzer HY, Matsubara S, Lee JC (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251:238–246
Meltzer HY, Park S, Kessler R (1999) Cognition, schizophrenia, and the atypical antipsychotic drugs. Proc Natl Acad Sci (USA) 96:13591–13593
Meltzer LT, Serpa KA, Christoffersen CL (1997) Metabotropic glutamate receptor-mediated inhibition and excitation of substantia nigra dopamine neurons. Synapse 26:184–193
Mercuri NB, Calabresi P, Bernardi G (1989) The mechanism of amphetamine-induced inhibition of rat substantia nigra compacta neurones investigated with intracellular recording in vitro. Br J Pharmacol 98:127–134
Mercuri NB, Calabresi P, Bernardi G (1990) Effects of glycine on neurons in the rat substantia nigra zona compacta: in vitro electrophysiological study. Synapse 5: 190–200
Mercuri NB, Stratta F, Calabresi P, Bernardi G (1992) Electrophysiological evidence for the presence of ionotropic and metabotropic excitatory amino acid receptors on dopaminergic neurons of the rat mesencephalon: an in vitro study. Funct Neurol 7:231–234
Mercuri NB, Stratta F, Calabresi P, Bonci A, Bernardi G (1993) Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons. Neuroscience 56:399–407
Mercuri NB, Grillner P, Bernardi G (1996) N-Methyl-D-aspartate receptors mediate a slow excitatory postsynaptic potential in the rat midbrain dopaminergic neurons. Neuroscience 74:785–792
Mercuri NB, Saiardi A, Bonci A, Picetti R, Calabresi P, Bernardi G, Borrelli E (1997) Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice. Neuroscience 79:323–327
Mereu G, Gessa GL (1985) Low doses of ethanol inhibit the firing of neurons in the substantia nigra pars reticulata: A GABAergic effect? Brain Res 360:325–330
Mereu G, Fadda F, Gessa GL (1984a) Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain Res 292:63–69
Mereu G, Fanni B, Gessa GL (1984b) General anesthetics prevent dopaminergic neuron stimulation by neuroleptics. In: Catecholamines: Neuropharmacology and Central Nervous System-Theoretical Aspects. New York, Alan R Liss, pp 353–358
Mereu G, Westfall TC, Wang RY (1985) Modulation of terminal excitability of mesolim-bic dopaminergic neurons by D-amphetamine and haloperidol. Brain Res 359: 88–96
Mereu G, Yoon KW, Boi V, Gessa GL, Naes L, Westfall TC (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur J Pharmacol 141:395–399
Mereu G, Costa E, Armstrong DM, Vicini S (1991) Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices. J Neurosci 11:1359–1366
Mereu G, Lilliu V, Vargiu P, Muntoni AL, Diana M, Gessa GL (1994) Failure of chronic haloperidol to induce depolarization inactivation of dopamine neurons in unanesthetized rats. Eur J Pharmacol 264:449–453
Mereu G, Lilliu V, Vargiu P, Muntoni AL, Diana M, Gessa GL (1995) Depolarization inactivation of dopamine neurons: an artifact? J Neurosci 15:1144–1149
Mereu G, Lilliu V, Casula A, Vargiu PF, Diana M, Musa A, Gessa GL (1997) Spontaneous bursting activity of dopaminergic neurons in midbrain slices from immature rats: Role of N-methyl-D-aspartate receptors. Neuroscience 77:1029–1036
Meyerhoff JL, Kant GJ (1978) Release of endogenous dopamine from corpus striatum. Life Sci 23:1481–1486
Miller AS, Walker JM (1995) Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata. Eur J Pharmacol 279:179–185
Moghaddam B, Bunney BS (1993) Depolarization inactivation of dopamine neurons: terminal release characteristics. Synapse 14:195–200
Moon-Edley S, Graybiel AM (1983) The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus, pars compacta. J Comp Neurol 217:187–215
Moore KE, Demarest KT, Lookingland KJ (1987) Stress, prolactin and hypothalamic dopaminergic neurons. Neuropharmacology 26:801–808
Moore H, Todd CL, Grace AA (1998) Striatal extracellular dopamine levels in rats with haloperidol-induced depolarization block of substantia nigra dopamine neurons. J Neurosci 18:5068–5077
Morelli M, Mennini T, DiChiara G (1988) Nigral dopamine autoreceptors are exclusively of the D2 Type: Quantitative autoradiography of [125I]iodosulpride and [125I]SCH 23982 in adjacent brain sections. Neuroscience 27:865–870
Mori S, Matsuura T, Takino T, Sano Y (1987) Light and electron microscopic immuno-histochemical studies of serotonin nerve fibers in the substantia nigra of the rat, cat and monkey. Anat Embryol (Berl) 176:13–18
Naito A, Kita H (1994) The cortico-nigral projection in the rat: an anterograde tracing study with biotinylated dextran amine. Brain Res 637:317–322
Nakamura S, Iwatsubo K, Tsai C-T, Iwama K (1979) Cortically evoked inhibition of neurons of rat substantia nigra (pars compacta). Jpn J Physiol 29:353–357
Nakanishi H, Kita H, Kitai ST (1987) Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation. Brain Res 437:45–55
Nedergaard S, Greenfield SA (1992) Sub-populations of pars compacta neurons in the substantia nigra: The significance of qualitatively and quantitatively distinct conductances. Neuroscience 48:423–437
Nedergaard S, Bolam JP, Greenfield SA (1988) Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature 333:174–177
Nedergaard S, Flatman JA, Engberg I (1991) Excitation of substantia nigra pars compacta neurones by 5-hydroxy-tryptamine in-vitro. NeuroReport 2:329–332
Nedergaard S, Flatman JA, Engberg I (1993) Nifedipine- and w-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neurones. J Physiol (Lond) 466:727–747
Nestler EJ (1992) Molecular mechanisms of drug addiction. J Neurosci 12:2439–2450
Nestler EJ (1993) Cellular responses to chronic treatment with drugs of abuse. Crit Rev Neurobiol 7:23–39
Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119–128
Nitsch C, Riesenberg R (1988) Immunocytochemical demonstration of GABAergic synaptic connections in rat substantia nigra after different lesions of the striatonigral projection. Brain Res 461:127–142
Overton P, Clark D (1992) Iontophoretically administered drugs acting and the N-methyl-D-aspartate receptor modulate burst firing in A9 dopamine neurons in the rat. Synapse 10:131–140
Overton PG, Clark D (1997) Burst firing in midbrain dopaminergic neurons. Brain Res Rev 25:312–334
Paden C, Wilson CJ, Groves PM (1976) Amphetamine-induced release of dopamine from the substantia nigra in vitro. Life Sci 19:1499–1506
Paladini CA, Tepper JM (1999) GABAA and GABAB antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse 32:165–176
Paladini CA, Celada P, Tepper JM (1999a) Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABAA receptors in vivo. Neuroscience 89:799–812
Paladini CA, Iribe Y, Tepper JM (1999b) GABAA receptor stimulation blocks NMDA-induced bursting of dopaminergic neurons in vitro by decreasing input resistance. Brain Res 832:145–151
Paladini CA, Fiorillo CD, Morikawa H, Williams JT (2001) Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons. Nat Neurosci 4: 275–281
Phillipson OT (1979) Afferent projections to the ventral tegmental area of Tsai and the interfascicular nucleus: A horseradish peroxidase study in the rat. J Comp Neurol 187:117–144
Pickel VM, Beckley SC, Joh TH, Reis DJ (1981) Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum. Brain Res 225:373–385
Pidoplichko VI, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390:401–404
Pieribone VA, Nicholas AP, Dagerlind A, Hokfelt T (1994) Distribution of alpha-1 adrenoceptors in rat brain reveal;ed by in sitgu hybridization experiments utilizing subtype-specific probes. J Neurosci 14:4252–4268
Ping H, Shepard PD (1996) Apamine-sensitive Ca2+-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. NeuroReport 73:809–814
Pinnock RD, Dray A (1982) Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P. Neurosci Lett 29:153–158
Plantje JF, Dijcks FA, Verheijden PFHM, Stoof JC (1985) Stimulation of D-2 dopamine receptors in rat mesocortical areas inhibits the release of [3H]dopamine. Eur J Pharmacol 114:401–402
Plantje JF, Steinbusch HWM, Schipper J, Dijcks FA, Verheijden PFHM, Stoof JC (1987) D-2 dopamine-receptors regulate the release of {3H} dopamine in rat cortical regions showing dopamine immunoreactive fibers. Neuroscience 20:157–168
Precht W, Yoshida M (1971) Monosynaptic inhibition of neurons of the substantia nigra by caudatonigral fibers. Brain Res 32:225–228
Pucak ML, Grace AA (1994) Evidence that systemically administered dopamine antagonists activate dopamine neuron firing primarily by blockade of somatodendritic autoreceptors. J Pharmacol Exp Ther 271:1181–1192
Pucak ML, Grace AA (1996) Effects of haloperidol on the activity and membrane physiology of substantia nigra dopamine neurons recorded in vitro. Brain Res 713:44–52
Pulvirenti L, Diana M (2001) Drug dependence as a disorder of neural plasticity: focus on dopamine and glutamate. Neurosci Rev 12:41–59
Rasmussen K, Czachura JF (1995) Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons. Neuroreport 7:329–332
Ribak CE, Vaughn JE, Saito K, Barber R, Roberts E (1976) Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra. Brain Res 116:287–298
Ribak CE, Vaughn JE, Roberts E (1980) GABAergic nerve terminals decrease in the substantia nigra following hemitransections of the striatonigral and pallidonigral pathways. Brain Res 192:413–420
Robledo P, Féger J (1990) Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data. Brain Res 518:47–54
Roth RH, Salzman PM, Nowycky MC (1978) Impulse flow and short-term regulation of transmitter biosynthesis in central catecholaminergic neurons. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: A Generation of Progress. New York, Raven Press, pp 185–198
Rothman RB, Herkenham M, Pert CB, Liang T, Cascieri MA (1984) Visualization of rat brain receptors for the neuropeptide, substance P. Brain Res 309:47–54
Rye DB, Saper CB, Lee RJ, Wainer BH (1987) Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 252:483–528
Santiago M, Westerink BHC (1992) The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: dual probe microdialysis study in awake rats. Eur J Pharmacol 219:175–181
Scarnati E, Pacitti C (1982) Neuronal responses to iontophoretically applied dopamine, glutamate, and GABA of identified dopaminergic cells in the rat substantia nigra after kainic acid-induced destruction of the striatum. Exp Brain Res 46:377–382
Scarnati E, Campana E, Pacitti C (1984) Pedunculopontine-evoked excitation of substantia nigra neurons in the rat. Brain Res 304:351–361
Schwyn RC, Fox CA (1974) The primate substantia nigra: A golgi and electron microscopic study. Journal Fur Hirnforschung 15:95–126
Sesack SR, Pickel VM (1992) Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J Comp Neurol 320: 145–160
Sesack SR, Aoki C, Pickel VM (1994) Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. J Neurosci 14:88–106
Seutin V, Verbanck P, Massotte L, Dresse A (1990) Evidence for the presence of N-methyl-D-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study. Brain Res 514:147–150
Shafer RA, Levant B (1998) The D3 dopamine receptor in cellular and organismal function. Psychopharmacology (Berl). 135:1–16
Shen RY, Chiodo LA (1993) Acute withdrawal after repeated ethanol treatment reduces the number of spontaneously active dopaminergic neurons in the ventral tegmental area. Brain Res 622:289–293
Shen KZ, Johnson SW (1997) Presynaptic GABAB and adenosine A1 receptors regulate synaptic transmission to rat substantia nigra reticulata neurones. J Physiol (Lond) 505:153–163
Shepard PD, German DC (1984) A subpopulation of mesocortical dopamine neurons possesses autoreceptors. Eur J Pharmacol 98:455–456
Shepard PD, Bunney BS (1988) Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro. Brain Res 463:380–384
Shepard PD, Connelly ST (1999) Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the γ-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons. Neuropsychopharmacology 21:650–661
Shim SS, Bunney BS, Shi W-X (1996) Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. Neuropsychopharmacology 15: 437–441
Sibley DR, Monsma JFJ (1992) Molecular biology of dopamine receptors. Trends Pharmacol Sci 13:61–69
Silva NL, Pechura CM, Barker JL (1990) Postnatal rat nigrostriatal dopaminergic neurons exhibit five types of potassium conductances. J Neurophysiol 64:262–272
Skarsfeldt T (1988) Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats. Life Sci 42:1037–1044
Skarsfeldt T (1995) Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat. Eur J Pharmacol 281:289–294
Skirboll LR, Grace AA, Bunney BS (1979) Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206:80–82
Skirboll SR, Grace AA, Hommer DW, Goldstein M, Hokfelt T, Bunney BS (1981) Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 6:2111–2124
Sklair-Tavron L, Shi WX, Lane SB, Harris HW, Bunney BS, Nestler EJ (1996) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci (USA) 93:11202–11207
Smith ID, Grace AA (1992) Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity. Synapse 12:287–303
Smith Y, Bolam JP (1989) Neurons of the substantia nigra reticulata receive a dense GABA-containing input from the globus pallidus in the rat. Brain Res 493:160–167
Smith Y, Charara A, Parent A (1996) Synaptic innervation of midbrain dopaminergic neurons by glutamate- enriched terminals in the squirrel monkey. J Comp Neurol 364:231–253
Somogyi P, Bolam JP, Totterdell S, Smith AD (1981) Monosynaptic input from the nucleus accumbens-ventral striatum region to retrogradely labelled nigrostriatal neurones. Brain Res 217:245–263
Sorenson EM, Shiroyama T, Kitai ST (1998) Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience 87:659–73
Stanford IM, Lacey MG (1996) Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. J Neurosci 16:7566–7573
Stanwood GD, Artymyshyn RP, Kung M-P, Kung HF, Lucki I, McGonigle P (2000) Quantitative autoradiographic mapping of rat brain dopamine D3 binding with [125I]7-OH-PIPAT: Evidence for the presence of D3 receptors on dopaminergic and nondopaminergic cell bodies and terminals. J Pharmacol Exp Ther 295:1223–1231
Starke K, Gothert M, Kilbinger H (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 69:864–989
Stockton ME, Rasmussen K (1996) Olanzapine, a novel atypical antipsychotic, reverses d-amphetamine- induced inhibition of midbrain dopamine cells. Psychopharma-cology 124:50–56
Sugimoto T, Hattori T (1984) Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspect. Neuroscience 11:931–946
Sugita S, Johnson SW, North RA (1992) Synaptic inputs to GABAA and GABAB receptors originate from discrete afferent neurons. Neurosci Lett 134:207–211
Suppes T, Pinnock RD (1987) Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and SCH 23390. Neuropharmacology 26:331–337
Surmeier DJ, Kitai ST (1993) D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons. In: Arbuthnott GW, Emson PC (ed) Progress in Brain Research. Vol. 99 Elsevier Science Publishers B.V., pp 309–324
Surmeier DJ, Eberwine J, Wilson CJ, Cao Y, Stefani A, Kitai ST (1992) Dopamine receptor subtypes colocalize in rat striatonigral neurons. Proc Natl Acad Sci (USA) 89:10178–10182
Surmeier DJ, Song W-J, Yan Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci 16:6579–6591
Svensson TH, Tung C-S (1989) Local cooling of prefrontal cortex induced pacemakerlike firing of dopaminergic neurons in rat ventral tegmental area in vivo. Acta Physiol Scand 136:135–136
Takakusaki K, Shiroyama T, Yamamoto T, Kitai ST (1996) Cholinergic and noncholinergic tegmental pedunculopontine projection neurons in rats revealed by intracellular labeling. J Comp Neurol 371:345–361
Tanda G, Pontieri FE, Di Chiara G (1997) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mul opioid receptor mechanism. Science 276:2048–2050
Tepper JM, Groves PM (1990) In vivo electrophysiology of central nervous system terminal autoreceptors. In: Kalsner S, Westfall TC (eds) Presynaptic Autoreceptors and the Question of the Autor emulation of Neurotransmitter Release. Ann New York Acad Sci 604:470–487
Tepper JM, Nakamura S, Spanis CW, Squire LR, Young SJ, Groves PM (1982) Sub-sensitivity of catecholaminergic neurons to direct acting agonists after single or repeated electroconvulsive shock. Biol Psych 17:1059–1079
Tepper JM, Nakamura S, Young SJ, Groves PM (1984a) Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of striatal drug infusions. Brain Res 309:317–333
Tepper JM, Young SJ, Groves PM (1984b) Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of increases in impulse flow. Brain Res 309:309–316
Tepper JM, Groves PM, Young SJ (1985) The neuropharmacology of the autoinhibition of monoamine release. Trends Pharmacol Sci 6:251–256
Tepper JM, Gariano RF, Groves PM (1987a) The neurophysiology of dopamine nerve terminal autoreceptors. In: Chiodo LA, Freeman AS (eds) Neurophysiology of Dopaminergic Systems — Current Status and Clinical Perspectives. Grosse Point, Lakeshore Publishing Co., pp 93–127
Tepper JM, Sawyer SF, Groves PM (1987b) Electrophysiologically identified nigral dopaminergic neurons intracellularly labeled with HRP: Light-microscopic analysis. J Neurosci 7:2794–2800
Tepper JM, Martin LP, Anderson DR (1995) GABAA receptor-mediated inhibition of nigrostriatal dopaminergic neurons by pars reticulata projection neurons. J Neurosci 15:3092–3103
Tepper JM, Sun B-C, Martin LP, Creese I (1997) Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo. J Neurosci 17:2519–2530
Tepper JM, Celada P, Iribe Y, Paladini CA (2002) Afferent control of nigral dopaminergic neurons — The role of GABAergic inputs. In: Graybiel AM et al. (eds) The Basal Ganglia VI, Kluwer Academic Publishers, Norwell (in press)
Teranishi T, Negishi K, Kato S (1983) Dopamine modulates S-potential amplitude and dye-coupling between external horizontal cells in carp retina. Nature 301:243–246
Tersigni TJ, Rosenberg HC (1996) Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA. Brain Res 733: 184–192
Tong Z-Y, Overton PG, Clark D (1996) Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse 22:195–208
Trent F, Tepper JM (1991) Dorsal raphé stimulation modifies striatal-evoked antidromic invasion of nigral dopaminergic neurons in vivo. Exp Brain Res 84: 620–630
Tsou K, Patrick SL, Walker JM (1995) Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur J Pharmacol 280:R13–15
Ungerstedt U (1971) Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl 367:1–48
Usiello A, Balk J-H, Rougé-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borelli E (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408:199–203
Usunoff KG (1984) Tegmentonigral projections in the cat: Electron microscopic observations. In: Hassler RG, Christ JF (eds) Advances in Neurology Vol. 40, Raven Press, New York, pp 55–61
Usunoff KG, Romansky KV, Malinov GB, Ivanov DP, Blagov ZA, Galabov GP (1982) Electron microscopic evidence for the existence of a corticonigral tract in the cat. J Hirnforsch 23:23–29
Vallar L, Meldolesi J (1989) Mechanisms of signal transduction at the dopamine D2 receptor. Trends Pharmacol Sci 10:74–77
Walters JR, Roth RH (1976) Dopaminergic Neurons: An in vivo system for measuring drug interactions with presynaptic receptors. Naunyn Schmiedebergs Arch Pharmacol 296:5–14
Wang RY (1981a) Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization. Brain Res Rev 3:123–140
Wang RY (1981b) Dopaminergic neurons in the rat ventral tegmental area. II. Evidence for autoregulation. Brain Res Rev 3:141–151
Wang RY (1981c) Dopaminergic neurons in the rat ventral tegmental area. III. Effects of D- and L-amphetamine. Brain Res Rev 3:152–165
Wang T, French ED (1993) L-Glutamate excitation of A10 dopamine neurons is preferentially mediated by activation of NMDA receptors: extra- and intracellular electrophysiological studies in brain slices. Brain Res 627:299–306
Wassef M, Berod A, Sotelo C (1981) Dopaminergic dendrites in the pars reticulata of the rat substantia nigra and their striatal input. Combined immunocytochemical localization of tyrosine hydroxylase and anterograde degeneration. Neuroscience 6:2125–2139
Werkman TR, Kruse CG, Nievelstein H, Long SK, Wadman WJ (2000) Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and ventral tegmental area. Neuroscience 95:417–423
White FJ (1996) Synaptic regulation of mesocorticolimbic dopamine neurons. Ann Rev Neurosci 19:405–436
White FJ, Wang RY (1983) Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons. Science 221:1054–1057
Wilson CJ, Callaway JCV (2000) Coupled oscillator model of the dopaminergic neuron of the substantia nigra. J Neurophysiol 83:3084–3100
Wilson CJ, Young SJ, Groves PM (1977) Statistical properties of neuronal spike trains in the substantia nigra: cell types and their interactions. Brain Res 136:243–260
Wilson CJ, Fenster GA, Young SJ, Groves PM (1979) Haloperidol-induced alteration of post-firing inhibition in dopaminergic neurons of rat substantia nigra. Brain Res 179:165–170
Wolf ME, Roth RH (1990) Autoreceptor regulation of dopamine synthesis. In: Kalsner S, Westfall TC (eds) Presynaptic Receptors and the Question of Autoregulation of Neurotransmitter Release. Ann NY Acad Sci 604:232–343
Wu T, Wang H-L (1994) CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance. Neurosci Lett 170:229–232
Wu X, French ED (2000) Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology 39:391–398
Yoshida M, Precht W (1971) Monosynaptic inhibition of neurons of the substantia nigra by caudato-nigral fibers. Brain Res 32:225–228
Yung WH, Hausser MA, Jack JJB (1991) Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro. J Physiol (Lond) 436:643–667
Zhang H, Lee TH, Ellinwood EH Jr (1992a) The progressive changes of neuronal activities of the nigral dopaminergic neurons upon withdrawal from continuous infusion of cocaine. Brain Res 594:315–318
Zhang J, Chiodo LA, Freeman AS (1992b) Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons. Brain Res 590:153–163
Zhang J, Chiodo LA, Freeman AS (1993) Effects of phencyclidine, MK-801 and 1,3-di(tolyl)guanidine on non-dopaminergic midbrain neurons. Eur J Pharmacol 230:371–374
Zhang J, Chiodo LA, Freeman AS (1994) Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopamin-ergic neurons in rat substantia nigra. J Pharmacol Exp Ther 269:313–321
Zhang W, Tilson H, Stachowiak MK, Hong JS (1989) Repeated haloperidol administration changes basal release of striatal dopamine and subsequent response to haloperidol challenge. Brain Res 484:389–892
Zhang XF, Hu XT, White FJ, Wolf ME (1997) Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors. J Pharmacol Exp Ther 281:699–706
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Diana, M., Tepper, J.M. (2002). Electrophysiological Pharmacology of Mesencephalic Dopaminergic Neurons. In: Di Chiara, G. (eds) Dopamine in the CNS II. Handbook of Experimental Pharmacology, vol 154 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06765-9_1
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