Skip to main content
SpringerLink
Log in

Tumoren im Kopf- und Halsbereich

  • Chapter
Die Onkologie

Zusammenfassung

Das Robert-Koch-Institut Berlin (www.rki.de) gab für das Jahr 1998 für Tumoren der Mundhöhle und des Pharynx (unter Einschluss von Karzinomen der Lippe und der Speicheldrüsen, ICD Coo-C13) eine Inzidenzrate von 19,71 für Männer und 7,05 für Frauen an. Damit liegt die Inzidenz im Vergleich zu anderen EU-Ländern für Männer im oberen Drittel und für Frauen im Mittelfeld.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ackervall J,Wennerberg L,Mertens F (2000) Chromosomal abnormalities in squamous cell carcinoma of the head and neck.Adv Otorhinolaryngol 56: 261–267

    Google Scholar 

  • Adelstein DJ,Sharan VM,EarleASetal. (1990) Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer. Cancer 65: 1685–1691

    Google Scholar 

  • Aebersold DM, Beer KT, Laissue J, Hug S, Lollar A, Greiner RH, Djonov V (2000) Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx. Int J Radiat Oncol Biol Phys 48: 17–25

    PubMed  CAS  Google Scholar 

  • Al-Sarraf M, LeBlanc M, Giri PG et al. (1998) Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase Ill randomized Intergroup study 0099. J Clin Oncol 16: 1310–1317

    PubMed  CAS  Google Scholar 

  • Ang KK, Peters U, Weber RS et al. (1994) Postoperative radiotherapy for cutaneous melanoma of the head and neck region.IntJ Radiat Oncol Biol Phys 30: 795–798

    CAS  Google Scholar 

  • Arcangeli G, Nervi C, Righini R, Creton G, Mirri MA, Guerra A (1983) Combined radiation and drugs: The effect of intraarterial chemotherapy followed by radiotherapy in head and neck cancer. Radiother Oncol 1: 101–107

    Google Scholar 

  • Bachaud JM, Cohen-Jonathan E, Alzieu C, David JM, Serrano E, DalySchveitzer N (1996) Conbined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized study. Int J Radiat Oncol Biol Phys 36: 999–1004

    PubMed  CAS  Google Scholar 

  • Bailey BJ (1993) Head u. Neck Surgery - Otolaryngology. JB Lippincott, Philadelphia

    Google Scholar 

  • Bataini P, Brugère J, Bernier j,Jaulerry C, Picot C,Ghossein NA (1982) Results of radical radiotherapeutic treatment of carcinoma of the pyriform sinus. Int J Radiat Oncol Biol Phys 8: 1277–86

    CAS  Google Scholar 

  • Beck-Bornhold HP, Dubben HH, Liertz-Petersen C, Willers H (1997) Hyper-fractionation: where do we stand? Radiother Oncol 43: 1–21

    Google Scholar 

  • Becker A, Bloching M, Klautke G, Kuhnt T, Koehler A, Buechele T, Berghaus A, Fietkau R, Dunst J (2000) Twice-a-week paclitaxel and two courses cisplatin simultaneous with hyperfractionated accelerated radiotherapy for advanced squamous cell carcinoma of the head and neck: phase I study. Proc Am Soc Clin Oncol 19: Abstr. 1683

    Google Scholar 

  • Becker N,WahrendorfJ (1997) Krebsatlas der Bundesrepublik Deutschland 1981–1990 Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Bernier J, Domenge C, Eschwege F et al. (2001) Chemo-radiotherapy, as compared to radiotherapy alone, significantly increases disease-free and overall survival in head and neck cancer patients after surgery:results of EORTC Phase Ill Trial 22931. Int J Radiat Oncol Biol Phys 51 [Suppl 1]:Abstr 1

    Google Scholar 

  • Bier H (1994) Krebsepidemiologie. HNO 42: 390–392

    PubMed  CAS  Google Scholar 

  • Bier H (1997)Therapieentscheidungen bei fortgeschrittenen Malignomen des Oropharynx

    Google Scholar 

  • Bier H, Schultze M, Ganzer U (1993) Anmerkungen zur Nachsorge von Tumorpatienten. HNO 41: 47–54

    PubMed  CAS  Google Scholar 

  • Bissett RJ, Fitzpatrick PJ (1988) Malignant submandibular gland tumors. A review of 91 patients. Am 1 Clin Oncol 11: 46–51

    CAS  Google Scholar 

  • Bocca E, Pignataro O (1967) A conservation technique in radical neck dissection. Ann Otol 76: 975–987

    CAS  Google Scholar 

  • Bockmühl U (1998) Bedeutung der Analyse genetischer Alterationen bei Kopf-Hals-Karzinomen. HNO 46: 74–83

    PubMed  Google Scholar 

  • Bockmühl U, Küchler I, Petersen I (2000) Verbesserte Prognoseeinschätzung bei Kopf-Hals-Karzinomen durch neue genetische Marker. HNO 48: 451–456

    PubMed  Google Scholar 

  • Borthne A, Kjellevold K, Kaalhus O,Vermund H (1986) Salivary gland malignant neoplasms:Treatment and prognosis.lnt J Radiat Oncol Biol Phys 12: 747–54

    CAS  Google Scholar 

  • Bosch FX, Homann N, Conradt C, Dietz A, Erber R (1999) p53-Mutationen/p53-Proteinüberexpression. HNO 47: 833–848

    Google Scholar 

  • Boyle JO, Hakim 1, Koch W et al. (1993) The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53: 4477–4480.

    PubMed  CAS  Google Scholar 

  • Bradford CR, Zhu S, Poore J et al. (1997) p53 mutations as a prognostic marker in advanced laryngeal carcinoma. Department of Verterans Affairs Laryngeal Cancer Cooperative Study Group.Arch Otolarnyngol Head Neck Surg 123: 605–9

    Google Scholar 

  • Brizel DM, Albers ME, Fisher SR et al. (1998) Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. NEJM 338: 1798–804

    PubMed  CAS  Google Scholar 

  • Brizel DM, Wasserman TH, Henke M et al. (2000) Phase Ill randomized trial of amifostine as a radiotprotector in head and neck cancer.J Clin On-col 18: 3339–3345

    CAS  Google Scholar 

  • Browman GP, Wong G, Hodson I, Sathya J, Russell R, McAlpine L, Skingley P, Levine MN (1993) Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer. N Engl J Med 328: 159–163

    PubMed  CAS  Google Scholar 

  • Brugere J, Guenel P, Leclerc A, Rodriguez J (1986) Differential effects of tobacco and alcohol in cancer of the larynx, pharynx and mouth.Cancer 57: 391–395

    CAS  Google Scholar 

  • Bschorer R, LingenfelserT, Kaiserling E,Schwenzer N (1993) Malignant lymphoma of the mucosa-associated lymphoid tissue (MALT)-consecutive unusual manifestation in the rectum and gingiva.J Oral Pathol Med 22: 190–192

    CAS  Google Scholar 

  • Burmeister BH, Smithers BM, Poulsen M, McLeod GR, Bryant G,Tripcony L, Thorpe C (1995) Radiation therapy for nodal disease in malignant melanoma. World J Surg 19: 369–371

    CAS  Google Scholar 

  • Byfield JE, Calabro-Jones P, Klisak I, Kulhanian F (1982) Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and x-rays. Int J Radiat Oncol Biol Phys 8: 1923–1933

    PubMed  CAS  Google Scholar 

  • Catterall M,Errington RD (1987) The implications of improved treatment of malignant salivary gland tumors by fast neutron radiotherapy. Intl Radiat Oncol Biol Phys 13: 1313–1318

    Google Scholar 

  • Clamon G H, Baatz L, Hoffman HT, Hussey DGH, Glascock M, McCulloch TM, Graham SM (1996) Neurotoxicity in a phase I trial of continuous infusion cisplatin with hyperfractionated radiotherapy for locally advanced head and neck cancer. Head and Neck 18: 236–241

    PubMed  CAS  Google Scholar 

  • Conley JJ,von Fraenkel T (1956) Historical aspect of head and neck surgery. Ann Otol 65: 643–655

    Google Scholar 

  • Constantinidis J, Federspil P, Iro H (2000) Die funktionell und ästhetisch orientierte Rekonstruktion von Lippendefekten. HNO 48: 517–526

    PubMed  CAS  Google Scholar 

  • Cooper JS, Pajak TF, Forastiere AA et al. (2002) Pattern of failure for resected advanced head and neck cancer treated by concurrent chemotherapy and radiation therapy:an analysis of RTOG 9501/Intergroup Phase III Trial.Int J Radiat Oncol Biol Phys 54 [Suppl]: Abstr 3

    Google Scholar 

  • Cummings BJ, Keane TJ, Pintilie M et al. and the ENT Group (1996) A prospective randomized trial of hyperfractionated versus conventional once daily radiation for advanced squamous cell carcinoma of the larynx and pharynx. Int J Radiat Oncol Biol Phys 36 Suppl 1: 235

    Google Scholar 

  • Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Schuller DE (1993) Otolaryngology - head and neck surgery,2nd edition.Mosby,St.Louis

    Google Scholar 

  • De Crevoisier R, Bourhis J, Domenge C et al. (1998) Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients. J Clin Oncol 16: 3556–3562

    PubMed  Google Scholar 

  • deBurgh Norman JE, McGurk M (1995) Color atlas and text of the salivary glands. Mosby-Wolfe, London St. Louis

    Google Scholar 

  • Decker DA (1983) et al. Adjuvant chemotherapy with cis-diamminedichloroplatinum II and 1–2-hour infusion 5-fluorouracil in stage III and IV squamous cell carcinoma of the head and neck. Cancer 51: 1353–1355

    Google Scholar 

  • Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (1997) Verhandlungsbericht. Springer, Berlin Heidelberg New York Tokyo, S 87–111

    Google Scholar 

  • Deutsche Krebsgesellschaft (2000) Kurzgefasste Interdisziplinäre Leitlinien 2000. Zuckschwerdt, München, S 69–91

    Google Scholar 

  • deVita VT, Hellman S, Rosenberg SA (eds) (2001) Cancer–principles and practice of oncology, 6th edition. Lippincott-Raven, Philadelphia pp 789–916

    Google Scholar 

  • deVries N, Gluckman JL (1991) Multiple primary tumors in the head and neck.Thieme, Stuttgart

    Google Scholar 

  • Dische S, Saunders M, Barrett A, Harvey A, Gibson D, Parmar M (1997) A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 44: 123–136

    PubMed  CAS  Google Scholar 

  • Dobrowsky W, Naudé J (2000) Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers.Radiother Oncol 57: 119–124

    CAS  Google Scholar 

  • Dost P, Schrader M,Talanow D (1994) Nutzen der Abdomensonographie und der Skelettszintigraphie bei derTNM-Einteilung von Tumoren im Kopf-Hals-Bereich. HNO 42: 418–421

    CAS  Google Scholar 

  • Dost P,Talanow DD, Kaiser S, Hirche H, Jahnke K (1996) Zum Zeitintervall zwischen Symptom- und Behandlungsbeginn bei Kopf- und Halstumoren. HNO 44: 492–496

    Google Scholar 

  • Draf W, Berghaus A (1993) Tumoren und Pseudotumoren („tumorähnliche Läsionen“) der frontalen Schädelbasis, ausgehend von der Nase, den Nasennebenhöhlen und dem Nasenrachenraum (einschließlich der operativen Zugänge). Rhinochirurgisches Referat. Eur Arch Otorhinolaryngol [Suppl I]: 105–186

    Google Scholar 

  • Duncan W, Orr JA, Arnott SJ,Jack WJ (1987) Neutron therapy for malignant tumours of the salivary glands.A report of the Edinburgh experience. Radiother Oncol 8: 97–104

    CAS  Google Scholar 

  • Eckardt A, Wildfang I, Karstens JH (1999) Simultaneous radiochemotherapy with taxol/carboplatin in advanced operable head-neck tumors. Preliminary results.Strahlenther Onkol 175: 11–13

    Google Scholar 

  • EI Gueddari B (1998) Final results of the VUMCA I randomized trial comparing neoadjuvant chemotherapy (CT) (BEC) plus radiotherapy (RT) to RT alone in undifferntiated nasopharyngeal carcinoma (UCNT). Proc Am Soc Clin Oncol 17: 1482 [Abstract]

    Google Scholar 

  • EI-Sayed S, Nelson N (1996) Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region: a meta-analysis of prospective and randomized trials.! Clin On-col 14: 838–847

    Google Scholar 

  • English GM (1996) Otolaryngology volume 5: Oncology of the head and neck.J.B. Lippincott, Philadelphia

    Google Scholar 

  • Ensley JF, Gutkind JS, Jacobs JR, Lippman SM (eds) (2003) Head and neck cancer. Emerging perspectives. Academic Press, Amsterdam

    Google Scholar 

  • Eschwege F, Sancho-Gamier H, Chassagne D et al. (1997) Results of a randomized trial of etanidazole combined with radiotherapy in head and neck carcinoma. Int J Radiat Oncol Biol Phys 39: 275–281

    PubMed  CAS  Google Scholar 

  • Fahlbusch R, Neubauer U,Wigand M,Weidenbecher M, Röckelein G,Thierauf P, Sauer R (1989): Neuro-rhinosurgical treatment of aesthesioneuroblastoma. Acta Neurochir 100: 93–100

    PubMed  CAS  Google Scholar 

  • Ferlito A (2000) Diseases of the larynx. Arnold, London

    Google Scholar 

  • Fietkau R, Steiner W (1997) Moderne Aspekte der Strahlen- und Chemotherapie im Hals-Nasen-Ohrenbereich. Verhandlungsbericht 1997, Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Springer, Berlin Heidelberg New York Tokyo, S 87–130

    Google Scholar 

  • Fietkau R, Steiner W (1997) Moderne Aspekte der Strahlen- und Chemotherapie im Hals-Nasen-Ohrenbereich. Verhandlungsbericht 1997, Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Springer, Berlin Heidelberg New York Tokyo, S 87130

    Google Scholar 

  • Fletcher GH (1980) Textbook of radiotherapy, 3rd edition. Lea and Febiger, Philadelphia

    Google Scholar 

  • Forastiere AA, Metch B, Schuller DE et al. (1992) Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versusmethotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study.) Clin Oncol 10: 1245–1251

    CAS  Google Scholar 

  • Fracchiolla NS,Pignataro L,Capaccio P,Trecca D,Boletini A,Ottaviani A,PoIli E, Maiolo AT, Neri A (1995) Multiple genetic lesions laryngeal squamous cell carcinoma.Cancer 75: 1291–1301

    Google Scholar 

  • Fu KK, Leibel SA, Levine ML, Frielander LM, Boles R, Phillips TL (1977) Carcinoma of the major and minor salivary glands:Analysis of treatment results and sites and causes of failures. Cancer 40: 2882–2890

    PubMed  CAS  Google Scholar 

  • Fu KK, PajakTF,Trotti A et al.for the RTOG (2000) A radiation therapy oncology group (RTOG) phase Ill randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 90003. Int J Radiat Oncol Biol Phys 48: 7–16

    Google Scholar 

  • Fu KK, Phillips TL, Silverberg IJ et al. (1987) Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: Update of a Northern California Oncology Group Randomized Trial.J Clin Oncol 5: 1410–1418

    CAS  Google Scholar 

  • Gilligan D, Slevin NJ (1991) Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses. Br J Radiol 64: 1147–1150

    PubMed  CAS  Google Scholar 

  • Giri PGS,AI-Sarraf M, Fu KK et al. (1996) Improved survival with chemotherapy and radiation therapy versus radiation therapy alone in advanced nasopharyngeal cancer. Preliminary results of an intergroup randomized trial. INT 0099, SWOG 8892, RTOG 8817, ECOG 2388. Int J Radiat Oncol Biol Phys 36 [Suppl]: 162

    Google Scholar 

  • Glanzmann C (1990) Long-term results of postoperative and primary radiotherapy of carcinoma of the salivary glands: importance of dosage and target volume. Strahlenther Onkol 166: 183–189

    PubMed  CAS  Google Scholar 

  • Grabenbauer GG, Mühlfriedel C, Rödel F et al. (2000) Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy. Intl Radiat Oncol Biol Phys; 48: 1041–1050

    CAS  Google Scholar 

  • Griffin TW, Pajak TF, Laramore GE, Duncan W, Richter MP, Hendrickson FR, Maor MH (1988) Neutron vs. photon irradiation of inoperable salivary gland tumors: results of an RTOG-MRC Cooperative Randomized Study. Int J Radiat Oncol Biol Phys 15: 1085–1090

    PubMed  CAS  Google Scholar 

  • Habermalz Hi, FischerJJ (1976) Radiation therapy of malignant melanoma: Experience with high individual treatment doses. Cancer 38: 22582262

    Google Scholar 

  • Harwood AR, Beale FA, Cummings Bj, Keane TJ, Payne DG, Rider WD Rawlinson E, Elhakim T (1983) Supraglottic laryngeal carcinoma:An analysis of dose-time volume factors in 410 patients. Int J Radiat Oncol Biol Phys 9: 311–319

    PubMed  CAS  Google Scholar 

  • Harwood AR, Lawson VG (1982) Radiation therapy for melanomas of the head and neck. Head Neck Surg 4: 468–474

    PubMed  CAS  Google Scholar 

  • Head and Neck Contracts Program (1987) Adjuvant chemotherapy for advanced head and neck squamous carcinoma: Final report of the Head and Neck Contracts Program. Cancer 60: 301–311

    Google Scholar 

  • Hoederat A, Sark H, Stuschke M et al. (1996) Radiation therapy of primary extranodal non-Hodgkin’s lymphoma of head and neck. Results of a prospective multicenter study. Strahlenther Onkol 172: 356–366

    Google Scholar 

  • Hölzel D, Klamert A, Schmidt M (1996) Krebs.Häufigkeiten,Befunde und Behandlungsergebnisse. Zuckschwerdt, München

    Google Scholar 

  • Hong WK, Itri LM (1994) Retinoids and human cancer.In:Sporn MB, Roberts AB, Goodman DS (eds) The retinoids. Biology, chemistry, and medicine, 2nd edition. Raven Press, Philadelphia, pp 597–630

    Google Scholar 

  • Horiot IC, Le Fur R,N’GuyenTetal. (1992) Hyperfractionated versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 25: 231–241

    PubMed  CAS  Google Scholar 

  • Hornstein OP (1996) Erkrankungen des Mundes. Kohlhammer, Stuttgart, S 459–532

    Google Scholar 

  • International Union Against Cancer (1997)TNM Klassifikation malignerTumoren, 5. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Iro H, Hosemann W (1993) Minimally invasive surgery in otorhinolaryngology. Eur Arch Otorhinolaryngol 250: 1–10

    PubMed  CAS  Google Scholar 

  • Iro H,Waldfahrer F (1996) Präoperatives Staging und chirurgischeTherapie von Kopf-Hals-Tumoren.Onkologe 2: 339–345

    Google Scholar 

  • Iro H, Waldfahrer F, Gewalt K, Zenk J, Altendorf-Hofmann A (1995) Enoral/transoral surgery of malignancies of the oral cavity and the oropharynx. Adv Otorhinolaryngol 49: 191–195

    PubMed  CAS  Google Scholar 

  • Iro H,Waldfahrer F, Altendorf-Hofmann A,Weidenbecher M, Sauer R, Steiner W (1998) transoral laser surgery of supraglottic cancer:a follow-up of 141 patients. Arch Otolaryngol Head Neck Surg 124: 1245–1250

    Google Scholar 

  • Jarez P, Fernandez PL, Campo E et al. (1994) PRAD-1/Cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res 54: 48134817

    Google Scholar 

  • Jeremic B, Shibamoto Y, Milicic B, Nikolic N, Dagovic A, Aleksandrovic J, Vaskovic Z, Tadic L (2000) Hyperfractionated radiotherapy with or without concurrent low dose daily cis-platin in locally advanced squamous cell carcinoma of the head and neck:a prospective randomized trial.) Clin Oncol 18: 1458–1464

    CAS  Google Scholar 

  • Jones AS (2000)Tumour suppressor genes and head and neck cancer. Adv Otorhinolaryngol 56: 249–260

    Google Scholar 

  • Kadish S, Goodman M, Wine CC (1976) Olfactory neuroblastoma: A clinical analysis of 17 cases.Cancer 37: 1571–1576

    CAS  Google Scholar 

  • Kagei K, Shirato H, Nishioka T et al. (2000) Ipsilateral irradiation for carcinomas of tonsillar region and soft palate based on computed tomo-graphic simulation. Radiother Oncol 54: 117–121

    PubMed  CAS  Google Scholar 

  • Kingdom TT, Kaplan MJ (1995) Mucosal melanoma of the nasal cavity and paranasal sinuses. Head Neck 17: 184–189

    PubMed  CAS  Google Scholar 

  • Kirschner MJ,Fietkau R,Waldfahrer H,Iro H, Sauer R (1997) ZurTherapie von zervikalen Lymphknotenmetastasen ohne bekannten Primärtumor. Strahlenther Onkol 173: 362–368

    Google Scholar 

  • Kish,JA, EnsleyJF,Jacobs J,Weaver A, Cummings G,AI-Sarraf M (1985) Randomised trial of cisplatin (CACP) + 5-fluorouracil (5-FU) infusion and CACP + 5-FU bolus for recurrent and advanced squamous cell carcinoma of the head and neck. Cancer 56: 2740–2744

    Google Scholar 

  • Kleinsasser O (1987) Tumoren des Larynx und des Hypopharynx.Thieme, Stuttgart Kraus DH, Levine HL ( 1997 ) Nasal neoplasia.Thieme, Stuttgart

    Google Scholar 

  • Kropveld A, Slootweg PJ, Blankenstein MA,Terhaard CH, Hordijk GJ (1998) Ki-67 and p53 in T2 laryngeal cancer. Laryngoscope 108: 1548–1552

    CAS  Google Scholar 

  • Krull A, Schwarz R, Engenhardt R et al. (1996) European results in neutron therapy of malignant salivary gland tumours.Bull Cancer Radiother 83 Suppl 125s-129 s

    Google Scholar 

  • Krull A, Schwarz R, Heyer D,Timm H, Schmidt R (1995) Results of neutron therapy in recurrent malignant salivary gland tumors in the head and neck area. Strahlenther Onkol 171: 265–271

    CAS  Google Scholar 

  • Kwong D, Sham J, Choy D (1994) The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: an analysis of 1301 patients. Int J Radiat Oncol Biol Phys 30: 1029–1036

    PubMed  CAS  Google Scholar 

  • Laramore GE, Scott CB, AI-Sarraf M et al. (1992) Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck:Report on intergroup study 0034. Int J Radiat Oncol Biol Phys 23: 705–713

    PubMed  CAS  Google Scholar 

  • Lazar AD, Winter MR, Nogueira CP et aI. (1998). Loss of heterozygosity at 11 q23 in squamous cell carcinoma of the head and neck is associated with recurrent disease. Clin Cancer Res 4: 2787–2793

    CAS  Google Scholar 

  • Lee AW, Poon YF, Foo W et al. (1992) Retrospective analysis of 5037 patients with naospharyngeal carcinoma treated during 1976–1985: Overall survival and pattern of failure. Intl Radiat Oncol Biol Phys 23: 261–270

    Google Scholar 

  • Leemans CR,Tiwari R, Nauta JJP, von der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma.Cancer 71: 452–456

    Google Scholar 

  • Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T (1996) Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 88: 890–899

    Google Scholar 

  • Leibel SA, Scott CB, Muhiuddin M, Marcial VA, Coia LR, Davis LW, Fuks Z (1991) The effect of loco-regional control on distant metastatic dis-semination in carcinoma of the head and neck: Results of an analysis from the RTOG database. Int J Radiat Oncol Biol Phys 21: 549–556

    Google Scholar 

  • Leitlinien der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- and Halschirurgie (2000) Onkologie des Kopf-Hals-Bereiches. H NO 48:104–118

    Google Scholar 

  • Lindberg R (1972) Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 29: 1446–1449

    PubMed  CAS  Google Scholar 

  • Lippert BM, Werner JA (2001) Metastases in Head and Neck Cancer. Proceedings of the 2nd international Symposium.Tectum, Marburg

    Google Scholar 

  • Lucente FE, Lawson W, Novick NL (1995) The external ear. Saunders, Philadelphia

    Google Scholar 

  • Maier H, Weidauer H (1991) Krebsrisiken im Kopf-Hals-Bereich. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Martin H,Sugerbaker EL (1941) Cancer of the tonsil. Am J Surg 52: 158–196

    Google Scholar 

  • McDonald S, Meyerowitz C, Smudzin T, Rubin P (1994) Preliminary results of a pilot study using WR 2721 before fractionated irradiation of the head and neck to reduce salivary gland dysfunction. Int J Radiat On-col Biol Phys 29: 747–754

    CAS  Google Scholar 

  • Mendenhall WM, Parsons JT, Buatti JM, Stringer SP, Million RR, Cassisi NJ (1995) Advances in radiotherapy for head and neck cancer. Semin Surg Oncol 11: 256–264

    PubMed  CAS  Google Scholar 

  • Meoz-Mendez RT, Fletcher GH, Guillamondeque OM (1978) Analysis of the results of irradiation in the treatment of squamous cell carcinoma of the pharyngeal walls. Int J Radiat Oncol Biol Phys 4: 579–585

    PubMed  CAS  Google Scholar 

  • Merino OR, Lindberg RD, Fletcher GH (1977) An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 40: 145–151

    PubMed  CAS  Google Scholar 

  • Merlano M, Benasso M, Corvo R et al. (1996) Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck.) Natl Cancer Inst 88: 583–589

    CAS  Google Scholar 

  • Merlano M,Vitale V, Rosso R et al. (1992) Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 327: 1115–1121

    Google Scholar 

  • Mika H (1987) Vergleich von intraarterieller and systemischer Chemotherapie bei Kopf- and Halstumoren. In:Sauer R, Schwab W (Hrsg) Kombinationstherapie der Oropharynx- and Hypopharynxkarzinome. Urban and Schwarzenberg, München, 5 155–157

    Google Scholar 

  • Million RR,Cassisi NJ (1994) Management of head and neck cancer,2nd edition.J.B. Lippincott, Philadelphia

    Google Scholar 

  • Moore C (1971) Cigarette smoking and cancer of the mouth, pharynx and Iarynx.JAMA 218: 553–558

    CAS  Google Scholar 

  • Munro Ai (1995) An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer. Br J Cancer 71: 83–91

    Google Scholar 

  • Mutirangura A, Tanunyutthawongese C, Pornthanakasem W, Kerekhanjanarong V,Sriuranpong V,Yenrudi S,Supiyaphun P,Voravud N (1997) Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection. Br J Cancer 76: 770–776

    PubMed  CAS  Google Scholar 

  • Myers EN, Suen JY (1996) Cancer of the head and neck, 3rd edition. Saunders Philadelphia

    Google Scholar 

  • Niewald M, Barbie O, Schnabel K, Engel M, Schedler M, Nieder C, Berberich W (1996) Risk factors and dose-effect relationship for osteoradionecrosis after hyperfractionated and conventionally fractionated radiotherapy for oral cancer. Br J Radio! 69: 847–851

    CAS  Google Scholar 

  • O’Sullivan, Warde P, Grice B et al. (1996) Assessment of contralateral neck failure in 229 cases of carcinoma of the tonsillar region treated with techniques desinged to spare contralateral parotid function. Int J Radiat Oncol Biol Phys 36 [Suppl]: 165

    Google Scholar 

  • Olsen KD, Caruso M, Foote RL et al. (1994) Primary head and neck cancer: Hisotpathologic predictors of recurrence after neck dissection in patients with lymph node involvement. Arch Otolaryngol Head Neck Surg 120: 1370–1374

    Google Scholar 

  • Overgaard J (1994) Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.Oncol Res 6: 509–518

    CAS  Google Scholar 

  • Overgaard J, Gonzalez-Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Melia O, Bentzen SM (1996) Hyperthermia as adjuvant to radiation therapy for recurrent or metastatic malignant melanoma. A multicenter randomised trial by the European Society for Hyperthermic Oncology. Int J Hyperthermia 12: 3–20

    Google Scholar 

  • Overgaard J, Overgaard M, Hansen PV, von der Maase H (1986) Some factors of importance in the radiation treatment of malignant melanoma. Radiother Oncol 5: 183–192

    PubMed  CAS  Google Scholar 

  • Pernot M, Mal issa rd L, Hoffstetter S et al. (1994) The study of tumoral, radio-biological, and general health factors that influence resutls and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation. Int J Radiat Oncol Biol Phys 29: 673–679

    PubMed  CAS  Google Scholar 

  • Peters L J, Harrison ML, Dimery IW, Fields R, Goepfert H, Oswald KU (1988) Acute and late toxicity associated with sequential bleomycin-containing chemotherapy regimens and radiation therapy in the treatment of carcinoma of the nasopharynx.Inti Radiat Oncol Biol Phys 14: 623–633

    CAS  Google Scholar 

  • Peters LJ, Goepfert H, Ang KK et al. (1993) Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prespective randomized trial. Int J Radiat Oncol Biol Phys 26: 3–11

    PubMed  CAS  Google Scholar 

  • Pignon JP, Bourhis J, Domenge C, Designé, on behalf of the MACH-HN Collaborative Group (2000) Chemotherapy added to locoregional treatment for head and neck squamous cell carcinomas:three metaanalyses of updated individual data. Lancet 355: 949–955

    Google Scholar 

  • Pindborg JJ (1982) Krebs und Vorkrebs der Mundhöhle. Quintessenz, Berlin

    Google Scholar 

  • Pless M (2000) Bedeutung der Chemotherapie in der kurativen Therapie von Kopf-Hals-Tumoren. HNO 48: 873–878

    PubMed  CAS  Google Scholar 

  • Poppendieck J (1987) Zur Häufigkeit von Mehrfachtumoren im oberen Aerodigestivtrakt. Routinemäßige Panendoskopie? HNO 35: 19–23

    PubMed  CAS  Google Scholar 

  • Ravasz LA,Terhaard CHJ, Hordijk GJ (1990) Radiotherapy in epithelial tumors of the parotid gland:case presentation and literature review. Int J Radiat Oncol Biol Phys 19: 55–59

    Google Scholar 

  • Renan MJ (1993) How many mutations are required fortumorigenesis? Implications from human cancer data. Mol Carcinog 7: 139–146

    PubMed  CAS  Google Scholar 

  • Robbins KT (2000) The evolving role of combined modality therapy in head and neck cancer. Arch Otolaryngol Head Neck Surg 126: 265269

    Google Scholar 

  • Rudert H (1991) Larynx- und Hypopharynxkarzinome–Endoskopische Chirurgie mit dem Laser.Möglichkeiten und Grenzen. Eur Arch Otorhinolaryngol 1 [Suppl]: 3–18

    CAS  Google Scholar 

  • Sanchíz F, Milli A,Torner J, Bonet F, Artola N, Carreno L, Moya LM, Riera D, Ripol S,Cirera L (1990) Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int J Radiat Oncol Biol Phys 19: 1347–1350

    Google Scholar 

  • Sanguinati G,Geara FB, Garden AS,Tucker SL, Ang KK, Morrison WH, Peters U (1997) Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys 37: 985–996

    Google Scholar 

  • Schantz SP (1993) Carcinogenesis, markers, staging, and prognosis of head and neck cancer. Curr Op Oncol 5: 483–490

    CAS  Google Scholar 

  • Schuller DE, Metch B, Stein DW, Mattox D, McCracken JD (1988) Preoperative chemotherapy in advanced resectable head and neck cancer: Final report of the Southwest Oncology Group. Laryngoscope 98: 1205–1211

    Google Scholar 

  • Schwab W, Clasen B, Steinhoff Hi (1987) Neue und geänderte Richtlinien zum TNM-System im Kopf-Hals-Bereich. HNO 35: 112–118

    PubMed  CAS  Google Scholar 

  • Scully C, Field JK,Tanzawa H 2000 ) Genetic abberations in oral or head and neck squamous cell carcinoma (3 parts). Oral Oncol 36: 256–263, 311–327, 404–413

    Google Scholar 

  • SECOG, Cancer Research Campaign Clinical Trial Centre (1986) A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. Europ J Surg Oncol 12: 289–295

    Google Scholar 

  • Seifert G (1996) Oralpathologie I. Pathologie der Speichedrüsen. Springer, Berlin Heidelberg New York TokyoSeifert G, Miehlke A, Haubrich J, Chilla R ( 1984 ) Speicheldrüsenkrankheiten.Thieme, Stuttgart

    Google Scholar 

  • Shanmugaratnam K (1991) Histological typing of tumours of the upper respiratory tract and ear, 2nd edition. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Shin DM, Kim J, Ro JY, Hittelman J, Roth JA, Hong WK, Hittelman WN (1994) Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54: 321–326

    PubMed  CAS  Google Scholar 

  • Shockley WW, Pillsbury HC (1993) The neck. Diagnosis and surgery. Mosby, St. Louis

    Google Scholar 

  • Sidransky D (2001) Cancer of the head and neck. molecular biology of head and neck tumors. In: de Vita VT, Hellman S, Rosenberg SA (eds) Cancer–principles and practice of oncology, 6th edition. Lippincott-Raven, Philadelphia, pp 789–796

    Google Scholar 

  • Silver CE, Ferlito A (1996) Surgery for cancer of the larynx and related structures, 2nd edition. Saunders, Philadelphia

    Google Scholar 

  • Spiro RH (1986) Salivary neoplasms.Overview ofa 35-year experience with 2807 patients. Head Neck Surg: 8: 177–184

    PubMed  CAS  Google Scholar 

  • Staar S, Rudat V, Stuetzer H et al. (2001) Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy results of a multicentric randomized German trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 50: 1161–1171

    PubMed  CAS  Google Scholar 

  • Steiner W (1988) Experience in endoscopic laser surgery of malignant tumours of the upper aerodigestive tract. Adv Otorhinolaryngol 3: 9 135–144

    Google Scholar 

  • Steiner W (1993) Krebsfrüherkennung im Bereich der oberen Luft- und Speisewege. HNO 41:360–367, 497–503

    Google Scholar 

  • Steiner W (1994) Therapie des Hypopharynxkarzinoms. HNO 42: 4–13, 84–88,104–112,147–156, 157–165

    Google Scholar 

  • Steiner W (1997) Endoskopische Laserchirurgie der oberen Luft- und Speisewege.Thieme, Stuttgart

    Google Scholar 

  • Steiner W, Reck R, Dühmke E (1990) Funktionserhaltende Therapie des frühen Larynxkarzinoms.Thieme, Stuttgart

    Google Scholar 

  • Steinhart H,ConstantinidisJ,Iro H (1998) Kehlkopferhaltende Chirurgie bei Karzinomen der Rachenhinterwand durch Rekonstruktion mit freien Lappen. HNO 46: 135–139

    Google Scholar 

  • Stranc MF, Fogel M,Dische S (1987) Comparison of lip function:surgeryversus radiotherapy. Br J Plastic Surg 40: 598–604

    CAS  Google Scholar 

  • Strauch B, Vasconez LO, Hall-Findley EJ (1998) Grabb’s encyclopedia of flaps,volume 1:head and neck, 2nd edition. Lippincott Raven, Philadelphia

    Google Scholar 

  • Suarez 0 (1963) El problema de las metastasis linfaticas y alejadas del cancer de laringe e hipofaringe. Rev Otorrinolaringol 23: 83–99

    Google Scholar 

  • Subramaniam R, Chilla R (1995) Halslymphknotenmetastasen bei unbekanntem Primärtumor.HNO43:299–303

    Google Scholar 

  • Taylor IV SG, Murthy AK, Vannetzel JM et al. (1994) Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer. J Clin Oncol 12: 385–395

    PubMed  Google Scholar 

  • Trog D, Bank P, WendtTG, Koscielny S, Beleites E (1999) Daily Amifostine given concomitantly to chemoradiation in head and neck cancer:A pilot study. Strahlenther Oncol 175: 444–449

    Google Scholar 

  • Turner SL,Slevin NJ, Gupta NK, Swindell R (1996) Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavity–evaluation of late morbidity and a watch policy for the clinically negative neck. Radiother Oncol 41: 21–29

    Google Scholar 

  • Tuyns AJ, Estève J, Raymond L et al. (1988) Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC International Case-Control Study in Turin and Varese (Italy), Zaragoza and Navarra ( Spain ), Geneva (Switzerland) and Calvados (France). Int J Cancer 41: 483–491

    Google Scholar 

  • UICC- International Union Against Cancer, Wittekind C, Meyer HJ, Bootz F (2002) TNM-Klassifikation maligner Tumoren, 6. Auflage. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Urken ML, Cheney ML, Sullivan MJ, Billder HF (1995) Atlas of regional and free flaps for head and neck reconstruction. Raven Press, Philadelphia

    Google Scholar 

  • Van den Bogaert W, van der Schueren E, Horiot JC et al. (1995) The EORTC randomized trial on three fractions per day and misonidazole (trial no. 22811) in advanced head and neck cancer:long-term results and side effects. Radiother Oncol 35: 91–99

    PubMed  Google Scholar 

  • Van der Planken, HJM,Tiwari RM, Karim ABM (1997) Treatment of cervical lymph node metastasis form an unknown primary tumor, with a review of the literature. Strahlenther Onkol 173: 163–169

    Google Scholar 

  • Van Dieren EB,Nowak PJCM,Wijers OB,van Sörnsen de Koste JR,van der Est H, Binnekamp DP, Heijmen BJM, Levendag PD (2000) Beam intensity modulation using tissue compensators or dynamic multileaf collimation in three-dimensional conformal radiotherapy of primary caners of the oropharynx and larynx, including the elective neck. Int J Radiat Oncol Biol Phys 47: 1299–1309

    PubMed  Google Scholar 

  • Vanderbrouck C, Sancho H, Le Fur R, Richard JM, Cachin Y (1977) Results of a randomized clinical trial of preoperative irradiation versus postoperative in treatment of tumors of the hypopharynx. Cancer 39: 1445–1449

    Google Scholar 

  • Venook AP, Tseng A Jr, Meyers FJ, Silverberg I, Boles R, Fu KK, Jacobs CD (1987) Cisplatin, doxorubicin, and 5-fluorouracil chemotherapy for salivary gland malignancies: a pilot study of the NorthernCalifornia Oncology Group.J Clin Oncol 5: 951–955

    CAS  Google Scholar 

  • Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients wich advanced laryageal cancer. N Engl J Med 324: 1685–1690

    Google Scholar 

  • Vidyasagar MS, Fernandes DJ, Kasturi DP,Akhileshwaran R,Rao K, Rao S, Rao RV, Solomon JG (1992) Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases. Acta Oncol 31: 43–47

    CAS  Google Scholar 

  • Vokes EE,Weichselbaum RR, Lippman SM, Hong WK (1993) Head and neck cancer. N Engl J Med 328: 184–194

    Google Scholar 

  • VUMCA I trial (1996) International Nasopharynx Cancer Study Group Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cis-platin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV (=N2, MO) undifferentiated nasopharyngeal carcinoma: a positive effect on progression-free survival.lnt J Radiat Oncol Biol Phys 35: 463–469

    Google Scholar 

  • Wagner G, Hermanek P (1995) Organspezifische Tumordokumentation. Springer, Berlin

    Google Scholar 

  • Waldfahrer F, Heinritz H, Kraus T, Iro H (1995) Plasmozytome im HNO-Bereich. HNO 43: 111–129

    PubMed  CAS  Google Scholar 

  • Waldfahrer F, Iro H (2001) Tumormarker und andere Laborparameter In: Böttcher HD, Wendt TG, Henke M (Hrsg) Klinik des Rezidivtumors im Kopf-Hals-Bereich. Zuckschwerdt, München

    Google Scholar 

  • Wang CC (1991) Improved local control of nasopharyngeal carcinoma after intracavitary brachytherapy boost. Am J Clin Oncol 14: 5–8

    PubMed  CAS  Google Scholar 

  • Wang CC (1997) Radiation therapy for head and neck neoplasms, 3rd edition. Wiley-Liss, New York

    Google Scholar 

  • Weber PC,Johnson JT, Myers EN (1994) The impact of bilateral neck dissection on pattern of recurrence and survival in supraglottic carcinoma. Arch Otolaryngol Head Surg 120: 703–706

    Google Scholar 

  • Wendt TG, Grabenbauer GG, Rödel C et al. (1998) Simultaneous radio-chemotherapy versus radiotherapy alone in advanced head and neck cancer:a randomized multicenter study.J Clin Oncol 16: 1318–1324

    CAS  Google Scholar 

  • WernerJA (1997) Aktueller Stand der Versorgung des Lymphabflusses maligner Kopf-Hals-Tumoren. Verhandlungsbericht 1997, Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Springer, Berlin Heidelberg New Yorl Tokyo, S 47–86

    Google Scholar 

  • Wildfang I et al. (1999) Low-dose gemcitabine with radiotherapy in advanced head and neck and thyroid tumors: a phase II study. Proc Am Soc Clin Oncol 17:Abstract

    Google Scholar 

  • Withers HR, Peters U,Taylor JMG et al. (1995) Local control of the tonsil by radiation therapy: An analysis of pattern of fractionation in nine Insitutions. Int J Radiat Oncol Biol 33: 549–562

    Google Scholar 

  • Zelefsky MJ, Harrison LB, Fass DE, Armstrong JG, Shah JP, Strong EW(1992) Postoperative radiation therapy for squamous cell carcinoma of the oral cavity and oropharynx:impact of therapy on patients with positive surgical margins. Int J Radiat Oncol Biol Phys 25: 17–21

    Google Scholar 

Download references

Authors
  1. T. G. Wendt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Iro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Waldfahrer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wendt, T.G., Iro, H., Waldfahrer, F. (2004). Tumoren im Kopf- und Halsbereich. In: Die Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06670-6_59

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06670-6_59

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06671-3

  • Online ISBN: 978-3-662-06670-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation