Skip to main content

Maligne Hodentumoren

  • Chapter
Die Onkologie

Zusammenfassung

Hodentumoren sind zu 98% Keimzelltumoren, der Rest sind Tumoren des Stroma- und Stützgewebes. In diesem Kapitel werden beide Gruppen getrennt dargestellt. Maligne Keimzelltumoren stellen die häufigsten bösartigen Tumoren junger Männer zwischen 20 und 35 Jahren dar. Bei einem Lebenszeitrisiko von 1: 500 (Davies 1981), an einem Keimzelltumor zu erkranken, bedeutete die Erkrankung vor der Ara cisplatinhaltiger Polychemotherapien wegen der hohen Malignität und Metastasierungsrate zugleich auch die häufigste Krebstodesursache von Männern in dieser Altersgruppe. Durch die Einführung der cisplatinhaltigen Polychemotherapien Ende der siebziger Jahre konnte die Heilungsrate auf insgesamt 90–95% gesteigert werden (Schmoll 1999a). Damit handelt es sich um den derzeit am besten behandelbaren Tumor im Erwachsenenalter mit der höchsten Heilungsrate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abell A (1994) Organic food and sperm counts in men. Food Magazine 25:

    Google Scholar 

  • Agrons GA, Wagner BJ, Lonergan GJ et al (1997) From the archives of the AFIP. Genitourinary rhabdomyosarcoma in children: radiologicpathologic correlation. Radiographics 17: 919–937

    PubMed  CAS  Google Scholar 

  • Albers P, Dieckmann KP (1998) Hodentumoren: Diagnostik and Therapie des Primärtumors. Onkologe 6: 487–493

    Google Scholar 

  • Albers P, Dommer K, Müller S (1998) Testicular tumors. Mortality and recurrence after inadequate therapy. Urologe A 37: 625–628

    PubMed  CAS  Google Scholar 

  • Albrecht P, Bender H, Yilmaz H, Schoeneich G, Biersack H, Müller S (1999) Positron emission tomography in the clinical staging of patients with stage I and Il testicular germ cell tumors. Urology 53: 808–811

    Google Scholar 

  • Atkin NB, Baker MC (1995) High chromosome numbers of testicular germ cell tumours. Cancer Genet Cytogenet 88: 90

    Google Scholar 

  • Bajorin DF, Mazumdar M, Meyers M, Motzer RJ, Vlamis V, Lin P, Bost GJ (1998) Metastatic germ cell tumors: Modeling for Response to Chemotherapy. Clin Oncol 16: 707–715

    CAS  Google Scholar 

  • Baniel J, Foster RS, Gonin R, Messemer JE, Donohue JP, Einhorn LH (1995) Late relapse of testicular cancer. Clin Oncol 13: 1170–1176

    CAS  Google Scholar 

  • Bauman G, Venkatesan V, Ago C, Ratwan 1, Dar A, Vinquist W (1998) Postoperative radiotherapy for stage I/11 in seminoma: results for 212 in patients. Int J Radiat Oncol 42: 313–317

    CAS  Google Scholar 

  • Beard CM, Benson RC, Kelalis PP (1977) The incidence and outcome of mumps orchitis in Rochester, Minnesota 1935–1974. Mayo Clin Proc 52: 3–7

    PubMed  CAS  Google Scholar 

  • Bertram KA, Bratloff B, Hodges GF, Davidson H (1991) Treatment of malignant Leydig cell tumor. Cancer 68: 2324–2329

    PubMed  CAS  Google Scholar 

  • Beyer J, Bokemeyer C, Schmoll HJ, Siegert W (1994) Treatment intensifica- tion in disseminated germ cell tumors. World J Urol 12: 207–218

    PubMed  CAS  Google Scholar 

  • Beyer J, KramarA, Mandanas R et al. (1996) High dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables. Clin Oncol 14: 2338–2345

    Google Scholar 

  • Beyer J, Bokemeyer C, Schmoll HJ, Siegert W (1998) Salvagetherapie rezidivierter and refraktärer Hodentumoren. Onkologe 6: 541–546

    Google Scholar 

  • Beyer J, Schmoll Hi (1998) Prognostic factors in metastatic germ cell tumors. Semin Oncol 25: 174–186

    PubMed  Google Scholar 

  • Birch R, Williams S, Cone A et a1. (1986) Prognostic factors for favorable out- come in disseminated germ cell tumors. Clin Oncol 4: 400–407

    CAS  Google Scholar 

  • Bokemeyer C, Gonnermann D, Harstrick A, Schöffski P, Schmoll HJ, Poliwoda H (1992) Metastatic Leydig-cell tumours of the testis: report of three cases. Poster, Jahrestagung der Deutschen Gesellschaft für Hämatologie and Onkologie, Berlin, 4. -7. Oktober 1992. Ann Hematol 65 [Suppl]: Abstract 39

    Google Scholar 

  • Bokemeyer C, Schmoll H-J (1993) Secondary neoplasms following treat- ment of malignant germ cell tumors. Clin Oncol 11: 1703–1709

    CAS  Google Scholar 

  • Bokemeyer C, Droz JP, Hanauske A et al. (1993) Treatment of relapsed nonseminomatous germ cell tumors with vinorelbine: a trial of the phase I/II study group of the Association for Medical Oncology of the German Cancer Society. Onkologie 16: 29–31

    Google Scholar 

  • Bokemeyer C, Schmoll Hi (1995) Treatment of testicular cancer and the development of secondary malignancies. Clin Oncol 13: 283–292

    CAS  Google Scholar 

  • Bokemeyer C, Beyer J, Metzner B et al. (1996a) Phase I l study of paclitaxel in patients with relapsed or cisplatin-refractory testicular cancer. Ann Oncol 7: 31–34

    PubMed  CAS  Google Scholar 

  • Bokemeyer C, Berger CC, Kuczyk MA, Schmoll HJ (1996b) Evaluation of long-term toxicity after chemotherapy for testicular cancer. J Clin Oncol 14: 2923–2932

    PubMed  CAS  Google Scholar 

  • Bokemeyer C, Kuczyk MA, Dunn T et al. (1996c) Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours. Cancer Res Clin Oncol 122: 301–306

    CAS  Google Scholar 

  • Bokemeyer C, Gerl A, Harstrick A, Schmoll HJ (1998) Therapie des fortgeschrittenen nichtseminomatösen Keimzelltumors. Onkologe 6: 532–540

    Google Scholar 

  • Bokemeyer C, Schöffski P (1999a) Sertoli-Zelltumoren. In: Schmoll H1, Höffken K, Possinger K (Hrsg) Kompendium Internistische Onkologie II, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 1733–1736

    Google Scholar 

  • Bokemeyer C, Schöffski P (1999b) Leydig-Zelltumoren. In: Schmoll HJ, Höffken K, Possinger K (Hrsg) Kompendium Internistische Onkologie II, 3. Aufl. Springer, Berlin Heidelberg New YorkTokyo, S 1737–1740

    Google Scholar 

  • Bokemyer C, Schöffski P (1999c) Paratestikuläres Rhabdomyosarkom. In: Schmoll HJ, Höffken K, Possinger K (Hrsg) Kompendium Internistische Onkologie II. 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, 51745–49

    Google Scholar 

  • Bronson DL, Ritzi DM, Fraley EE, Dalton AJ (1978) Morphologic evidence for retrovirus production by epithelial cells derived from human testicular tumor metastasis. Natl Cancer Inst 60: 1305–1308

    CAS  Google Scholar 

  • Capelouto CC, Clark PE, Ransil BJ et al. (1995) A review of scrotal violation in testicular cancer: is adjuvant local therapy necessary? J Urol 153: 981–985

    PubMed  CAS  Google Scholar 

  • Carlsen E, Giwercman A, Keiding N, Skakkebaek NE (1992) Evidence for decreasing quality of semen during the past 50 years. Br Med J 305: 609–612

    CAS  Google Scholar 

  • Cavalli F, Monfardini Setal. (1980) Report of the international workshop on staging and treatment of testicular cancer. EurJ Cancer 16: 1367–1372

    CAS  Google Scholar 

  • Chaganti RSK, Rodriguez E, Mathew S (1994) Origin of adult male mediastinal germ-cell tumours. Lancet 343: 1130–1132

    PubMed  CAS  Google Scholar 

  • Chaganti RSK, Murty WS, Bosl G (1996) Molecular genetics of male germ cell tumors. In: Vogelzang NJ, Scardino PT, Shipley WU, Coffey DS (Hrsg) Comprehensive Textbook of genitourinary oncology, 6th edn. pp 932–940

    Google Scholar 

  • Chaganti RSK, Houldsworth J (2000) Gentics and biology of adult human male germ cell tumors. Cancer Res 60: 1475–1482

    PubMed  CAS  Google Scholar 

  • Chilvers CED, Forman D, Oliver RTD, Pike MC (1994) Testicular Cancer Study Group. Social, behavioural and medical factors in the aetiology of testicular cancers: results from the UK study. Br J Cancer 70: 513–520

    Google Scholar 

  • Christensen TB, Daugaard G, Geertsen PF et al. (1998) Effect of chemotherapy on carcinoma in situ of the testis. Ann Oncol 9: 657–60

    PubMed  CAS  Google Scholar 

  • Claßen J, Souchon R, Bamberg M (1998) Therapie der frühen Stadien des Seminoms. Onkologe 6: 501–510

    Google Scholar 

  • Clemm C, Bokemeyer C (1998) Therapie des fortgeschrittenen Seminoms. Onkologe 6: 524–531

    Google Scholar 

  • Clemmesen J (1968) A doubling in mortality from testis carcinoma in Copenhagen 1943–62. Acta Pathol Microbiol Scand 72: 348

    PubMed  CAS  Google Scholar 

  • Collette L, Sylvester RJ, Stenning SP et al. (1999) Impact of the Treating Institution on Survival of patients with „poor-prognosis“ metastatic nonseminoma. J Natl Cancer Inst 91: 839–846

    PubMed  CAS  Google Scholar 

  • Collins GM, Kim DU, Gogrone R, Richert RR, Zablow A, Breen JL (1993) Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature. Mod Pathol 6: 89–93

    PubMed  CAS  Google Scholar 

  • Culine S, Theodore C, Farhat F et al. (1996) Cisplatin-based chemotherapy after retroperitoneal lymph node dissection in patients with pathological stage II nonseminomatous germ cell tumors. J Surg Oncol 61: 195

    PubMed  CAS  Google Scholar 

  • Culine S, Kerbrat P, Bouzy J, Theodore C, Biron P, Geoffrois L et al. (1999) Are 3 cycles of bleomycin, etoposide and cisplatin (3BEP) or 4 cycles or etoposide and cisplatin (4 EP) equivalent regimens for patients (pts) with good risk metastatic non seminomatous germ cell tumors (NSGCT)? Preliminary results of a randomzed trial. Proc Am Soc Clin On-col 18: 309a

    Google Scholar 

  • Davies JM (1981) Testicular cancer in England and Wales; some epidemiological aspects. Lancet 2: 928

    Google Scholar 

  • Davies T, Palmer CR, Ruja E (1996) Adolescent milk, dairy product and fruit consumption and testis cancer. Br J Cancer 74: 657–660

    PubMed  CAS  Google Scholar 

  • Derigs HG, Huber C, Schmoll HJ (1994) Stadienorientierte Therapie bei nichtseminomatösen Hodentumoren. Dtsch Med Wochenschr 119: 156–164

    PubMed  CAS  Google Scholar 

  • Desefano F., Annest JL, Kresnow M. (1989) Semen characteristics ofVietnam veterans. Reprod Toxicol 3: 165–173

    Google Scholar 

  • De Graaff WE, Ooosterhuis JW, de Jong B et al. (1992) Ploidy of testicular carcinoma in situ. Lab Invest 66: 166

    PubMed  Google Scholar 

  • De Wit R, Stoter G, Sleijfer CT et al. (1998) Four cycles of BEP vs. four cycles of VIP in patients with intermediate-prognosis metastatic testicular non-seminoma: a randomized study of the EORTC Genitourinary Tract Cancer Cooperative Group. Br J Cancer 78: 828–832

    PubMed  Google Scholar 

  • De Wit R, Collette L, Sylvester R, de Mulder PH, Sleijer DT, ten Bokkel HWW et al. (1998) Serum alpha-seroprotein surge after the initiation of chemotherapy for non-seminomatous testicular cancer has an adverse prognostic significance. Br J Cancer 78: 1350–1355

    PubMed  Google Scholar 

  • De Wit R, Roberts JT, Wilkinson Petal. (2000) Final analysis demonstrating the equivalence of 3 BEP vs. 4 Cycles and the 5 day schedule vs. 3 days per cycle in good prognosis germ cell cancer. An EORTC/MRC Phase III study. Proc Am Soc Clin Oncol: 1281

    Google Scholar 

  • Dieckmann KP, Klaen R, Buente S (1993a) HLA-antigenes, levis antigens and blood groups in patients with testicular germ cell tumors. Oncology 50: 252–258

    PubMed  CAS  Google Scholar 

  • Dieckmann K. P, Besserer A., Loy V. (1993b) Low-dose radiation therapy for testicular intreaepithelial neoplasia. J Cancer Res Clin Oncol 119: 355–359

    PubMed  CAS  Google Scholar 

  • Dieckmann KP, Loy V (1994) Management of testicular intraepithelial neoplasia. World J Urol 12: 131–135

    PubMed  CAS  Google Scholar 

  • Dieckmann KP, Loy V (1996) Prevalence of contralateral testicular intreaepithelial neoplasia in patients with testicular germ cell neoplasms. J Clin Oncol 14: 3126–3132

    PubMed  CAS  Google Scholar 

  • Dieckmann KP, Loy V (1998) The value of the biopsy of the contralateral testis in patients with testicular germ cell cancer: the recent German experience. APMIS 106: 13–20

    PubMed  CAS  Google Scholar 

  • Dieckmann KP, Claßen J, Souchon R (2001) Therapie der testikulären intraepithelialen Neoplasie (TIN)–eine Übersicht auf der Grundlage der evidenzbasierten Medizin (EBM). Wien Klin Wochenschr 113: 7–14

    PubMed  CAS  Google Scholar 

  • Donohue JP, Thornhill JA, Foster RS et al. (1994) Nonseminomatous germ-cell testicular cancer–management options and risk-benefit considerations. World J Urol 12: 170–177

    PubMed  CAS  Google Scholar 

  • DonohueJP, Thornhill JA, Foster RS et al. (1995) Clinical stage B nonseminomatous germ cell testis cancer: The Indiana University experience (1965–1989) using routine primary retroperitoneal lymph node dissection. Eur J Cancer 31A /10: 1599–1604

    Google Scholar 

  • Droz JP, Kramar A, Nichols CR, Schmoll Hi, Auperin A, Harstrick A, Einhorn LH (1993) Second line chemotherapy with ifosfamide, cisplatin and either etoposide or vinblastine in recurrent germ cell cancer: assignment of prognostic groups. Proc Am Soc Clin Oncol 12: 229

    Google Scholar 

  • Ducatman AM (1989) Dimethylformamide, metal dyes and testicular cancer. Lancet 1: 911

    PubMed  CAS  Google Scholar 

  • Duchesne GM, Stenning SP, Aass N et al. (1997) Radiotherapy after chemotherapy for metastatic seminoma–a diminishing role. MRC Testicular Tumour Working Party. Eur J Cancer 33: 829–835

    PubMed  CAS  Google Scholar 

  • Dunn TA, Schmoll RI, Grünewald V et al. (1997a) Comparative cytotoxicity of oxaliplatin and cisplatin in non-seminomatous germ cell cancer cell lines. Invest New Drugs 15: 109–114

    PubMed  CAS  Google Scholar 

  • Dunn TA, Schmoll HJ, Grünewald V et al. (1997b) Pre-clinical activity of taxol in nonseminomatous germ cell tumor cell lines and nude mouse xenografts. Invest New Drugs 15: 91–98

    PubMed  CAS  Google Scholar 

  • Dunn T, Schmoll Hi, Rie C, Hartmann K, Casper J (1998) Production and pre-clinical significance of hematopoietic peptide growth factor (HPGF) in human non-seminomatous germ cell tumor (NSGCT) cell Iines. J Cancer Res Clin Oncol 124: 435–43

    PubMed  CAS  Google Scholar 

  • Einhorn LH, Williams SD, Loehrer PJ et al. (1989) Evaluation of optimal duration of chemotherapy in favorable prognosis disseminated germ cell tumors: a Southeastern Cancer Study Group protocol. Clin Oncol 7: 387–391

    CAS  Google Scholar 

  • Fizazi K, Culine S, Droz JP, Kramar A, Theodore C, Ruffle P, Le Chevalier T (1998) Primary mediastinal nonseminomatous germ cell tumors: Results of modern therapy including cisplatin-based chemotherapy. J Clin Oncol 16: 725–732

    PubMed  CAS  Google Scholar 

  • Forman D, Chilvers CA (1989) A survey of sexual characteristics of yound and middle aged males in England and Wales. Br Med J 298: 1137

    CAS  Google Scholar 

  • Forman D, Oliver RTD, Brett AR et al. (1992) Familial testicular cancer: a report of the UK-family register, estimation of risk and an HLA class 1 sib-pair analysis. Br J Cancer 65: 255–262

    PubMed  CAS  Google Scholar 

  • Forman D, Chilvers C, Oliver R, Pike M (1994) The aetiology of testicular cancer: Association with congenital abnormalities, age at puberty, infertility and exercise. Br Med J 308: 1393–1399

    Google Scholar 

  • Fossa SD, Ous Set al. (1985) Post-treatment fertility in patients with testicular advanced seminoma. Clin Oncol 3: 1325–1332

    Google Scholar 

  • Fossa SD, Aass N, Ous Set al. (1989) Histology of tumor residuals following chemotherapy in patients with advanced nonseminomatous testicular cancer. Urol 142: 1239–1242

    CAS  Google Scholar 

  • Fossa SD, Oliver RT, Stenning SP et al. (1997) Prognostic factors for patients with advanced seminoma treated with platinum-based chemotherapy. Eur J Cancer 33: 1380–1387

    PubMed  CAS  Google Scholar 

  • Fossa S, Kaye S, Mead G, Cullen M, de Wit R, Bodrogi I et al. (1998) Filgrastim during combination chemotherapy of patients with poor-prognosis metastatic germ cell malignancy. Clin Oncol 16: 716–724

    CAS  Google Scholar 

  • Fossa SD, Bokemeyer C, Gerl A et al. (1999) Treatment outcome of patients with brain metastases from malignant germ cell tumors. Cancer 85: 988–97

    PubMed  CAS  Google Scholar 

  • Frohlich MW, Small EJ (1998) Stage nonseminomatous testis cancer: The roles of primary and adjuvant chemotherapy. Urol Clin North Am 25: 451–459

    PubMed  CAS  Google Scholar 

  • Fukuda S, Shirahama T, Imazono Y, Tsushima T, Ohmori H, Kayajima T et al. (1999) Expression of vascular endothelial growth factor 1 in patients with testicular germ cell tumors as an indicator of metastatic disease. Cancer 85: 1323–1330

    PubMed  CAS  Google Scholar 

  • Garland FC, Gorham ED, Garland CF (1988)Testicular cancer in US Navy personnel. AmJ Epidemiol 127: 411

    Google Scholar 

  • Gen A, Clemm C, Schmeller N, Hartenstein R, Lamerz R, Wilmanns W (1995) Prognosis after salvage treatment for unselected male patients with germ cell tumours. Br J Cancer 72: 1026–1032

    Google Scholar 

  • Germa-Lluch JR, Garcia del Muro X, Tabernero JM, Sanchez M, Aparicio J, Alba E, Barnadas A (1999) BOMP/EPI intensive alternating chemotherapy for IGCCC poor-prognosis germ-cell tumors: The Spanish Germ-Cell Cancer Group experience (GG). Ann Oncol 10: 289–293

    PubMed  CAS  Google Scholar 

  • Geurts van Kessel A, Suijkerbuijk RF, Sinke RJ, Looijenga L, Oosterhuis JW, de Jong B (1993) Molecular cytogenetics of human germ cell tumors: i(12p) and related chromosomal anomalies. Eur Urol 23: 23

    PubMed  CAS  Google Scholar 

  • Giwercman A, Maase H von der, Skakkebaek NE (1993a) Epidemiological and clinical aspects of carcinoma in situ of the testis. Eur Urol 23: 104–110

    PubMed  CAS  Google Scholar 

  • Giwercman A, Carlson E, Keiding N, Skakkebaek NE (1993b) Evidence for increasing incidence of abnormalities of the human testis review. Ann Viron Health Perspect 101: 65–71

    Google Scholar 

  • Giwercman A, von der Maase H, Rorth M et al. (1994) Current concepts of radiation treatment of carcinoma in situ of the testis. World J Urol 12: 125–130

    PubMed  CAS  Google Scholar 

  • Giwercman ER, Rajpert-De Meyts E, Skakkebaek NE (1996) Carcinoma in situ of the testis: A new biological concept of urological relevance and implications for detection and management. In: Vogelzang N et al. (eds) ( 1991 ) Urological oncology. Liz Weyley, pp 941–952

    Google Scholar 

  • Goedert JJ, Cote TR, Virgo P et al. (1998) Spectrum of AIDS-associated malignant disorders. Lancet 351: 1833–1839

    PubMed  CAS  Google Scholar 

  • Gospodarowicz MK, Sturgeon JFG, Jewett MAS (1998) Early stage and advanced seminoma: role of radiation therapy, surgery, and chemotherapy. Semin Oncol 25: 160–173

    Google Scholar 

  • Grocork LA, Charlton HM, Pike MC (1988) Role of foetal pituitary in cryptorchidism induced by exongenous oestrogen during pregnancy in mice. J Reprod Fertil 83: 295–300

    Google Scholar 

  • Grundmann E, Hermanek P, Wagner G (1997) Tumorhistologieschlüssel, 2. Aufl. ADT: Tumordokumentation in Klinik and Praxis, Bd 4. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Guberman E, Usel M, Raymond L (1989) Disability, mortality and incidence of cancer among Geneva painters and electricians; a historical perspective study. Br J Ind Med 46: 16

    Google Scholar 

  • Harding M, Paul J, Kaye SB (1995) Does delayed diagnosis or scrotal incision affect outcome for men with nonseminomatous germ cell tumors? BritJ Urol 76: 491–494

    CAS  Google Scholar 

  • Harland S, Cook P, Fossa S, Norwich A, Mead G, Parkinson M et al. (1998) Intratubular germ cell neoplasia of the contralateral testis in testicular cancer: defining a high risk group. J Urol 160: 1353–1357

    PubMed  CAS  Google Scholar 

  • Harstrick A, Schmoll Hi, Wilke H et al. (1991) Cisplatin, etoposide and ifosfamide salvage therapy for refractory or relapsing germ cell carcinoma. ] Clin Oncol 9: 1549–1555

    CAS  Google Scholar 

  • Hartmann JT, Schmoll HJ, Kuczyk MA et al. (1997) Postchemotherapy resections of residual masses from metastatic non-seminomatous germ cell tumors. Ann Oncol 8: 531–538

    PubMed  CAS  Google Scholar 

  • Heidenreich A, Bonfig R, Derschum W et al. (1995) A conservative approach to bilateral testicular germ cell tumors. J Urol 153: 10–13

    PubMed  CAS  Google Scholar 

  • Heidenreich A, Vorreuther R, Braun M et al. (1995) 1st eine schnellschnittgesteuerte Therapieplanung bei testikulären Raumforderungen sinnvoll? Urologe A 34: 113

    Google Scholar 

  • Heidenreich A, Höltl W, Albracht W et al. (1997)Testis-preserving surgery in bilateral testicular germ cell tumors. Brit J Urol 79: 253–257

    Google Scholar 

  • Heidenreich A, Sesterhenn I, Mostofi A, Moul J (1998) Prognostic factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis. Cancer 83: 1002–1011

    PubMed  CAS  Google Scholar 

  • Hentrich MU, Brack NG, Schmid P, Schuster T, Clemm C, Hartenstein RC (1996) Testicular germ cell tumors in patients with human immunodeficiency virus infection. Cancer, 77: 2109–2116

    PubMed  CAS  Google Scholar 

  • Hoff-Wanderas E, Fossa SD, Heilo A, Stenwig AE, Norman N (1990) Serum follicle stimulating hormone–predictor of cancer in the remaining testis in patients with unilateral testicular cancer. Br J Cancer 66: 315–317

    Google Scholar 

  • Horwich A (1991) Testicular germ cell tumors: an introductory overview. In: Norwich A (Hrsg) Testicular cancer: investigation and management. Chapman & Hall Medical, London, pp: 1–14

    Google Scholar 

  • Horwich A, Dearnaley DP (1992) Treatment of seminoma. Semin Oncol 19: 171–180

    PubMed  CAS  Google Scholar 

  • Norwich A, Dearnaley DP, Duchesne GM et al. (1993a) Simple nontoxic treatment of advanced metastatic seminoma with Carboplatin. J Clin Oncol 7: 1150–1156

    Google Scholar 

  • Norwich A, A’Hearn R, Gilderslve J, Dearnaley D (1993b) Prognostic factor analysis of conventional dose salvage therapy of patients with metastatic non seminomatous germ cell cancer. Proc Am Soc Clin Oncol 12: 232

    Google Scholar 

  • Norwich A, Cullen M, Stenning S (1998) Primary chemotherapy after orchidectomy for stage I and Il nonseminoma. Semin Oncol 25: 154–159

    Google Scholar 

  • Houldsworth J, Reuter V, Bosl GJ et al. (1997) Aberrant expression of cyclin D2 is an early event in human male germe cell tumorigenesis. Cell Growth Differentiation 8: 293–299

    PubMed  CAS  Google Scholar 

  • Houldsworth J, Murty VVVS, Bosl GJ, Chaganti RSK (2001) Advances in the understanding of germ cell tumour biology. In: Harnden P, Joffe JK, Jones WG (Hrsg) Germ cell tumours V. pp 23–29

    Google Scholar 

  • International Germ Cell Cancer Collaborative Group (IGCCCG) (1997) The International Germ Cell Consensus Classification: a prognostic factor based staging system for metastatic germ cell cancer. J Clin Oncol 15: 594–603

    Google Scholar 

  • Jaeger N, Weißbach L (1990) Indikation and Ausmaß der Salvage-Lymphadenektomie beim germinalen Hodentumor. Aktuel Urol 21: 57–63

    Google Scholar 

  • Johnstone JA, Ross CAC, Dunn M (1972) Meningitis and encephalitis associated with mumps infection: a 10 year survey. Arch Dis Child 47: 647–651

    PubMed  CAS  Google Scholar 

  • Jones WG, Fossa SD, Mead GM, Roberts JT, Sokal M, Naylor S, Stenning SP (2001) A randomised trial of two radiotherapy schedules in the adjuvant treatment of stage I seminoma (MRCTE18), for ECCO 2001

    Google Scholar 

  • Jorgensen N, MullerJ, Giwercman A, Skakkebaek NE (1990) Clinical and biological significance of carcinoma in situ of the testis. Cancer Suvr 9: 287–302

    CAS  Google Scholar 

  • Kattan J, Culine S, Terrier-Lacombe M-J et al. (1993) Paratesticular rhabdomyosarcoma in adult patients: 16-year experience at Institut Gustave-Roussy. Ann Oncol 4: 871–75

    PubMed  CAS  Google Scholar 

  • Kaye S, Mead G, Fossa S, Cullen M, de Wit R, Bodrogi I et al. (1998) Intensive induction-sequential chemotherapy with BOPNIP-B compared with treatment with BEP/EP for poor-prognosis metastatic nonseminomatous germ cell tumor: a randomized Medical Research Council/European Organization for Research and Treatment of Cancer study. J Clin Oncol 16: 692–701

    PubMed  CAS  Google Scholar 

  • Klepp O, Olsson AM, Ous Set al. (1991) Early clinical stages of nonseminomatous testis cancer. Evaluation of the primary treatment and follow-up procedure of the SWENOTECA project. Scand J Urol Nephrol 25: 179–190

    PubMed  CAS  Google Scholar 

  • Krege S, Weißbach L, Höltl W (1998) Therapie der frühen Stadien des nichtseminomatösen Hodentumors. Onkologe 6: 511–517

    Google Scholar 

  • Kollmannsberger C, Beyer J, Droz JP et al. (1998) Secondary leukemia following high cumulative doses for Etoposide in patients treated for advanced germ cell tumors J Clin Oncol 16: 3386–3391

    CAS  Google Scholar 

  • Kollmannsberger C, Nichols C, Bamberg M et al. (2000) First-line high-dose chemotherapy +/- radiation in patients with metastatic germ-cell cancer and brain metastases. Ann Oncol 11: 553–559

    PubMed  CAS  Google Scholar 

  • Kotzerke et al. (2002) Results of the 3. German Interdisciplinary Consensus Conference: Onko-PET (submitted)

    Google Scholar 

  • Lashley D, Lowe B (1998) A rational approach to managing stage I nonseminomatous germ cell cancer. Urol Clin North Am 25: 405–423

    PubMed  CAS  Google Scholar 

  • Leibovitch I, Baniel J, Foster RS et al. (1995)The clincial implications of procedural deviations during orchiectomy for nonseminomatous testis cancer. J Urol 154: 935–939

    Google Scholar 

  • Leibovitch I, Little JS, Foster RS et al. (1996) Delayed orchiectomy after chemotherapy for metastatic nonseminomatous germ cell tumors. J Urol 155: 952–954

    PubMed  CAS  Google Scholar 

  • Leibovitch I, Foster R, Kopecky K et al. (1998) Identification of clinical stage A nonseminomatous testis cancer patients at extremely low risk for metastatic disease: a combined approach using quantitive immunohistochemical, histopathologic, and radiologic assessment. J Clin Oncol 16: 261–268

    PubMed  CAS  Google Scholar 

  • Loehrer PJ, Gonin R, Nichols CR, Weathers T, Einhorn LH (1998) Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor. Clin Oncol 16: 2500–2504

    CAS  Google Scholar 

  • Looijenga LHJ (1994) Pathobiology of germ cell tumors of the adult testis. Ridderprint BV, Ridderkerk, pp: 1–160

    Google Scholar 

  • Mann K (1990) Tumormarker beim Hodenkarzinom. Urologe A29: 77–86

    PubMed  CAS  Google Scholar 

  • MasurY, Steffens J, Ziegler M, Remberger K (1996) Leydig cell tumors of the testis–clinic and morphologic aspects. Urologe A 35: 468–471

    Google Scholar 

  • McCaffrey J, Mazumdar M, Bajorin DF, Bosl GJ, Vlamis V, Motzer RJ (1997) Ifosfamide- and cisplatin-containing chemotherapy as first-line salvage therapy in germ cell tumors: Response and Survival. Clin Oncol 15: 2559–2563

    CAS  Google Scholar 

  • Mead GM (1995) International consensus prognostic classification for metastatic germ cell tumors treated with platinum-based chemotherapy: final report of the International Germ Cell Cancer Colaborative Group (IGCCCG). Proc Am Soc Clin Oncol 15: Abstr 615

    Google Scholar 

  • Mead GM, Stenning SP, Parkinson A et al. (1992) The second Medical Research Council study of prognostic factors in nonseminomatous germ cell tumors. Clin Oncol 10: 85–94

    CAS  Google Scholar 

  • Mead GM (1995) International consensus prognostic classification for metastatic germ cell tumours treated with platinum based chemotherapy: Final report of the International Germ Cell Cancer Collaborative Group (IGCCCG). Proc Am Soc Clin Oncol 14: 235, abstract 615

    Google Scholar 

  • Mill P, Newell G, Hohnson DE (1984) Testicular cancer associated with employment in agriculture and oil and natural gas extraction. Lancet 1: 207

    Google Scholar 

  • Moller H (1993) Clinics to the aetiology of testicular germ cell tumors from descriptive epidemiology. Eur Urol 23: 8–15

    PubMed  CAS  Google Scholar 

  • Mostofi FK, Sobin LH (1977) Histological typing of testis tumours. In: International histological classification of tumours, No 16. World Health Organization, Geneve

    Google Scholar 

  • Mostofi FK, Sesterhenn IA (1993) Revised international histological classification of testicular tumours. Adv Biosci 91: 153–158

    Google Scholar 

  • Motzer RJ, BosI GJ, Heelan Retal. (1987) Residual mass: an indication for further therapy in patients with advanced seminoma following systemic chemotherapy. Clin Oncol 5: 1064–1070

    CAS  Google Scholar 

  • Motzer RJ, Sheinfeld J, Mazumdar M, Bains M, Mariani T, Bacik J, Bajorin D and Bosl GJ (2000) Paclitaxel, Ifosfamide and Cisplatin Second-line therapy for patient with relapsed Testicular Germ Cell Cancer. J Clin Oncol Vol 18, 12: 2413–2418

    Google Scholar 

  • Muller J, Skakkebaek NE, Nielson OH (1984) Cryptorchidism and testis cancer. Cancer 54: 629–634

    PubMed  CAS  Google Scholar 

  • Murty VVVS, Renault B, Falk CT, Bosl GJ, Jucherlapati R, Chaganti RSK (1996) Physical mapping of a commonly deleted region, the site of a candidate tumor suppressor gene, at 12p22 in human male germ cell tumors. Genomics 35: 562–570

    PubMed  CAS  Google Scholar 

  • Murty VVVS, Chaganti RSK (1998) A genetic perspective of male germ cell tumors. Semin Oncol 25: 133–144

    PubMed  CAS  Google Scholar 

  • Murty VVVS, Montgmoery K, Dutta S et al. (1999) A 3-Mb high-resolution BAC, PAC contig of 12g22 encompassing the 830 kb consensus minimal deletion in male germ cell tumors. Genome Res 9: 662–671

    PubMed  CAS  Google Scholar 

  • Nichols CR, Catalano PJ, Crawford ED, Vogelzang NJ, Einhorn LH, Loehrer PJ (1998) Randomized comparison of cisplatin and etopsoide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study. Clin Oncol 16: 1287–1293

    CAS  Google Scholar 

  • Nicholson PW, Harland SJ (1995) Inheritance and testicular cancer. BrJ Cancer 71: 421–426

    CAS  Google Scholar 

  • Nieschlag E, Behre HM (1997) Therapie mit Testosteron. In: Nieschlag E, Behre HM (Hrsg) Andrologie -Grundlagen and Klinik der reproduktiven Gesundheit des Mannes. Springer, Berlin Heidelberg New York, S 316–329

    Google Scholar 

  • Nieschlag E, Behre HM (1999) Pharmacology and clinical use of testosterone. In: Nieschlag E, Behre HM (eds) Testosterone–action, deficiency, substitution. Springer, Berlin Heidelberg New York, pp 92–114

    Google Scholar 

  • Oliver RTD (1987) HLA phenotype and clinical pathological behavior of germ cell tumors possible evidence for clonal evolution from semino-mas to nonseminomas. Int J Androl 10: 85–99

    PubMed  CAS  Google Scholar 

  • Oliver RTD (1990) Atrophy, hormones, genes and viruses in aetiology of germ cell tumours. Cancer Sury 9: 263–268

    CAS  Google Scholar 

  • Oliver RTD (1996) Seventeen years experience of phase I/II studies of single agent platinum compounds as alternatives to radiation for metastatic and stage I seminoma. Proc Am Soc Clin Oncol 15: 244

    Google Scholar 

  • Oliver RTD (1996) Epidemiology of testis cancer In: Vogelzang NJ, Scardino PT, Shipley WU, Coffey DS (eds) Comprehensive textbook of genitourinary oncology. Williams & Wilkins, Baltimore, pp 923–931

    Google Scholar 

  • Ooosterhuis JW, Looijenga LH (1993) The biology of human germ cell tumors: retrospective speculations and new perspectives. Eur Urol 23: 245

    Google Scholar 

  • Oosterhuis W et al. (1997) Testicular germ cell tumors. In: Raghavan D, Scher HI, Leibel SA, Lange P (eds) Principles and practice of genitourinary oncology. Lippincott-Raven, Philadelphia New York, pp 631–42

    Google Scholar 

  • Oosterhuis W, van Gurp RJHLM, Rosenberg C (2001) Overexpression of the short arm of chromosome 12 is related to invasive growth of testicular seminomas and non-seminomas. In: Harnden P, Joffe JK, Jones WG (eds) Germ cell tumors, V. Springer, London Berlin Heidelberg, pp 34–37

    Google Scholar 

  • Ornstein DK, Dierks SM, Colberg JW (1996) Metachronous presentation of bilateral Leydig cell tumors. Urol 155: 1703

    CAS  Google Scholar 

  • Orozco RE, Murphy WM (1993) Carcinoma of the rete testis: Case report and review of the literature. Urol 150: 974–77

    CAS  Google Scholar 

  • Petersen PM, Giwercman A, Skakkebaek NE, Rorth M (1998) Gonadal function in men with testicular cancer. Semin Oncol 25: 224–233

    PubMed  CAS  Google Scholar 

  • Philp T (1984) Complications of vasectomy, review of 16. 000 patients. Br J Urol 56: 745–748

    PubMed  CAS  Google Scholar 

  • Pont J (1990) Risk-adapted treatment choice in stage I nonseminomatous testicular germ cell cancer by regarding vascular invasion in the primary tumor: a prospective trial. Clin Oncol 8: 16–20

    CAS  Google Scholar 

  • Raja M, Oliver RTD, Badenoch D, Blandy JP (1992) Orchidopexy and transformation of seminoma to nonseminoma. Lancet 339: 930

    PubMed  CAS  Google Scholar 

  • Rapley EA, Crockford GP, Teare D et al. (2000) Localization to Xp27 of a susceptibility gene for testicular germ cell tumours. Nat Genet 24: 197–200

    PubMed  CAS  Google Scholar 

  • Rhomberg W, Schmoll H-J (1978) High incidence of metalworks among patients with testicular cancer detection and prevention of cancer. 2: 1737–1743

    Google Scholar 

  • Rhomberg W, Schmoll HJ, Schneider B (1995) High frequency of metalworkers among patients with seminomatous tumors of the testis: a case-control study. Am J Ind Med 28: 79–87

    PubMed  CAS  Google Scholar 

  • Robertson GS (1995) Radical orchiectomy and benign testicular condition. BrJSurg 82: 342–345

    CAS  Google Scholar 

  • Rosti V et al. (2002) High-dose chemotherapy (HDC) in the salvage treatment of patients failing first-line platinum chemotherapy for advanced germ cell tumors (GCT); first results of a prospective randomised trial of the European Group for Blood and Marrow Transplantation (EBMT): IT-94 study. Proc Am Soc Clin Oncol 716:

    Google Scholar 

  • Sandberg AA, Meloni AM, Suijkerbuijk RF (1996) Reviews of chromosome studies in urological tumors. Ill. Cytogenetics and genes in testicular tumors. Urol 155: 1531–1565

    CAS  Google Scholar 

  • Saxman SB, Finch D, Gonin R, Einhorn LH (1998) Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indiana University Experience. Clin Oncol 16: 702–706

    CAS  Google Scholar 

  • Schmidberger H, Bamberg M (1995) Therapieoptionen bei testikulären Seminomen in den frühen Stadien. Strahlenther Onkol 171: 125–139

    Google Scholar 

  • Schmoll HJ, Harstrick A, Bokemeyer C et al. (1993) Single-agent carboplatinum for advanced seminoma: A phase II study. Cancer 72: 237–243

    PubMed  CAS  Google Scholar 

  • Schmoll HJ, Harstrick A, Bokemeyer C et al. (1993) Single-agent carboplatinum for advanced seminoma: A phase II study. Cancer 72: 237–243

    PubMed  CAS  Google Scholar 

  • Schmoll HJ (1997) Prognostic factors for advanced seminoma–a solid basis for clinical trials. Eur J Cancer 33: 1347–1350

    PubMed  CAS  Google Scholar 

  • Schmoll HJ, Weißbach L, Bamberg M (1997) Interdisziplinäre Konsensus-Konferenz zur Diagnostik und Therapie von Hodentumoren. Onkologie 20: 164–170

    Google Scholar 

  • Schmoll HJ (1998) The optimal second line treatment of testicular cancer. ESMO Educ Book: 213–221

    Google Scholar 

  • Schmoll HJ, Beyer J (1998a) Prognostic factors in metastatic germ cell tumors. 5emin Oncol 25: 174–186

    CAS  Google Scholar 

  • Schmoll HJ, Beyer J (1998b) Prognosefaktoren bei metastasierten seminomatösen und nichtseminomatösen Hodentumoren. Onkologe 6: 518–523

    Google Scholar 

  • Schmoll HJ (1999a) Maligne Keimzelltumoren des Mannes In: Schmoll Hi, Höffken K, Possinger K (Hrsg. Kompendium Internistische Onkologie II, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 1659–1732

    Google Scholar 

  • Schmoll Hi (1999b) Treatment of testicular tumours based on risk factors. C u rr O p i n Urol 9: 431–438

    Google Scholar 

  • Schmoll HJ, Krege S, Souchon R (2000) Interdisziplinärer Konsensus zur Diagnostik und Therapie von Hodentumoren: Ergebnisse einer Update-Konferenz auf Grundlage evidenzbasierter Medizin. Onkologie 23: 603–613

    PubMed  Google Scholar 

  • Schöffski P, Bokemeyer C, Harstrick A, Schmoll HJ (1991) Aetiologie und Epidemiologie von Keimzelltumoren. Onkologie 14 [Suppl 4]: 1

    Google Scholar 

  • Schultz SM, Einhorn LH, Conces DJ et al. (1989) Management of post-chemotherapy residual mass in patients with advanced seminoma. lndiana University experience. Clin Oncol 7: 1497

    CAS  Google Scholar 

  • Schwartz GG (2002) Hypothesis: does ochratoxin A cause testicular cancer? Cancer Causes Control 13: 91–100

    PubMed  Google Scholar 

  • Sesterhenn IA, Weiss RB, Mostofi FK (1992) Prognosis and other clinical correlates of pathologic review in stage I and II testicular carcinoma: A report from the testicular cancer intergroup study. J Clin Oncol 10: 69–78

    PubMed  CAS  Google Scholar 

  • Sewell CM, Castle SP, Hull HF (1986) Testicular cancer and employment in agriculture and oil and natural gas extraction. Lancet 1: 553

    PubMed  CAS  Google Scholar 

  • Sicinski P, Dohaher JL, Geng Yet al. (1996) Ciyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384: 470–474

    PubMed  CAS  Google Scholar 

  • Siegert W, Beyer J, Strohscheer I et al. (1994) High dose treatment with carboplatin, etoposide and ifosfamide followed by autologous stem cell transplantation in relapsed or refractory germ cell cancers. A phase I/II study. Clin Oncol 12: 1223–1231

    CAS  Google Scholar 

  • Siegert W, Beyer J (1998) Germ cell tumors: Dose-intensive therapy. Semin Oncol 25: 215–223

    PubMed  CAS  Google Scholar 

  • Simmonds PD, Mead GM, Lee AHS et al. (1995) Orchiectomy after chemotherapy in patients with metastatic testicular cancer. Cancer 74: 1018–1024

    Google Scholar 

  • Skakkebaek NE (1978) Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. Histopathology 2: 157

    PubMed  CAS  Google Scholar 

  • Skakkebaek NE, Berthelsen JG, Müller J (1982) Carcinoma in situ of the un-descended testis. Urol Clin North Am 9: 377–385

    PubMed  CAS  Google Scholar 

  • Souchon R, Schmidberger H (1998) Diagnostische Maßnahmen zur Definition des klinischen Stadiums. Onkologe 6: 494–500

    Google Scholar 

  • Sternberg CN (1998) The management of stage I testis cancer. Urol Clin North Am 25: 435–449

    PubMed  CAS  Google Scholar 

  • Steyerberg EW, Keizer Hi, Fossa SD et al. (1995) Prediction of residual retroperitoneal mass histology after chemotherapy for metastatic non-seminomatous germ-cell tumor. J Clin Oncol 13: 1177–1187

    PubMed  CAS  Google Scholar 

  • Strader CH, Weiss NS, Daling JR (1988) Vasectomy and the incidence of testicular cancer. Am J Epidemiol 128: 56

    PubMed  CAS  Google Scholar 

  • StrohmeyerT, Peter S, Hartmann M et al. (1991) Expression of the hast-1 and c-kit protooncogenes in human testicular germ cell tumors. Cancer Res 51: 1811–1816

    Google Scholar 

  • Swerdlow AJ, Huttly SRA, Smith PG (1988) Is the incidence of testis cancer related to trauma or temperature? Br J Ural 61: 518–521

    CAS  Google Scholar 

  • Swerdlow AJ (1993) The epidemiology of testicular cancer. Eur Urol 23: 35–38

    PubMed  Google Scholar 

  • Swerdlow AJ (1997) Principles and practice of genitourinary oncology. Epidemiology of Testicular Cancer: 643–652

    Google Scholar 

  • Tarone RE, Hayes HM, Hoover RN, Rosenthal JF (1990) Service in Vietnam and risk of testicular cancer. ] Natl Cancer Inst 83: 1497–1499

    Google Scholar 

  • Tessler A, Catanese A (1987) Aids and germ cell tumours of testis. Urology 30: 203

    PubMed  CAS  Google Scholar 

  • Teuvo L, Tammela J et. al. (1991) Intrascrotal Adenomatoid Tumors. J Urol 146: 61–65

    Google Scholar 

  • Thonneau P, Abell A, Larsen SB et al. (1999) Effects of pesticide exposure on time to pregnancy: results of a multicenter study in France and Denmark. ASCLEPIOS Study Group. Am J Epidemiol 150: 157–163

    PubMed  CAS  Google Scholar 

  • Thornill JA, Conroy RM, Kelly DG (1988) An evaluation of predisposing factors for testis cancer in Ireland. Eur Ural 14: 429

    Google Scholar 

  • Tokuc R, Sakr W, Pontes J E et al. (1992) Accuracy of frozen section examination of testicular tumors. Urology 40: 521–526

    Google Scholar 

  • Tollerud DJ, Blattner WA, Fraser MC et al. (1985) Familial testicular cancer and urogenital developmental anomalies. Cancer 55: 1849–1854

    PubMed  CAS  Google Scholar 

  • Toner C, Motzer RJ (1998) Poor prognosis germ cell tumors: Current status and future directions. Semin Oncol 25: 194–202

    PubMed  CAS  Google Scholar 

  • Travis LB, Curtis RE, Storm H et al. (1997) Risk of second malignant neoplasms among long-term survivors of testicular cancer. Natl Cancer Inst 89: 1429–1439

    CAS  Google Scholar 

  • Travis L, Andersson M, Holowarty E et al. (1999) Risk of leukemia following radiotherapy and chemotherapy for testicular cancer. Proc Am Soc Clin Onc 18: 308a (Abstract 1185)

    Google Scholar 

  • Turek PJ, Lowther DN, Carroll PR (1998) Fertility issues and their management in men with testis cancer. Urol Clin North Am 25: 517–531

    PubMed  CAS  Google Scholar 

  • Vogelzang NJ, Scardino PT, Shipley WU, Coffey DS (1996) Comprehensive textbook of genitourinary oncology. Williams & Wilkins, Baltimore

    Google Scholar 

  • Von der Maase H, Rorth M, Walbom-Jorgensen S, Sorensen B, Christophersen I, Hald T et al. (1986) Carcinoma in situ of the contralateral testis in patients with testicular germ cell cancer. A study of 27 cases in 500 patients. Br Med J (Clin Res Ed) 293: 1398–1401

    Google Scholar 

  • Warde P, Gospodarowicz MK, Panzarella T et al. (1995) Stage I testicular seminoma: Results of adjuvant irradiation and surveillance. J Clin Oncol 13: 2255–2262

    PubMed  CAS  Google Scholar 

  • Warde P, von der Masse H, Norwich A, Gospodarowicz M, Panzarella T, Specht L (1998) Prognostic factors for relapse in stage I seminoma managed by surveillance. Proc Am Soc Clin Oncol 17: 309a

    Google Scholar 

  • Warde P, Jewett M (1998) Surveillance for stage I testicular seminoma. Is it a good option? Urol Clin North Am 25: 425–433

    PubMed  CAS  Google Scholar 

  • Weißbach L (1995) Organ preserving surgery of malignant germ cell tumors. Urol 153: 90–93

    Google Scholar 

  • Weißbach L, Bussar-Maatz R (1995) Können Risikofaktoren die Strategien im Stadium I des Nichtseminoms bestimmen? Aktuel Urol 26: 79–88

    Google Scholar 

  • Williams SD, Birch R, Einhorn LH et al (1987a) Treatment of disseminated germ cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316: 1435–1440

    PubMed  CAS  Google Scholar 

  • Williams SD, Stablein DM, Einhorn LH et al. (1987b) Immediate adjuvant chemotherapy versus observation with treatment at relapse in pathological stage Il testicular cancer. N Engl J Med 317: 1433–1488

    PubMed  CAS  Google Scholar 

  • Willich N (1991) Radiotherapie des Seminoms. In: Clemm (Hrsg) Urogenitaltumoren: Ergebnisse der Diagnostik, Therapie und Nachsorge, Teil 2. Zuckschwerdt, München, S 44–55

    Google Scholar 

  • Winfield HN (1998) Laparoscopic retroperitoneal lymphadenectomy for cancer of the testis. Urol Clin North Am 25: 469–478

    PubMed  CAS  Google Scholar 

  • Wittekind C, Loy V (1998) Pathologie und pathomorphologische Diagnostik von Hodentumoren. Onkologe 6: 476–486

    Google Scholar 

  • World Health Organisation/WHO (1998) International histological classification of tumours. In: Mostofi FK, Sesterhenn IA (eds) Histological typing of testis tumours, 2nd edn. Springer, Berlin Heidelberg New York Tokyo, pp 1433–1488

    Google Scholar 

  • Zon RT, Nichols C, Einhorn LH (1998) Management strategies and outcomes of germ cell tumor patients with very high human chorionic gonadotropin levels. J Clin Oncol 16: 1294–1297

    PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schmoll, H.J. (2004). Maligne Hodentumoren. In: Die Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06670-6_53

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06670-6_53

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06671-3

  • Online ISBN: 978-3-662-06670-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics