Zusammenfassung
Wie bei keiner anderen Krankheit wird bei Tumorpatienten der Schmerz zum Signal des unaufhaltsamen Fortschreitens der lebensbedrohenden Erkrankung und zählt zu den häufigsten und am meisten gefürchteten Symptomen (Bonica 1985; Coyle et al. 1990). Zahlreiche Übersichtsarbeiten haben gezeigt, dass 30–50% der Patienten bei Diagnosestellung und 60–90% der Patienten mit fortgeschrittener Tumorerkrankung an Dauerschmerzen leiden (Daut et al.1982; Foley 1979; Levin et al.1985;Twycross et al.1982; World Health Organization 1996).
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Literatur
Ahmedzai S, Brooks D (1997) Transdermal Fentanyl versus sustained-release oral morphine in cancer pain: Preference, efficacy, and quality of Iife. J Pain Sympt Manage 5: 254–261
American College of Physicians Health and Public Committee (1983) Drug therapy for severe chronic pain in terminal illness.Ann Intern Med 99: 870
Angarola RT,Wray SD (1989) Legal impediments to cancer pain treatment. In: Hill CS, Fields WS (eds) Advances in pain research and therapy, vol 11. Raven Press, New York, p 213
Bach V, Kamp-Jensen M, Jensen N-H, Eriksen J (1991) Buprenorphine and sustained release morphine–effect and side-effects in chronic use. Pain Clinic 4: 87–93
Bailey PL, Stanley TH (1994) Intravenous opioid Anesthetics. In: Miller RD (ed) Anesthesia, 4th edn. Churchill Livingstone, New York, pp 291–387
Bajwa ZH.Borsook D (1996) The pain management imperative. In: Borsook D, LeBel AA, McPeek B (eds) The Massachusetts General Hospital handbook of pain management. Little, Brown and Company, Boston New York Toronto London Little, pp 3–7
Beaver WT (1988) Impact of non-narcotic analgesics on pain management. Am J Med 84: 3–15
Berina LF, Guernsey BG, Hokanson JA, Doutre WH, Fuller LE (1985) Physician perception of a triplicate prescription law. Am J Hosp Pharm 42: 857
Berkowitz BA, Ngai SH,Yang JC (1975) The disposition of morphine in surgical patients. Clin Pharmacol Ther 17: 629–635
Bonica JJ (1977) Neurophysiologic and pathologic aspects of acute and chronic pain. Arch Surg 112: 750–761
Bonica JJ (1979) Important clinical aspects of acute and chronic pain. In: Mechanisms of pain and analgesic compounds.ln: Beers RF, Bassett EG (eds) Raven Press, New York, pp 15–29
Bonica JJ (1985) Treatment of cancer pain: current status and future need. In:Fields HL, Dubner R,Cervero R (eds) Advances in pain research and therapy, vol 9. Raven Press, New York, pp 617–628
Bonica JJ (1990) Cancer pain.ln:Bonica JJ (ed)The management of pain. Lea Febiger, Philadelphia, p 400
Breitbart W, Holland JC (1988) Psychiatric complications of cancer. Curr Ther Hematol Oncol 3: 268
Bruera E, Roca E,Cedaro L,Carrao S,Chacon R (1985) Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double blind study. Cancer Treat Rep 69: 751–754
Bruera E, Fainsinger R, Spachynski K (1995) Clinical efficacy and safety of a novel controlled release morphine suppository and subcutaneous morphine in cancer pain: a randomized evaluation. J Clin Oncol 13: 1520–1527
Brune K, Beck WS (1993) Nichtopioidanalgetika. In: Zenz M, Jurna I (Hrsg) Lehrbuch der Schmerztherapie. Wissenschaftliche Verlagsgesellschaft,Stuttgart,S 121–136
Campora E, Merlini L, Pace M, Bruzzone M, Luzzani M, Gottlieb A, Rosso R (1991) The incidence of narcotic induced emesis. J Pain Symptom Manage 6: 428–430
Cherny NI, Portenoy RK, Raber M, Zenz M (1994) Medikamentöse Therapie von Tumorschmerzen. Eigenschaften von Nichtopioiden und Opioiden. Schmerz 8: 195–209
Cherny NI, Portenoy RK, Raber M, Zenz M (1995) Medikamentöse Therapie von Tumorschmerzen.Teil Ill: Adjuvantien. Schmerz 9: 55–69
Cleeland CS, Gonin R, Hatfield AK, Edmonson JH, Blum RH, Stewart JA, Pandya IO (1994) Pain and its treatment in outpatients with metastatic cancer. N Engl J Med 330: 592–596
Cleeland CS, Cleeland LM, Dar R, Rinehardt LC (1986) Factors influencing physican management of cancer pain. Cancer 58: 796–800
Cooper K, Bennet W (1987) Nephrotoxicity of common drugs used in clinical practice. Arch Intern Med 147: 1213–1218
Coyle N,AdelhardtJ,Foley KM, Portenoy RK (1990) Character of terminal illness in the advanced cancer patient:pain and other symptoms during the last four weeks of life.J Pain Symptom Manage 5: 83–93
Dar R, Beach C, Barden P, Cleeland CS (1992) Cancer pain in the marital system: a study of patients and spouses. J Pain Symptom Manage 7: 87–93
Daut RL, Cleeland CS (1982) The prevalence and severity of pain in cancer. Cancer 50: 1913–1918
DeConno, Ripamonti C, Saita L (1995) The role of the rectal route in treating cancer pain: a randomized crossover clinical trial of oral vs. rectal morphine administration of opioid-naive cancer patients with pain.J Clin Oncol 13: 1004–1008
Devor M, Govrin-lippman R, Raber P (1985) Corticosteroids reduce neuro-ma hyperexcitability. In: Fields HL, Dubner R, Crevero F (eds) Proceedings of the Fourth World Congress on Pain. Advances in pain research and therapy, vol 9. Raven Press, New York, p 451
Dittrich C (1996) Strategie der Schmerztherapie/Schmerzkontrolle bei Patienten mit Malignomen. Hausarzt 6: 6–13
Doyle D (1991) Morphin: myths, morality and economics. Postgrad Med J 67 [Suppl 21: 70
Elliot F, Little A,Milbrandt W (1976) Carbamazepine for phantom limb phenomena. N Engl J Med 295: 678
Elliott TE, Murray DM, Oken MM, Johnson KM, Braun BL, Elliott BA, Post-White J (1997) Improving cancer pain mangement in communities: main results from a randomized controlled trial.J Pain Symptom Manage 13: 191–203
Fainsinger R, Schoeller T, Bruera E (1993) Methadone in the management of cancer pain:a review. Pain 52: 137–147
Fazeny B, Huber H (2000) Der Wunsch nach assistiertem Selbstmord bei unheilbaren Krebspatienten–Eine Standortbestimmung der Hauptursachen für die zunehmenden Diskussionen. In: Bonelli J, Prat EH (Hrsg) Leben–Sterben–Euthanasie? Springer, Wien New York, pp 97–102
Fazeny B, Muhm M, Hauser I et al. (2000) Barriers in cancer pain management. Wien Klin Wochenschr 112: 987–981
Fazeny B, Muhm M, Berzlanovich A, Wenzel C, Hagmeister H, Marosi Ch (2000) Schmerztherapie im Lichte rezenter Gesetzesnovellierungen und deren praktische Konsequenzen. Wien Klin Wochenschr 112: 372–375
Foldes FF, Sverdlow M, Siker ES (1964) Narcotics and Narcotic Antagonists. Charles C Thomas, Springfield, IL
Foley KM (1979) Pain syndromes in patients with cancer. In: Bonica JJ, Ventafridda V (eds) Advances in pain research and therapy. Raven Press, New York, pp 59–75
Foley KM (1985) The treatment of cancer pain. N Engl J Med 313: 84–95
Foley KM (1991) Clinical tolerance to opioids. In: Basbaum AI, Bessom JM (eds) Towards a new pharmacotherapy of pain, Dahlem Konferenzen. John Wiley Sons,Chinchester, p 181
Foley KM (1993) Management of cancer pain. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: Principles Practice ofOncology,4th edn. JB Lippincott, Philadelphia, pp 2417–2448
Foley KM (1996) Pain relief into practice:rhetoric without reform.J Clin On-col 13: 2149–2151
Foley KM, Inturrisi CE (1987) Analgesic drug therapy in cancer pain: Principles and practice. Med Clin North Am 72: 207–232
Forth W, Henschler D, Rummel W, Starke K (1992) Pharmakologie und Toxikologie. B. I. Wissenschaftsverlag, Mannheim
Fromm GH (1989)Trigeminal neuralgia and related disorders. In: Portenoy RK (ed) Pain:Mechanisms and syndromes. Neruologic clinics,vol 7. WB Saunders, Philadelphia, p 305
Gonzales GR, Elliott KJ, Portenoy RK, Foley KM (1991) Impact of a comprehensive evaluation in the management of cancer pain. Pain 47: 141–144
Green WR, David WH (1991) Titrated intravenous barbiturates in the control of symptoms in patients with terminal cancer. South Med J 84: 332–337
Grond S, Zech D, Dahlmann H, Schug SA, Stobbe B, Lehmann KA (1990) Uberweisungsgrund:,,therapieresistente“ Tumorschmerzen. Analyse der Schmerzmechanismen und der medikamentösen Vorbehand1 u ng. Schmerz 4: 193–200
Hanks GW,Twycross RG (1984) Pain, the physiological antagonist of opioid analgesics. Lancet 1: 1477–1478
Hanks GW, Justins D (1992) Cancer pain: management. Lancet 339: 1031–1036
Hanks GW,Twycross RG, Lloyd JW (1981) Unexpected complication of successful nerveblock. Anaesthesia 36: 37–39
Hanks GW,Trueman T,Twycross RG (1983) Corticoids in terminal cancer. Postgrad Med J 59: 702
Hayward J (1979) Psychological and social aspects of pain. Nursing 1: 1–7
Hodes R (1989) Cancer patients’ needs and concerns when using narcotic analgesics. In: Hill CS, Fields WS (eds) Advances in pain research and therapy, vol 11. Raven Press, New York, pp 91–94
Houde RW (1982) Methods for measuring clinical pain in humans. Acta Anesthesiol Scand [Suppl] 74: 25–20
Hsieh JC, Carr D (1996) Choosing a therapeutic approach: opioids. In: Borsook D, LeBel AA, McPeek B (eds) The Massachusetts General Hospital handbook of pain management. Little, Brown and Company, Boston New York Toronto London pp 47–75
Insel PA (1990) Analgesic antipyretics and antiinflammatory agents. Drugs employed in the treatment of rheumatic arthritis and gout. In: Gillan AG, RaIITW,Teylor P (eds) The pharmacologic basis oftherapeutics,8th edn. Pergamon Press, New York, p 638
Inturrisi CE (1989) Management of cancer pain. Cancer 63: 2308–2320
Jacox A, Carr DB, Payne R (1994) New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med 330: 651–655
Jaffe JH, Martin WR (1990) Opioid analgesics and antagonists. In: Gillamn AG, Rall TW, Nies AS,Teylor P (eds) The pharmacological basis of therapeutics, 8th edn. Pergamon Press, New York, p 485
Jage J (1990) Morphin-Mythos - Ausführungen zur Opiat-Analgesie. Med Welt 41: 92
Jaksch W (1 996) Analgetika bei akuten Schmerzen. pm-Verlag, Kössen
Jurna I, Motsch J (1993a) Nichtanalgetika: Antidepressiva, Antikonvulsiva, Neuroleptika, Tranquilanzien und zentrale Muskelrelaxanzien, Clonidin,Cortison.In:Zenz M,Jurna I (Hrsg) Lehrbuch der Schmerztherapie. Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 155–165
Jurna I, BaldaufJ (1993b) Retardiert freigesetztes Naloxon oral:Aufhebung der Obstipation durch orales Morphin ohne Beseitigung der Analgesie.Schmerz 7: 314–321
Jurna I, Spohrer B, Bock R (1992) Intrathecal injection of salicylic acid. Salicylic acid and indomethacine depress c-fibre evoked activity in the rat thalamus and spinal cord. Pain 49: 249–255
Kanner RM, Foley KM (1981) Patterns of narcotic drug use in a cancer pain clinic. Ann NY Acad Sci 362: 161–172
Kaufman PN, Krevsky B,Malmud LS, Maurer AH, Somers MB, Siegel JA, Fisher RS (1988) Role of opiate receptors in the regulation of colonic transit. Gastroenterology 94: 1351–1356
Kloke M (1995) Therapie chronischer Tumorschmerzen. In: Therapiekonzepte Onkologie.Seeber S, Schütte J (Hrsg) Springer, Berlin Heidelberg NewYork,Tokyo,S 1092–1113
Kloke M, Höffken K, Olbrich H, Schmidt CG (1991) Antidepressants and anticonvulsants for the treatment of neuropathic pain-syndromes in cancer patients. Oncology 14: 40–43
Kuhar MJ, Pert CB, Snyder SH (1973) Regional distribution of opiate receptor binding in monkey and human brain. Nature 245: 447–450
Leiberman A (1977) Use of high-dose corticosteroids in patients with inoperable brain tumors.J Neurol Neurosurg Psychiatry 40: 678
Levin D, Cleeland CS, Dar R (1985) Public attitudes toward cancer pain.Cancer 56: 2337–2339
Lindena G, Müller S, Zenz T (1994) Opioidverschreibung durch niedergelassene Ärzte. Schmerz 8: 228–234
Ling GSFF, Spiegel K, Lockhart SH, Pasternak GW (1985) Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanism.J Pharmacol Exp Ther 232: 149–155
Martin WR, Eades CG, Thompson JA (1976) The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog.J Pharmacol Exp Ther 197: 517–532
McCaffery M (1983) Nursing the patient in pain. Harper and Row, London
Mc Quay HJ, Carroll D, Faura CC, Gavaghan DJ, Hand CW, Moore RA (1990) Oral morphine in cancer pain: influences on morphine and metabolite concentration. Clin Pharmacol Ther 48: 236–244
Melzack R (1986) Neurophysiological foundations of pain. In: Sternbach RA:The Psychology of Pain. Raven Press, New York, pp 1–24
Mercadante S,Agnello A,Armata MG, Pumo S (1997)The inappropriate use of the epidural route in cancer pain. J Pain Symptom Manage 13: 233–237
Miller R (1986) Midazolam as an adjunct to meperidine analgesia for postoperative pain.Clin J Pain 2: 37
Moulin DE, Foley KM (1990) A review of a hospital-based pain service.In:Foley KM, Bonica JJ, Ventafridda V (eds) Advances in pain research and therapy. Raven Press, New York, pp 413–428
O’Rourke K (1992) Pain Relief:The perspective of Catholic Tradition. J Pain Symptom Manage 7: 485–491
Paul D, Standifier KM, Inturrisi CE, Pasternak GW (1989) Pharmacological characterization of morphine-6-glucuronide,a very potent morphine metabolite.J Pharmacol ExpTher 251: 477–483
Paul D, Pick CG,Tive LA, Pasternak GW (1991) Pharmacological characterization of nalorphine, a kappa3 analgesic. J Pharmacol Exp Ther 257: 1–7
Pert CB, Snyder SH (1973) Opiate receptor: demonstration in nervous tissue.Science 179: 1011
Piletta P, Porchet HC, Dayer P (1991) Central analgesic effect of acetaminophene but not of aspirin. Clin Pharm Ther 49: 350–354
Portenoy RK (1993) Cancer pain management. Sem Oncol 2 [Suppl 1]: 19–35
Portenoy RK, Moulin DE, Rogers A, Inturrisi CE, Foley KM (1985) Intravenous infusion of opioids in cancer pain: Clinical review and guidelines for use. Cancer Treat Rep 70: 575–581
Portenoy RK, Foley KM, Stulman J (1991) Plasma morphine and morphine6-glucuronide during chronic morphine therapy for cancer pain: Plasma profiles, steady-state concentrations and the consequences of renal failure. Pain 47: 13–19
Portenoy RK,Thaler HT, Inturrisi CE, Friedlander-Klar H, Foley KM (1992) The metabolite, morphine-6-glucuronide, contributes to the analgesia produced by morphine infusion in pain patients with normal renal function. Clin Pharmacol Therap 51: 422–431
Principles of analgesic use in the treatment of acute pain and chronic cancer pain (1989) A concise guide to medical practice.2nd ed.Skokie, III.: American Pa in Society
Ripamonti C,Bruera E (1991) Rectal, buccal,and sublingual narcotics for the management of cancer pain.J Palliat Care 7: 30–35
Rogers M, Cerda JJ (1989) The narcotic bowel syndrome. J Clin Gastroenterol 11: 132–135
Roy D (1990) Need they sleep before they die. J Palliat Care 6: 3–4
Seff LB, Cuccherini BA, Zimmermann HI, Adler E, Benjamin SB (1986) Acetaminophene hepatotoxicity in alcoholics. Ann Int Medicine 104: 399–404
Simon EJ, Hiller JM, Edelman I (1973) Stereospecific binding of the potent narcotic analgesic [3H]-etorphine to rat-brain homogenate. Proc Natl Acad Sci US 70: 1947–1949
Singh PN, Sharma P, Gupta PK, Panday K (1981) Clinical evaluation of diazepam for relief of postoperative pain. Br J Anesth 53: 831
Sorge J, Lüders B, Werry C, Pichlmayr I (1996) Die Versorgung von ambulanten Tumorpatienten mit Opioidanalgetika. Schmerz 10: 283–291
Stein C (1993) Peripheral mechanisms ofopioid analgesia.Anesth Analg 76: 182–191
Sunshine A, Olson NZ (1988) Analgesic efficacy of ketoprofene in postpartum, general surgery and chronic cancer pain. J Clin Pharmacol 28: 47–54
Sverdlow M,Cundill JG (1981) Anticonvulsant drugs used in the treatment of lancinating pain. A comparison. Anesthesia 36: 1129
Sykes NP (1991) Oral naloxone in opioid-associated constipation. Lancet II: 1475
Tannock I, Gospdarowicz M, Meakin W, Panzarella T, Stewart L, Rider W (1989) Treatment of metastatic prostatic cancer with low-dose prednisone:evaluation of pain and quality of life as pragmatic indices of response.J Clin Oncol 7: 590
Terenius L (1973) Characteristics of the„receptor“for narcotic analgesics in synaptic plasma membrane fractions from rat brain. Acta Pharmacol Toxicol Kopenh 33: 377–384
Twycross RG (1974) Clinical experience with diamorphine in advanced malignant disease. Int J Pharmacol Therap Toxicol 9: 184–198
Twycross RG (1984) Relief of pain. In: Saunders C (ed) The Management of Terminal Malignant Disease. Edward Arnold, London, pp 64–90
Twycross RG (1995) Therapeutics in terminal cancer, 3rd edn. RadcliffeMedical Press, Oxford
Twycross RG, Ventafridda V (1979) Non-narcotic corticosteroid and psychotropic drugs in the continuing care of terminal cancer patients. In: Proceedings of an international seminar on continuing care of terminal cancer patients. Pergamon Press, New York
Twycross RG, Fairfield S (1982) Pain in far-advanced cancer. Pain 14: 303–310
Twycross RG, Lack SA (1983) Pain–a broader concept. In: Symptom Control in far advanced cancer. Pitman, London, pp 49–55
Twycross RG (1998) Opioid analgesics in cancer pain:current practice and controversies. Cancer Surveys 7: 29–51
Ulsenheimer K (1999) Arzt und Drogenwesen. In: Laufs A, Uhlenbruck W (Hrsg) Handbuch des Arztrechts.C.H. Beck, München 1079–1084
Van Holten-Verzantvoort ATM,Zwinderman AH,Aaronson RK (1991)The effect of supportive pamidronate treatment on aspects of quality of life of patients with advanced breast cancer. Eur J Cancer 27:544–549
Ventafridda V, Fochi C, DeConno F, Sganzerla E (1980) Use of NSAIDs in the treatment of pain in cancer. Br J Clin Pharmacol 10: 343–346
Ventafridda V,Tamburini M, DeConno F (1985) Comprehensive treatment of cancer pain.ln:Fields HL,Dubner R,Cervero F (eds) Advances in pain research and therapy. Raven Press, New York, pp 617–628
Ventafridda V,Tamburini M,Caraceni A, DeConno F, Naldi F (1987) A validation study of the WHO method for cancer pain relief. Cancer 59: 850–856
VentafriddaV,Bianchi M, Ripamonti C,Sacerdote P,DeConno F,Zecca R,Paneari AE (1990a) Studies on the effects of antidepressant drugs on the antinoceptive action of morphine and on plasma morphine in rat and man. Pain 43: 155–162
Ventafridda V, Ripamonti C, DeConno F, Tamburini M (1990b) Symptom prevalence and control during cancer patients’ last days of life. J Palli-at Care 6: 7–11
Wallenstein SL (1975) Analgesic studies of aspirin in cancer patients. Proceedings of the aspirin symposium. Aspirin Foundation, London, p 5
Walsh SL, Preston KL, Stitzer ML, Cone EJ, Bigelow GE (1994) Clinical pharmacology of buprenorphine: Ceiling effects at high doses. Clin Pharmacol Ther 55: 569–580
Walsh TD (1990) Prevention of opioid side effects.J Pain Symptom Manage 5: 362–367
Ward SE, Goldberg N, Miller-McCauley V et al. (1993) Patient-related barriers to management of cancer pain. Pain 52: 319–324
Watanabe S, Belize M, Kuehn N (1996) Capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. Clinical and economic considerations.Cancer Treat Rev 22: 131–136
Waugh L (1988) Psychological aspects of cancer pain. Professional Nurse 9: 504–508
Weissman DE (1988) Glucosteroid therapy for brain metastases and epidural spinal cord compression:a review.J Clin Oncol 6: 543
Weissman DE (1996) Cancer pain education for physicians in practice: es- tablishing a new paradigm.J Pain Symptom Manage 12: 364–371
Weissman DE, Dahl JL (1990) Attitudes about cancer pain: a survey of Wisconsin’s first-year medical students. J Pain Symptom Manage 5: 345–349
Willer IC, DeBrouckertT, Bussel B, Robi-Brauni A, Harrewyn JM (1989) Central analgesic effect of ketoprofen in humans: electrophysiologic evidence for a supraspinal mechanism in a double blind and crossover study. Pain 38: 1–7
Willcox JC, Corr J, Shaw J, Richardson M, Calman KC, Drennan M (1984) Prednisolone as appetite stimulant in patients with cancer pain. Br Med J 288: 27
World Health Organization (1996) Cancer pain relief,2nd edn.WHO, Geneva
Yamada K, Ushio Y, Hayakawa T, Kato A, Arita N, Yamada N (1983) Effects of methylprednisolone on peritumoral brain edema.J Neurosurg 59: 612
Zagon IS, Gibo DM, McLaughlin PI (1991) Zeta (),a growth-related opioid receptor in developing rat cerebellum: identification and characterization. Brain Res 551: 28–35
Zech DFJ, Grond S, Lynch J, Hertel D, Lehmann KA (1995) Validation of World Health Organization guidelines for cancer pain relief: a 10-year prospective study. Pain 63: 65–76
Zenz M (1993) Neues und Bewährtes in der medikamentösen Behandlung des chronischen Schmerzes.Schmerz [Suppl] 5: 52
Zenz M, Willweber-Strumpf A (1993) Opiophobia and cancer pain in Europe. Lancet 341: 1075–1076
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Fazeny-Dörner, B., Dittrich, C. (2004). Medikamentöse Schmerztherapie in der Onkologie. In: Die Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06670-6_28
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