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Behandlung von Patienten mit HIV-Infektion auf der Intensivstation

  • I. Schedel

Zusammenfassung

HIV-infizierte Patienten können aus einer Reihe von Indikationen heraus der Intensivbehandlung bedürfen (Abb. 60-1; [7 17, 19, 33, 41, 44, 51]). In 50–75% der Fälle stellt akutes respiratorisches Versagen die Indikation für die Behandlung HIV-Infizierter auf der Intensivstation dar [7, 17, 19, 33, 41, 44, 51]. Bei 55–90% dieser Patienten mit intensiv behandlungsbedürftigem respiratorischen Versagen stellt Pneumocystis carinii das für die Erkrankung verantwortliche Pathogen dar [7, 33, 44].

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Literatur

  1. 1.
    Ahuja TS, BoruckiM,Grady. (2000) Highly active antiretroviral therapy improves survival of HIV-infected hemodialysis patients. Am J Kidney Dis 36: 574–580Google Scholar
  2. 2.
    Antinori A, Maiuro G, Pallavicini F et al. (1993) Prognostic factors of early fatal outcome and long-term survival in patients with pneumocystis carinii pneumonia and acquired immunodeficiency syndrome. Eur J Epidemiol 9 /2: 183–189PubMedCrossRefGoogle Scholar
  3. 3.
    Bastian L, Bennett CL, Adams J et al. (1993) Differences between men and women with HIV-related pneumocystis carinii pneumonia: Experience from 3,070 cases in New York City in 1887. J Acquin Immune Defic Syndr 6 /6: 617–623Google Scholar
  4. 4.
    Bedos JP, Chastang C, Lucet C et al. (1995) Early predictors of outcome for HIV patients with neurologic failaure [see comments].JAMA 273 /1: 35–40Google Scholar
  5. 5.
    Bennett CL, Garfinkle JB, Greenfield S et al. (1989) The relation between hospital experience and in-hospital mortality for patients with AIDS-related PCP. JAMA 261: 2975–2979PubMedCrossRefGoogle Scholar
  6. 6.
    Bennett RL, Gilman SC, George L et al. (1993) Improved outcomes in intensive care units for AIDS-related pneumocystis carinii pneumonia: 1987–1991.) Acquir Immune Defic Syndr 6 /12: 1319–1321Google Scholar
  7. 7.
    Bozette SA, Feigal D, Chiu J et al. (1992) Length of stay and survival after intensive care for severe pneumocystis carinii pneumonia. Chest 101: 1404–1407CrossRefGoogle Scholar
  8. 8.
    Bozette SA, Sattler FR, Chiu J et al. (1990) A controlled trial of early adjunctive treatment with corticosteroids for pneumocystis carinii pneumonia in the acquired inmmunodeficiency syndrome. California Collaborative Treatment Group [see comments]. Engl J Med 323 /21: 1451–1457CrossRefGoogle Scholar
  9. 9.
    Brown MC, Crede WB (1995) Predictive ability of acute physiology and chronic health evaluation II scoring applied to human immunodeficiency virus-positive patients [see comments] [pbulished erratum appears in Crit Care Med 1995, 23/8: 1454]. Crit Care Med 23 /5: 848–853Google Scholar
  10. 10.
    Chu DY (1993) Predicting survival in AIDS patients with respiratory failure. Application of the APACHE II scoring system. Crit Care Clin 9 /1: 89–105PubMedGoogle Scholar
  11. 11.
    Clumeck N Coordinator (2001) European Guidelines for the clinical management and treatment of HIV-infected adults in Europe 2001. European Aids Clinical Society (EACS)Google Scholar
  12. 12.
    Cohen BA, Pomeranz S, Rabinowitz JG et al. (1984) Pulmonary complications of AIDS: Radiologic features. FUR Am J Roentgenol 143 /1: 115–122CrossRefGoogle Scholar
  13. 13.
    Consensus statement on the use of corticosteroids as adjunctive therapy for pneumocystis pneumonia in the acquired inmmunodeficiency syndrome (1990) The National Institut of Health–University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocystis Pneumonia [see comments]. N Engl J Med 323 /21: 1500–1504Google Scholar
  14. 14.
    CROI 2002 (Abstr. 125; 655-M)Google Scholar
  15. 15.
    Curtis JR, Greenberg DL, Hudson LD et al. (1994) Changing use of intensive care for patients with AIDS. Pneumocystis carinii pneumonia. Am J Respsir Crit Care Med 150: 1305–1310Google Scholar
  16. 16.
    de Gaetano Donati K, Bertagnolio S,Tumbarello M et al. (2000) Effect of highly active antiretroviral subjects. Int J Antimicrob Agents 16: 357–360CrossRefGoogle Scholar
  17. 17.
    De Palo VA, Millstein BH, Mayo PH et al. (1995) Outcome of intensive care in patients with HIV infection. Chest 107 /2: 506–510PubMedCrossRefGoogle Scholar
  18. 18.
    Deutsch-österreichische Empfehlungen zur antiretroviralen Therapie (2002)Google Scholar
  19. 19.
    Efferen LS, Nadarajah D, Palat DS (1989) Survival following mechanical ventilation for pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. A different perspective. Am J Med 87 /4: 401–404PubMedCrossRefGoogle Scholar
  20. 20.
    Franklin C, Friedman Y, Wong T et al. (1995) Improving long-term prognosis for survivors of mechanical ventilation in patients with AIDS with PCP and acute respiratory failure. Arch Intern Med 155: 91–95PubMedCrossRefGoogle Scholar
  21. 21.
    Gagnon S, Boota AM, Fischl MA et al. (1990) Corticosteroids as adjunctive therapy for severe pneumocystis carinii pneumonia in the acquired inmmunodeficiency syndrome. A double-blind, placebo controlled trial. N Engl J Med 323 /21: 1444–1450PubMedCrossRefGoogle Scholar
  22. 22.
    Garay SM, Greene J (1989) Prognostic indicators in the initial presentation of pneumocystis carinii pneumonia. Chest 95 /4: 663–671CrossRefGoogle Scholar
  23. 23.
    Gregg RW, Friedman BC, Williams JF et al. (1990) Continuous positive airway pressure by face mask in pneumocystis carinii pneumonia. Crit Care Med 18 /1: 21–24PubMedCrossRefGoogle Scholar
  24. 24.
    Grover SA, Coupai L, Szussa S et al. (1992) the clinical utility of serum lactate dehydroganase in diagnosing pneumocystis carinii pneumonia among hospitalized AIDS patiens. Clin Invest Med 15/4: 309–317Google Scholar
  25. 25.
    Hawley PH, Ronco JJ, Guillemi SA et al. (1994) Decreasing frequency but worsening mortality of acute respiratory failure secondary to AIDS-related pneumocystis carinii pneumonia [see comments]. Chest 106 /5: 1456–1459PubMedCrossRefGoogle Scholar
  26. 26.
    Hrischtick RE, Glassroth J, Jordan MC et al. (1995) Bacterial pneumonia in persons infected with the human immunodeficiency virus: Pulmonary Complications of HIV Infection Study Group. N Engl J Med 333 /13: 845–851CrossRefGoogle Scholar
  27. 27.
    Huang L, Stasell JD (1996) AIDS and the lung. Med Clin North Am 80 /4: 775–801PubMedCrossRefGoogle Scholar
  28. 28.
    Jasmer RM, Gotway MB, Creasman JM et al. (2002) Clinical and radiographic predictors of the etiology of computed tomography-diagnosed intrathoracic lymphadenopathy in HIV-infected patients. J Acquir Immune Defic Syndr 31: 3, 291: 8Google Scholar
  29. 29.
    Katz MH, Baron RB, Grady D (1991) Risk stratification of ambulatory patient suspected of pneumocystis carinii pneumonia. Arch Intern Med 151 /1: 105–110PubMedCrossRefGoogle Scholar
  30. 30.
    Kovacs JA, Gill VJ, Meshnik S, Masur H (2001) New insights into transmission, diagnosis, and drug treatment of pneumocystis carinii pneumonia. JAMA 286 /19: 2450–2460PubMedCrossRefGoogle Scholar
  31. 31.
    Kovacs JA, Hiemenz JW, Macher AM et al. (1984) Pneumocystis carinii pneumonia: A comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med 100 /5: 663–671PubMedCrossRefGoogle Scholar
  32. 32.
    LaRocco A Jr, Amundson DE, Wallace MR et al. (1992) Corticosteroids for pneumocystis carinii pneumonia with acute respiratory failure. Experience with rescue therapy. Chest 102 /3: 892–895PubMedCrossRefGoogle Scholar
  33. 33.
    LazardT,Retel O, Guide B et al. (1996) AIDS in medical intensive care unit: Immediate prognosis and long-term survival.JAMA 276 /15: 1240–1245Google Scholar
  34. 34.
    Levy RM, Berger JR (1993) Neurologic critical care in patients with human immunodeficiency virus 1 infection. Crit Care Clin 9 /1: 49–72PubMedGoogle Scholar
  35. 35.
    Lonergan JT, Behling C, Pfander H, Hassanein TI, Mathews WC (2000) Hyperlactatemia and hepatic abnormalities in 10 immunodeficiency virus infected patients receiving nucleoside analogue combination regimens. Clin Infect Dis 31: 162–166PubMedCrossRefGoogle Scholar
  36. 36.
    Marolda J, Pace B, Bonforte JR et al. (1989) Outcome of mechanical ventilation in children with acquired immunodeficiency syndrome. Pediatr Pu l mono) 7 /4: 230–234CrossRefGoogle Scholar
  37. 37.
    Meeker DP, Matysik GA, Stelmach K et al. (1993) Diagnostic utility of lactate dehydrogrnase levels in patients receiving aerosolized pentamidine. Chest 104 /2: 386–388PubMedCrossRefGoogle Scholar
  38. 38.
    Metersky ML, Colt HG, Olson LKet al. (1995)AIDS-related spontaneous pneumothorax. Risk factors and treatment. Chest 108/4: 946–951Google Scholar
  39. 39.
    Milberg JA, Davis DR, Steinberg KP et al. (1995) Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983–1993. JAMA 273 /4: 306–309PubMedCrossRefGoogle Scholar
  40. 40.
    Notterman DA (1993) Pediatric AIDS and critica care. Crit Care Med 21 (9 Suppl): 5319–5321Google Scholar
  41. 41.
    Peruzzi WT, Sloutelis A, Shapiro BA et al. (1991) Intensive care unit patients with acquired immunodeficiency syndrome and pneumocystis carinii pneumonia. suggested predictors of hospital outcome. Crit Care Med 19 /7: 892–900PubMedCrossRefGoogle Scholar
  42. 42.
    Postexpositionelle Prophylaxe nach HIV-Infektion. Deutsch-österreichische Empfehlungen (2002)Google Scholar
  43. 43.
    Quist J, Hill AR (1995) Serum lactate dehydrogenase levels and pneumocystis carinii pneumonia, tuberculosis and bacterial pneumonia. Chest 108 /2: 415–418PubMedCrossRefGoogle Scholar
  44. 44.
    Rogers PL, Lane HC, Henderson DK et al. (1989) Admission of AIDS patients to a medical intensive care unit: Causes and outcome [see comments]. Crit Care Med 1989 17 /2: 113–117CrossRefGoogle Scholar
  45. 45.
    Rosen MJ, De Palo VA (1993) Outcome of intensive care for patients with AIDS. Crit Care Clin 9 /1: 107–114PubMedGoogle Scholar
  46. 46.
    Soni N, Pozniak (2001) A continuing HIV therapy in the ICU. Crit Care 5: 247–248Google Scholar
  47. 47.
    Staikowski F, Lafon B, Guidet B et al. (1993) Mechanical ventilation for pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Is the prognosis really improved? [see comments]. Chest 104 /3: 756–762CrossRefGoogle Scholar
  48. 48.
    Stone VE, Seage GD, Hertz T et al. (1992)The relation between hospital experience and mortality for patients with AIDS [see comments]. JAMA 268: 2655–2661Google Scholar
  49. 49.
    Wachter RM, Lo B (1993) Advance directives for patients with human immunodeficiency virus infection. Crit Care Clin 9 /1: 125–136PubMedGoogle Scholar
  50. 50.
    Wachter RM, Luce JM, Hopewell PC (1992) Critical care of patients with AIDS. JAMA 267 /4: 541–574PubMedCrossRefGoogle Scholar
  51. 51.
    Wachter RM, Luce JM, Safrin Set al. (1995) Cost and outcome of inten- sive care for patients with AIDS, pneumocystis carinii pneumonia, and severe respiratory failure. JAMA 273 /3: 230–235PubMedCrossRefGoogle Scholar
  52. 52.
    Wilcox CM (1993) Serious gastrointestinal disorders associated wit human immunodeficiency virus infection. Crit Care Clin 9 /1: 73–88PubMedGoogle Scholar
  53. 53.
    WOlffA1, O’Donnell AE (2001) Pulmonary manifestations of HIV-infec- tion in the era of highly active antiretroviral treatment. Chest 120 /6: 1888–1893Google Scholar
  54. 54.
    Zaman MK, White DA (1988) Serum lactate dehydrogenase levels and pneumocystis carinii pneumonia. Diagnosis and prognostic signifi-cance. Am Rev Resspir Dis 137 /4: 796–800CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2004

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  • I. Schedel

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