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Diagnostic Nuclear Medicine pp 7–35Cite as

Neurochemical Imaging with Emission Tomography: Clinical Applications

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Part of the book series: Diagnostic Imaging ((Med Radiol Diagn Imaging))

Abstract

The assessment of neurochemical and neurophysio-logic variables by emission tomography can be based on two strategies in relation to the goal to be achieved. A first approach is aimed at the assessment of basic variables related to brain functional activity and energy metabolism, such as blood flow, rates of glucose and oxygen metabolism, and incorporation of amino acids into proteins. A second approach is based on the measurement of neurotransmitter synthesis and reuptake, receptor density, and enzyme activity, variables related to the function of the chemically heterogeneous neuronal populations that compose the central nervous system. The two approaches are complementary and can be used for the assessment of regional derangements of cerebral energy metabolism and chemical transmission.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Milan, H.S. Raffaele, Via Olgettina 60, I-20132, Milan, Italy

    G. Lucignani

  2. Johns Hopkins Hospital, 600 N. Wolfe Street, Nelson Tower Bl-130, Baltimore, MD, 21205, USA

    J. J. Frost

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  1. G. Lucignani
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  2. J. J. Frost
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Editors and Affiliations

  1. Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 10833 Le Conte Avenue, AR-144 CHS, Los Angeles, CA, 90095-6942, USA

    Christiaan Schiepers MD, PhD (Associate Professor) (Associate Professor)

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© 2000 Springer-Verlag Berlin Heidelberg

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Lucignani, G., Frost, J.J. (2000). Neurochemical Imaging with Emission Tomography: Clinical Applications. In: Schiepers, C. (eds) Diagnostic Nuclear Medicine. Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06590-7_2

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  • DOI: https://doi.org/10.1007/978-3-662-06590-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06592-1

  • Online ISBN: 978-3-662-06590-7

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