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Imaging Gene Expression: Concepts and Future Outlook

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Book cover Diagnostic Nuclear Medicine

Part of the book series: Diagnostic Imaging ((Med Radiol Diagn Imaging))

Abstract

Advances in molecular biology are making it possible to develop assays for imaging specific molecular processes, including those directly related to gene expression. Imaging gene expression entails determining the location(s) of those cells expressing a particular gene of interest, as well as monitoring the magnitude and persistence of gene expression. The gene of interest may be an endogenous gene or it may be an “exogenous” gene introduced into the organism/ tissue(s) of interest. Imaging gene expression with generalized approaches applicable to any gene of interest have recently been reported. Conventional nuclear imaging techniques can be used to image gene expression if a radiolabeled substrate can be developed to interact with the protein of the gene of interest. However, more general methods are emerging to image gene expression without the need for developing new radiolabeled substrates for each new gene of interest.

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Authors and Affiliations

  1. Crump Institute for Biological Imaging, Department of Molecular & Medical Pharmacology, Laboratory of Structural Biology & Molecular Medicine (DOE), UCLA School of Medicine, 700 Westwood Plaza, Los Angeles, CA, USA

    S. S. Gambhir

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  1. S. S. Gambhir
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Editors and Affiliations

  1. Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 10833 Le Conte Avenue, AR-144 CHS, Los Angeles, CA, 90095-6942, USA

    Christiaan Schiepers MD, PhD (Associate Professor) (Associate Professor)

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© 2000 Springer-Verlag Berlin Heidelberg

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Gambhir, S.S. (2000). Imaging Gene Expression: Concepts and Future Outlook. In: Schiepers, C. (eds) Diagnostic Nuclear Medicine. Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06590-7_15

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  • DOI: https://doi.org/10.1007/978-3-662-06590-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06592-1

  • Online ISBN: 978-3-662-06590-7

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