Abstract
The radiation that has to be used in diagnostic nuclear medicine is, unfortunately, of sufficiently high energy to be ionising. Thus, although there is a benefit to the patient, there is also a risk to both the patient and the community as a whole. Recommendations on controlling this risk are made by a number of organisations, based on an evaluation of the detriment to the individual caused by the absorbed radiation dose. Of prime importance, in this, is the estimation of the radiation dose and hence the likely biological consequences, resulting from the interaction of the radiation with matter. It has been stated that: a key factor in sustaining the growth in nuclear medicine while retaining the confidence of the referring clinician, the patient and the public, is for practitioners to maintain an up to date knowledge of the radiation risks associated with the procedures, an understanding of the methodology used to assess these risks and an appreciation of the associated limitations (Mountford 1997).
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Abbreviations
- BEIR:
-
United States National Academy of Sciences Biological Effects of Ionizing Radiation committee
- BSS:
-
basic safety standards
- DNA:
-
deoxyribose nucleic acid
- HVT:
-
half-value thickness
- IACRS:
-
Inter-Agency Committee on Radiation Safety
- IAEA:
-
International Atomic Energy Agency
- ICRP:
-
International Commission on Radiological Protection
- ICRU:
-
International Commission on Radiation Units and Measurements
- LET:
-
linear energy transfer
- MIRD:
-
Medical Internal Radiation Dose committee
- RBE:
-
relative biological effectivenesses
- SI:
-
specific ionisation
- TVT:
-
tenth-value thickness
- WHO:
-
World Health Organization
References
Bardies M, Myers MJ (1996) Computational methods in radionuclide dosimetry. Phys Med Biol 41: 1941–1955
Clairand I, Ricard M, Gouriou J, di Paola M, Aubert B (1999) DOSE3D: EGS4 Monte Carlo code-based software for internal radionuclide dosimetry. J Nucl Med 40:1517–1523
Clairand I, Bouchet LG, Ricard M, Durigon M, di Paola M, Aubert B (2000) Improvement of internal dose calculations using mathematical models of different adult heights. Phys Med Biol 45: 2771–2785
Delacroix D, Guerre JP, Leblanc P, Hickman C (1998) Radionuclide and radiation protection data handbook. Rad Prot Dos 76:1–2
Gadd R, Mountford PJ, Oxtoby JW (1999) Effective dose to children and adolescents from radiopharmaceuticals. Nucl Med Commun 20:569–573
Groenewald W, Wasserman H (1990) Constants for calculating ambient and directional dose equivalents from radioactive point sources. Health Phys 58:655–658
Harding K, Thomson WH (1997) Radiological protection and safety in medicine — ICRP 73. Eur J Nucl Med 24:1207–1209
Howell RW, Wessels BW, Loevinger R in collaboration with the Medical Internal Radiation Dose Committee Watson EE, Bolch WE, Brill AB, Charkes ND, Fisher DR, Hays MT, Howell RW, Robertson JS, Siegel JA, Thomas SR, Wessels BW (1999) The MIRD perspective 1999. J Nucl Med 40: 3S–10S
IAEA (1996) International Atomic Energy Agency international basic safety standards for protection against ionizing radiation and for the safety of radiation sources: a safety standard. IAEA, Vienna (International Atomic Energy Agency safety series 115)
ICRP (1977) International Commission on Radiological Protection publication 26; 1977 recommendations of the International Commission on Radiological Protection. Pergamon, Oxford
ICRP (1991) International Commission on Radiological Protection publication 60; 1990 recommendations of the International Commission on Radiological Protection. Pergamon, Oxford
ICRP (1992) International Commission on Radiological Protection publication 60 — user’s edn; 1990 recommendations of the International Commission on Radiological Protection. Pergamon, Oxford
ICRP (1996) International Commission on Radiological Protection publication 73 radiological protection and safety in medicine. Pergamon, Oxford
Johansson L (2003) Hormesis, an update of the present position. Eur J Nucl Med 30:921–933
Loevinger R, Budinger TF, Watson EE (eds) (1988) MIRD primer for absorbed dose calculations. Society of Nuclear Medicine, New York
Loevinger R, Budinger TF, Watson EE (eds) (1991) MIRD primer for absorbed dose calculations, revised. Society of Nuclear Medicine, New York
Mountford PJ (1996) Internal dosimetry: developments and limitations. Eur J Nucl Med 23:491–493
Mountford PJ (1997) Risk assessment of the nuclear medicine patient. Br J Radiol 70:671–684
NCRP (1983) National Council on Radiation Protection and Measurements report 73. Protection in nuclear medicine and ultrasound diagnostic procedures in children. NCRP, Bethesda, Maryland
Ott RJ (1996) Imaging technologies for radionuclide dosimetry. Phys Med Biol 41:1885–1894
Overbeek F, Pauwels EKJ, Broerse JJ (1994) Carcinogenic risk in diagnostic nuclear medicine: biological and epidemiological considerations. Eur J Nucl Med 21:997–1012
Parker RP, Smith PHS, Taylor DM (1984) Basic science of nuclear medicine. Churchill Livingstone, Edinburgh
Simpkin DJ (1999) Radiation interactions and internal dosimetry in nuclear medicine. Radiographics 19:155–167
Sont WN, Zielinski JM, Ashmore JP, Jiang H, Krewski D, Fair ME, Band PR, Letourneau EG (2001) First analysis of cancer incidence and occupational radiation exposure based on the national dose registry of Canada. Am J Epidemiol 153:309–317
Sorenson JA, Phelps ME (1987) Physics in nuclear medicine, 2nd edn. Grune and Stratton, New York
Stabin MG (1996) MIRDOSE: personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 37:538–546
Stabin MG, Gelfand MJ (1998) Dosimetry of pediatric nuclear medicine procedures. Q J Nucl Med 42:93–112
Stabin MG, Tagesson M, Thomas SR, Ljungberg M, Strand SE (1999) Radiation dosimetry in nuclear medicine. Appl Radiat Isot 50:73–87
Thierens HM, Monsieurs MA, Brans B, van Driessche T, Christiaens I, Dierckx RA (2001) Dosimetry from organ to cellular dimensions. Comput Med Imaging Graph 25:187–193
Thomas SR, Maxon HR III, Kereiakes JG (1988) Techniques for quantitation of in vivo radioactivity. In: Gelfand MJ, Thomas SR (eds) Effective use of computers in nuclear medicine. McGraw-Hill, New York, pp 348–383
Toohey RE, Stabin MG, Watson EE (2000) The AAPM/RSNA physics tutorial for residents: internal radiation dosimetry: principles and applications. Radiographics 20:533–546
Van Wyngaarden KE, Pauwels EKJ (1995) Hormesis: are low doses of radiation harmful or beneficial? Eur J Nucl Med 22:481–486
Watson EE, Stabin MG, Siegel JA (1993) MIRD formulation. Med Phys 20:511–514
Zaidi H, Hasegawa B (2003) Determination of the attenuation map in emission tomography. J Nucl Med 44:291–315
Zanzonico PB (2000) Internal radionuclide radiation dosimetry: a review of basic concepts and recent developments. J Nucl Med 41:297–308
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Hamilton, D. (2004). Biological Effects of Radiation. In: Diagnostic Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06588-4_4
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DOI: https://doi.org/10.1007/978-3-662-06588-4_4
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