Zusammenfassung
Die Anwendung rückenmarknaher („spinal“) Opiate hat die akute und chronische Schmerztherapie in den beiden letzten Jahrzehnten erheblich bereichert [35, 36,150, 152]. Ihr Wirkungsmechanismus beruht auf einer Hemmung der Übertragung afferenter nozizeptiver Impulse im Hinterhorn, wo reichlich Opiatrezeptoren vorkommen. Als wichtigster Vorteil wird angesehen, daß rückenmarknahe Opioide weder die motorische noch die vegetative Reaktionsfähigkeit des Organismus beeinträchtigen [8, 146].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abboud TK, Dror A, Mosaad P, Zhu J, Mantilla M, Swart F, Gangolly J, Silao P, Makar A, Mocre J, Davis H, Lee J (1988) Mini-dose intrathecal morphine for the relief of post-cesarean section pain: safety, efficacy, and ventilatory response to carbon dioxide. Anesth Analg 67: 137 - 143
Abouleish E (1988) Apnoea associated with the intrathecal administration of morphine in obstetrics. A case report. Br J Anaesth 60: 592 - 494
Abouleish E, Rawal N, Fallon K, Hernandez D (1988) Combined intrathecal morphine and bupivacaine for cesarean section. Anesth Analg 67: 370 - 374
Acalovschi I, Ene V, Lörinczi E, Nicolaus F (1986) Saddle block with pethidine for perineal operations. Br J Anaesth 58: 1012 - 1016
Ahigren FIH, Ahlgren MBE (1987) Epidural administration of opiates by a new device. Pain 31: 353 - 357
Amer S, Amer B (1985) Differential effects of epidural morphine in the treatment of cancer-related pain. Acta Anaesthesiol Scand 29: 32 - 36
Amer S, Rawal N, Gustafsson LL (1988) Clinical experience of long-term treatment with epidural and intrathecal opioids - a nationwide survey. Acta Anaesthesiol Scand 32: 253 - 259
van der Auwera D, Verborgh C, Camu F (1987) Analgesic and cardiorespiratory effects of epidural sufentanil and morphine in humans. Anesth Analg 66: 999 - 1003
Bach V, Carl P, Ravlo O, Crawford ME, Werner M (1986) Potentiation of epidural opioids with epidural droperidol. A one year retrospective study. Anaesthesia 41: 11161119
Bailey PW, Smith BE (1980) Continuous epidural infusion of fentanyl for postoperative analgesia. Anaesthesia 35: 1002 - 1006
Baraka A, Noueihed R, Hajj S (1981) Intrathecal injection of morphine for obstetric analgesia. Anesthesiology 54: 136 - 140
Barron DW, Strong JE (1984) The safety and efficacy of intrathecal diamorphine. Pain 18: 279 - 285
Beeby D, Macintosh KC, Bailey M, Welch DB (1984) Postoperative analgesia for caesarean section using epidural methadone. Anaesthesia 39: 61 - 63
Berger JM, Ontell R (1987) Intrathecal morphine in conjunction with a combined spinal and general anesthetic in a patient with multiple sclerosis. Anesthesiology 66: 400 - 402
Bilsback P, Rolly G, Tampbulon 0 (1985) Efficacy of the extradural administration of lofentanil, buprenorphine or saline in the management of postoperative pain. A double-blind study. Br J Anaesth 57: 943-948
Blanco J, Blanco E, Carceller JM, Sarabia A, Solares G (1987) Epidural analgesia for post-cesarean pain relief: a comparison between morphine and fentanyl. Eur J Anaesth 4: 395 - 399
Blond S, Meynadier J, Chrubasik J, Dupard T, Dubar M, Combelles-Pruvot M, Christiaens JL, Demaille A (1985) Intrathekale and intraventrikuläre MorphinAnalgesie bei Karzinompatienten. Langzeit-Erfahrungen. Schmerz-Pain-Douleur 6: 129-135
Boersma FP, Buist AB, Thie J (1987) Epidural pain treatment in the northern Netherlands. Organizational and treatment aspects. Acta Anaesthesiol Belg 38: 213-216
Bohannon TW, Estes MD (1987) Evaluation of subarachnoid fentanyl for postoperative analgesia. Anesthesiology 67: A237
Brodsky JB, Kretzschmar KM, Mark JBD (1988) Caudal epidural morphine for postthoracotomy pain. Anesth Analg 67: 409 - 410
Bromage PR, Camporesi E, Chestnut D (1980) Epidural narcotics for postoperative analgesia. Anesth Analg 59: 473 - 480
Brownridge P, Wrobel J, Watt-Smith J (1983) Respiratory depression following accidental subarachnoid pethidine. Anaesth Intensive Care 11: 237 - 240
Brownridge P, Frewin DB (1985) A comparative study of techniques of postoperative analgesia following Cesarean section and lower abdominal surgery. Anaesth Intensive Care 13: 123 - 130
Buatti M, Pasternak GW (1981) Multiple opiate receptors: phylogenetic differences. Brain Res 218: 400 - 405
Busch EH, Stedman PM (1987) Epidural morphine for postoperative pain on medical-surgical wards - a clinical review. Anesthesiology 67: 101 - 104
Carl P, Crawford ME, Ravlo O, Bach V (1986) Longterm treatment with epidural opioids. A retrospective study comprising 150 patients treated with morphine chloride and buprenorphine. Anaesthesia 41: 32 - 38
Chrubasik J, Wiemers K (1985) Continuous-plus-on-demand epidural infusion of morphine for postoperative pain relief by means of a small, externally worn infusion device. Anesthesiology 62: 263 - 267
Clemensen SE, Thayssen P, Hole P (1987) Epidural morphine for outpatients with severe anginal pain. Br Med J 294: 475 - 476
Clergue F, Montembault C, Despierres O, Ghesquiere F, Harari A, Viars P (1984) Respiratory effects of intrathecal morphine after upper abdominal surgery. Anesthesiology 61: 677 - 685
Cohen SE, Tan S, Albright GA, Halpern J (1987) Epidural fentanyl/bupivacaine mixtures for obstetric analgesia. Anesthesiology 67: 403 - 407
Colpaert FC, Niemegeers CJE, Janssen PAJ, Maroli AN (1980) The effects of prior fentanyl administration and of pain on fentanyl analgesia: tolerance to and enhacement of narcotic analgesia. J Pharmacol Exp Therap 213: 418 - 426
Coombs DW, Fratkin JD, Meier FA, Nierenberg DW, Saunders RL (1985) Neuropathological lesions and CSF concentrations during continuous intraspinal morphine infusion. A clinical and post-mortem study. Pain 22: 337-351
Coombs DW, Saunders RL, Lachange D, Savage S, Ragnarsson TS, Jensen LE (1985) Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine. Anesthesiology 62: 358-363
Coombs DW (1986) Management of chronic pain by epidural and intrathecal opioids. Newer drugs and delivery systems. Int Anesthesiol Clin 24: 59 - 74
Cousins MJ, Mather LE (1984) Intrathecal and epidural administration of opioids. Anesthesiology 61: 276 - 310
Cousins MJ (1988) The spinal route of analgesia. Acta Anaesthesiol Belg 39 (Suppl 2): 71 - 82
Crawford JS (1980) Site of action of intrathecal morphine. Br Med J 281: 680
Crawford JS (1980) Site of action of intrathecal morphine. Br Med J 281: 1144
Crawford ME, Anderson HB, Augestenberg G, Bay J, Beck O, Benveniste D, Larsen LB, Carl P, Djernes M, Eriksen J (1983) Pain treatment on outpatient basis utilizing extradural opiates: a Danish multicentre study comprising 105 patients. Pain 16: 41 - 47
Crone LAL, Conly JM, Clark KM, Crichlow AC, Wardell GC, Zbitnew A, Rea LM, Cronk SL, Anderson CM, Tan LK, Albritton WL (1988) Recurrent herpes simplex virus labialis and the use of epidural morphine in obstetric patients. Anesth Analg 67: 318 - 323
Cullen ML, Staren ED, El-Ganzouri A, Logas WG, Ivkanovich AD, Economou SG (1985) Continuous epidural infusion for analgesia after major abdominal operations: a randomised prospective double-blind study. Surgery 98: 718 - 726
Cuocolo R, Amantea B, Savoia G (1984) Subarachnoid morphine for labor and delivery. Pain Suppl 2: S334
Dailey PA, Brookshire L, Abboud TK, Kotelko DM, Noueihed R, Thipgen JW, Khoo SS, Raya JA, Foutz SE, Vrizgys RV, Goebelsmann U, Lo MW (1985) The effects of naloxone associated with the intrathecal use of morphine in labor. Anesth Analg 64: 658 - 666
Davis I (1987) Intrathecal morphine in aortic aneurysm surgery. Anaesthesia 42: 491497
Di Chiro G (1966) Observations on the circulation of the cerebrospinal fluid. Acta Radiolog 5: 988 - 1002
Donadoni R, Capiau P (1987) Cardiac arrest after spinal sufentanil: a case report. Acta Anaesthesiol Belg 38: 175 - 177
Douglas MJ, Kim JHK, Ross PLE, McMorland GH (1986) The effect of epinephrine in local anaesthetic on epidural morphine-induced pruritus. Can Anaesth Soc J 33: 737740
Downing JW, Williams V, Porte D, Woods S, Fogel K, Horn JH (1984) Rostral spread of epidural morphine. Anesth Analg 63: 371 - 376
Duckett JE, McDonnell T, Zebrowski M, Witte M (1987) Lumbar versus thoracic continuous epidural sufentanil for postoperative analgesia after upper abdominal surgery. Anesth Analg 66: S45
Duffy BL, Read MD (1984) Epidural pethidine for relief of episiotomy pain. Anaesth Intensive Care 12: 137 - 139
DuPen SL, Ramsey D, Chin S (1987) Chronic epidural morphine and preservative-induced injury. Anesthesiology 67: 987 - 988
Editorial (1980) Epidural opiates. Lancet 1: 962 - 963
Erickson DL, Lo J, Michaelson M (1984) Intrathecal morphine for treatment of pain due tomalignancy. Pain Suppl 2: S19
van Essen EJ, Bovill JG, Ploeger EJ, Beerman h (1988) Intrathecal morphine and clonidine for control of intractable cancer pain. A case report. Acta Anaesthesiol Belg 39: 109-112
Evron S, Samueloff A, Simon A, Drengler B, Magora F (1985) Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients. Pain 23: 135 - 144
Famewo CE, Naguib M (1985) Spinal anaesthesia with meperidine as the sole agent. Can Anaesth Soc J 32: 533 - 537
Feldstein GS, Waldmann SD, Allen ML (1987) Reversal of apparent tolerance to epidural morphine by epidural methylprednisolone. Anesth Analg 66: 264 - 266
Fischer RL, Lubenow TR, Liceaga A, McCarthy RJ, Ivankovich AD (1988) Comparison of continuous epidural infusion of fentanyl-bupivacaine and morphine-bupivacaine in management of postoperative pain. Anesth Analg 67: 559 - 563
Fitzpatrick GJ, Moriarty DC (1988) Intrathecal morphine in the management of pain following cardiac surgery. A comparison with morphine i.v. Br J Anaesth 60: 639-644
Glass PSA (1984) Respiratory depression following only 0.4 mg of intrathecal morphine. Anesthesiology 60: 256 - 257
Glynn CJ, McQuay HJ, Lloyd JW, Moore RA, Teddy CJ (1984) Intrathecal buprenorphine for the treatment of painful muscle spasms in paraplegic patients. Pain Suppl 2: S341
Gourlay GK, Cherry DA, Cousins MH (1985) Cephalad migration of morphine in CSF following lumbar epidural administration in patients with cancer pain. Pain 23: 317 - 326
Gourlay GK, Cherry DA, Plummer JL, Armstrong PJ, Cousins MJ (1987) The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine. Pain 31: 297 - 305
Gray JR, Fromme GA, Nauss LA, Wang JK, Ilstrup DM (1986) Intrathecal morphine for post-thoracotomy pain. Anesth Analg 65: 873 - 876
Gundersen RY, Andersen R, Narverud G (1986) Postoperative pain relief with high-dose epidural buprenorphine: a double-blind study. Acta Anaesthesiol Scand 30: 664 - 667
Gustafsson LL, Frieberg-Nielson S, Garle M, Mohall A, Rane A, Schildt B, Symreng T (1982) Extradural and parenteral morphine: kinetics and effects in postoperative pain. A controlled clinical study. Br J Anaesth 54: 1167-1174
Gustafsson LL, Schildt B, Jacobsen K (1982) Adverse effects of extradural and intrathecal opiates: report of a nationwide survey in Sweden. Br J Anaesth 54: 479 - 486
Henderson SK, Matthew EB, Cohen H, Avram MJ (1987) Epidural hydromorphone: a double-blind comparison with intramuscular hydromorphone for postcesarean section analgesia. Anesthesiology 66: 825 - 830
Hendrick P, Abou Hatem R, Nicaise C (1984) Implantable injection port for epidural opiates self-administration. Acta Anaesthesiol Belg 35 (Suppl): 279 - 284
Hill RG (1981) The status of naloxone in the identification of pain control mechanisms operated by endogenous opioids. Neuroscience Letters 21: 217 - 222
Houlton PG, Reynolds F (1981) Epidural diamorphine and fentanyl for postoperative pain. Anaesthesia 36: 1144 - 1147
Hughes SC, Rosen MA, Shnider SM, Abboud TK, Stefani SJ, Norton M (1984) Maternal and neonatal effects of epidural morphine for labor and delivery. Anesth Analg 63: 319 - 324
Hyde NH, Harrison DM (1986) Intrathecal morphine in a parturient with cystic fibrosis. Anesth Analg 65: 1357 - 1358
Inturrisi CE, Max MB, Foley KM, Schultz M, Shin SU, Houde RW (1984) The pharmacokinetics of heroin in patients with chronic pain. N Engl J Med 31: 1213 - 1217
Jamous MA, Hand CW, Moore RA, Teddy PJ, McQuay HJ (1986) Epinephrine reduces systemic absorption of extradural diacetylmorphine. Anesth Analg 65: 1290 - 1294
Jyu C, Lamb JD (1985) Respiratory depression following epidural morphine. Can Anaesth Soc J 32: 99 - 100
Kaiser KG, Bainton CR (1987) Treatment of intrathecal morphine overdose by aspiration of cerebrospinal fluid. Anesth Analg 66: 475 - 477
Kalia PK, Madan R, Saksena R, Batra RK, Gode GR (1983) Epidural pentazocine for postoperative pain relief. Anesth Analg 62: 949 - 950
Kalso E (1983) Effect of intrathecal morphine injected with bupivacaine on pain after orthopaedic surgery. Br J Anaesth 55: 415 - 422
Knape JTA (1986) Early respiratory depression resistant to naloxone following epidural buprenorphine. Anesthesiology 64: 382 - 384
Knill RL, Clement JL, Thompson WR (1981) Epidural morphine causes delayed and prolonged ventilatory depression. Can Anaesth Soc J 28: 537 - 543
Kotob HIM, Hand CW, Moore RA, Evans PJD, Wells J, Rubin AP, McQuay HJ (1986) Intrathecal morphine and heroin in man: six hour drug analysis in spinal fluid and plasma. Anesth Analg 65: 718 - 722
Krane EJ, Jacobson LE, Lynn AM, Parrot C, Tyler DC (1987) Caudal morphine for postoperative analgesia in children: a comparison with caudal bupivacaine and intravenous morphine. Anesth Analg 66: 647 - 653
Krane EJ (1988) Delayed respiratory depression in a child after caudal epidural morphine. Anesth Analg 67: 79 - 82
Krantz T, Christensen CB (1987) Respiratory depression after intrathecal opioids. Report of a patient receiving long-term epidural opioid therapy. Anaesthesia 42: 168170
Lanz E, Simon G, Theiss D, Glocke MH (1984) Epidural buprenorphine - a double blind study of postoperative analgesia and side effects. Anesth Analg 63: 593 - 598
Lipp M, Daubländer M, Lanz E (1987) Buprenorphin 0,15 mg intrathecal zur postoperativen Analgesia. Eine klinische Doppelblindstudie. Anaesthesist 36: 233-238
Lobato RD, Madrid JL, Fatela LV, Rivas JJ, Gozalo J, Barcena A (1984) Analgesia elicited by low-dose intraventricular morphine in terminal cancer patients. Pain Suppl 2: 5342
Lobato RD, Madrid JL, Fatela LV, Sarabia R, Rivas JJ, Gozalo A (1987) Intraventricular morphine for intractable cancer pain: rationale, methods, clinical results. Acta Anaesthesiol Scand 31 (Suppl 85): 68 - 74
Logas WG, El-Baz N, El-Ganzouri A, Cullen M, Staren E, Faber LP, Ivankovich AD (1987) Continuous thoracic epidural analgesia for postoperative pain relief following thoracotomy. Anesthesiology 67: 787 - 791
Lutze M, Kaden B, Weigel K, Brock M (1987) Intraventrikuläre Opiatapplikation mit implantierten Medikamentenpumpen. Dtsch Ärzteblatt 84: 1762 - 1768
Macrae DJ, Munishankrappa S, Burrow LM, Milne MK, Grant IS (1987) Double-blind comparison of the efficacy of extradural diamorphine, extradural phenoperidine and i.m. diamorphine following cesarean section. Br J Anaesth 59: 354 - 359
Malins AF, Goodman NW, Cooper GM, Prys-Roberts C, Baird RN (1984) Ventilatory effects of pre-and postoperative diamorphine. A comparison of extradural with intramuscular administration. Anaesthesia 39: 118-125
Martin R, Tetrault JP, Tetrault L, Lamarche Y, Veilleux LJ (1983) Epidural morphine in obstetrical analgesia: effect of epinephrine addition. Can Anaesth Soc J 30: 72
Mathews ET, Abrams LD (1980) Intrathecal morphine in open heart surgery. Lancet 1: 543
McQuay HJ, Bullingham RES, Evans PJD, Lloyd JW, Moore RA (1980) Demand analgesia to assess pain relief from epidural opiates. Lancet 1: 768 - 769
McQuay HJ, Bullingham RES, Moore RA (1981) Acute opiate tolerance in man. Life Sci 28: 2513 - 2517
Meier FA, Coombs DW, Saunders RL, Pageau MG (1982) Pathologic anatomy of constant morphine infusion by intraspinal silastic catheter. Anesthesiology 57: A206
Molke Jensen F, Jensen NH, Holk IK, Ravnborg M (1987) Prolonged and biphasic respiratory depression following epidural buprenorphine. Anaesthesia 42: 470 - 475
Moore RA, Bullingham RES, McQuay HJ, Hand CW, Aspel JB, Allen MC, Thomas D (1982) Dural permeability to narcotics: in vitro determination and application to extradural administration. Br J Anaesth 54: 1117 - 1128
Moore RA, Bullingham RES, McQuay HJ, Allen MC, Cole A (1984) Spinal fluid kinetics of morphine and heroin. Clin Pharmacol Therap 35: 40 - 45
Moulin D, Max M, Kaiko R, Inturrisi C, Maggard J, Foley K (1984) The analgesic efficacy of intrathecal D-Ala2-D-Leu5 Enkephalin ( DADL) in cancer patients with chronic pain. Pain Suppl 2: 5343
Moulin DE, Inturrisi CE, Foley KM (1986) Epidural and intrathecal opioids: cerebrospinal fluid and plasma pharmacokinetics in cancer pain patient. Adv Pain Res Ther 8: 369 - 383
Müller H, Gips H, Krumholz W, Zierski J, Lüben U, Hempelmann G (1986) Pharmakokinetik der kontinuierlichen periduralen Morphininfusion. Anaesthesist 35: 672 - 678
Niv D, Rudick V, Golan A, Chayen MS (1986) Augmentation of bupivacaine analgesia in labor by epidural morphine. Obstet Gynecol 67: 206 - 209
Nordberg G (1984) Pharmacokinetic aspects of spinal morphine analgesia. Acta Anaesthesiol Scand 28 (Suppl 79): 1 - 39
Nordberg G, Hedner T, Mellstrand T, Dahlstrom B (1984) Pharmacokinetic aspects of intrathecal morphine analgesia. Anesthesiology 60: 448 - 454
Nordberg G, Mellstand T, Borg L, Hedner T (1986) Extradural morphine: influence of adrenaline admixture. Br J Anaesth 58: 598 - 604
Nurchi G (1984) Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. Neurosurgery 15: 801 - 803
Obbens EAMT, Hill CS, Leavens ME, Ruthenbeck SS, Otis F (1987) Intraventricular morphine administration for control of chronic cancer pain. Pain 28: 61 - 68
Oyama T, Murakawa T, Baba S, Nagao h (1987) Continuous vs. bolus epidural morphine. Acta Anaesthesiol Scand 31 (Suppl 85): 77 - 79
Pasqualucci V, Tantucci C, Paoletti F, Dottorini ML, Bifarini G, Belfiori R, Berioli MB, Sorbini CA (1987) Buprenorphine vs. morphine via the epidural route: a controlled comparative clinical study of respiratory effects and analgesic activity. Pain 29: 273 - 286
Paterson GMC, McQuay HJ, Bullingham RES, Moore RA (1984) Intradural morphine and diamorphine dose-response studies. Anaesthesia 39: 113 - 117
Paulus DA, Paul WL, Munson ES (1981) Neurologic depression after intrathecal morphine. Anesthesiology 54: 517 - 518
Payne R (1987) CSF distribution of opioids in animals and man. Acta Anaesthesiol Scand 31 (Suppl 85): 38 - 46
Perrot G, Muller A, Laugner B (1983) Surdosage accidentel en morphine intrarachidienne. Traitement par naloxone intravéneuse seule. Ann Fr Anesth Reanim 2: 412-414
Pert CB, Snyder SH (1973) Opiate receptor: demonstration in nervous tissue. Science 179: 1011 - 1014
Petry T, Cloez O, Pertek JP, Heck M, Auque J (1985) Dépression respiratoire après injection intrathécale de morphine: intert de la naloxone in situe. Ann Fr Anesth Reanim 4: 424 - 426
Phillips DM, Moore RA, Bullingham RES, Allen MC, Baldwin D, Fisher A, Lloyd JW, McQuay HJ (1984) Plasma morphine concentrations and clinical effects after thoracic morphine and diamorphine. Br J Anaesth 56: 829 - 836
Pybus A, Torda T, McQuay HJ, Moore RA (1984) Opiates and sexual function. Nature 310: 636
Rawal N, Mollefors K, Axelsson K, Lingardh G, Widman B (1983) An experimental study of urodynamic effects of epidural morphine and naloxone reversal. Anesth Analg 42: 641 - 647
Rawal N, Sjostrand UH (1986) Clinical application of epidural and intrathecal opioids for pain management. Int Anesthesiol Clin 24:43-57 •
Rawal N, Amer S, Gustafsson LL, Allvin R (1987) Present state of extradural and intrathecal opioid analgesia in Sweden. A nationwide follow-up survey. Br J Anaesth 59: 791-799
Rosseel PMJ, van den Broek WGM, Boer EC, Prakash O (1988) Epidural sufentanil for intra-and postoperative analgesia in thoracic surgery: a comparative study with intravenous sufentanil. Acta Anaesthesiol Scand 32: 193 - 198
Rutter DV, Skewes DG, Morgan M (1981) Extradural opioids for postoperative analgesia. A double-blind comparison of pethidine, fentanyl and morphine. Br J Anaesth 55: 915-920
Samuelsson H, Nordberg G, Hedner T, Lindqvist J (1987) CSF and plasma morphine concentrations in cancer patients during chronic morphine therapy and its relation to pain relief. Pain 30: 303 - 310
Scott PV, Bowen FE, Cartwright P, Rao BCM, Deeley D, Wotherspoon HG, Sumrein IMA (1980). Intrathecal morphine as sole analgesic during labour. Br Med J 281: 35 1355
Semple AJ, Macrae DJ, Munishankarappa S, Burrow LM, Milne MK, Grant IS (1988) Effects of the addition of adrenaline to extradural diamorphine analgesia after caesarean section. Br J Anaesth 60: 632 - 638
Shulman MS, Wakerlin G, Yamaguchi L, Brodsky JB (1987) Experience with epidural hydromorphone for post-thoracotomy pain relief. Anesth Analg 66: 1331 - 1333
Siegismund K, Beutner M, Fiedler C (1982) Postoperative Analgesie durch peridurale Piritramidapplikation. Zentralbl Gynaecol 104: 615 - 622
Simpson KH, Madej TH, McDowell HM, Macdonald R, Lyons G (1988) Comparison of extradural buprenorphine and extradural morphine after caesarean section. Br J Anaesth 60: 627 - 631
Sjöström S, Hartvig P, Persson P, Tamsen A (1987) Pharmacokinetics of epidural morphine and meperidine in humans. Anesthesiology 67: 877 - 888
Sjöström S, Tamsen A, Persson P, Hartvig P (1987) Pharmacokinetics of intrathecal morphine and meperidine in humans. Anesthesiology 67: 889 - 895
Stein C, Brechner T (1987) Epidural morphine tolerance: use of norepinephrine. Clin J Pain 2: 267 - 269
Sullivan SP, Cherry DA (1987) Pain from an invasive facial tumor relieved by lumbar epidural morphine. Anesth Analg 66: 777 - 779
Tamsen A, Sjöström S, Hartvig P (1986) The Uppsala experience of patient-controlled analgesia. Adv Pain Res Ther 8: 325 - 332
Torda TA, Pybus DA (1982) Comparison of four narcotic analgesics for extradural analgesia. Br J Anaesth 54: 291 - 295
Twycross RG, Lack SA (1983) Symptom Control in Far Advanced Cancer: Pain Relief. Pitman, London
Verborgh C, van der Auwera D, van Droogenbroek E, Camu F (1986) Epidural sufentanil for postsurgical pain relief. Eur J Anaesth 3: 313 - 320
Waldman SD, Feldstein GS, Allen ML, Turnage G (1986) Selection of patients for implantable intraspinal narcotic delivery systems. Anesth Analg 65: 883 - 885
Wang JK, Nauss LE, Thomas JE (1979) Pain relief by intrathecally applied morphine in man. Anesthesiology 50: 149 - 151
Wang JK (1985) Intrathecal morphine for intractable pain secondary to cancer of pelvic organs. Pain 21: 99 - 102
Watson J, Moore A, McQuay H, Teddy P, Baldwin D, Allen M, Bullingham R (1984) Plasma morphine concentrations and analgesic effects of lumbar extradural morphine and heroin. Anesth Analg 63: 629 - 634
Welchew EA, Thornton JA (1982) Continuous thoracic epidural fentanyl. Anaesthesia 37: 309 - 316
Wells DG, Davies G (1987) Profound central nervous system depression from epidural fentanyl for extracorporeal shock wave lithotrypsy. Anesthesiology 67: 991 - 992
Willer JC, Bergeret S, Gaudy JH (1985) Epidural morphine strongly depresses nociceptive flexion reflexes in patients with postoperative pain. Anesthesiology 63: 675680
Writer WDR, Hurtig JB, Evans D, Needs RE, Hope CE, Forrest JB (1985) Epidural morphine prophylaxis of postoperative pain: report of a double-blind multicentre study. Can Anaesth Soc J 32: 330 - 338
Wüst HJ, Bromage PR (1987) Delayed respiratory arrest after epidural hydromorphone. Anaesthesia 42: 404 - 406
Yaksh TL, Rudy TA (1976) Analgesia mediated by direct spinal action of narcotics. Science 192: 1357 - 1358
Yaksh TL (1981) Spinal opiate analgesia: characteristics and principles of action. Pain 11: 293 - 346
Yaksh TL (1983) Spinal narcotics. In: Bullingham R (ed) Opiate Analgesia. Clinics in Anesthesiology Vol 1. Saunders, London
Yaksh TL, Noueihed R (1985) The physiology and pharmacology of spinal opiates. Annu Rev Pharmacol Toxicol 25: 433 - 462
Yaksh TL, Onofrio BM (1987) Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 19 physicians. Pain 31: 211 - 223
Yeung JC, Rudy TA (1980) Sites of antinociceptive action of systemically injected morphine: involvement of supraspinal loci as revealed by intracerebroventricular injection of naloxone. J Pharmacol Exp Therap 215: 626 - 632
Zenz M, Schappler-Scheele B, Neuhans R, Piepenbrock S, Hilfrich J (1981) Long term peridural morphine analgesia in cancer pain. Lancet 1: 91
Zenz M (1984) Epidural opiates for the treatment of cancer pain. In: Zimmermann M, Drings P, Wagner G (eds) Pain in the Cancer Patient: Pathogenesis, Diagnosis and Therapy, Vol 89. Springer, Berlin Wien, S 107 - 115
Zinck B, Fritz KW (1982) Atemdepression nach epiduraler Opiat-Analgesie mit Buprenorphin-Hydrochlorid? Anaesth Intensivther Notfallmed 17: 345 - 347
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
McQuay, H.J., Moore, R.A., Lehmann, K.A. (1990). Rückenmarknahe Blockaden: Opiate. In: Lehmann, K.A. (eds) Der postoperative Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06539-6_21
Download citation
DOI: https://doi.org/10.1007/978-3-662-06539-6_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-06540-2
Online ISBN: 978-3-662-06539-6
eBook Packages: Springer Book Archive