Zusammenfassung
Lokalanästhetika sind Medikamente, deren Wirkungsmechanismus auf einer reversiblen Blockade elektrisch erregbarer Gewebe beruht. In der klinischen Anwendung zählen hierzu vornehmlich freie Nervenendigungen und Nervenfasern in der Körperperipherie bzw. im Rückenmark. Andere exzitable Strukturen im Herzen sowie im Gehirn werden natürlich ebenfalls beeinflußt; Lokalanästhetika werden deshalb auch als Antiarrhythmika bzw. Antikonvulsiva eingesetzt. Für die therapeutische Lokalanästhesie ist damit das Spektrum der wichtigsten Nebenwirkungen vorgezeichnet.
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Literatur
Albright GA (1979) Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 51: 285–287
Armitage EN (1986) Local anesthetic techniques for prevention of postoperative pain. Br J Anaesth 58: 790–800
Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 62: 396–405
Covino BG (1988) Toxicity of local anesthetic agents. Acta Anaesthesiol Belg 39 (Suppl 2): 159–164
Covino BG, Vassallo HG (1976) Local Anesthetics. Mechanisms of Action and Clinical Use. The Scientific Basis of Clinical Anesthesia, Grune and Stratton, New York
Greene NM (1983) Uptake and elimination of local anesthetics during spinal anesthesia. Anesth Analg 62: 1013–1024
Gribomont BF (1988) Sudden complications in regional anesthesia. Acta Anaesthesiol Belg 39 (Suppl 2): 165–170
Hille B (1977) Ionic channels of nerve: questions for the theoretical chemist. Biosystems 8: 195–199
Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug receptor reaction. J Gen Physiol 69: 497–515
Hondeghem LM, Katzung BG (1984) Antiarrhythmic agents: the modulated receptor mechanism of actions of sodium and calcium channel-blocking drugs. Annu Rev Pharmacol Toxicol 24: 387–423
Lehmann KA (1986) Pharmakokinetische und -dynamische Aspekte bei der repetitiven Anwendung von Lokalanaesthetika. In: Hempelmann G, Biscoping J (Hrsg) Kontinuierliche Verfahren der Regionalanästhesie. Astra Chemicals, S 7–26
Moore DC, Mather LE, Bridenbaugh LD, Thompson GE, Balfour RI Lysons DF, Horton WG (1977) Bupivacaine (Marcaine®): an evaluation of its tissue and systemic toxicity in humans. Acta Anaesthesiol Scand 21: 109–121
Moore DC, Bridenbaugh LD, Thompson GE, Balfour RI, Horton WG (1978) Bupivacaine: a review of 11,080 cases. Anesth Analg 57: 42–53
Nolte H (1986) Zur Problematik der Cardiotoxizität von Bupivacain 0,75%. Reg Anaesth 9: 57–59
Park WY (1988) Factors influencing distribution of local anesthetics in the epidural space. Regional Anesthesia 13: 49–57
Strichartz G (1976) Molecular mechanisms of nerve block by local anaesthetics. Anesthesiology 45: 421–442
Tucker GT, Mather LE (1979) Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 4: 241–278
Widman B (1975) Plasma concentrations of local anaesthetic agents in regard to absorption, distribution and elimination, with special reference to bupivacaine. Br J Anaesth 47: 231–236
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© 1990 Springer-Verlag Berlin Heidelberg
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Lehmann, K.A. (1990). Lokalanästhetika: Allgemeine Pharmakologie. In: Lehmann, K.A. (eds) Der postoperative Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06539-6_17
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DOI: https://doi.org/10.1007/978-3-662-06539-6_17
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