Skip to main content
SpringerLink
Log in

On-demand-Analgesie

  • Chapter
Der postoperative Schmerz

Zusammenfassung

Viele Gründe lassen sich anführen, warum der postoperative Schmerz in aller Regel nicht adäquat angegangen wird: Zeitüberlastung der behandelnden Ärzte, die dem Pflegepersonal den Vollzug der analgetischen Therapie übertragen (müssen), daher zwangsläufig starre intramuskuläre Dosierungsanweisungen ohne Anpassung des Präparats und des Applikationsmusters an die individuellen Bedürfnisse des Patienten oder Angst vor Nebenwirkungen bzw. der Entwicklung von Abhängigkeit [82, 101, 144, 150]. Die meist fehlende Rückkopplung, die bei allen ärztlichen Maßnahmen zur Erfolgskontrolle unerläßlich ist, die kritiklose Übernahme tradierter Behandlungskonzepte und die Gewißheit, daß akute Schmerzen schließlich von selbst abklingen — all dies trägt dazu bei, die Probleme der postoperativen Analgesie zu verharmlosen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Atwell JR, Flanigan RC, Bennett RL, Allen DC, Lucas BA, McRoberts JW (1984) The efficacy of patient-controlled analgesia in patients recovering from flank incisions. J Urol 132: 701–703

    PubMed  CAS  Google Scholar 

  2. Austin KL, Stapleton JV, Mather LE (1980) Multiple intramuscular injections: a major source of variability in analgesic response to meperidine. Pain 8: 47–62

    Article  PubMed  CAS  Google Scholar 

  3. Austin KL, Stapleton JV, Mather LE (1980) Relationship between blood meperidine concentrations and analgesic response: a preliminary report. Anesthesiology 53: 460466

    Google Scholar 

  4. Bahar M, Rosen M, Vickers MD (1985) Self-administered nalbuphine, morphine and pethidine. Comparison, by intravenous route, following cholecystectomy. Anaesthesia 40: 529–532

    Google Scholar 

  5. Barrier G, Harmer M (1985) Patient-controlled analgesia in obstetrics. In: Harmer M, Rosen M, Vickers MD (eds) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford, pp 170–179

    Google Scholar 

  6. Bates CP, McEwen JA, Leighton KM (1987) Modification of IVAC 530 infusion pump for patient controlled analgesia. Can J Anaesth 34: 200–202

    Article  PubMed  CAS  Google Scholar 

  7. Bennett RL, Batenhorst RL, Graves D, Foster TS, Baumann T, Griffen WO, Wright BD (1982) Morphine titration in postoperative laparatomy patients using patient-controlled analgesia. Curr Ther Res 32: 45–52

    Google Scholar 

  8. Bennett RL, Batenhorst RL, Bivins BA, Bell RM, Baumann T, Graves DA, Foster TS, Griffen WO, Wright BD (1982) Drug use pattern in patient-controlled analgesia. Anesthesiology 57: A210

    Article  Google Scholar 

  9. Bennett RL, Batenhorst RL, Bivins BA, Bell RM, Graves D, Foster TS, Wright BD, Griffen WO (1982) Patient-controlled analgesia. A new concept of postoperative pain relief. Ann Surg 195: 700–705

    Google Scholar 

  10. Bennett RL (1985) Patient-controlled analgesia for the treatment of the pain of terminal cancer: description of an initial clinical experience. In: Harmer M, Rosen M, Vickers MD (eds) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford, pp 160–169

    Google Scholar 

  11. Bennett RL (1987) External versus implantable devices for chronic narcotic infusion therapy. Anesth Analg 66: 369

    PubMed  CAS  Google Scholar 

  12. Bennett R, Batenhorst RL, Foster TS, Griffen WO, Wright BD (1982) Postoperative pulmonary function with patient-controlled analgesia. Anesth Analg 61: 171

    Google Scholar 

  13. Bennett R, Batenhorst R, Graves DA, Foster TS, Griffen WO, Wright BD (1982) Variation in postoperative analgesic requirements in the morbidly obese following gastric bypass surgery. Pharmacotherapy 2: 50–53

    PubMed  CAS  Google Scholar 

  14. Bennett RL, Griffen WD (1983) Patient-controlled analgesia (PCA): optimization of in-hospital narcotic analgesia therapy. Contemp Surg 23: 75–89

    Google Scholar 

  15. Bennett RL, Griffen WO (1984) Effect of patient-controlled analgesia on nocturnal sleep and spontaneous activity following laparatomy. Anesthesiology 61: A205

    Article  Google Scholar 

  16. v. Bormann B, Boldt J, Sturm G, Kling D, Weidler B, Lohmann E, Hempelmann G (1985) Calciumantagonisten in der Anaesthesie. Additive Analgesie durch Nimodipin während cardiochirurgischer Eingriffe. Anaesthesist 34: 429–434

    Google Scholar 

  17. Bromage PR, Camporesi E, Chestnut D (1980) Epidural narcotics for postoperative analgesia. Anesth Analg 59: 473–480

    Article  PubMed  CAS  Google Scholar 

  18. Brown RE, Broadman LM (1987) Patient-controlled analgesia ( PCA) for postoperative pain control in adolescents. Anesth Analg 66: S22

    Google Scholar 

  19. Bullingham RES, McQuay HJ, Dwyer D, Allen MC, Moore RA (1981) Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis. Br J Clin Pharmacol 12: 117–122

    Article  PubMed  CAS  Google Scholar 

  20. Bullingham RES, O’Sullivan G, McQuay HJ, Poppleton P, Rolfe M, Weir L, Moore A (1984) Mandatory sublingual buprenorphine for postoperative pain. Anaesthesia 39: 329–334

    Article  PubMed  CAS  Google Scholar 

  21. Bullingham RES, Jacobs OLR, McQuay HJ, Moore RA (1986) The Oxford system of patient-controlled analgesia. Adv Pain Res Ther 8: 319–324

    Google Scholar 

  22. Carl P, Crawford ME, Madsen NBB, Ravlo O, Bach V, Larsen AI (1987) Pain relief after major abdominal surgery: a double-blind controlled comparison of sublingual buprenorphine, intramuscular buprenorphine, and intramuscular meperidine. Anesth Analg 66: 142–146

    Article  PubMed  CAS  Google Scholar 

  23. Cartwright PD (1985) Pain control after surgery: a survey of current practice. Ann R Coll Surg Engl 67: 13–16

    PubMed  CAS  Google Scholar 

  24. Chakravarty K, Tucker W, Rosen M, Vickers MD (1979) Comparison of buprenorphine and pethidine given intravenously on demand to relieve postoperative pain. Br Med J 2: 895–897

    Article  PubMed  CAS  Google Scholar 

  25. Chrubasik J (1984) Epidural, on-demand, low-dose morphine infusion for postoperative pain. Lancet 1: 107–108

    Article  PubMed  CAS  Google Scholar 

  26. Chrubasik J (1984) Individuelle postoperative Schmerzbehandlung durch kleine, extern tragbare, programmierbare Morphinpumpe. Anaesth Intensivther Notfallmed 19: 30–33

    Article  CAS  Google Scholar 

  27. Chrubasik J, Vogel W, Friedrich G (1984) Morphinkonzentrationen im Serum unter bedarfsgesteuerter periduraler Morphininfusion. Anaesth Intensivther Notfallmed 19: 231–234

    Article  CAS  Google Scholar 

  28. Chrubasik J, Wiemers K (1985) Continuous-plus-on-demand epidural infusion of morphine for postoperative pain relief by means of a small, externally worn infusion device. Anesthesiology 62: 263–267

    Article  PubMed  CAS  Google Scholar 

  29. Dahlström B, Tamsen A, Paalzow L, Hartvig P (1982) Patient-controlled analgesic therapy, part IV: pharmacokinetics and analgesic plasma concentrations of morphine. Clin Pharmacokinet 7: 266–279

    Article  PubMed  Google Scholar 

  30. Dick W (1984) Zentrale patientengesteuerte postoperative Analgesie. In: Bergmann H, Bischko J, Gerstenbrand F, Klinger D, Steinbereithner K, Tilscher h (Hrsg) Moderne Schmerzbehandlung. Beiträge zur Anaesthesiologie and Intensivmedizin 7: 140–148

    Google Scholar 

  31. Eimerl D, Magora F, Shir Y, Chrubasik J (1986) Patient-controlled analgesia with epidural methadone by means of an external infusion pump. Schmerz-Pain-Douleur 7: 156–160

    Google Scholar 

  32. Ellis R, Haines D, Shah R, Cotton BR, Smith G (1982) Pain relief after abdominal surgery - a comparison of i.m. morphine, sublingual buprenorphine and self-administered i.v. pethidine. Br J Anaesth 54: 421–428

    Article  PubMed  CAS  Google Scholar 

  33. Evans JM, David H, Rosen M, Revill S, Robinson J, McCarthy J, Hogg MIJ (1976) Patient activated intravenous narcotic. Anaesthesia 31: 847–848

    Article  Google Scholar 

  34. Evans JM, Rosen M, MacCarthy J, Hogg MIJ (1976) Apparatus for patient controlled administration of intravenous narcotics during labour. Lancet 1: 17–18

    Article  PubMed  CAS  Google Scholar 

  35. Forrest WH (1968) Treatment of postoperative pain. Modern Treatment 5–6; Harper, and Row, New York 1968: 1154–1163

    Google Scholar 

  36. Forrest WH, Smethurst PWR, Kienitz ME (1970) Self-administration of intravenous analgesics. Anesthesiology 33: 363–365

    Article  PubMed  Google Scholar 

  37. Gibbs JM, Johnson HD, Davis FM (1982) Patient administration of i.v. buprenorphine for postoperative pain relief using the „Cardiff“ demand analgesia computer. Br J Anaesth 54: 279–284

    Article  PubMed  CAS  Google Scholar 

  38. Glavin RJ, Owen h (1986) Effect of a non-steroidal antiinflammatory drug ( NSAID) on postoperative pain. Br J Anaesth 58: 813P

    Google Scholar 

  39. Gourlay GK, Willis RJ, Wilson PR (1984) Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration-response relationships. Anesthesiology 61: 19–26

    PubMed  CAS  Google Scholar 

  40. Graves DA, Batenhorst RL, Bennett RL, Wettstein JG, Griffen WO, Wright BD, Foster TS (1983) Morphine requirements using patient-controlled analgesia: influence of diurnal variation and morbid obesity. Clin Pharm 2: 49–53

    PubMed  CAS  Google Scholar 

  41. Graves DA, Foster TS, Batenhorst RL, Bennett RL, Baumann TJ (1983) Patient-controlled analgesia. Ann Intern Med 99: 360–66

    Article  PubMed  CAS  Google Scholar 

  42. Hackl W, Fitzal S, Lackner F, Weindlmayr-Goettel M (1986) Vergleich von Fentanyl and Tramadol zur Schmerzbehandlung mittels On-Demand-Analgesia-Computer in der frühen postoperativen Phase. Anaesthesist 35: 665–671

    PubMed  CAS  Google Scholar 

  43. Harmer M, Slattery Pi, Rosen M, Vickers MD (1983) Intramuscular on demand analgesia: double blind controlled trial of pethidine, buprenorphine, morphine, and meptazinol. Br Med J 286: 680–682

    Article  CAS  Google Scholar 

  44. Harmer M, Slattery PJ, Rosen M, Vickers MD (1983) Comparison between buprenorphine and pentazocine given i.v. on demand in the control of postoperative pain. Br J Anaesth 55: 21–25

    Article  PubMed  CAS  Google Scholar 

  45. Harmer M, Rosen M, Vickers MD (eds) (1985) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford

    Google Scholar 

  46. Harper NJN, Thomson J, Brayshaw SA (1983) Experience with self-administered pethidine with special reference to the general practitioner obstetric unit. Anaesthesia 38: 52–55

    Article  PubMed  CAS  Google Scholar 

  47. Hendrick P, Abou Hatem R, Nicaise C (1984) Implantable injection port for epidural opiates self-administration. Acta Anaesthesiol Belg 32 (Suppl): 279–284

    Google Scholar 

  48. Hodsman N, Gillies GWA, Kenny GNC (1987) PCA and a speech-synthesizer. Br J Anaesth 59: 126 P

    Google Scholar 

  49. Hoffmeister F, Tettenbom D (1986) Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-p-receptor agonists and neuropharmacological actions in rodents. Psychopharmacology 90: 299–307

    PubMed  CAS  Google Scholar 

  50. Hogg MIJ, Rosen M (1985) Self-administered analgesia - pharmacokinetic limitations. In: Stoeckel H (ed) Quantitation, Modelling and Control in Anaesthesia. Thieme, Stuttgart, pp 291–301

    Google Scholar 

  51. Hull JH (1981) Fentanyl - applications of pharmacokinetics. In: Anaesthesiology, Excerpta Medica, pp 700–702

    Google Scholar 

  52. Hull CJ (1982) Postoperative buprenorphine. Br J Anaesth 54: 1144

    Article  Google Scholar 

  53. Hull CJ (1985) The pharmacokinetics of opioid analgesics, with special reference to patient-controlled analgesia. In: Harmer M, Rosen M, Vickers MD (eds) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford, pp 7–17

    Google Scholar 

  54. Hull CJ, Sibbald A, Johnson MK (1979) Demand analgesia for postoperative pain. Br J Anaesth 51: 570–571

    Article  Google Scholar 

  55. Hull CJ, Sibbald A (1981) Control of postoperative pain by interactive demand analgesia. Br J Anaesth 53: 385–391

    Article  PubMed  CAS  Google Scholar 

  56. Jacobs OLR, Bullingham RES, Lammer P, McQuay HJ, O’Sullivan G, Reasbeck MP (1985) Modelling estimation and control in the relief of post-operative pain. Automatica 21: 349–360

    Article  Google Scholar 

  57. Jones RM, Cashman JN, Foster JMG, Wedley JR, Adams AP (1985) Comparison of infusions of morphine and lysine acetyl salicylate for the relief of pain following thoracic surgery. Br J Anaesth 57: 259–263

    Article  PubMed  CAS  Google Scholar 

  58. Judkins KC, Harmer M (1982) Haloperidol as an adjunct analgesic in the management of postoperative pain. Anaesthesia 37: 1118–1120

    Article  PubMed  CAS  Google Scholar 

  59. Kay B (1981) Postoperative pain relief. Use of an on-demand analgesia computer (ODAC) and a comparison of the rate of use of fentanyl and alfentanyl. Anaesthesia 36: 949–951

    Article  PubMed  CAS  Google Scholar 

  60. Kay B (1983) On-demand nalbuphine for post-operative pain. Anaesthesist 32 (Suppl): 366–367

    Google Scholar 

  61. Kay B (1984) Patient-controlled analgesia. Can Anaesth Soc J 31: 120–121

    Article  Google Scholar 

  62. Kay B (1985) Relative potency of agonist and partial antagonist opioids. Br J Anaesth 57: 719–720

    Article  PubMed  CAS  Google Scholar 

  63. Kay B (1985) Narcotic analgesia - ceiling effect. Anesthesiology 62: 371–372

    Article  PubMed  CAS  Google Scholar 

  64. Kay B, Krishnan A (1986) On-demand nalbuphine for post-operative pain relief. Acta Anaesthesiol Belg 37: 33–37

    PubMed  CAS  Google Scholar 

  65. Keeri-Szanto M (1971) Apparatus for demand analgesia. Can Anesth Soc J 18: 581

    Article  CAS  Google Scholar 

  66. Keeri-Szanto M (1976) Demand analgesia for the relief of pain problems in „terminal“ illness. Anesthesiology Review 3: 19–21

    Google Scholar 

  67. Keeri-Szanto M (1979) Drugs or drums: what relieves postoperative pain? Pain 6: 217230

    Google Scholar 

  68. Keeri-Szanto M (1980) Demand analgesia. In: Aldrete JA, Stanley TH (eds) Trends in Intravenous Anesthesia. Symposia Specialists, Miami, p 417

    Google Scholar 

  69. Keeri-Szanto M (1980) The kinetics of postoperative analgesia. Clin Pharmacol Ther 27: 263

    Google Scholar 

  70. Keeri-Szanto M (1983) Demand analgesia. Br J Anaesth 55: 919–920

    Article  PubMed  CAS  Google Scholar 

  71. Keeri-Szanto M (1984) Patient-controlled analgesia. Can Anaesth Soc J 31: 121–122

    Article  Google Scholar 

  72. Keeri-Szanto M, Heaman S (1972) Postoperative demand analgesia. Surg Gynecol Obstet 134: 647–651

    PubMed  CAS  Google Scholar 

  73. Lehmann KA (1983) „On-Demand“-Analgesie. Ein neuer Ansatz zur Optimierung der Schmerztherapie. Dtsch Med Wochenschr 108:647–650

    Google Scholar 

  74. Lehmann KA (1984) On-Demand Analgesie: Neue Möglichkeiten zur Behandlung akuter Schmerzen. Arzneim Forsch 34: 1108–1114

    CAS  Google Scholar 

  75. Lehmann KA (1985) Autoregulation de l’analgésie postopératoire. Cahiers d’Anesthésiologie 33: 119–123

    CAS  Google Scholar 

  76. Lehmann KA (1985) Discussion. In: Harmer M, Rosen M, Vickers MD (eds) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford, pp 18–29

    Google Scholar 

  77. Lehmann KA (1985) Practical Experience with demand analgesia for postoperative pain. In: Harmer M, Rosen M, Vickers MD (eds) Patient-Controlled Analgesia. Blackwell Scientific Publications, Oxford, pp 134–139

    Google Scholar 

  78. Lehmann K (1985) Relative Wirkstärke von Alfentanil bei postoperativer On-Demand Zufuhr. In: Zindler M, Hartung E (Hrsg) Alfentanil. Ein neues, ultrakurzwirkendes Opioid. Urban, and Schwarzenberg, München, S 33–37

    Google Scholar 

  79. Lehmann KA (1985) Pharmakologie intravenöser Analgetika. In: Just OH, Wiedemann K (Hrsg) Die anästhesiologische Poliklinik. Anästhesieambulanz -Ambulanznarkose - Schmerzambulanz. Thieme, Stuttgart, S 64–75

    Google Scholar 

  80. Lehmann KA (1985) Opioid-Plasmakonzentrationen und pharmakodynamische Wirkung. Untersuchungen mit Fentanyl. Fortschr Med 103: 938–942

    PubMed  CAS  Google Scholar 

  81. Lehmann KA (1986) Pharmakokinetik: gibt es analgetische Blutkonzentrationen? In: Kettler D, Croizier T, Metzler h (Hrsg) Analgesie in der Anästhesie. Urban, and Schwarzenberg, München, S 28–39

    Google Scholar 

  82. Lehmann KA (1987) Pharmakotherapie des akuten Schmerzes. Arzneimitteltherapie 5: 46–55

    Google Scholar 

  83. Lehmann KA, Daub D (1982) Kinetik der Dynamik — Plädoyer für eine Synthese. Anästh Intensivmed 23: 393–402

    Google Scholar 

  84. Lehmann KA, Daub D (1983) Fentanyl-Pharmakokinetik und Analgesie. Anaesthesist 32: 454–458

    Google Scholar 

  85. Lehmann KA, Rehme U, Dworzak h (1984) On-Demand Analgesie mit Tramadol bei doppelseitiger Rippenserienfraktur. Ein Fallbericht. Dtsch Med Wochenschr 109: 14491450

    Google Scholar 

  86. Lehmann KA, Gördes B, Hoeckle W (1985) Postoperative On-Demand Analgesie mit Morphin. Anaesthesist 34: 494–501

    PubMed  CAS  Google Scholar 

  87. Lehmann KA, Jung C, Hoeckle W (1985) Tramadol und Pethidin zur postoperativen Schmerztherapie: Eine randomisierte Doppelblindstudie unter den Bedingungen der intravenösen On-Demand Analgesie. Schmerz-Pain-Douleur 6: 88–100

    Google Scholar 

  88. Lehmann KA, van Heihs R, Gördes B, Reichling U, Ribbert N (1985) Postoperative On-Demand Analgesie mit Alfentanil, Buprenorphin und Fentanyl: Plasmakonzentrationen und Effektivität. Anaesthesist 34 (Suppl): 121

    Google Scholar 

  89. Lehmann KA, Tenbuhs B, Hoeckle W (1985) Postoperative On-Demand Analgesie mit Pentazocin ( Fortral ). Langenbecks Arch Chir 367: 27–40

    Google Scholar 

  90. Lehmann KA, Brand-Stavroulaki A, Dworzak h (1986) The influence of demand and loading dose on the efficacy of postoperative patient-controlled analgesia with tramadol. A randomized double-blind study. Schmerz-Pain-Douleur 7: 146–152

    Google Scholar 

  91. Lehmann KA, Tenbuhs B (1986) Patient-controlled analgesia with nalbuphine, a new narcotic agonist-antagonist, for the treatment of postoperative pain. Eur J Clin Pharmacol 31: 267–276

    Article  PubMed  CAS  Google Scholar 

  92. Lehmann KA, Tenbuhs B, Hoeckle W (1986) Patient-controlled analgesia with piritramid for the treatment of postoperative pain. Acta Anaesthesiol Belg 37: 247–257

    PubMed  CAS  Google Scholar 

  93. Lehmann KA, Henn C (1987) Zur Lage der postoperativen Schmerztherapie in der Bundesrepublik Deutschland. Ergebnisse einer Repräsentativumfrage. Anaesthesist 36: 400–406

    Google Scholar 

  94. Lehmann KA, Mehler 0 (1987) Postoperative On-Demand Analgesie mit Fentanyl unter Verwendung des Infusionssystems CODIC®: erste klinische Erfahrungen. Anaesthesist 36: 595–598

    CAS  Google Scholar 

  95. Lehmann KA, Gördes B (1988) Postoperative On-Demand Analgesie mit Buprenorphin. Anaesthesist 37: 65–70

    PubMed  CAS  Google Scholar 

  96. Lehmann KA, Heinrich C, van Heiss R (1988) Balanced anaesthesia and patient-controlled postoperative analgesia with fentanyl: minimum effective concentrations, accumulation and acute tolerance. Acta Anaesthesiol Belg 39: 11–23

    PubMed  CAS  Google Scholar 

  97. Lehmann KA, Reichling U, Wirtz R (1988) Influence of naloxone on the postoperative analgesic and respiratory effects of buprenorphine. Eur J Clin Pharmacol 34: 343–352

    Article  PubMed  CAS  Google Scholar 

  98. Lehmann KA, Kriegel R, Eueki M (1989) Zur klinischen Bedeutung von Arzneimittelinteraktionen zwischen Opiaten und Kalziumantagonisten. Eine randomisierte Doppelblindstudie mit Fentanyl und Nimodipin im Rahmen der postoperativen intravenösen On-Demand Analgesie. Anaesthesist 38: 110–115

    Google Scholar 

  99. Lehmann KA, Schlüsener M, Arabatsis P (1989) Failure of proglumide, a cholecystokinin antagonist, to potentiate clinical morphine analgesia. A randomized double-blind postoperative study using patient-controlled analgesia ( PCA ). Anesth Analg 68: 51–56

    Google Scholar 

  100. Lehmann KA, Abu-Shibika M, Horrichs-Haermeyer G (1990) Postoperative Schmerztherapie mit 1–Methadon und Metamizol. Eine randomisierte Untersuchung im Rahmen der intravenösen On-Demand Analgesie. Anaesth Intensivther Notfallmed 25: 152–159

    Google Scholar 

  101. Marks RM, Sachar EJ (1973) Undertreatment of medical inpatients with narcotic analgesics. Ann Int Med 78: 173–181

    Article  PubMed  CAS  Google Scholar 

  102. Masson AHB (1971) The role of analgesic drugs in the treatment of postoperative pain. Br J Anaesth 39: 713–720

    Article  Google Scholar 

  103. Mather LE (1983) Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet 8: 422–426

    Article  PubMed  CAS  Google Scholar 

  104. Mather LE (1983) Pharmacokinetic and pharmacodynamic factors influencing the choice, dose and route of administration of opiates for acute pain. In: Bullingham RES (ed) Opiate Analgesia. Saunders, London, pp 17–40

    Google Scholar 

  105. Mather L, Mackie J (1983) The incidence of postoperative pain in children. Pain 15: 271282

    Google Scholar 

  106. McCarthy JP, Evans JM, Hogg MIJ, Rosen M (1976) Patient controlled administration of intravenous analgesics. Proceedings of Institute of Electronic and Radio Engineers, Southhampton, 1976: 273–283

    Google Scholar 

  107. McQuay HJ, Bullingham RES, Evans PJD, Lloyd JW, Moore RA (1980) Demand analgesia to assess pain relief from epidural opiates. Lancet 1: 768–769

    Article  PubMed  CAS  Google Scholar 

  108. McQuay HJ, Bullingham RES, Moore A (1981) Acute opiate tolerance in man. Life Sci 28: 2513–2517

    Article  PubMed  CAS  Google Scholar 

  109. Owen H, Glavin RJ, Shaw NA (1986) Ibuprofen in the management of postoperative pain. Br J Anaesth 58: 1371–1375

    Article  PubMed  CAS  Google Scholar 

  110. Parkhouse J, Lainbrechts W, Simpson BRJ (1961) The incidence of postoperative pain. Br J Anaesth 33: 345–353

    Article  PubMed  CAS  Google Scholar 

  111. Peeters M, Brugmans J (1980) Postoperative pain relief by demand analgesia. Acta Anaesthesiol Belg 31 (Suppl): 233–237

    PubMed  Google Scholar 

  112. Perry S, Heidrich G (1982) Management of pain during debridement: a survey of U.S. burn units. Pain 13: 267–280

    Article  PubMed  CAS  Google Scholar 

  113. Phillips DM, Moore RA, Bullingham RES, Allen MC, Baldwin D, Fisher A, Lloyd JW, McQuay HJ (1984) Plasma morphine concentrations and clinical effects after thoracic extradural morphine or diamorphine. Br J Anaesth 56: 829–836

    Article  PubMed  CAS  Google Scholar 

  114. Porter EBJ, McQuay HJ, Bullingham RES, Weir L, Allen MC, Moore RA (1983) Comparison of effects of intraoperative and postoperative methadone: acute tolerance to the postoperative dose? Br J Anaesth 55: 325–332

    Article  PubMed  CAS  Google Scholar 

  115. Price DD, von der Gruen A, Miller J, Rafii A, Price C (1985) Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist. Anesth Analg 64: 801–806

    Article  PubMed  CAS  Google Scholar 

  116. Purves PG, Sperring SJ, Dykes V, Stanley TD (1987) Improved postoperative analgesia: epidural vs patient controlled intravenous morphine. Anesth Analg 66: S143

    Article  Google Scholar 

  117. Robinson JO, Rosen M, Evans JM, Revill SI, David H, Rees GAD (1980) Self-administered intravenous and intramuscular pethidine. A controlled trial in labour. Anaesthesia 35: 763–770

    Google Scholar 

  118. Rosen M (1977) The measurement of pain. In: Harcus AW, Smith R, Whittle B (eds) Pain: New Perspectives in Measurement and Management. Churchill Livingstone, London, pp 13–20

    Google Scholar 

  119. Rosen M, Vickers MD (1979) Relief of postoperative pain. Br Med J 1: 1278–1279

    Article  PubMed  CAS  Google Scholar 

  120. Rosen M, Slattery PJ (1983) On demand analgesia. Anaesthesia 38: 599

    Google Scholar 

  121. Rosen M, Slattery P, Vickers MD (1983) Cardiff palliator. Br J Anaesth 55: 922

    Article  PubMed  CAS  Google Scholar 

  122. Rosenberg PH, Heino A, Scheinin B (1984) Comparison of intramuscular analgesia, intercostal block, epidural morphine and on-demand-i.v.-fentanyl in the control of pain after upper abdominal surgery. Acta Anaesthesiol Scand 28: 603–607

    Article  PubMed  CAS  Google Scholar 

  123. Säwe J, Hansen J, Ginman C, Hartvig P, Jakobsson PA, Nilsson MI, Rane A, Änggard E (1981) Patient-controlled dose regimen of methadone for chronic cancer pain. Br Med J 282: 771–773

    Article  Google Scholar 

  124. Scott JS (1970) Obstetric analgesia. A consideration of labour pain and a patient-controlled technique for its relief with meperidine. Am J Obstet Gynecol 106: 959–978

    PubMed  CAS  Google Scholar 

  125. Sechzer PH (1968) Objective measurement of pain. Exerpta Medica 1970: 941–950

    Google Scholar 

  126. Sechzer PH (1968) Objective measurement of pain. Anesthesiology 29: 209–210

    Article  Google Scholar 

  127. Sechzer PH (1971) Studies in pain with the analgesic-demand system. Anesth Analg 50: 1–10

    Article  PubMed  CAS  Google Scholar 

  128. Serrao J, Rosen M (1986) Postoperative patient-controlled analgesia (PCA): a method of comparing intermittent demands with and without background infusion. Br J Anaesth 58: 812P - 813 P

    Google Scholar 

  129. Shah MV, Jones DI, Rosen M (1986) „Patient-demand“ postoperative analgesia with buprenorphine. Comparison between sublingual and i.m. administration. Br J Anaesth 58: 508–511

    Google Scholar 

  130. Slattery PJ, Harmer M, Rosen M, Vickers MD (1981) Comparison of meptazinol and pethidine given i.v. on demand in the management of postoperative pain. Br J Anaesth 53: 927–931

    Article  PubMed  CAS  Google Scholar 

  131. Slowey HF, Reynolds AD, Mapleson WW, Vickers MD (1985) Effect of premedication with controlled-release oral morphine on postoperative pain. A comparison with intramuscular morphine. Anaesthesia 40: 438–440

    Google Scholar 

  132. Sprigge JS, Otton PE (1983) Nalbuphine versus meperidine for postoperative analgesia: a double-blind comparison using the patient controlled analgesic technique. Can Anaesth Soc J 30: 517–521

    Article  PubMed  CAS  Google Scholar 

  133. Stoffregen J (1985) „CODIC“-gesteuerte Infusionsprofile in der Kombinationsnarkose und zur On-Demand Analgesia — klinische Erfahrungen nach zweieinhalb Jahren. Anaesthesist 34 (Suppl): 168

    Google Scholar 

  134. Stoffregen J (1985) Das therapeutische System CODIC®. Anaesth Intensivther Notfallmed 20: 210–212

    Article  CAS  Google Scholar 

  135. Tamsen A (1985) Facteurs affectant l’analgésie. L’autoadministration d’analgésiques. Cahiers d’Anesthésiologie 33: 115–118

    CAS  Google Scholar 

  136. Tamsen A, Hartvig P, Dahlström B, Linderström B, Holmdahl MH (1979) Patient controlled analgesic therapy in the early postoperative period. Acta Anaesthesiol Scand 23: 462–470

    Article  PubMed  CAS  Google Scholar 

  137. Tamsen A, Bondesson U, Dahlström B, Hartvig P (1982) Patient-controlled analgesic therapy, part III: pharmacokinetics and analgesic plasma concentrations of ketobemidone. Clin Pharmacokinet 7: 252–265

    Article  PubMed  CAS  Google Scholar 

  138. Tamsen A, Hartvig P, Fagerlund C, Dahlström B (1982) Patient-controlled analgesic therapy, part I: pharmacokinetics of pethidine in the per-and postoperative period. Clin Pharmacokinet 7: 149–163

    Article  PubMed  CAS  Google Scholar 

  139. Tamsen A, Hartvig P, Fagerlund C, Dahlström B (1982) Patient-controlled analgesic therapy, part II: individual analgesic demand and plasma concentrations of pethidine in postoperative pain. Clin Pharmacokinet 7: 164–175

    Article  PubMed  CAS  Google Scholar 

  140. Tamsen A, Hartvig P, Fagerlund C, Dahlström B, Bondesson U (1982) Patient-controlled analgesic therapy — clinical experience. Acta Anaesthesiol Scand (Suppl) 74: 157–160

    Article  CAS  Google Scholar 

  141. Tamsen A, Sakurada T, Wahlström A, Terenius L, Hartvig P (1982) Postoperative demand for analgesics in relation to individual levels of endorphins and substance P in cerebrospinal fluid. Pain 13: 171–183

    Article  PubMed  CAS  Google Scholar 

  142. Tamsen A, Sjöström S, Hartvig P (1986) The Uppsala experience of patient-controlled analgesia. Adv Pain Res Ther 8: 325–332

    Google Scholar 

  143. Terenius L, Tamsen A (1982) Endorphins and the modulation of acute pain. Acta Anaesthesiol Scand (Suppl 74 ): 21–24

    Article  CAS  Google Scholar 

  144. Twycross RG (1983) Narcotic analgesics in clinical practice. Adv Pain Res Ther 5: 435459

    Google Scholar 

  145. Vickers A, Derbyshire DR, Burt DR, Bagshaw PF, Pearson H, Smith G (1985) Comparison of the Cardiff Palliator and Leicester Micropalliator in the relief of postoperative pain. Br J Anaesth 57: 820 P

    Article  Google Scholar 

  146. Vickers AP, Derbyshire DR, Burt DR, Bagshaw PF, Pearson H, Smith G (1987) Comparison of the Leicester micropalliator and the Cardiff palliator in the relief of postoperative pain. Br J Anaesth 59: 503–509

    Article  PubMed  CAS  Google Scholar 

  147. Watkins LR, Kinschek IB, Mayer DJ (1984) Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science 224: 395–396

    Article  PubMed  CAS  Google Scholar 

  148. Watson PJQ, McQuay HJ, Bullingham RES, Allen MC, Moore RA (1982) Single-dose comparison of buprenorphine 0.3 and 0.6 mg i.v. given after operation: clinical effects and plasma concentrations. Br J Anaesth 54: 37–43

    Article  PubMed  CAS  Google Scholar 

  149. Watson J, Moore A, McQuay H, Teddy P, Baldwin D, Allen M, Bullingham R (1984) Plasma morphine concentrations and analgesic effects of lumbar extradural morphine and heroin. Anesth Analg 63: 629–634

    Article  PubMed  CAS  Google Scholar 

  150. Weis OF, Sriwatanakul K, Alloza JL, Weintraub M, Lasagna L (1983) Attitudes of patients, housestaff, and nurses toward postoperative analgesic care. Anesth Analg 62: 70–74

    PubMed  CAS  Google Scholar 

  151. Welchew EA (1983) On-demand analgesia. A double blind comparison of on-demand intravenous fentanyl with regular intramuscular morphine. Anaesthesia 38: 19–25

    Article  PubMed  CAS  Google Scholar 

  152. Welchew EA (1985) An open comparison of patient-controlled on-demand fentanyl delivered either extradurally or i.v. Br J Anaesth 57: 346P - 347 P

    Google Scholar 

  153. Welchew EA, Hosking J (1985) Patient-controlled postoperative analgesia with alfentanil. Adaptive, on-demand intravenous alfentanil or pethidine compared double-blind for postoperative pain. Anaesthesia 40: 1172–1177

    Google Scholar 

  154. White WD, Pearce DJ, Norman J (1979) Postoperative analgesia: a comparison of intravenous on-demand fentanyl with epidural bupivacaine. Br Med J 2: 166–167

    Article  PubMed  CAS  Google Scholar 

  155. White PF (1985) Patient-controlled analgesia: a new approach to the management of postoperative pain. Seminars in Anesthesia 4: 255–266

    Google Scholar 

  156. White PF (1986) Postoperative pain management with patient-controlled analgesia. Seminars in Anesthesia 5: 116–122

    Google Scholar 

  157. White PF (1987) Mishaps with patient-controlled analgesia. Anesthesiology 66: 81–83

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. K. A. Lehmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Anästhesiologie und operative Intensivmedizin, Universität zu Köln, Josef-Stelzmann-Straße 9, D-5000, Köln 41, Deutschland

    Klaus A. Lehmann

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lehmann, K.A. (1990). On-demand-Analgesie. In: Lehmann, K.A. (eds) Der postoperative Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06539-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06539-6_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06540-2

  • Online ISBN: 978-3-662-06539-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation