Zusammenfassung
Das peptische Ulkus ist eine chronische Krankheit, die durch spontane Remissionen und Rezidive charakterisiert ist und die zu potentiell letalen Komplikationen — wie Blutung und Perforation — führen kann. Die Dauer der Krankheit ist bei einem Patienten nicht vorhersehbar, dauert aber meistens viele Jahre, gelegentlich sogar das ganze Leben über. Daher ist die Planung einer Langzeitbehandlung oft sinnvoll und notwendig. In den vergangenen Jahren sind verschiedene therapeutische Möglichkeiten, die Krankheit in Remission zu halten, verfügbar geworden. Dabei hat jede Therapieform eine Reihe von Vorteilen und Nachteilen. Die vorliegende Übersichtsarbeit befaßt sich mit den verschiedenen Strategien der Langzeitbehandlung der Ulcus pepticum-Krankheit. Dabei soll die Möglichkeit der Prophylaxe von Rezidiven und Komplikationen besonders herausgearbeitet werden.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bardhan KD (1988) Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety. Aliment Pharmacol Therap 2: 395–405
Bardhan KD (1988) Intermittent treatment of duodenal ulcer for long-term medical management: a review. Postgrad Med J 64 (Suppl 1): 40–46
Bardhan KD, Cole DS, Hawkins BW, Franks CR (1982) Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Brit Med J 284: 621–624
Baverdörffer E, Mannes GA, Sommer A et al. (1992) High-dose omeprazole treatment combined with amoxicillin eradicates H. pylori. Eur J Hepatol Gastroenterol 4, 697–702
Bianchi Porro G (1985) Symposium proceedings. XII International Congress of Gastroenterology, Lisbon, pp 33–38, Universitetsforlaget, Oslo
Bianchi Porro G, Parente F (1991) Long-term treatment of duodenal ulcer. A review of management options. Drugs 41: 38–51
Bianchi Porro G, Petrillo M, Lazzaroni M, Sangaletti 0 (1982) The longer-term treatment of duodenal ulceration with cimetidine. In Bianchi Porro & Bardhan (Eds) Peptic ulcer disease: advances in pathogenesis and treatment, Cortina International, Verona, pp 107–113
Bianchi Porro G, Bolling E, Barbara L et al. (1990) Maintenance treatment with omeprazole in the prevention of duodenal ulcer relapse: a double-blind comparative trial. Digestive Disease Week, S. Antonio, May 13–16, 213-A
Blasi A, Magiameli A, Castelli G et al. (1987) Long term (24 month) ranitidine in prevention of duodenal ulcer relapse: comparison of continuous and seasonal treatment. Ital J Gastroenterol; 19: 141–4
Dobrilla G, Vallaperta P, Amplatz S (1988) Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. Gut 29: 181–187
Fry J (1964) Peptic ulcer: a profile. Br Med J 2: 808–12
George L, Hyland L, Morgan A et al. (1990) Smoking does not contribute to duodenal ulcer relapse after eradication. Gastroenterology 98: A48 (Abstract.)
Greibe J, Bugge P, Gjorup T, Lauritsen T, Bonnevie O, Wulff HR (1977) Long term prognosis of duodenal ulcer; follow-up study and survey, of doctor’s estimates. Br Med J 2: 1572–4
Gustaysson S, Holmberg L, Nyren D, Ohrvall U, Wells L (1990) Risk of serious complications in patients with duodenal or prepyloric ulcers. Gastroenterology, 98, 54A
Heatley RV (1991) Review Article: the treatment of H. pylori infection. Aliment Pharmacol Ther 6: 291–303
Krag E (1966) Long-term prognosis in medically treated peptic ulcer. Acta Med Scand 180, 657–668
Krause U (1963) Long term results of medical and surgical treatment of peptic ulcer. Acta Chir Scand 125 (Suppl 310): 5–111
Kurata JH, Koch GG, Nogawa AN (1987) Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 9: 644–650
Lane MR, Lee SP (1988) Recurrence of duodenal ulcer after medical treatment. Lancet 1: 1147–1149
Lauritsen K, Andersen BN, Laurse LS et al. (1991) Omeprazole 20 mg three days a week and 10 mg daily in the prevention of duodenal ulcer relapse. Double-blind comparative trial. Gastroenterology 100: 663–669
Martin L, Lewis N (1949) Peptic ulcer cases reviewed after 10 years. Lancet 11: 1115–20
Penston J, Wormsley KG (1989) Efficacy and safety of long-term maintenance therapy of duodenal ulcers. Scand J Gastroenterol 24: 1145–1152
Penston JG, Wormsley KG (1990) Long term maintenance treatment of gastric ulcers with ranitidine. Aliment Pharmacol Therap 4: 339–55
Penston JG, Wormsley KG (1992) Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease. Aliment Pharmacol Therap 6: 3–29
Pulvertaft CN (1968) Incidence of natural history of gastric and duodenal ulcer. Postgrad Med J 44: 597–602
Susi D, Ianetti G, Di Pietro AM (1987) Long term therapy of peptic ulcer: our experience with ranitidine after 4 years. Ital J Gastroenterol 19: 69S
Tytgat GNJ, Noach LA, Rauws E (1992) H. pylori. Eur J Gastroenterol Hepatol; 4 (Suppl 1 ): 57–515
Unge P, Eriksson K, Bergman B et al. (1992) Omeprazole and amoxicillin in patients with duodenal ulcer: H. pylori eradication and remission of ulcers and symptoms during a 6-month follow-up. Digestive Disease Week, S. Francisco, May 10–13, A163
Viskum A (1976) A comparison of the course of the disease among patients with gastric ulcer, duodenal ulcer, and ulcer dyspepsia without ulcer demonstrable by X-ray. Dan Med Bull 23: 129–36
Walan A, Bianchi Porro G, Hentschel E, Bardhan KD, Delattre M (1987) Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years. Scand J Gastroenterol 22: 397–405
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Porro, G.B., Parente, F. (1993). Rationale Langzeittherapie der Ulcus pepticum-Krankheit. In: Domschke, W., Konturek, S.J. (eds) Der Magen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06526-6_20
Download citation
DOI: https://doi.org/10.1007/978-3-662-06526-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-56612-0
Online ISBN: 978-3-662-06526-6
eBook Packages: Springer Book Archive