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Der Magen pp 299-310 | Cite as

Rationale Langzeittherapie der Ulcus pepticum-Krankheit

  • G. Bianchi Porro
  • F. Parente
Conference paper

Zusammenfassung

Das peptische Ulkus ist eine chronische Krankheit, die durch spontane Remissionen und Rezidive charakterisiert ist und die zu potentiell letalen Komplikationen — wie Blutung und Perforation — führen kann. Die Dauer der Krankheit ist bei einem Patienten nicht vorhersehbar, dauert aber meistens viele Jahre, gelegentlich sogar das ganze Leben über. Daher ist die Planung einer Langzeitbehandlung oft sinnvoll und notwendig. In den vergangenen Jahren sind verschiedene therapeutische Möglichkeiten, die Krankheit in Remission zu halten, verfügbar geworden. Dabei hat jede Therapieform eine Reihe von Vorteilen und Nachteilen. Die vorliegende Übersichtsarbeit befaßt sich mit den verschiedenen Strategien der Langzeitbehandlung der Ulcus pepticum-Krankheit. Dabei soll die Möglichkeit der Prophylaxe von Rezidiven und Komplikationen besonders herausgearbeitet werden.

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Literatur

  1. 1.
    Bardhan KD (1988) Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety. Aliment Pharmacol Therap 2: 395–405CrossRefGoogle Scholar
  2. 2.
    Bardhan KD (1988) Intermittent treatment of duodenal ulcer for long-term medical management: a review. Postgrad Med J 64 (Suppl 1): 40–46PubMedGoogle Scholar
  3. 3.
    Bardhan KD, Cole DS, Hawkins BW, Franks CR (1982) Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Brit Med J 284: 621–624CrossRefGoogle Scholar
  4. 4.
    Baverdörffer E, Mannes GA, Sommer A et al. (1992) High-dose omeprazole treatment combined with amoxicillin eradicates H. pylori. Eur J Hepatol Gastroenterol 4, 697–702Google Scholar
  5. 5.
    Bianchi Porro G (1985) Symposium proceedings. XII International Congress of Gastroenterology, Lisbon, pp 33–38, Universitetsforlaget, OsloGoogle Scholar
  6. 6.
    Bianchi Porro G, Parente F (1991) Long-term treatment of duodenal ulcer. A review of management options. Drugs 41: 38–51Google Scholar
  7. 7.
    Bianchi Porro G, Petrillo M, Lazzaroni M, Sangaletti 0 (1982) The longer-term treatment of duodenal ulceration with cimetidine. In Bianchi Porro & Bardhan (Eds) Peptic ulcer disease: advances in pathogenesis and treatment, Cortina International, Verona, pp 107–113Google Scholar
  8. 8.
    Bianchi Porro G, Bolling E, Barbara L et al. (1990) Maintenance treatment with omeprazole in the prevention of duodenal ulcer relapse: a double-blind comparative trial. Digestive Disease Week, S. Antonio, May 13–16, 213-AGoogle Scholar
  9. 9.
    Blasi A, Magiameli A, Castelli G et al. (1987) Long term (24 month) ranitidine in prevention of duodenal ulcer relapse: comparison of continuous and seasonal treatment. Ital J Gastroenterol; 19: 141–4Google Scholar
  10. 10.
    Dobrilla G, Vallaperta P, Amplatz S (1988) Influence of ulcer healing agents on ulcer relapse after discontinuation of acute treatment: a pooled estimate of controlled clinical trials. Gut 29: 181–187PubMedCrossRefGoogle Scholar
  11. 11.
    Fry J (1964) Peptic ulcer: a profile. Br Med J 2: 808–12CrossRefGoogle Scholar
  12. 12.
    George L, Hyland L, Morgan A et al. (1990) Smoking does not contribute to duodenal ulcer relapse after eradication. Gastroenterology 98: A48 (Abstract.)Google Scholar
  13. 13.
    Greibe J, Bugge P, Gjorup T, Lauritsen T, Bonnevie O, Wulff HR (1977) Long term prognosis of duodenal ulcer; follow-up study and survey, of doctor’s estimates. Br Med J 2: 1572–4PubMedCrossRefGoogle Scholar
  14. 14.
    Gustaysson S, Holmberg L, Nyren D, Ohrvall U, Wells L (1990) Risk of serious complications in patients with duodenal or prepyloric ulcers. Gastroenterology, 98, 54AGoogle Scholar
  15. 15.
    Heatley RV (1991) Review Article: the treatment of H. pylori infection. Aliment Pharmacol Ther 6: 291–303CrossRefGoogle Scholar
  16. 16.
    Krag E (1966) Long-term prognosis in medically treated peptic ulcer. Acta Med Scand 180, 657–668PubMedCrossRefGoogle Scholar
  17. 17.
    Krause U (1963) Long term results of medical and surgical treatment of peptic ulcer. Acta Chir Scand 125 (Suppl 310): 5–111Google Scholar
  18. 18.
    Kurata JH, Koch GG, Nogawa AN (1987) Comparison of ranitidine and cimetidine ulcer maintenance therapy. J Clin Gastroenterol 9: 644–650PubMedCrossRefGoogle Scholar
  19. 19.
    Lane MR, Lee SP (1988) Recurrence of duodenal ulcer after medical treatment. Lancet 1: 1147–1149PubMedCrossRefGoogle Scholar
  20. 20.
    Lauritsen K, Andersen BN, Laurse LS et al. (1991) Omeprazole 20 mg three days a week and 10 mg daily in the prevention of duodenal ulcer relapse. Double-blind comparative trial. Gastroenterology 100: 663–669Google Scholar
  21. 21.
    Martin L, Lewis N (1949) Peptic ulcer cases reviewed after 10 years. Lancet 11: 1115–20CrossRefGoogle Scholar
  22. 22.
    Penston J, Wormsley KG (1989) Efficacy and safety of long-term maintenance therapy of duodenal ulcers. Scand J Gastroenterol 24: 1145–1152PubMedCrossRefGoogle Scholar
  23. 23.
    Penston JG, Wormsley KG (1990) Long term maintenance treatment of gastric ulcers with ranitidine. Aliment Pharmacol Therap 4: 339–55CrossRefGoogle Scholar
  24. 24.
    Penston JG, Wormsley KG (1992) Review article: maintenance treatment with H2-receptor antagonists for peptic ulcer disease. Aliment Pharmacol Therap 6: 3–29CrossRefGoogle Scholar
  25. 25.
    Pulvertaft CN (1968) Incidence of natural history of gastric and duodenal ulcer. Postgrad Med J 44: 597–602PubMedCrossRefGoogle Scholar
  26. 26.
    Susi D, Ianetti G, Di Pietro AM (1987) Long term therapy of peptic ulcer: our experience with ranitidine after 4 years. Ital J Gastroenterol 19: 69SGoogle Scholar
  27. 27.
    Tytgat GNJ, Noach LA, Rauws E (1992) H. pylori. Eur J Gastroenterol Hepatol; 4 (Suppl 1 ): 57–515Google Scholar
  28. 28.
    Unge P, Eriksson K, Bergman B et al. (1992) Omeprazole and amoxicillin in patients with duodenal ulcer: H. pylori eradication and remission of ulcers and symptoms during a 6-month follow-up. Digestive Disease Week, S. Francisco, May 10–13, A163Google Scholar
  29. 29.
    Viskum A (1976) A comparison of the course of the disease among patients with gastric ulcer, duodenal ulcer, and ulcer dyspepsia without ulcer demonstrable by X-ray. Dan Med Bull 23: 129–36PubMedGoogle Scholar
  30. 30.
    Walan A, Bianchi Porro G, Hentschel E, Bardhan KD, Delattre M (1987) Maintenance treatment with cimetidine in peptic ulcer disease for up to 4 years. Scand J Gastroenterol 22: 397–405PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. Bianchi Porro
  • F. Parente

There are no affiliations available

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