Zusammenfassung
Ein Ulkus ist eine tiefe nekrotische Läsion der gastroduodenalen Mukosa, welche durch die Muscularis mucosae in die Submukosa penetriert (Abb. 1) [1]. Ein Ulkus entwickelt sich als Ergebnis eines ausgeprägten Ungleichgewichtes zwischen aggressiven Faktoren (wie z.B. HC1, Pepsin, Lysolecithin, Äthanol, nicht-steroidalen Antiphlogistika, H. pylori, Infektionen etc.), die im Magenoder Duodenallumen vorhanden sind, und den Abwehrmechanismen der Schleimhaut (s. Tabelle 1) [2–4]. Zahlreiche Faktoren wie genetische, neurale, humorale und iatrogene (z.B. nicht-steroidale Antiphlogistika) wurden als kausale Faktoren bei der Entstehung gastroduodenaler Ulzerationen diskutiert [2–4].
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Tarnawski, A. (1993). Zelluläre Heilungsmechanismen beim Magenulkus. In: Domschke, W., Konturek, S.J. (eds) Der Magen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06526-6_12
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