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The Interaction Between Dendritic Cells and Herpes Simplex Virus-1

  • D. Kobelt
  • M. Lechmann
  • A. Steinkasserer
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 276)

Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells, because they are also able to induce native T cells. Thus they are crucial in the induction of antiviral immune responses. Several viral immune escape mechanisms have been described; here we concentrate on the interaction between DCs and herpes simplex virus type 1 (HSV-1). DCs can be infected by HSV-1; however, only immature DCs generate infectious viral particles, whereas mature DCs do not support virus production and only immediate-early and early viral transcripts are generated. To induce potent immune responses DCs must mature. Interestingly, HSV-1 interferes with this maturation process, thus inhibiting antiviral T cell stimulation. Furthermore, HSV-1 strongly interferes with DC-mediated T cell proliferation. A striking finding was the complete degradation of CD83, the best-known marker for mature DC, after HSV-1 infection in lysosomal compartments. This CD83 degradation coincided with a clearly reduced T cell stimulation representing an additional new escape strategy. The functional role and the importance of CD83 are discussed in detail.

Keywords

Herpes Simplex Genital Herpes Soluble CD83 Cell Stimulatory Capacity CD83 Degradation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • D. Kobelt
    • 1
  • M. Lechmann
    • 1
  • A. Steinkasserer
    • 1
  1. 1.Department of DermatologyUniversity of ErlangenErlangenGermany

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