Models of Genetic Regulatory Networks

  • M. Schilstra
  • H. Bolouri
Part of the Natural Computing Series book series (NCS)


This chapter provides a short review of the modelling of Genetic Regulatory Networks (GRNs). GRNs have a basic requirement to model (at least) some parts of a biological system using some kind of logical formalism. They represent the set of all interactions among genes and their products for determining the temporal and spatial patterns of expression of a set of genes. The origin of modelling the regulation of gene expression goes back to the Nobel-prize winning work of Lwoff, Jacob and Monod on the mechanisms underlying the behaviour of bacterial viruses that switch between so-called lytic and lysogenic states. Some of the circuit-based approaches to GRNs such as the work of Kauffman, Thomas, and Shapiro and Adam are discussed.


Genetic Regulatory Network Genetic Circuit Microelectronic Circuit Encode Heat Shock Protein Genetic Regulatory System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • M. Schilstra
    • 1
  • H. Bolouri
    • 2
    • 3
  1. 1.Science and Technology Research CentreUniversity of HertfordshireUK
  2. 2.Institute for Systems BiologySeattleUSA
  3. 3.Division of Biology 156-29California Institute of TechnologyUSA

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