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Stabilizing Calcium Homeostasis

  • M. P. Mattson
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 155)

Abstract

The premise of this chapter is that disruption of cellular calcium homeostasis plays a pivotal role in the neurodegenerative process that occurs in many different neurological disorders, with a focus on cerebral ischemia. I will not attempt to review the extensive literature supporting the involvement of calcium in ischemic injury to neurons (see Choi 1995; Mattson and Mark 1996 for review), but rather will provide selected examples of such evidence, together with a more thorough account of preventative and therapeutic approaches that target systems involved in either disruption or stabilization of neuronal calcium homeostasis. A variety of cell culture and animal models of neurodegenerative processes relevant to ischemic brain injury have been developed. Such experimental models have allowed the manipulation and monitoring of Ca2+ movements in living neurons exposed to conditions relevant to humans suffering from stroke and other neurodegenerative conditions, thus clarifying roles of calcium in neuronal cell death processes. Other chapters in this volume expand upon some of the mechanisms that contribute to the sustained elevations of intracellular free calcium level ([Ca2+]i) that occur in neurons following ischemic or traumatic insults — these include energy failure, overstimulation of glutamate receptors, and oxidative stress.

Keywords

Hippocampal Neuron Middle Cerebral Artery Occlusion Calcium Homeostasis Focal Cerebral Ischemia Ischemic Brain Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2002

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  • M. P. Mattson

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