Target Description for Radiotherapy of Soft Tissue Sarcoma
One of the most common yet difficult issues in the treatment of soft tissue sarcoma (STS) is the choice of the radiotherapy (RT) target volume. The existence of a zone of uncertain size and location that may contain subclinical disease in proximity to the presenting site of the primary tumor presents a frequent dilemma. The size and extent of the putative ‘risk zone’ depends on a number of factors, and taking this into account will affect the target volume chosen for RT. Also, perhaps more than for most cancers, the pathway to appropriate treatment may already have been declared by events that have taken place prior to referral. For example, the type of biopsy that may have already been performed, or a prior inappropriate excision may jeopardize the form and outcome of local treatment thereafter (Mankin et al. 1996). In addition, the choice of target volume may also be influenced by the type of reconstruction chosen following tumor resection. In fact numerous factors may impact on the local management of STS with RT and surgery, a more complete account of which is available (O’Sullivan et al. 1999).
KeywordsOncol Sarcoma Osteosarcoma Etoposide Ifosfamide
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- Bramwell VH, Rouesse J, Steward W et al (1994) Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma-reduced local recurrence but no improvement in survival: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 12: 1137–1149PubMedGoogle Scholar
- Holt GE, Wunder JS, Griffin AM et al (2002) Fractures following radiation therapy and limb salvage surgery for soft tissue sarcomas: high versus low dose radiotherapy. Proc Muskuloskelet Tumor Soc p 41Google Scholar
- ICRU Report 50 (1993) Prescribing, recording, and reporting photon beam therapy. International Commission on Radiation Units and Measurement, BethesdaGoogle Scholar
- ICRU Report 62 (1999) Prescribing, recording, and reporting photon beam therapy (supplement to ICRU Report 50 ). International Commission on Radiation Units and Measurement, BethesdaGoogle Scholar
- Mankin HJ, Mankin CJ, Simon MA (1996) The hazards of the biopsy, revisited. Members of the Musculoskeletal Tumor Society (see comments). J Bone Jt Surg Am 78: 656–663Google Scholar
- Noria S, Davis A, Kandel R et al (1996) Residual disease following unplanned excision of soft tissue sarcoma of an extremity. J Bone Jt Surg 78: 650–655Google Scholar
- O’Sullivan B, Davis A (2001) A randomized phase III trial of pre-operative compared to post-operative radiotherapy in extremity soft tissue sarcoma. Proceedings of the 43rd annual meeting of the American Society of Therapeutic Radiology and Oncology. Int J Radiat Oncol Biol Phys 51: 151CrossRefGoogle Scholar
- O’Sullivan B, Gullane P, Irish J et al (2000) Preoperative radiotherapy for adult head and neck soft tissue sarcoma (STS): assessment of wound complication rates and cancer outcome in a prospective series. Proceedings of the 5th international conference on head and neck cancer. Abstract #215, p 120Google Scholar
- O’Sullivan B, Bell RS, Bramwell VHC (2002b) Sarcomas of the soft tissues. In: Souhami RL, Tannock I, Hohenberger P, Horiot J-C (eds) Oxford textbook of oncology, 2nd edn. Oxford University Press, Oxford, pp 2495–2523Google Scholar
- Sobin L, Wittekind C (2002) TNM classification of malignant tumours, 6th edn. Wiley-Liss, New YorkGoogle Scholar
- Stevens MCG (2002) Malignant mesenchymal tumours of childhood. In: Souhami RL, Tannock I, Hohenberger P, Horiot J-C (eds) Oxford textbook of oncology, 2nd edn. Oxford University Press, Oxford, pp 2525–2538Google Scholar