Target Description for Radiotherapy of Soft Tissue Sarcoma

  • B. O’Sullivan
  • J. Wunder
  • P. W. T. Pisters
Part of the Medical Radiology book series (MEDRAD)

Abstract

One of the most common yet difficult issues in the treatment of soft tissue sarcoma (STS) is the choice of the radiotherapy (RT) target volume. The existence of a zone of uncertain size and location that may contain subclinical disease in proximity to the presenting site of the primary tumor presents a frequent dilemma. The size and extent of the putative ‘risk zone’ depends on a number of factors, and taking this into account will affect the target volume chosen for RT. Also, perhaps more than for most cancers, the pathway to appropriate treatment may already have been declared by events that have taken place prior to referral. For example, the type of biopsy that may have already been performed, or a prior inappropriate excision may jeopardize the form and outcome of local treatment thereafter (Mankin et al. 1996). In addition, the choice of target volume may also be influenced by the type of reconstruction chosen following tumor resection. In fact numerous factors may impact on the local management of STS with RT and surgery, a more complete account of which is available (O’Sullivan et al. 1999).

Keywords

Oncol Sarcoma Osteosarcoma Etoposide Ifosfamide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • B. O’Sullivan
    • 1
  • J. Wunder
    • 2
    • 3
  • P. W. T. Pisters
    • 4
  1. 1.Department of Radiation OncologyPrincess Margaret Hospital, University Health Network, University of TorontoTorontoCanada
  2. 2.Department of Surgical OncologyPrincess Margaret Hospital, University Health Network, University of TorontoTorontoCanada
  3. 3.University Musculoskeletal Oncology UnitMount Sinai Hospital, University of TorontoTorontoCanada
  4. 4.Department of SurgeryUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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