Abstract
Clear-cell sarcoma of tendons and aponeuroses (CCS) was first described and named by Enzinger (1965) and is currently recognized as a rare and distinct clinicopathologic entity among soft tissue sarcomas. Originally it was suspected that there was a relationship between CCS and synovial sarcoma (Enzinger 1965; Kubo 1969; Hajdu et al. 1977). The light-microscopic similarity to malignant melanoma, the occurrence of melanin in some cases (Enzinger 1965), and the ultrastructural finding of melanosomes (Hoffman and Carter 1973) led Chung and Enzinger (1983) to suggest that the term clear-cell sarcoma of tendons and aponeuroses should be changed to malignant melanoma of soft parts. However, melanocytic features are not consistently found, and differentiation along Schwann’s cell lines has also been observed (Kindblom et al. 1983; Azumi and Turner 1983; Ohno et al. 1986). The present knowledge of CCS, including electron microscopy, immuno-cytochemistry and cytochemistry, indicates that this entity is of neural crest origin presenting variable degrees of differentiation along melanocytic and Schwann’s cell lines.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Åman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willén H, Rydholm A, Mitelman F. Rearrangement of the transcription factor gene CHOP in myxoid liposarcoma with t(12;16)(q13;p11). Genes Chrom Cancer 5:278–285
Aurias A, Rimbaut C, Buffe C, Dubousset J, Mazabraud A (1983) Chromosomal translocations in Ewing’s sarcoma. N Engl J Med 309:496–497
Azumi N, Turner RR (1983) Clear cell sarcoma of tendons and aponeuroses: electron microscopic findings suggesting Schwann cell differentiation. Hum Pathol 14:1084–1089
Bridge JA, Borek DA, Neff JR, Huntrakoon M (1990) Chromosomal abnormalities in clear cell sarcoma. Implications for histogenesis. Am J Clin Pathol 93:26–31
Bridge JA, Screekantaiah C, Neff JR, Sandberg AA (1991) Cytogenetic findings in clear cell sarcoma of tendons and aponeuroses. Malignant melanoma of soft parts. Cancer Genet Cytogenet 52:101–106
Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W (1987) Rearrangements of chromosome region 12q13–15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet Cell Genet 45:187–190
Chung EB (1991) Clear cell sarcoma: a tumor of probable neuroectodermal origin. In: Ninfo V, Chung EB, Cavazzana AO (eds) Tumors and tumorlike lesions of soft tissue. Churchill Livingstone, New York, pp 259–263
Chung EB, Enziner FM (1983) Malignant melanoma of soft parts; a reassessment of clear cell sarcoma. Am J Surg Pathol 39:405–413
Craig IW, McBride OW (1991) Report of the committee on the genetic constitution of chromosome 12. Human gene mapping 11 (1991). 11th international workshop on human gene mapping. Cytogenet Cell Genet 58:555–579
Enzinger FM (1965) Clear-cell sarcoma of tendons and aponeuroses: an analysis of 21 cases. Cancer 18:1163–1174
Enzinger FM, Weiss SW (1988) Soft tissue tumors. Mosby, St. Louis, pp 945–951
Hajdu SI, Shiu MH, Fortner JG (1977) Tendosynovial sarcoma: a clinicopathological study of 136 cases. Cancer 42:1201–1217
Hoffman GJ, Carter D (1973) Clear-cell sarcoma of tendons and aponeuroses with melanin. Arch Pathol 95:22–25
Kindblom L-G, Lodding P, Angervall A (1983) Clear-cell sarcoma of tendons and aponeuroses. An immunohistochemical and electron microscopic analysis indicating neural crest origin. Virchows Arch (Pathol Anat) 409:109–128
Kubo T (1969) Clear-cell sarcoma of patellar tendon studied by electron microscopy. Cancer 24:948–953
Limon J, Rao U, Dal Cin P, Gibas Z, Sandberg AA (1986). Translocation (13;22) in a hemangiopericytoma. Cancer Genet Cytogenet 21:309–318
Meltzer PS, Jankowski SA, Dal Cin P, Sandberg AA, Paz IB, Coccia MA (1991) Identification and cloning of a novel amplified DNA sequence in a human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth Differ 2:1–7
Mii Y, Miyauchi Y, Hohnoki K, Maruyama H, Tsutsumi M, Dohmae K, Tamai S, Konishi Y, Yamanouchi T (1989) Neural crest origin of clear cell sarcoma of tendons and aponeuroses: ultrastructural and enzyme cytochemical study of human and nude mouse-transplanted tumors. Virchows Arch [A] 415:51–60
Mitelman (1991) Catalog of chromosome aberrations in cancer. Wiley-Liss, New York
Nilbert M, Heim S (1990) Uterine leiomyoma cytogenetics. Genes Chrom Cancer 2:3–13
Ohno T, Park P, Utsunomiya Y, Hirahata H, Inoue K (1986) Ultrastructural study of a clear cell sarcoma suggesting schwannoma differentiation. Ultrastruct Pathol 10:39–48
Peulvé P, Michot C, Vannier J-P, Tron P, Hemet J (1991) Clear cell sarcoma with t(12;22)-(q13–14;q12). Genes Chrom Cancer 3:400–402
Rodriguez E, Sreekantaiah C, Reuter VE, Motzer RJ, Chaganti RSK (1992) t(12;22)(q13;q13) and trisomy 8 are nonrandom aberrations in clear-cell sarcoma. Cancer Genet Cytogenet 64:107–110
Sahlin P, Mark J, Stenman G (1992) The INT1 and GLI genes are not rearranged or amplified in benign pleomorphic adenomas with chromosome abnormalities of 12q13–15. Cancer Genet Cytogenet 58:85–88
Sandros J, Stenman G, Mark J (1990) Cytogenetic and molecular observations in human and experimental salivary gland tumors. Cancer Genet Cytogenet 44:153–167
Speleman F, Colpaert C, Goovaerts G, Leroy JG, Van Marck E (1992) Malignant melanoma of soft parts — further cytogenetic characterization. Cancer Genet Cytogenet 60:176–179
Sreekantaiah C, Leong SPL, Karakousis CP, McGee DL, Rappaport WD, Villar HV, Neal D, Fleming S, Wankel A, Herrington PN, Carmona R, Sandberg AA (1991) Cytogenetic profile of 109 lipomas. Cancer Res 51:422–433
Stenman G, Kindblom L-G, Angervall A (1992) Reciprocal translocation t(12;22)(ql3;ql3) in clear-cell sarcoma of tendons and aponeuroses. Genes Chrom Cancer 4:122–127
Turc-Carel C, Limon J, Dal Cin P, Rao U, Karakousis C, Sandberg AA (1986) Cytogenetic studies of adipose tissue tumors. II. Recurrent reciprocal translocation t(12;16)(q13;p11). Cancer Genet Cytogenet 23:291–299
Turc-Carel C, Aurias A, Mugneret F, Lizard Sidaner I, Volk C, Thiery JP, Olschwang S, Philip I, Berger MP, Philip T, Lenoir GM, Mazabraud A (1988a) Chromosomes in Ewing’s sarcoma. An evaluation of 85 cases and remarkable consistency of t(ll;22)(q24;ql2). Cancer Genet Cytogenet 32:229–238
Turc-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA (1988b) Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma. Cancer Genet Cytogenet 30:145–150
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Stenman, G., Sahlin, P., Angervall, L., Meltzer, P., Kindblom, LG. (1994). Cytogenetic and Molecular Studies of Clear-Cell Sarcoma of Tendons and Aponeuroses. In: Bullerdiek, J., Bartnitzke, S. (eds) Chromosome 12 Aberrations in Human Solid Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06255-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-662-06255-5_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-06257-9
Online ISBN: 978-3-662-06255-5
eBook Packages: Springer Book Archive