Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections
Limited data are available about the chromosomal constitution of the precursor to all testicular germ cell tumors of human adults (TGCTs) (Walt et al. 1989; Giwercman et al. 1990; Vos et al. 1990) — the so-called carcinoma in situ (CIS) (Skakkebæk et al. 1987). Therefore questions about the early chromosomal events in the pathogenesis of TGCTs still remain to be answered. In addition, possible chromosomal heterogeneity of CIS, in itself and in relation to the histology of invasive tumors — seminomas (SE) and nonseminomatous TGCTs (NS) — is unknown. The chromosomal basis of the heterogeneity found in some invasive TGCTs by ploidy analysis (Oosterhuis et al. 1989; Fosså et al. 1991a,b; Ky Sela and Matoska 1991) is also not understood.
KeywordsCentromeric Region Mature Teratoma Spermatocytic Seminoma Interphase Cytogenetic Nonseminomatous Testicular Germ Cell Tumor
Unable to display preview. Download preview PDF.
- Cremer T, Landegent J, Bruckner A, Scholl HP, Schardin M, Hager HD, Devilee P, Pearson P, Van der Ploeg (1986) Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomi 18 with probe L1.84. Hum Genet 74:346–352Google Scholar
- Jacobsen GK, Pedersen BN (1984) Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. Acta Pathol Microbiol Immunol Scand [A] 92:323–329Google Scholar
- Ky Sela B, Matoska J (1991) Flow cytometric analysis of ploidy and proliferation activity in classical and spermatocytic seminoma. Neoplasma 38:3–11Google Scholar
- Looijenga LHJ, Oosterhuis JW, Ramaekers FCS, De Jong B, Dam A, Beck JLM, Sleijfer DTH, Schraffordt Koops H (1991) Dual parameter flow cytometry for deoxyribonucleic acid and intermediate filament proteins of residual mature teratoma: all tumor cells are aneuploid. Lab Invest 64:113–117PubMedGoogle Scholar