Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections

  • L. H. J. Looijenga
  • A. J. M. Gillis
  • W. L. J. Van Putten
  • J. W. Oosterhuis
Conference paper

Abstract

Limited data are available about the chromosomal constitution of the precursor to all testicular germ cell tumors of human adults (TGCTs) (Walt et al. 1989; Giwercman et al. 1990; Vos et al. 1990) — the so-called carcinoma in situ (CIS) (Skakkebæk et al. 1987). Therefore questions about the early chromosomal events in the pathogenesis of TGCTs still remain to be answered. In addition, possible chromosomal heterogeneity of CIS, in itself and in relation to the histology of invasive tumors — seminomas (SE) and nonseminomatous TGCTs (NS) — is unknown. The chromosomal basis of the heterogeneity found in some invasive TGCTs by ploidy analysis (Oosterhuis et al. 1989; Fosså et al. 1991a,b; Ky Sela and Matoska 1991) is also not understood.

Keywords

Teratoma Smit Seminoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • L. H. J. Looijenga
    • 1
  • A. J. M. Gillis
    • 1
  • W. L. J. Van Putten
    • 1
  • J. W. Oosterhuis
    • 1
  1. 1.Laboratory of Experimental Patho-OncologyDr. Daniel den Hoed Cancer CenterRotterdamThe Netherlands

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