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Amplification of the GLI and LRP/A2MR Loci in Tumor Cells: Is GLI only by Chance Coamplified Together with Another Gene Related to Tumor Progression?

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Chromosome 12 Aberrations in Human Solid Tumors

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Abstract

One property of tumor cells is their genomic instability. This is observed at several levels, as increased mutation and amplification frequency, chromosomal deletions, duplications, and translocations. We are particularly interested in translocations and amplifications of the ql3–14 segment of chromosome 12. Aberrations of the segment ql3–15 on chromosome 12 has been found in several tumor types, notably benign lipomas and (malignant) myxoid liposarcomas, as well as in uterine leoimyomas and pleomorphic adenomas of the salivary gland (Turc-Carel et al. 1986; Bullerdiek et al. 1987; Mandahl et al. 1987; Heim et al. 1988). The most specific of these rearrangements are those found in the myxoid liposarcomas, where the distal part of chromosome 12 (ql3-qter) is reciprocally translocated to 16pll. Several putative oncogenes have been localized to this chromosomal region and thus could be candidate target genes for the rearrangements.

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Author information

Authors and Affiliations

  1. Department of Tumor Biology, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, N-0310, Norway

    A. Forus, G. M. Maelandsmo, Ø Fodstad & O. Myklebost

  2. Department of Hematology/Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

    E. C. Douglass

Authors
  1. A. Forus
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  2. G. M. Maelandsmo
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  3. Ø Fodstad
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  4. E. C. Douglass
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  5. O. Myklebost
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Editor information

Editors and Affiliations

  1. Zentrum f. Humangenetik u. Genetische Beratung, Universität Bremen, Leobener Straße, 28359, Bremen, Germany

    J. Bullerdiek  & S. Bartnitzke  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Forus, A., Maelandsmo, G.M., Fodstad, Ø., Douglass, E.C., Myklebost, O. (1994). Amplification of the GLI and LRP/A2MR Loci in Tumor Cells: Is GLI only by Chance Coamplified Together with Another Gene Related to Tumor Progression?. In: Bullerdiek, J., Bartnitzke, S. (eds) Chromosome 12 Aberrations in Human Solid Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06255-5_15

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  • DOI: https://doi.org/10.1007/978-3-662-06255-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06257-9

  • Online ISBN: 978-3-662-06255-5

  • eBook Packages: Springer Book Archive

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