Chromosome 12 Aberrations in Human Germ Cell Tumors: A Fluorescence In Situ Hybridization Inventory

  • R. F. Suijkerbuijk
  • R. J. Sinke
  • L. H. J. Looijenga
  • B. de Jong
  • J. W. Oosterhuis
  • J. J. Cassiman
  • A. Geurts van Kessel
Conference paper


Human germ cell tumors (GCTs) consist of a heterogeneous group of solid neoplasms occurring in the testis, the ovary, and several extragonadal sites (Mostofi and Price 1973; Scully 1979; Gonzales-Crussi 1982). Basically, two entities can be distinguished: (1) tumors composed of neoplastic germ cells, called seminoma in the testis, dysgerminoma in the ovary, and germinoma in extragonadal sites and (2) nonseminomatous GCTs composed of embryonic (embryonal carinoma, immature teratoma, and mature teratoma) and/or extraembryonic tissues (yolk sac tumor and choriocarcinoma; Martineau 1969; Oosterhuis et al. 1990). Testicular GCTs (TGCTs) themselves are also heterogeneous (Atkin 1973; De Jong et al. 1990) and can epidemiologically be subdivided into three groups: infantile tumors, tumors in adults, and tumors in elderly men.


Germ Cell Tumor Testicular Germ Cell Tumor Mature Teratoma Mixed Gonadal Dysgenesis Mediastinal Germ Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. F. Suijkerbuijk
    • 1
  • R. J. Sinke
    • 1
  • L. H. J. Looijenga
    • 2
  • B. de Jong
    • 3
  • J. W. Oosterhuis
    • 2
  • J. J. Cassiman
    • 4
  • A. Geurts van Kessel
    • 1
  1. 1.Department of Human GeneticsUniversity Hospital NijmegenNijmegenThe Netherlands
  2. 2.Dr. Daniel den Hoed Cancer CenterRotterdamThe Netherlands
  3. 3.Department for Medical GeneticsUniversity of GroningenThe Netherlands
  4. 4.Center for Human GeneticsUniversity of LeuvenBelgium

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