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Chiral Xenobiotics in the Environment

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Chiral Environmental Pollutants

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Abstract

The authors of the present monograph would like to leave it to the reader’s judgment as to whether the rapid development of the enantioselective analytical approaches and the results that have thus become accessible during the last decade, as summarised in the subsequent chapters, still justify the critical remarks cited above.

Neglect of stereoselectivity of biological objects and stereospecifity of bioactive agents nevertheless is a still persisting aspect of today’s pharmacology and toxicology. It results in heavily biased “scientific” data such as half-life times, biological availabilities, concentration response relationships etc. for racemates and mixtures of isomers in general. It is like presenting the age or body weight of a married couple or even a four-person family (a mixture of 4 stereoisomers) in one figure. Such impressive nonsense is still rather common.

Ariëns, 1988 [150]

In the case of chiral pollutants, environmental studies have historically neglected to determine the adverse effects associated with particular enantiomers, and which enantiomers may persist in the environment. Consequently, much of the environmental data that has been collected for chiral pollutants, including many of the chemicals raising the greatest public concern, may have represented only the presence of relatively innocuous enantiomers.

Lewis et al., Oct. 1999 [164]

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  1. Polar Environmental Centre, Norwegian Institute for Air Research (NILU), 9296, Tromsø, Norway

    Roland Kallenborn

  2. Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany

    Heinrich Hühnerfuss

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Kallenborn, R., Hühnerfuss, H. (2001). Chiral Xenobiotics in the Environment. In: Chiral Environmental Pollutants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06243-2_3

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