Cellular Genealogy of In-Vitro Senescence and Immortalization
A population of mammalian somatic cells in culture in most cases terminates its proliferation after a period of vigorous growth. Occasionally, either through the action of extraneous effectors or spontaneously, it becomes immortalized, resulting in a continuously growing cell population (Hayflick and Moorhead 1961; Todaro and Green 1963).
KeywordsAttenuation Adenocarcinoma Stein Thymidine
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