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Cell Immortalization pp 23–50Cite as

Cell Immortality: Maintenance of Cell Division Potential

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 24))

Abstract

Cell immortality refers to the ability to reproduce indefinitely. This property does not imply constancy of genetic information from generation to generation, since mutation coupled with natural selection and genetic drift may cause genetic changes over successive generations. Furthermore, cells of a germ line ordinarily undergo periodic recombination with cells of other germ lines causing additional genetic change. Nevertheless, all extant cells reflect the ability to reproduce indefinitely, since the ancestry of each cell presumably traces back, in an unbroken lineage for over 3 billion years, to the origin of life. As pointed out by Avise (1993), it is not actually cells which are immortal, but cell lineages.

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  1. Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, Arizona, 85724, USA

    C. Bernstein, H. Bernstein & C. Payne

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  1. INSERM, 73 bis, Rue du Meréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

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Bernstein, C., Bernstein, H., Payne, C. (1999). Cell Immortality: Maintenance of Cell Division Potential. In: Macieira-Coelho, A. (eds) Cell Immortalization. Progress in Molecular and Subcellular Biology, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06227-2_2

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