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Current Perspectives on Gene and Cell-Based Therapies for Myocardial Protection, Rescue and Repair

  • Chapter
Cardiovascular Pharmacogenetics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 160))

  • 184 Accesses

Abstract

Despite significant therapeutic advances, heart disease remains the prevalent cause of premature death across all age and racial groups, accounting for a significant proportion of all hospital admissions and putting enormous financial strain on health delivery systems. Recent developments in the understanding of the molecular mechanisms of myocardial disease have led to the identification of novel therapeutic targets, and the availability of efficient cardiotropic vectors offers the opportunity for the design of gene therapies for both protection and rescue of the myocardium. Genetic therapies have been devised to treat complex diseases such as myocardial ischemia, hypertension, atherosclerosis, restenosis and inherited myopathies in various animal models. Some of these experimental therapies have made a successful transition to clinical trial and are now being considered for use in human patients. The recent isolation of regeneration-competent endothelial and cardiomyocyte precursor cells from adult bone marrow provides the opportunity for repair of the damaged heart using autologous cell transplantation. Cell-based therapies may have potential application in neovascularization and regeneration of ischemic and infarcted myocardium, in blood vessel reconstruction and in bioengineering of artificial organs and vascular prostheses. With advances in the field occurring at a rapid pace, we can expect the development of vectors and delivery methods with enhanced safety, efficacy and specificity. The advent of genomic screening technology will allow not only the identification of novel therapeutic targets, but will also facilitate the detection of disease-causing polymorphisms and permit the design of individualized gene and cell-based therapies.

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Authors and Affiliations

  1. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    L. G. Melo, A. S. Pachori, D. Kong & V. J. Dzau

  2. Department of Physiology, Queen’s University, 20 Stuart Street, Kingston, K7L 3N6, Ontario, Canada

    L. G. Melo

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  1. L. G. Melo
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  2. A. S. Pachori
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  3. D. Kong
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  4. V. J. Dzau
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Editors and Affiliations

  1. Experimental Medicine & Toxicology Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK

    Martin R. Wilkins (Professor) (Professor)

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© 2004 Springer-Verlag Berlin Heidelberg

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Melo, L.G., Pachori, A.S., Kong, D., Dzau, V.J. (2004). Current Perspectives on Gene and Cell-Based Therapies for Myocardial Protection, Rescue and Repair. In: Wilkins, M.R. (eds) Cardiovascular Pharmacogenetics. Handbook of Experimental Pharmacology, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06214-2_15

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  • DOI: https://doi.org/10.1007/978-3-662-06214-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07291-8

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