Genetic Disruption of Nitric Oxide Synthases and Cardiovascular Disease: Lessons from a Candidate Gene

  • P. L. Huang
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 160)

Abstract

The nitric oxide (NO) system is vitally important to the function of the cardiovascular system. Abnormalities in NO signaling have been linked to a wide variety of cardiovascular diseases, including atherosclerosis, hypertension, congestive heart failure, thrombosis, stroke, and diabetes mellitus. This chapter will review the roles that NO synthases play in normal vascular function and in the molecular mechanisms of disease processes, focusing on information gained from the study of mutant mice in which the NO synthase genes have been disrupted or modified. Specifically, we wil review the various genetic polymorphisms that have been described in the NO synthase genes, their association with disease processes and their functional effects on NO synthase function or expression levels. The cellular pathways that involve NO are complex and offer not only insights into how abnormalities in NO signaling can lead to disease but also opportunities and targets on which to intervene to prevent or treat disease.

Keywords

Nitric oxide Enzyme Knockout Endothelial Neuronal Inducible 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • P. L. Huang
    • 1
  1. 1.Cardiovascular Research Center, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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