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Calreticulin and Ca2+ Storage

  • Karl-Heinz Krause
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Ca2+ “stores” are intra-cellular compartments that are characterized by their high intra-luminal Ca2+ content, and by their participation in the regulation of cytosolic free Ca2+ concentration ([Ca2+]c) through rapid Ca2+ accumulation and release*. These Ca2+ stores, which are thought to reside either within the entire endoplasmic reticulum, within the rough endoplasmic reticulum, or within smooth-surfaced endoplasmic reticulum-subcompartments (for review see refs. 1–6) play a crucial role in stimulus response coupling. In resting cells, Ca2+ stores contain high concentrations of Ca2+. During cellular activation this stored Ca2+ is released into the cytosol. [Ca2+], is around 100 nM in resting cells, but may increase to micromolar levels as Ca2+ is released. The release of Ca2+ from intracellular stores occurs through two families of Ca2+ release channels (Ins(1,4,5)P3 receptors and ryanodine receptors). Ca2+ uptake into intracellular Ca2+ stores is energy-dependent and occurs through a family of Ca2+-ATPases (Sarco-Endoplasmic Reticulum Ca2+-ATPases=SERCA).

Keywords

Endoplasmic Reticulum Sarcoplasmic Reticulum Ryanodine Receptor Intracellular Store Store Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Karl-Heinz Krause

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