Calreticulin and Ca2+ Storage

  • Karl-Heinz Krause
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Ca2+ “stores” are intra-cellular compartments that are characterized by their high intra-luminal Ca2+ content, and by their participation in the regulation of cytosolic free Ca2+ concentration ([Ca2+]c) through rapid Ca2+ accumulation and release*. These Ca2+ stores, which are thought to reside either within the entire endoplasmic reticulum, within the rough endoplasmic reticulum, or within smooth-surfaced endoplasmic reticulum-subcompartments (for review see refs. 1–6) play a crucial role in stimulus response coupling. In resting cells, Ca2+ stores contain high concentrations of Ca2+. During cellular activation this stored Ca2+ is released into the cytosol. [Ca2+], is around 100 nM in resting cells, but may increase to micromolar levels as Ca2+ is released. The release of Ca2+ from intracellular stores occurs through two families of Ca2+ release channels (Ins(1,4,5)P3 receptors and ryanodine receptors). Ca2+ uptake into intracellular Ca2+ stores is energy-dependent and occurs through a family of Ca2+-ATPases (Sarco-Endoplasmic Reticulum Ca2+-ATPases=SERCA).


Endoplasmic Reticulum Sarcoplasmic Reticulum Ryanodine Receptor Intracellular Store Store Volume 
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© Springer-Verlag Berlin Heidelberg 1996

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  • Karl-Heinz Krause

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