Basic Characteristics and Ion Binding to Calreticulin

  • Shairaz Baksh
  • Marek Michalak
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Calreticulin is a protein that binds several different cations. In particular, this protein has been shown to have two distinct Ca2+ binding sites: a high capacity, low affinity site and a high affinity, low capacity site.1,2 Because of its high capacity for Ca2+ binding (>20 moles of Ca2+/mole of protein), it has been proposed that calreticulin may be a Ca2+ storage protein.3 This possibility is reviewed, in detail, in Chapter 5. However, in addition to this potential role in Ca2+ storage, several other diverse functions have been proposed for calreticulin (see other chapters in this book).4


Protein Disulfide Isomerase Schistosoma Mansoni Plasmic Reticulum Rabbit Skeletal Muscle Endoplasmic Reticulum Protein 
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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Shairaz Baksh
  • Marek Michalak

There are no affiliations available

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