Skip to main content

Physiologische Bedeutung von Calcium — Calcium-Antagonismus

  • Chapter
Calcium-Antagonisten

Zusammenfassung

Calciumionen (Ca2+) erfüllen im tierischen und menschlichen Organismus vielfältige Aufgaben; u.a. sind sie Kofaktoren von Enzymen bei der Blutgerinnung, Substrate im Knochenstoffwechsel sowie Träger der elektromechanischen Kopplung in Skelett- und Herzmuskel sowie in der glatten Muskelzelle (Antmann et al. 1980). Katz (1985c) unterscheidet strukturelle Funktionen von Calcium (z. B. im Knochen) und regulatorische Funktionen bei der Steuerung von Zellfunktionen, Berridge (1985) spricht sogar — in Anlehnung an cAMP — von Calcium als „second messenger“ (z. B. bei der elektromechanischen Kopplung oder der Insulinsekretion). Eine aktuelle Übersicht zum „calcium messenger system“ gibt Rasmussen (1986).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Referenzen

  • Adelstein RS (1983) Regulation of contractile proteins by phosphorylation. J Clin Invest 72: 1863–1866

    Article  PubMed  CAS  Google Scholar 

  • Antmann EM, Stone PH, Muller JE, Braunwald E (1980) Calcium channel blocking agents in the treatment of cardiovascular diseases Part I: Basic and clinical electrophysiologic effects Ann Intern Med 93: 875–885

    Article  Google Scholar 

  • Bayer R (1984) Grundprozesse der elektromechanischen Kopplung im Myokard In: Riecker G (ed) Herzinsuffizienz Springer Berlin pp 87–122

    Chapter  Google Scholar 

  • Berridge MJ (1985) Calcium: a universal second messenger Triangel 24: 79–90

    Google Scholar 

  • Braunwald E (1982) Mechanism of action of calcium channel blocking agents. N Engl J Med 307: 1618–1627

    Article  PubMed  CAS  Google Scholar 

  • Braunwald E, Sonnenblick EH, Ross J (1984) Contraction of the normal heart In: Braunwald E (ed) Heart disease — a textbook of cardiovascular medicine Saunders Philadelphia pp 409–446

    Google Scholar 

  • Burkart F, Heierli B (1984) Hämodynamik, Koronardurchblutung und Sauerstoffbedarf des normalen und insuffizienten Herzens In: Riecker G (ed) Herzinsuffizienz Springer Berlin pp 123–175

    Chapter  Google Scholar 

  • Carafoli E, Crompton M (1978) The regulation of intracellular calcium by mitochondria Ann NY Acad Sci 307: 269–284

    Article  PubMed  CAS  Google Scholar 

  • Carafoli E (1984) How calcium crosses plasma membranes including the sarcolemma In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 29–42

    Google Scholar 

  • Casteels R, Droogmanns G (1983) The role of calcium in contraction of vascular smooth muscle In: Stone PH, Antman EM (eds) Calcium channel blocking agents in the treatment of cardiovascular disorders Futura Press Mount Kisco pp 59–70

    Google Scholar 

  • Cohen CJ, Janis RA, Taylor DG, Scrabine A (1984) Where do calcium antagonists act? In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 151–164

    Google Scholar 

  • Dompert WU, Traber I (1984) Binding sites for dihydropyridine calcium antagonists In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 175–180

    Google Scholar 

  • Fabiato A, Fabiato F (1977) Calcium release from the sarcoplasmic reticulum Circ Res 40: 119–129

    Article  PubMed  CAS  Google Scholar 

  • Fabiato A, Fabiato F (1978) Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat and frog hearts and from fetal and newborn rat ventricles, Ann NY Acad Sci 307: 491–522

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein A (1971) Specific inhibitors and promotors of calcium action in the excitation — contraction coupling of heart muscle and the role in prevention or production of myocardial lesions In: Harris P, Opie LH (eds) Calcium and the heart Academic Press London pp 135–188

    Google Scholar 

  • Fleckenstein A (1980) Steuerung der myokardialen Kontraktilität, ATP-Spaltung, Atmungsintensität und Schrittmacherfunktion durch Calcium-Ionen — Wirkungsmechanismus der Calcium-Antagonisten In: Fleckenstein A, Roskamm H (eds) Calcium-Antagonismus Springer Berlin pp 1–27

    Chapter  Google Scholar 

  • Fleckenstein A (1982) Calcium-Antagonismus — ein neues Prinzip in der kardiovasculären Therapie In: Roskamm H, Reindell H (eds) Herzkrankheiten Springer Berlin pp 777–799

    Chapter  Google Scholar 

  • Fleckenstein A (1984) Calcium antagonism: history and prospects for a multifaceted pharmocodynamic principle In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 9–15

    Google Scholar 

  • Gevers W (1984a) The mechanisms of myocardial contraction in: Opie LH (ed) The heart Grune & Stratton London pp 98–107

    Google Scholar 

  • Gevers W (1984b) Calcium and the contractile mechanism in heart and smooth muscle In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 67–74

    Google Scholar 

  • Hopf R, Becker HJ, Kober G, Dowinsky S, Kaltenbach M (1982) Therapie der Angina pectoris mit Calcium-Antagonisten Herz 7: 221–234

    CAS  Google Scholar 

  • Katz AM, Reuter H (1979) Cellular calcium and cell death Am J Cardiol 44:188–190 (Editorial)

    Article  PubMed  CAS  Google Scholar 

  • Katz AM (1984) Calcium fluxes across the sarcoplasmatic reticulum In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 53–66

    Google Scholar 

  • Katz AM (1985a) Effects of digitalis on cell biochemistry: sodium pump inhibition J Am Coll Cardiol 5: 16 A

    Article  Google Scholar 

  • Katz AM, Hager WD, Messineo FC, Pappano AJ (1985b) Cellular actions and pharmacology of the calcium channel blocking drugs Am J Med 79 (Suppl 4 A): 2–10

    Article  CAS  Google Scholar 

  • Katz AM (1985c) Editorial Triangel 24: 75–78

    Google Scholar 

  • Krebs R (1984) Calcium antagonists: new vistas in theoretical basis and clinical use In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 347–358

    Google Scholar 

  • Lugnier C, Follenius A, Gerard D, Stocket JC (1984) Bepridil and flunarizine as calmodulin-inhibitors Eur J Pharmacol 98: 157–158

    Google Scholar 

  • Morad HJ, Tung L (1982) Jonic events responsible for the cardiac resting and action potential Am J Cardiol 49: 584–594

    Article  PubMed  CAS  Google Scholar 

  • Motulsky H J, Snavely MD, Hughes RJ, Insel PA (1983) Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2 adrenergic receptors Circ Res 52: 226–231

    Article  PubMed  Google Scholar 

  • Murphy RA, Gertshoffer WT (1984) Cell calcium and contractile system regulation in arterial smooth muscle In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 75–84

    Google Scholar 

  • Nayler WG, Horowitz DR (1983) Calcium antagonists: a new class of drugs. Pharmacol Ther 20: 203–262

    Article  PubMed  CAS  Google Scholar 

  • Nayler WG, Dillon JS, Dayly MJ (1984) Cellular sites of action of calcium antagonists and β-adrenoreceptor blockers In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 181–192

    Google Scholar 

  • Opie LH (1984) The heart Grune & Stratton London pp 40–87 und 230–260

    Google Scholar 

  • Opie LH, Nayler W, Gevers W (1984) Calcium fluxes In Opie LH (ed) The heart Grune & Stratton London pp 88–97

    Google Scholar 

  • Palmer JH, Worth PHL, Extan-Smith AN (1981) Flunarizine: a once-daily therapie for urinary incontinence, Lancet 2: 279–281

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen H (1986) The calcium messenger system N Engl J Med 314: 1094–1101 und 1164–1170

    Article  PubMed  CAS  Google Scholar 

  • Rosendorff C (1984) Calcium channel blockers and hypertension In: Opie LH (ed) Calcium antagonists cardiovascular disease Raven Press New York pp 323–332

    Google Scholar 

  • Schneider W, Bussmann WD, Kaltenbach M (1984) Aspekte zur Therapie von Herz-Kreislauf-Erkrankungen mit Calcium-Antagonisten und Betarezeptorenblockern Dtsch Ärztebl 81: 1349–1355

    Google Scholar 

  • Schrör K (1985) Physiologische Grundlagen, Pharmakologie und Prinzipien der klinischen Anwendung In: Hossmann V, Grötz J, Schrör K (eds) Kalzium Antagonisten und zerebrale Erkrankungen Springer Berlin pp 1–39

    Chapter  Google Scholar 

  • Singh BN, Josephson MA, Nademanee K (1984) Elektrophysiologische und hämodynamische Wirkungen von Calcium-Antagonisten: klinischer Überblick In: Althaus U, Burckhardt D Vogt E (eds) Calcium Antagonismus — Internat. Symposium on Calcium-Antagonism Universimed Frankfurt/Main pp 57–85

    Google Scholar 

  • Singh BN, Baky S, Nademanee K (1985) Second generation calcium antagonists: search for greater selectivity and versatility Am J Cardiol 55: 214B–221B

    Article  Google Scholar 

  • Snyder SH, Reynolds IJ (1985) Calcium antagonist drugs: receptor interactions that clarify therapeutic effects N Engl J Med 313: 995–1002

    Article  PubMed  CAS  Google Scholar 

  • Sperelakis N (1984) Properties of calcium-dependent slow action potentials: Their possible role in arrhythmias In: Opie LH (ed) Calcium antagonists and cardiovascular disease Raven Press New York pp 277–291

    Chapter  Google Scholar 

  • Tinkelman DG (1985) Calcium channel blocking agents in the prophylaxis of asthma Am J Med 78 (Suppl 2 B): 35–38

    Article  PubMed  CAS  Google Scholar 

  • Vanhoutte PM (1987) The expert committee of the world health organization on classification of calcium antagonists: the viewpoint of the raporteur Am J Cardiol 59: 3A–8A

    Article  Google Scholar 

  • Van Zwieten PA (1985) Calcium-Antagonisten — Terminologie, Klassifizierung und Vergleich Arzneimittelforschung 35 (I): 298–301

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lydtin, H., Trenkwalder, P. (1988). Physiologische Bedeutung von Calcium — Calcium-Antagonismus. In: Calcium-Antagonisten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06199-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06199-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18539-0

  • Online ISBN: 978-3-662-06199-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics